Christian Kaps

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Effects of initial boost with TGF-beta 1 and grade of intervertebral disc degeneration on 3D culture of human annulus fibrosus cells
    Aldemar Andres Hegewald
    Department of Neurosurgery, University Medical Center Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    J Orthop Surg Res 9:73. 2014
  2. pmc Biomechanical testing of a polymer-based biomaterial for the restoration of spinal stability after nucleotomy
    Aldemar A Hegewald
    Department of Neurosurgery, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Orthop Surg Res 4:25. 2009
  3. pmc Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage
    David Pretzel
    Experimental Rheumatology Unit, Department of Orthopedics, University Hospital Jena, Klosterlausnitzer Str, 81, Eisenberg, D 07607, Germany
    Arthritis Res Ther 13:R64. 2011
  4. pmc Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results
    Peter C Kreuz
    Department of Orthopaedic and Trauma Surgery, University Medical Center Rechts der Isar of the Technical University Munich, Munich, Germany
    Arthritis Res Ther 11:R33. 2009
  5. pmc Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results
    Christian Ossendorf
    Department of Traumotology and Orthopaedic Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Arthritis Res Ther 9:R41. 2007
  6. pmc Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis
    Carsten P Bramlage
    Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Arthritis Res Ther 8:R58. 2006
  7. ncbi request reprint Human platelet supernatant promotes proliferation but not differentiation of articular chondrocytes
    C Kaps
    Department of Rheumatology, Charite, Medical Faculty of Humboldt University, Berlin, Germany
    Med Biol Eng Comput 40:485-90. 2002
  8. ncbi request reprint [Molecular characterization of tissue-engineered articular chondrocyte transplants based on resorbable polymer fleece]
    C Kaps
    Labor für Tissue Engineering, Experimentelle Rheumatologie und klinische Immunologie, Medizinische Fakultat, Humboldt Universitat, Charite, Berlin
    Orthopade 33:76-85. 2004
  9. ncbi request reprint Gene expression profiling of human articular cartilage grafts generated by tissue engineering
    Christian Kaps
    Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystr 2, 10117 Berlin, Germany
    Biomaterials 27:3617-30. 2006
  10. doi request reprint Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiation
    Tilo Dehne
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Gene 462:8-17. 2010

Collaborators

Detail Information

Publications55

  1. pmc Effects of initial boost with TGF-beta 1 and grade of intervertebral disc degeneration on 3D culture of human annulus fibrosus cells
    Aldemar Andres Hegewald
    Department of Neurosurgery, University Medical Center Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    J Orthop Surg Res 9:73. 2014
    ....
  2. pmc Biomechanical testing of a polymer-based biomaterial for the restoration of spinal stability after nucleotomy
    Aldemar A Hegewald
    Department of Neurosurgery, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Orthop Surg Res 4:25. 2009
    ..abstract:..
  3. pmc Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage
    David Pretzel
    Experimental Rheumatology Unit, Department of Orthopedics, University Hospital Jena, Klosterlausnitzer Str, 81, Eisenberg, D 07607, Germany
    Arthritis Res Ther 13:R64. 2011
    ..The present study therefore assessed the relative percentage and particularly the zonal distribution of cartilage MPC using the markers CD105/CD166...
  4. pmc Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results
    Peter C Kreuz
    Department of Orthopaedic and Trauma Surgery, University Medical Center Rechts der Isar of the Technical University Munich, Munich, Germany
    Arthritis Res Ther 11:R33. 2009
    ....
  5. pmc Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results
    Christian Ossendorf
    Department of Traumotology and Orthopaedic Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Arthritis Res Ther 9:R41. 2007
    ..The results suggest that implanting BioSeed-C is an effective treatment option for the regeneration of posttraumatic and/or osteoarthritic defects of the knee...
  6. pmc Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis
    Carsten P Bramlage
    Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Arthritis Res Ther 8:R58. 2006
    ..In comparison with previous reports, these data underline the complex impact of these factors on homeostasis and remodeling in joint physiology and pathology...
  7. ncbi request reprint Human platelet supernatant promotes proliferation but not differentiation of articular chondrocytes
    C Kaps
    Department of Rheumatology, Charite, Medical Faculty of Humboldt University, Berlin, Germany
    Med Biol Eng Comput 40:485-90. 2002
    ..Therefore platelet lysate may be suitable for chondrocyte expansion, but not for maturation of tissue-engineered cartilage...
  8. ncbi request reprint [Molecular characterization of tissue-engineered articular chondrocyte transplants based on resorbable polymer fleece]
    C Kaps
    Labor für Tissue Engineering, Experimentelle Rheumatologie und klinische Immunologie, Medizinische Fakultat, Humboldt Universitat, Charite, Berlin
    Orthopade 33:76-85. 2004
    ..Three-dimensional arrangement of human articular chondrocytes in resorbable polyglactin-polydioxanon fleeces supports chondrogenic differentiation and the formation of a hyaline-like cartilaginous matrix in vitro and in vivo...
  9. ncbi request reprint Gene expression profiling of human articular cartilage grafts generated by tissue engineering
    Christian Kaps
    Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystr 2, 10117 Berlin, Germany
    Biomaterials 27:3617-30. 2006
    ..Three-dimensional tissue culture of expanded articular chondrocytes initiates chondrocyte re-differentiation in vitro and leads to the maturation of cartilage grafts towards hyaline cartilage in vivo...
  10. doi request reprint Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiation
    Tilo Dehne
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Gene 462:8-17. 2010
    ..Cultivation longer than 6 weeks leads to progressing dedifferentiation of chondrocytes that should be considered on long-term evaluations...
  11. pmc Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration
    Kristin Andreas
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Arthritis Res Ther 11:R15. 2009
    ..This study aimed to disclose major mechanisms of antirheumatic drug action on human chondrocytes and to reveal marker and pharmacological target genes that are involved in cartilage dysfunction and regeneration...
  12. doi request reprint Human platelet-rich plasma stimulates migration and chondrogenic differentiation of human subchondral progenitor cells
    Jan Philipp Krüger
    TransTissue Technologies GmbH, Chariteplatz 1, 10117 Berlin, Germany
    J Orthop Res 30:845-52. 2012
    ..These results suggest that human PRP may enhance the migration and stimulate the chondrogenic differentiation of human subchondral progenitor cells known from microfracture...
  13. doi request reprint Migration potential and gene expression profile of human mesenchymal stem cells induced by CCL25
    Tabea Binger
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, CCM, Tucholskystr 2, 10117 Berlin, Germany
    Exp Cell Res 315:1468-79. 2009
    ..These results suggest CCL25 as a new potential candidate for further in situ regeneration approaches...
  14. ncbi request reprint BMP7 promotes adipogenic but not osteo-/chondrogenic differentiation of adult human bone marrow-derived stem cells in high-density micro-mass culture
    Katja Neumann
    TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
    J Cell Biochem 102:626-37. 2007
    ..These results suggest that BMP7 promotes the adipogenic and not the osteogenic or chondrogenic lineage development of human stem cells when assembled three-dimensionally in micro-masses...
  15. pmc Chondrogenic differentiation of human subchondral progenitor cells is affected by synovial fluid from donors with osteoarthritis or rheumatoid arthritis
    Jan Philipp Krüger
    TransTissue Technologies GmbH, Chariteplatz 1, 10117 Berlin, Germany
    J Orthop Surg Res 7:10. 2012
    ..The aim of our study was to investigate the effects of joint disease conditions on the in vitro chondrogenesis of human CSP...
  16. doi request reprint Human periosteum-derived progenitor cells express distinct chemokine receptors and migrate upon stimulation with CCL2, CCL25, CXCL8, CXCL12, and CXCL13
    Stefan Stich
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
    Eur J Cell Biol 87:365-76. 2008
    ..These results are promising towards in situ bone repair therapies based on guiding PCs to bone defects, and encourage further in vivo studies...
  17. doi request reprint Gene expression profiling of human mesenchymal stem cells chemotactically induced with CXCL12
    Stefan Stich
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
    Cell Tissue Res 336:225-36. 2009
    ..The obtained data provide further insights into the molecular mechanisms involved in chemotactic processes in cell migration and designate CXCL12 as a promising candidate for in situ recruitment in regenerative therapies...
  18. doi request reprint Chondrogenic differentiation capacity of human mesenchymal progenitor cells derived from subchondral cortico-spongious bone
    Katja Neumann
    TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
    J Orthop Res 26:1449-56. 2008
    ..CSP cells from subchondral bone, as known from microfracture, are multipotent stem cell-like mesenchymal progenitors with a high chondrogenic differentiation potential...
  19. doi request reprint Chemokine profile of human serum from whole blood: migratory effects of CXCL-10 and CXCL-11 on human mesenchymal stem cells
    Gregor Kalwitz
    TransTissue Technologies GmbH and Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Connect Tissue Res 51:113-22. 2010
    ..Therefore, human serum derived from whole blood contains chemokines that may contribute to serum-mediated recruitment of human mesenchymal progenitors from bone marrow...
  20. doi request reprint Chondrogenic differentiation of human mesenchymal stem cells in micro-masses is impaired by high doses of the chemokine CXCL7
    Gregor Kalwitz
    TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
    J Tissue Eng Regen Med 5:50-9. 2011
    ..These results suggest that low doses of CXCL7 do not impair the chondrogenic differentiation of bone marrow-derived stem cells and may suited for in situ cartilage tissue engineering...
  21. ncbi request reprint BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
    Bernhard Schmitt
    Tissue Engineering Laboratory, Department of Rheumatology, Medical Faculty Charité, Humboldt University of Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Differentiation 71:567-77. 2003
    ..These results suggest BMP2 as a promising candidate for tissue engineering approaches regenerating articular cartilage on the basis of mesenchymal progenitors from bone marrow...
  22. doi request reprint Intervertebral disc regeneration after implantation of a cell-free bioresorbable implant in a rabbit disc degeneration model
    Michaela Endres
    Department of Rheumatology, Tissue Engineering Laboratory, Charite Universitatsmedizin Berlin, Germany
    Biomaterials 31:5836-41. 2010
    ..In controls, repair tissue containing type II collagen was not evident. In conclusion, the implantation of polymer-based constructs after discectomy induces tissue regeneration resulting in improvement of the disc water content...
  23. doi request reprint Extracellular matrix expression of human tenocytes in three-dimensional air-liquid and PLGA cultures compared with tendon tissue: implications for tendon tissue engineering
    Christiane Stoll
    Department of Trauma and Reconstructive Surgery, Charité University of Medicine, Campus Benjamin Franklin, Berlin, Germany
    J Orthop Res 28:1170-7. 2010
    ..These results suggest that the 3D high-density or biodegradable scaffolds cultures encourage the differentiation of expanded monolayer tenocytes in vitro to tendon-like tissue...
  24. pmc Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study
    Kristin Andreas
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Arthritis Res Ther 10:R9. 2008
    ..Hence, the objective of this study was to establish a standardized in vitro model to profile the key regulatory molecules of RA-related destruction of cartilage that are expressed by human chondrocytes...
  25. doi request reprint Karyotyping of human chondrocytes in scaffold-assisted cartilage tissue engineering
    Marc Trimborn
    Institut für Medizinische Genetik und Humangenetik, Charite Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburgerplatz 1, 13353 Berlin, Germany
    Acta Biomater 8:1519-29. 2012
    ....
  26. doi request reprint Tissue-engineered cartilage of porcine and human origin as in vitro test system in arthritis research
    Axel R Göhring
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Dept of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, Berlin, Germany
    Biotechnol Prog 26:1116-25. 2010
    ..Therefore, we demonstrate that engineered cartilage of porcine and human origin represents a powerful in vitro model for cartilage in vivo...
  27. doi request reprint Chondrogenic differentiation of human subchondral progenitor cells is impaired by rheumatoid arthritis synovial fluid
    Jan Philipp Krüger
    TransTissue Technologies GmbH, Berlin, Germany
    J Orthop Res 28:819-27. 2010
    ..These results suggest that SF from RA patients may impair the chondrogenic development of mesenchymal progenitors in microfracture, whereas osteoarthritic SF may has no negative effect on the cartilage matrix formation...
  28. ncbi request reprint Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrow
    Michaela Endres
    TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
    J Orthop Res 25:1299-307. 2007
    ..0001). The chemotactic activity of SF obtained from normal donors and from patients with degenerative joint diseases suggests that SF may be actively involved in the migration of progenitors in cartilage defects after microfracture...
  29. ncbi request reprint Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2
    Jochen Ringe
    Tissue Engineering Laboratory, Department of Rheumatology, Charite University Medicine Berlin, Berlin, Germany
    J Cell Biochem 101:135-46. 2007
    ..In combination with already known data on MSC recruitment and differentiation these are promising results towards in situ regenerative medicine approaches based on guiding of MSC to sites of degenerated tissues...
  30. doi request reprint Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7
    Gregor Kalwitz
    TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
    Int J Biochem Cell Biol 41:649-58. 2009
    ..Pathway analysis suggests that recruitment of human MSC by CXCL7 is supported by the induction of ligands of the interleukin 8 receptors, synergistically activating the respective signaling pathways...
  31. doi request reprint Tissue-engineered polymer-based periosteal bone grafts for maxillary sinus augmentation: five-year clinical results
    Wolfram Trautvetter
    Laboratory for Tissue Engineering, Department of Rheumatology, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Oral Maxillofac Surg 69:2753-62. 2011
    ..Therefore, the aim of our study was to evaluate the long-term clinical repair effect of autologous periosteal bone grafts on atrophic maxillary bone...
  32. pmc An ovine in vitro model for chondrocyte-based scaffold-assisted cartilage grafts
    Michaela Endres
    TransTissue Technologies GmbH, Berlin, Germany
    J Orthop Surg Res 7:37. 2012
    ..The aim of our study was to evaluate the in vitro re-differentiation capacity of expanded ovine chondrocytes in biomechanically characterized polyglycolic acid (PGA)/fibrin biomaterials for scaffold-assisted cartilage repair...
  33. ncbi request reprint Stem cells for regenerative medicine: advances in the engineering of tissues and organs
    Jochen Ringe
    Department of Rheumatology, Medical Faculty Charité, Humboldt University of Berlin, Germany
    Naturwissenschaften 89:338-51. 2002
    ..Furthermore, several issues of importance, especially with regard to the clinical application of mesenchymal stem cells, are discussed...
  34. doi request reprint Regeneration of intervertebral disc tissue by resorbable cell-free polyglycolic acid-based implants in a rabbit model of disc degeneration
    Alexander Abbushi
    Department of Neurosurgery, Charite, Campus Virchow Klinikum, University Medicine of Berlin, Germany
    Spine (Phila Pa 1976) 33:1527-32. 2008
    ..In our one-step-approach, a resorbable cell-free polyglycolic acid (PGA)-based implant is immersed in serum from whole blood and implanted into the disc defect directly after discectomy...
  35. ncbi request reprint Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs
    Thomas Häupl
    Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystrasse 2, 10117 Berlin, Germany
    J Biomol Screen 12:328-40. 2007
    ..Synovial fibroblasts reflect the disease-related pathophysiology and are useful tools for screening putative antirheumatic compounds...
  36. doi request reprint Regeneration of nucleus pulposus tissue in an ovine intervertebral disc degeneration model by cell-free resorbable polymer scaffolds
    Christian Woiciechowsky
    Tissue Engineering Laboratory, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Germany Spine Centre Berlin, Germany
    J Tissue Eng Regen Med 8:811-20. 2014
    ..In conclusion, implantation of cell-free polymer-based implants after nucleotomy induces nucleus pulposus tissue regeneration and improves disc water content in the ovine model...
  37. doi request reprint Suitability of porcine chondrocyte micromass culture to model osteoarthritis in vitro
    Niels Schlichting
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies BCRT, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    Mol Pharm 11:2092-105. 2014
    ..In conclusion, the porcine micromass model represents an alternative tissue platform for the evaluation of innovative substances and techniques for the treatment of OA. ..
  38. ncbi request reprint Porcine mesenchymal stem cells. Induction of distinct mesenchymal cell lineages
    Jochen Ringe
    Department of Rheumatology, University Medical Center, Charite, The Humboldt University of Berlin, Germany
    Cell Tissue Res 307:321-7. 2002
    ..Therefore, porcine MSC may be introduced as a valuable model system with which to study the mesenchymal lineages for basic research and tissue engineering...
  39. ncbi request reprint Changes in the gene expression pattern of cytokeratins in human respiratory epithelial cells during culture
    Michaela Endres
    Tissue Engineering Laboratory, University Medical Center Charite, Tucholskystr 2, 10117 Berlin, Germany
    Eur Arch Otorhinolaryngol 262:390-6. 2005
    ..Our results suggest that culture-expanded hREC have the potential to colonize collagen-coated biomaterials and to regenerate epithelial cell types for tracheal tissue engineering...
  40. doi request reprint Repair of focal cartilage defects with scaffold-assisted autologous chondrocyte grafts: clinical and biomechanical results 48 months after transplantation
    Peter C Kreuz
    Department of Orthopaedic Surgery, University Medical Center Rostock, Rostock, Germany
    Am J Sports Med 39:1697-705. 2011
    ..Scaffold-assisted autologous chondrocyte implantation is a clinically effective procedure for cartilage repair, but biomechanical evaluations are still missing...
  41. doi request reprint Human platelet-rich plasma induces chondrogenic differentiation of subchondral progenitor cells in polyglycolic acid-hyaluronan scaffolds
    Jan Philipp Krüger
    TransTissue Technologies GmbH, Chariteplatz 1, 10117, Berlin, Germany
    J Biomed Mater Res B Appl Biomater 102:681-92. 2014
    ..The results suggest that PRP induces chondrogenic differentiation of progenitor cells in PGA-HA scaffolds and may be therefore beneficial in scaffold-assisted cartilage repair approaches involving stem and progenitor cells...
  42. doi request reprint Identification of fibronectin as a major factor in human serum to recruit subchondral mesenchymal progenitor cells
    Rebecca Kulawig
    TransTissue Technologies GmbH, Chariteplatz 1, 10117 Berlin, Germany
    Int J Biochem Cell Biol 45:1410-8. 2013
    ..This study shows that fibronectin is a key factor in human serum to recruit mesenchymal progenitor cells and might be involved in subchondral mesenchymal progenitor cell migration into cartilage defects after microfracture...
  43. doi request reprint Bone repair by cell-seeded 3D-bioplotted composite scaffolds made of collagen treated tricalciumphosphate or tricalciumphosphate-chitosan-collagen hydrogel or PLGA in ovine critical-sized calvarial defects
    Kathrin Haberstroh
    Department of Rheumatology, Tissue Engineering Laboratory, Charite University Medical Center Berlin, Berlin, Germany
    J Biomed Mater Res B Appl Biomater 93:520-30. 2010
    ....
  44. ncbi request reprint Tissue engineering of bone for mandibular augmentation in immunocompetent minipigs: preliminary study
    Andreas Groger
    Interdisciplinary Laboratory for Tissue Engineering, Charite, Humboldt University Berlin, Berlin, Germany
    Scand J Plast Reconstr Surg Hand Surg 37:129-33. 2003
    ..1 (range 2-3). In contrast, the control group (n = 2) scored 1 and 2. The results show that a combination of periosteal cells and polymer fleeces may be a promising approach for clinical mandibular augmentation...
  45. doi request reprint The chemokines CXCL10 and XCL1 recruit human annulus fibrosus cells
    Aldemar A Hegewald
    Department of Neurosurgery, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Spine (Phila Pa 1976) 37:101-7. 2012
    ..Human annulus fibrosus tissue and cells were analyzed for the presence of chemokine receptors and the migratory effect of selected chemokines...
  46. doi request reprint Initial boost release of transforming growth factor-β3 and chondrogenesis by freeze-dried bioactive polymer scaffolds
    Jan Philipp Krüger
    TransTissue Technologies GmbH, Chariteplatz 1, 10117, Berlin, Germany
    Ann Biomed Eng 42:2562-76. 2014
    ..These results suggest that bio-activated, freeze-dried TGFB3-PGA scaffolds have chondrogenic potential and are a promising tool for stem cell-mediated cartilage regeneration. ..
  47. doi request reprint Fibronectin stimulates migration and proliferation, but not chondrogenic differentiation of human subchondral progenitor cells
    Richard Horst Kalkreuth
    TransTissue Technologies GmbH, Chariteplatz 1, 10117 Berlin, Germany
    Regen Med 9:759-73. 2014
    ..To evaluate the impact of human plasma-derived fibronectin (FN) on human subchondral mesenchymal progenitor cells regarding cell migration, proliferation, and chondrogenic differentiation...
  48. ncbi request reprint Treatment of articular cartilage defects in horses with polymer-based cartilage tissue engineering grafts
    Dirk Barnewitz
    Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany
    Biomaterials 27:2882-9. 2006
    ....
  49. ncbi request reprint Elastic cartilage engineering using novel scaffold architectures in combination with a biomimetic cell carrier
    Dietmar W Hutmacher
    Division of Bioengineering, Faculty of Engineering and Department of Orthopaedics, National University of Singapore, E3 05 15 10 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 24:4445-58. 2003
    ..Hence, future experiments will be designed to evaluate an initial 3D culture of chondrocytes, effect on cell phenotype and their subsequent culture within biomimetic 3D scaffold/cell constructs...
  50. ncbi request reprint Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction
    Christian Kaps
    Charite University Hospital, Humboldt University of Berlin, Germany
    Arthritis Rheum 46:149-62. 2002
    ..Therefore, this study was undertaken to investigate the potential of bone morphogenetic proteins (BMPs) in chondrocyte differentiation using current technologies of tissue engineering...
  51. ncbi request reprint Mechanical testing of fixation techniques for scaffold-based tissue-engineered grafts
    Sven Knecht
    Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
    J Biomed Mater Res B Appl Biomater 83:50-7. 2007
    ..Our findings serve as basis for selecting the most suitable fixation technique for scaffold-based tissue-engineered grafts according to the expected in vivo loads...
  52. ncbi request reprint Regeneration of ovine articular cartilage defects by cell-free polymer-based implants
    Christoph Erggelet
    Department of Traumatology and Orthopaedic Surgery, University of Freiburg, Hugstetter Street 55, 79106 Freiburg, Germany
    Biomaterials 28:5570-80. 2007
    ....
  53. ncbi request reprint The T-box transcription factor Brachyury mediates cartilage development in mesenchymal stem cell line C3H10T1/2
    Andrea Hoffmann
    Osteo Angiogenesis Group, Gesellschaft fur Biotechnologische Forschung GBF, Mascheroder Weg 1, 38124 Braunschweig, Germany
    J Cell Sci 115:769-81. 2002
    ..5 d.p.c.) of murine embryonic development...
  54. ncbi request reprint Development of a high-throughput screening assay based on the 3-dimensional pannus model for rheumatoid arthritis
    Yvonne Ibold
    Department of Bioprocess Engineering, Institute of Biotechnology, Technical University of Berlin, Germany
    J Biomol Screen 12:956-65. 2007
    ..In addition, automated cell seeding and media exchange increased the efficiency due to a reduction of labor intensity and handling time...
  55. ncbi request reprint Distinct roles of BMP receptors Type IA and IB in osteo-/chondrogenic differentiation in mesenchymal progenitors (C3H10T1/2)
    Christian Kaps
    Signaling and Gene Regulation, Gesellschaft fur Biotechnologische Forschung, Braunschweig, Germany
    Biofactors 20:71-84. 2004
    ..In addition this indicates that type IB and IA BMP receptors may transmit different signals during the specification and differentiation of mesenchymal lineages...