Uwe Kuhl

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Anti-viral treatment in patients with virus-induced cardiomyopathy
    U Kuhl
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite University Medicine Berlin, Germany
    Ernst Schering Res Found Workshop . 2006
  2. ncbi request reprint miRNA as activity markers in Parvo B19 associated heart disease
    U Kuhl
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Herz 37:637-43. 2012
  3. pmc Myocarditis: early biopsy allows for tailored regenerative treatment
    Uwe Kuhl
    Department of Cardiology and Pulmonology, Charite University Hospital, Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dtsch Arztebl Int 109:361-8. 2012
  4. doi request reprint Viral myocarditis: diagnosis, aetiology and management
    Uwe Kuhl
    Charite University Medicine Berlin, Medical Clinic II, Department of Cardiology and Pneumology, Campus Benjamin Franklin, Berlin, Germany
    Drugs 69:1287-302. 2009
  5. doi request reprint Prevalence of erythrovirus genotypes in the myocardium of patients with dilated cardiomyopathy
    U Kuhl
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite, Universitatsmedizin Berlin, Berlin, Germany
    J Med Virol 80:1243-51. 2008
  6. ncbi request reprint Antiviral treatment of myocarditis and acute dilated cardiomyopathy
    Uwe Kuhl
    Charite University Medicine Berlin, Berlin, Germany
    Heart Fail Clin 1:467-74. 2005
  7. ncbi request reprint Viral persistence in the myocardium is associated with progressive cardiac dysfunction
    Uwe Kuhl
    Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik II, Abteilung für Kardiologie und Pneumologie, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 112:1965-70. 2005
  8. ncbi request reprint High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction
    Uwe Kuhl
    Charite University Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 111:887-93. 2005
  9. doi request reprint Myocarditis in children
    Uwe Kuhl
    Department of Cardiology and Pneumology, University Medicine Berlin, Campus Benjamin Franklin, Medical Clinic II, Hindenburgdamm 30, Berlin 1210, Germany
    Heart Fail Clin 6:483-96, viii-ix. 2010
  10. ncbi request reprint Endothelium-dependent flow-mediated vasodilation of systemic arteries is impaired in patients with myocardial virus persistence
    Katja B Vallbracht
    Department of Cardiology, Charité Medical University, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 110:2938-45. 2004

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Anti-viral treatment in patients with virus-induced cardiomyopathy
    U Kuhl
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite University Medicine Berlin, Germany
    Ernst Schering Res Found Workshop . 2006
    ..The data also suggest that elimination of cardiotropic viruses and associated clinical effects may occur even in DCM patients presenting with a long history...
  2. ncbi request reprint miRNA as activity markers in Parvo B19 associated heart disease
    U Kuhl
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Herz 37:637-43. 2012
    ..Analyzing patients with latent and reactivated B19V infection, we found 29 differentially regulated miRNAs and, in order to test whether predicted genes are differentially expressed, selected mRNAs were tested by TaqMan-QPCR...
  3. pmc Myocarditis: early biopsy allows for tailored regenerative treatment
    Uwe Kuhl
    Department of Cardiology and Pulmonology, Charite University Hospital, Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dtsch Arztebl Int 109:361-8. 2012
    ..We present their clinical features, diagnostic evaluation, treatment, and prognosis on the basis of a selective review of the literature, current expert opinion, and our own clinical experience...
  4. doi request reprint Viral myocarditis: diagnosis, aetiology and management
    Uwe Kuhl
    Charite University Medicine Berlin, Medical Clinic II, Department of Cardiology and Pneumology, Campus Benjamin Franklin, Berlin, Germany
    Drugs 69:1287-302. 2009
    ....
  5. doi request reprint Prevalence of erythrovirus genotypes in the myocardium of patients with dilated cardiomyopathy
    U Kuhl
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite, Universitatsmedizin Berlin, Berlin, Germany
    J Med Virol 80:1243-51. 2008
    ..The erythrovirus genotype 2, not described previously in human heart tissue, is highly prevalent in the heart but the less prevalent genotype 1 is associated with more severe disturbed cardiac function...
  6. ncbi request reprint Antiviral treatment of myocarditis and acute dilated cardiomyopathy
    Uwe Kuhl
    Charite University Medicine Berlin, Berlin, Germany
    Heart Fail Clin 1:467-74. 2005
  7. ncbi request reprint Viral persistence in the myocardium is associated with progressive cardiac dysfunction
    Uwe Kuhl
    Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik II, Abteilung für Kardiologie und Pneumologie, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 112:1965-70. 2005
    ..Although adverse outcomes in dilated cardiomyopathy patients have been documented, the natural course of heart diseases caused by cardiotropic viruses is unknown...
  8. ncbi request reprint High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction
    Uwe Kuhl
    Charite University Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 111:887-93. 2005
    ....
  9. doi request reprint Myocarditis in children
    Uwe Kuhl
    Department of Cardiology and Pneumology, University Medicine Berlin, Campus Benjamin Franklin, Medical Clinic II, Hindenburgdamm 30, Berlin 1210, Germany
    Heart Fail Clin 6:483-96, viii-ix. 2010
    ....
  10. ncbi request reprint Endothelium-dependent flow-mediated vasodilation of systemic arteries is impaired in patients with myocardial virus persistence
    Katja B Vallbracht
    Department of Cardiology, Charité Medical University, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 110:2938-45. 2004
    ..Endothelial dysfunction in patients with cardiomyopathy is associated with inflammatory immunoresponses in myocardial biopsies. The aim of this study was to investigate the impact of myocardial virus persistence on endothelial function...
  11. ncbi request reprint Interferon-beta treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction
    Uwe Kuhl
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Freie Universitat Berlin, Germany
    Circulation 107:2793-8. 2003
    ..We investigated whether interferon (IFN)-beta therapy is safe and may achieve virus clearance and prevent deterioration of left ventricular (LV) function in patients with myocardial virus persistence...
  12. ncbi request reprint Parvovirus B19 infection mimicking acute myocardial infarction
    Uwe Kuhl
    Medical Clinic II, Department of Cardiology, University Hospital Benjamin Franklin, Berlin, Germany
    Circulation 108:945-50. 2003
    ..In the present study, we report on the association of parvovirus B19 (PVB19) genomes in the clinical setting of acute myocarditis...
  13. ncbi request reprint Differential aspects of endothelial function of the coronary microcirculation considering myocardial virus persistence, endothelial activation, and myocardial leukocyte infiltrates
    Katja B Vallbracht
    Charité Medical University Berlin, Campus Benjamin Franklin, Department of Cardiology, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 111:1784-91. 2005
    ..The aim of this study was to investigate the differential impact of myocardial virus persistence and inflammation on endothelial function of the coronary microcirculation...
  14. ncbi request reprint Immunohistological detection of Parvovirus B19 capsid proteins in endomyocardial biopsies from dilated cardiomyopathy patients
    Felicitas Escher
    Department of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    Med Sci Monit 14:CR333-338. 2008
    ..We investigated the detectability and the expression pattern of B19V proteins by immunohistology (IH) in endomyocardial biopsies (EMBs) from DCM patients, and its association with the standard proof of B19V genomes by nested PCR (nPCR...
  15. doi request reprint High leptin and resistin expression in chronic heart failure: adverse outcome in patients with dilated and inflammatory cardiomyopathy
    Peter Bobbert
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Eur J Heart Fail 14:1265-75. 2012
    ..Therefore, we performed for the first time a clinical study to elucidate the effects of leptin and resistin on progression of CHF in patients with non-ischaemic dilated (DCM) and inflammatory (DCMi) cardiomyopathy...
  16. ncbi request reprint Parvovirus B19 profiles in patients presenting with acute myocarditis and chronic dilated cardiomyopathy
    Felicitas Escher
    Department of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Med Sci Monit 14:CR589-97. 2008
    ....
  17. doi request reprint Expression of functional T-cell markers and T-cell receptor Vbeta repertoire in endomyocardial biopsies from patients presenting with acute myocarditis and dilated cardiomyopathy
    Michel Noutsias
    Department of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Eur J Heart Fail 13:611-8. 2011
    ..To quantify and functionally characterize the intramyocardial T-cells in endomyocardial biopsies (EMBs) from patients presenting with acute myocarditis (AMC) and dilated cardiomyopathy (DCM)...
  18. ncbi request reprint sICAM-1 correlates with myocardial ICAM-1 expression in dilated cardiomyopathy
    Michel Noutsias
    Department of Cardiology and Pneumonology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 1200 Berlin, Germany
    Int J Cardiol 91:153-61. 2003
    ..We investigated whether soluble ICAM-1 (sICAM-1) levels in the sera of DCM patients are associated with intramyocardial ICAM-1 expression...
  19. ncbi request reprint Viral heart disease: molecular diagnosis, clinical prognosis, and treatment strategies
    Matthias Pauschinger
    Department of Cardiology, Medical Clinic II, Charite, University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Med Microbiol Immunol 193:65-9. 2004
    ..Viral etiology of myocarditis and its contribution to the development of DCM have suggested antiviral therapy for myocarditis and DCM patients with proven viral infection...
  20. doi request reprint The management of myocarditis
    Heinz Peter Schultheiss
    Charite Hospital, Berlin, Germany
    Eur Heart J 32:2616-25. 2011
    ..We emphasize the gaps in our current clinical knowledge, particularly with respect to aetiology-based therapy, and suggest opportunities for high impact, translational investigations...
  21. ncbi request reprint Platelet activation is increased in patients with cardiomyopathy: myocardial inflammation and platelet reactivity
    Ulf Weikert
    Benjamin Franklin Hospital, Department of Cardiology, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Platelets 13:487-91. 2002
    ..001). In conclusion, platelet reactivity was increased in patients with cardiomyopathy and myocardial infiltrates. Measurement of platelet reactivity may be useful to identify patients with cardiomyopathy at risk for thrombotic events...
  22. pmc New echocardiographic findings correlate with intramyocardial inflammation in endomyocardial biopsies of patients with acute myocarditis and inflammatory cardiomyopathy
    Felicitas Escher
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Berlin, Germany
    Mediators Inflamm 2013:875420. 2013
    ..The diagnosis of acute myocarditis (AMC) and inflammatory cardiomyopathy (DCMi) can be difficult. Speckle tracking echocardiography with accurate assessments of regional contractility could have an outstanding importance for the diagnosis...
  23. doi request reprint Interferon beta modulates endothelial damage in patients with cardiac persistence of human parvovirus b19 infection
    Caroline Schmidt-Lucke
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Infect Dis 201:936-45. 2010
    ..In a phase 1 study, we investigated whether interferon beta reduced endothelial damage in patients with cardiac persistence of human parvovirus B19 (B19V) infection...
  24. ncbi request reprint [Antiviral therapy in viral heart disease]
    Matthias Pauschinger
    Medizinische Klinik II, Kardiologie, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin
    Herz 29:618-23. 2004
    ..g., beta-interferon) in the setting of randomized trials such as the BICC Study (Betaferon In Patients with Chronic Viral Cardiomyopathy)...
  25. ncbi request reprint Immunomodulatory treatment strategies in inflammatory cardiomyopathy: current status and future perspectives
    Michel Noutsias
    Department of Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Expert Rev Cardiovasc Ther 2:37-51. 2004
    ..However, dilated cardiomyopathy patients with viral persistence do not respond favorably to immunosuppression...
  26. doi request reprint Development of diastolic heart failure in a 6-year follow-up study in patients after acute myocarditis
    Felicitas Escher
    Department of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Heart 97:709-14. 2011
    ..The aim of this study was to analyse the long-term prognosis of patients with acute myocarditis (AMC) who had been discharged from hospital while having normal left ventricular (LV) function...
  27. pmc NS1 specific CD8+ T-cells with effector function and TRBV11 dominance in a patient with parvovirus B19 associated inflammatory cardiomyopathy
    Mathias Streitz
    Institute of Medical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 3:e2361. 2008
    ..Despite the importance of T-cells in antiviral defense, little is known about the role of B19V specific T-cells in this entity...
  28. doi request reprint Presence of perforin in endomyocardial biopsies of patients with inflammatory cardiomyopathy predicts poor outcome
    Felicitas Escher
    Department of Cardiology and Pneumology, CBF, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Heart Fail 16:1066-72. 2014
    ..However, the precise nature of immune system factors relevant for the prediction of long-term course remains elusive. The aim of this study was to analyse the prognostic relevance of perforin in a large cohort of patients with CMi...
  29. doi request reprint Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction
    Mario Kasner
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Am Coll Cardiol 57:977-85. 2011
    ..We attempted to correlate echocardiographic analysis of diastolic function with changes of myocardial collagen in middle-aged patients with heart failure (HF) despite normal ejection fraction (EF)...
  30. doi request reprint Complication rate of right ventricular endomyocardial biopsy via the femoral approach: a retrospective and prospective study analyzing 3048 diagnostic procedures over an 11-year period
    Matthias Holzmann
    Charité Center for Cardiovascular Diseases, Campus Benjamin Franklin, Berlin, Germany
    Circulation 118:1722-8. 2008
    ....
  31. doi request reprint Impact of myocardial inflammation on cytosolic and mitochondrial creatine kinase activity and expression
    Linda Ebermann
    Centrum 11, Cardiology, Charite, University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Basic Res Cardiol 104:247-57. 2009
    ..These changes may contribute to the progression of chronic inflammatory heart disease and malfunction of the heart...
  32. ncbi request reprint Long-term outcome of patients with virus-negative chronic myocarditis or inflammatory cardiomyopathy after immunosuppressive therapy
    Felicitas Escher
    Institute for Cardiac Diagnostics and Therapy IKDT, Berlin, Germany
    Clin Res Cardiol 105:1011-1020. 2016
    ..To analyze the long-term outcome after immunosuppressive treatment of patients with virus-negative chronic myocarditis or inflammatory cardiomyopathy (CMi)...
  33. ncbi request reprint Cardiac autoantibodies in viral myocarditis
    Andrea Dorner
    Charite University Medicine Berlin, Berlin, Germany
    Heart Fail Clin 1:333-43. 2005
  34. ncbi request reprint Endothelial dysfunction of peripheral arteries in patients with immunohistologically confirmed myocardial inflammation correlates with endothelial expression of human leukocyte antigens and adhesion molecules in myocardial biopsies
    Katja B Vallbracht
    University Hospital Benjamin Franklin, Department of Cardiology, Free University Berlin, Berlin, Germany
    J Am Coll Cardiol 40:515-20. 2002
    ..The aim of this study was to investigate whether myocardial inflammation (MC) and endothelial activation are associated with clinically detectable endothelial dysfunction...
  35. doi request reprint Chromosomally integrated human herpesvirus 6 in heart failure: prevalence and treatment
    Uwe Kuhl
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Heart Fail 17:9-19. 2015
    ..HHV-6 is integrated in the germline [chromosomically integrated HHV-6 (ciHHV-6)] in ∼0.8% of the human population. To date, the prevalence, species distribution, and treatment responses of ciHHV-6 are unknown for cardiac patients...
  36. doi request reprint Nicotinamide phosphoribosyltransferase/pre-B-cell colony enhancing factor/visfatin plasma levels and clinical outcome in patients with dilated cardiomyopathy
    Peter Bobbert
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Card Fail 21:330-8. 2015
    ..Therefore, we performed for the 1st time a clinical study to determine the effects of Nampt on cardiac function in patients with nonischemic dilated (DCM) and inflammatory (DCMi) cardiomyopathy...
  37. pmc Cardiac migration of endogenous mesenchymal stromal cells in patients with inflammatory cardiomyopathy
    Caroline Schmidt-Lucke
    Department of Cardiology, Charite University Medicine Berlin, Campus Benjamin Franklin, 12200 Berlin, Germany Berlin Brandenburg Center of Regenerative Therapies BCRT, 13353 Berlin, Germany Medico Academic Consultings MEDIACC, 14193 Berlin, Germany
    Mediators Inflamm 2015:308185. 2015
    ..73, P < 0.005). SDF-1α was the strongest predictor for increased MSC in EMB (P < 0.005, multivariate analysis). Conclusions. Endogenous MSC continuously migrate to the heart in patients with CMi triggered by cardiac inflammation. ..
  38. ncbi request reprint Autoimmunological features in inflammatory cardiomyopathy
    Angela Kallwellis-Opara
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik II, Abteilung für Kardiologie und Pneumologie, Hindenburgdamm 30, 12200 Berlin, Germany
    Clin Res Cardiol 96:469-80. 2007
    ....
  39. ncbi request reprint Cytotoxic perforin+ and TIA-1+ infiltrates are associated with cell adhesion molecule expression in dilated cardiomyopathy
    Michel Noutsias
    Department of Cardiology and Pneumonoly, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30 D 12200, Berlin, Germany
    Eur J Heart Fail 5:469-79. 2003
    ..To phenotypically characterize cytotoxic T-lymphocytes (CTLs: Perforin+ and TIA-1+ phenotypes) and to study the interactions with cell adhesion molecules (CAMs) in dilated cardiomyopathy (DCM)...
  40. ncbi request reprint Current insights into the pathogenesis, diagnosis and therapy of inflammatory cardiomyopathy
    Michel Noutsias
    Department of Cardiology and Pneumonology, University Hospital, Benjamin Franklin Free University of Berlin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Heart Fail Monit 3:127-35. 2003
    ....
  41. doi request reprint Increased plasma retinol binding protein 4 levels in patients with inflammatory cardiomyopathy
    Peter Bobbert
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Eur J Heart Fail 11:1163-8. 2009
    ..A complete understanding of the association of CHF and insulin resistance remains elusive. The purpose of this study was to examine the relationship between CHF and diabetes mellitus...
  42. doi request reprint Suspected chronic myocarditis at cardiac MR: diagnostic accuracy and association with immunohistologically detected inflammation and viral persistence
    Matthias Gutberlet
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, Charite, Campus Virchow Klinikum, Berlin, Germany
    Radiology 246:401-9. 2008
    ....
  43. ncbi request reprint The humoral immune response in viral heart disease: characterization and pathophysiological significance of antibodies
    Peter L Schwimmbeck
    Department of Internal Medicine Cardiology, Benjamin Franklin Hospital, Charite Medical School Berlin, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Med Microbiol Immunol 193:115-9. 2004
    ..However, the significance of the humoral immune responses needs to be tested in randomized, prospective studies using immunoadsorption of autoantibodies in patients with inflammatory cardiomyopathy...
  44. doi request reprint CCN1: a novel inflammation-regulated biphasic immune cell migration modulator
    Madlen Löbel
    Institute of Medical Immunology, Charite University Medicine Berlin, 13353, Berlin, Germany
    Cell Mol Life Sci 69:3101-13. 2012
    ....
  45. pmc Preamplification techniques for real-time RT-PCR analyses of endomyocardial biopsies
    Michel Noutsias
    Department of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, 12200 Berlin, Germany
    BMC Mol Biol 9:3. 2008
    ..We applied two preamplification techniques, the TaqMan(R) PreAmp Master Mix (T-PreAmp) and a multiplex preamplification following a sequence specific reverse transcription (SSRT-PreAmp)...
  46. pmc Magnetic resonance imaging findings in acute myocarditis and correlation with immunohistological parameters
    Rainer Röttgen
    Klinik fur Strahlenheilkunde, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Eur Radiol 21:1259-66. 2011
    ..To evaluate the role of MRI in diagnosing acute myocarditis by correlation with immunohistological parameters...
  47. doi request reprint Viral myocarditis
    Uwe Kuhl
    Medizinische Klinik für Kardiologie und Pulmologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Swiss Med Wkly 144:w14010. 2014
    ..These may allow a tailored cause-specific treatment that improves symptoms and prognosis of patients with acute and chronic disease. ..