Sven Jonas

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Extended resections of liver metastases from colorectal cancer
    S Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, University Medicine, Augustenburger Platz 1, 13353, Berlin, Germany
    World J Surg 31:511-21. 2007
  2. ncbi request reprint [Acute liver failure--surgical approach]
    S Jonas
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin
    Praxis (Bern 1994) 95:1878-80. 2006
  3. ncbi request reprint Extended indications in living-donor liver transplantation: bile duct cancer
    Sven Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Transplantation 80:S101-4. 2005
  4. ncbi request reprint Surgical resection of colorectal metastases
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University of Berlin, Berlin, Germany
    Front Radiat Ther Oncol 38:94-9. 2004
  5. ncbi request reprint Increased mortality after liver transplantation for hepatocellular carcinoma in hepatitis B-associated cirrhosis
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Transpl Int 16:33-6. 2003
  6. ncbi request reprint Primary immunosuppression with tacrolimus after liver transplantation: 12-years follow-up
    S Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Virchow Klinikum, University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Int Immunopharmacol 5:125-8. 2005
  7. ncbi request reprint Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis in a European center
    Sven Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, University Medicine Berlin, Germany
    Liver Transpl 13:896-903. 2007
  8. doi request reprint Influence of donor- and recipient-specific factors on the postoperative course after combined pancreas-kidney transplantation
    Peter Thomas Fellmer
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow, Berlin, Germany
    Langenbecks Arch Surg 395:19-25. 2010
  9. doi request reprint Salvage therapy for relapsed posttransplant lymphoproliferative disorders (PTLD) with a second progression of PTLD after Upfront chemotherapy: the role of single-agent rituximab
    Ralf U Trappe
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transplantation 84:1708-12. 2007
  10. doi request reprint Oncological superiority of hilar en bloc resection for the treatment of hilar cholangiocarcinoma
    Peter Neuhaus
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow, Berlin, Germany
    Ann Surg Oncol 19:1602-8. 2012

Detail Information

Publications88

  1. ncbi request reprint Extended resections of liver metastases from colorectal cancer
    S Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, University Medicine, Augustenburger Platz 1, 13353, Berlin, Germany
    World J Surg 31:511-21. 2007
    ..Indications for resection of liver metastases from colorectal cancer and surgical strategies are still under debate...
  2. ncbi request reprint [Acute liver failure--surgical approach]
    S Jonas
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin
    Praxis (Bern 1994) 95:1878-80. 2006
    ..The most important prognostic parameters are the severity of multi organ failures and the degree of encephalopathy prior to transplantation. However, long-term survival thereafter is mostly excellent...
  3. ncbi request reprint Extended indications in living-donor liver transplantation: bile duct cancer
    Sven Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Transplantation 80:S101-4. 2005
    ..Living donor liver transplantation may be beneficial in selected patients suffering from Klatskin tumors, whereas caution should prevail when considering intrahepatic cholangiocarcinoma...
  4. ncbi request reprint Surgical resection of colorectal metastases
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University of Berlin, Berlin, Germany
    Front Radiat Ther Oncol 38:94-9. 2004
  5. ncbi request reprint Increased mortality after liver transplantation for hepatocellular carcinoma in hepatitis B-associated cirrhosis
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Transpl Int 16:33-6. 2003
    ..22%; P<0.05). This difference was due to unspecific causes, not to tumor recurrence or re-infection. These findings may be indicative of a more complicated course in patients suffering from hepatitis B in general...
  6. ncbi request reprint Primary immunosuppression with tacrolimus after liver transplantation: 12-years follow-up
    S Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Virchow Klinikum, University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Int Immunopharmacol 5:125-8. 2005
    ..An increased number of de novo malignancies in the ciclosporin-based group may be attributable to the use of ATG as induction therapy...
  7. ncbi request reprint Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis in a European center
    Sven Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, University Medicine Berlin, Germany
    Liver Transpl 13:896-903. 2007
    ..So far, the outcome of the patients is in favor of a careful extension of the selection criteria for HCC in cirrhosis...
  8. doi request reprint Influence of donor- and recipient-specific factors on the postoperative course after combined pancreas-kidney transplantation
    Peter Thomas Fellmer
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow, Berlin, Germany
    Langenbecks Arch Surg 395:19-25. 2010
    ..Pancreas transplantation is associated with postoperative complications. We defined and identified donor- and recipient-specific factors related to postoperative complications...
  9. doi request reprint Salvage therapy for relapsed posttransplant lymphoproliferative disorders (PTLD) with a second progression of PTLD after Upfront chemotherapy: the role of single-agent rituximab
    Ralf U Trappe
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transplantation 84:1708-12. 2007
    ..Single-agent rituximab salvage therapy is an effective treatment option in this setting of intensively pretreated patients, with virtually no therapy-associated toxicity...
  10. doi request reprint Oncological superiority of hilar en bloc resection for the treatment of hilar cholangiocarcinoma
    Peter Neuhaus
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow, Berlin, Germany
    Ann Surg Oncol 19:1602-8. 2012
    ..The present study was conducted to analyze its oncological effectiveness compared to conventional hepatectomy...
  11. doi request reprint Microvessel density correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma
    Armin Thelen
    Department of General, Visceral and Transplantation Surgery, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Gastroenterol 43:959-66. 2008
    ..The present study was conducted to analyze tumor-associated neovascularization in hilar cholangiocarcinoma and to determine its influence on tumor growth, metastasis, recurrence, and prognosis...
  12. doi request reprint Eighteen years of liver transplantation experience in patients with advanced Budd-Chiari syndrome
    Frank Ulrich
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow Clinical Centre, Berlin, Germany
    Liver Transpl 14:144-50. 2008
    ..In conclusion, patients with reversible hepatic damage should be treated by combined strategies, including medical therapy and surgical or interventional shunting...
  13. doi request reprint Radiofrequency ablation prior to liver transplantation: focus on complications and on a rare but severe case
    Robert M Eisele
    Department of General, Visceral and Transplantation Surgery, Charite Virchow Clinic, Berlin, Germany
    Clin Transplant 22:20-8. 2008
    ..Complications are thought to be rare and mostly self-limiting. By contrast, we report on a life-threatening complication and discuss it in the context of other complications...
  14. ncbi request reprint Hepatic resection in liver transplant recipients: single center experience and review of the literature
    Olaf Guckelberger
    Department of General, Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany olaf
    Am J Transplant 5:2403-9. 2005
    ..In conclusion, partial graft hepatectomy can be considered a safe and beneficial procedure in selected liver transplant recipients with anatomical limited biliary injury, thereby, preserving scarce donor organs...
  15. doi request reprint Nonresponse to pre-operative chemotherapy does not preclude long-term survival after liver resection in patients with colorectal liver metastases
    Ulf P Neumann
    Department of General, Visceral, and Transplantation Surgery, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Surgery 146:52-9. 2009
    ..The aim of the study was to identify risk factors for poor outcome in patients with pre-operative chemotherapy of CRM...
  16. ncbi request reprint Salvage chemotherapy for refractory and relapsed posttransplant lymphoproliferative disorders (PTLD) after treatment with single-agent rituximab
    Ralf Trappe
    1Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transplantation 83:912-8. 2007
    ..This retrospective analysis was undertaken to determine the efficacy and safety of salvage therapy in recipients of solid organ transplants with progression of PTLD after rituximab first-line therapy...
  17. ncbi request reprint Validation of cardiovascular risk scores in a liver transplant population
    Olaf Guckelberger
    Department of General, Visceral and Transplantation Surgery, Charité Campus Vichow Klinikum, Berlin, Germany
    Liver Transpl 12:394-401. 2006
    ..Furthermore, calibrated PROCAM risk estimates are required to calculate the number of patients needed to treat in the setup of prospective intervention trials...
  18. ncbi request reprint Prognostic significance of the DNA-index in liver transplantation for hepatocellular carcinoma in cirrhosis
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, University Medicine Berlin, Berlin, Germany
    Ann Surg 250:1008-13. 2009
    ..This study was conducted to evaluate the prognostic significance of the tumor DNA index in patients receiving liver transplantation for hepatocellular carcinoma (HCC) in cirrhosis...
  19. doi request reprint VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma
    Armin Thelen
    Department of General, Visceral and Transplantation Surgery, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Int J Cancer 122:2471-81. 2008
    ..In conclusion, our study suggests that expression of VEGF-D is involved in growth and lymphatic spread of HCC. Therefore, VEGF-D might represent a therapeutic target in HCC...
  20. doi request reprint Long-term outcome of liver resection and transplantation for Caroli disease and syndrome
    Frank Ulrich
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow Clinical Centre, Berlin, Germany
    Ann Surg 247:357-64. 2008
    ....
  21. ncbi request reprint Retrograde reperfusion via vena cava lowers the risk of initial nonfunction but increases the risk of ischemic-type biliary lesions in liver transplantation--a randomized clinical trial
    Christoph Heidenhain
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow, Universitatsmedizin Berlin, Berlin, Germany
    Transpl Int 19:738-48. 2006
    ..053). Retrograde reperfusion seemed to be beneficial for hepatocytes, but was detrimental for the biliary epithelium. The unexplained increased incidence of ITBL after retrograde reperfusion will be focus of further investigation...
  22. ncbi request reprint Intrahepatic cholangiocarcinoma: indication for transplantation
    Andreas Pascher
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie CharitE, Campus Virchow Klinikum der Humboldt Universität zu Berlin, Augustenburgerplatz 1, 13353 Berlin, Germany
    J Hepatobiliary Pancreat Surg 10:282-7. 2003
    ..A discussion of the role of liver transplantation (LTx) for intrahepatic (IH)-CCC will be presented, based on a review of the international literature...
  23. ncbi request reprint Surgical management of proximal bile duct cancer: extended right lobe resection increases resectability and radicality
    Peter Neuhaus
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Charite, Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Langenbecks Arch Surg 388:194-200. 2003
    ..Surgical resection provides the only chance of cure for patients suffering from hilar cholangiocarcinoma. Although appropriate procedures are not agreed upon, an increase in radicality has been observed during the past 20 years...
  24. doi request reprint Extended liver resection for intrahepatic cholangiocarcinoma: A comparison of the prognostic accuracy of the fifth and sixth editions of the TNM classification
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charité Universitaetsmedzin Berlin, Germany
    Ann Surg 249:303-9. 2009
    ..The present study was conducted to analyze the outcome after liver resection for intrahepatic cholangiocarcinoma (IHC) and to compare the prognostic accuracy of the fifth and sixth editions of the TNM classification of malignant tumors...
  25. doi request reprint Distinct temporospatial expression patterns of glycolysis-related proteins in human hepatocellular carcinoma
    Katjana Daskalow
    Medizinische Klink mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Histochem Cell Biol 132:21-31. 2009
    ..In summary, we believe our analysis warrants the validation of glycolytic inhibitors as innovative treatment approaches of human HCC...
  26. doi request reprint Extended bile duct resection and [corrected] liver and transplantation in patients with hilar cholangiocarcinoma: long-term results
    Daniel Seehofer
    Department of General, Visceral, and Transplant Surgery, Charite Campus Virchow, Berlin, Germany
    Liver Transpl 15:1499-507. 2009
    ..To further improve the results, other approaches such as (neo)adjuvant therapy have to be increasingly investigated...
  27. ncbi request reprint Liver resection for metastases from breast cancer
    Armin Thelen
    Department of General, Visceral and Transplantation Surgery, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Surg Oncol 97:25-9. 2008
    ..This study was conducted to clarify safety and effectiveness of hepatectomy in this conditions and to identify selection criteria for patients suitable for liver resection...
  28. doi request reprint Tumor-associated lymphangiogenesis correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma
    Armin Thelen
    Department of General, Visceral and Transplantation Surgery, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Ann Surg Oncol 15:791-9. 2008
    ..Currently, nothing is known about the impact of lymphangiogenesis on progression and prognosis in hilar cholangiocarcinoma...
  29. ncbi request reprint Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation--a randomized, double-blind trial
    Nada Rayes
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Am J Transplant 5:125-30. 2005
    ..Early enteral nutrition supplemented with a mixture of LAB and fibers reduces bacterial infection rates following liver transplantation. Treatment with only fibers led to a low incidence of severe infections...
  30. ncbi request reprint Simultaneous versus staged liver resection of synchronous liver metastases from colorectal cancer
    Armin Thelen
    Department of General, Visceral and Transplant Surgery, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Colorectal Dis 22:1269-76. 2007
    ..This retrospective analysis was conducted to compare the postoperative outcome and survival of patients receiving simultaneous resection of liver metastases and primary colorectal cancer to those receiving staged resection...
  31. ncbi request reprint Human hepatocytes are protected from ethanol-induced cytotoxicity by DADS via CYP2E1 inhibition
    Masashi Shimada
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow, Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Toxicol Lett 163:242-9. 2006
    ..Our data show that DADS reduces ethanol-induced toxicity in human hepatocytes by reducing CYP2E1 activity and/or stabilizing the cellular GSH content, which might be of therapeutic interest...
  32. pmc Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth
    Guido Schumacher
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, Berlin 13353, Germany
    World J Gastroenterol 11:1420-5. 2005
    ..The purpose is to assess the effect on tumor growth of the immuno-suppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma...
  33. ncbi request reprint Epstein-Barr viral load in whole blood of adults with posttransplant lymphoproliferative disorder after solid organ transplantation does not correlate with clinical course
    Stephan Oertel
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Ann Hematol 85:478-84. 2006
    ..We conclude that in adult patients with PTLD, EBV load does not correlate with treatment response and is not suitable as a predictive marker for PTLD relapse...
  34. ncbi request reprint Increasing applicability of liver transplantation for patients with hepatitis B-related liver disease
    Thomas Steinmuller
    Department of General, Visceral, and Transplant Surgery, Charite Campus Virchow, Humboldt University of Berlin, Berlin, Germany
    Hepatology 35:1528-35. 2002
    ..Based on our experience, hepatitis B patients, including those with active viral replication, should not be excluded from liver transplantation...
  35. pmc Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature
    Antonino Spinelli
    Department of Ge neral, Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    World J Gastroenterol 12:2293-6. 2006
    ..Clinicians should include XGC among the possible differential diagnoses of masses in liver hilum...
  36. ncbi request reprint Changing impact of cytomegalovirus in liver transplantation -- a single centre experience of more than 1000 transplantations without ganciclovir prophylaxis
    Daniel Seehofer
    Department of General, Visceral and Transplant Surgery, Humboldt University of Berlin, Berlin, Germany
    Transpl Int 18:941-8. 2005
    ..As D+R- patients still more often develop symptomatic disease, pre-emptive therapy could be useful in this patient group...
  37. ncbi request reprint Harm from seat belt: transthoracic lung herniation and pericardial rupture
    Christoph Benckert
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow, Universitatsmedizin Berlin, Berlin, Germany
    J Thorac Cardiovasc Surg 133:588-9. 2007
  38. ncbi request reprint Effects of human hepatocyte growth factor on the proliferation of human hepatocytes and hepatocellular carcinoma cell lines
    Ekaterina A Efimova
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Eur Surg Res 36:300-7. 2004
    ..The aim of this study was to clarify the role of HGF in the regeneration of human hepatocyte and the growth of residual hepatocellular carcinoma cells after liver resection...
  39. ncbi request reprint [Living donor liver transplantation from the perspective of the donor: results of a psychosomatic investigation]
    Marc Walter
    Medizinische Klinik mit Schwerpunkt Psychosomatik der Charité, Berlin, Germany
    Z Psychosom Med Psychother 51:331-45. 2005
    ..The aims were to describe the clinical problems before and after transplantation and to contribute to the discussion of ethical issues based on empirical findings...
  40. ncbi request reprint Transforming growth factor beta 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells
    Christoph Benckert
    Department of General Visceral and Transplantation Surgery, Charite, Humboldt University, 13353 Berlin, Germany
    Cancer Res 63:1083-92. 2003
    ..These data suggest that overexpression and functional interaction of TGF-beta 1 and VEGF might contribute to the "angiogenic switch" and the malignant phenotype in human CCC...
  41. ncbi request reprint DNA analysis of cholangiocarcinoma cells: prognostic and clinical importance
    Hassan Abou-Rebyeh
    Department of Internal Medicine, Hepatology and Gastroenterology, Humboldt University, Charite, Berlin, Germany
    Cancer Detect Prev 26:313-9. 2002
    ..DNA ploidy reflecting irregularities of chromosome number and content might be an alternative predictor. In this study, we evaluated the DNA ploidy as a prognostic factor for survival of patients after resection of cholangiocarcinoma...
  42. ncbi request reprint Liver transplantation for hepatocellular carcinoma in cirrhosis: prognostic parameters
    C Benckert
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Transplant Proc 37:1693-4. 2005
    ..Exeptions from the morphometric rules may be justified for patients with HCC in cirrhosis who show well or moderately differentiated tumors with vascular invasion...
  43. ncbi request reprint Radical surgery for hilar cholangiocarcinoma
    S Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Surg Oncol 34:263-71. 2008
    ..A substantial drop out rate from this neoadjuvant regimen due to tumor progression or treatment related complications is still a problem...
  44. ncbi request reprint microRNA signatures in peripheral blood fail to detect acute cellular rejection after liver transplantation
    Nathanael Raschzok
    a Department of General, Visceral, and Transplantation Surgery, Experimental Surgery and Regenerative Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Biomarkers . 2016
    ..We investigated whether microRNA signatures in whole blood samples are associated with acute cellular rejection (ACR) after liver transplantation...
  45. ncbi request reprint Microscopic tumor cell dissemination in gastric cancer
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, D 13353, Berlin, Germany
    Surg Today 34:101-6. 2004
    ..We herein investigate such dissemination, predominantly restricted to the subserosa, in patients with gastric cancer...
  46. ncbi request reprint The impact of immune-activating processes following transplantation on chronic allograft nephropathy
    Christoph Heidenhain
    Department of General and Transplantation Surgery Charité Campus Virchow Clinic, Berlin, Germany
    Kidney Int 64:1125-33. 2003
    ..However, only very little information is presently available on the influence of systemic immune-activating processes following organ engraftment...
  47. ncbi request reprint A survival-based scoring-system for initial graft function following orthotopic liver transplantation
    Michael Heise
    Department of Surgery, Humboldt University of Berlin, Charite, Augustenburger Platz 1, 13353, Berlin, Germany
    Transpl Int 16:794-800. 2003
    ..We can conclude that the presented refined scoring-system for initial graft function provides a significant correlation to patient survival and initial non-function. We recommend the refined system for future studies...
  48. ncbi request reprint [Transplantation and liver resection for hepatocellular carcinoma in cirrhosis]
    C Benckert
    Klinik fUr Allgemein, Universitatsmedizin Berlin
    Dtsch Med Wochenschr 130:S245-7. 2005
  49. ncbi request reprint Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis
    S Jonas
    Department of General Surgery, Humboldt University, Berlin, Germany
    Hepatology 33:1080-6. 2001
    ..Tumor diameter and number of nodules in correlation with the histopathologic grading were predictive of a vascular invasion only in HCC larger than 5 cm...
  50. ncbi request reprint First results from a prospective randomized trial comparing steroid-free induction therapy with tacrolimus and MMF versus tacrolimus and steroids in patients after liver transplantation for HCV
    J M Langrehr
    Department of Surgery, Charite, Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Transplant Proc 34:1565-6. 2002
  51. ncbi request reprint Grafts from elderly donors elicit a stronger immune response in the early period posttransplantation: a study in a rat model
    A Reutzel-Selke
    Department of General and Transplantation Surgery, University of Medicine Berlin, Charite, Virchow Clinic, Berlin, Germany
    Transplant Proc 37:382-3. 2005
    ..Older grafts elicit a stronger immune response during the early period posttransplantation. This process is associated with an increased immunogenicity in older grafts. Clinical immunosuppressive protocols need to consider these effects...
  52. ncbi request reprint Salvage chemotherapy for refractory or relapsed post-transplant lymphoproliferative disorder in patients after solid organ transplantation with a combination of carboplatin and etoposide
    Stephan H Oertel
    Humboldt Universitat Berlin, Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Berlin, Germany
    Br J Haematol 123:830-5. 2003
    ....
  53. ncbi request reprint Heme oxygenase-1 protects human hepatocytes in vitro against warm and cold hypoxia
    Eda Tuzuner
    Department of General, Visceral, and Transplantation Surgery, Universitatsmedizin Berlin, Campus Virchow, Germany
    J Hepatol 41:764-72. 2004
    ..Hepatic injury induced by ischemia/reperfusion following surgery, transplantation, or circulatory shock combined with resuscitation is a major clinical problem...
  54. ncbi request reprint Liver transplantation and diabetes mellitus
    T H Steinmüller
    Department of Surgery, Charite Virchow Clinic, Humboldt University Berlin, Germany
    Exp Clin Endocrinol Diabetes 108:401-5. 2000
    ..Development of new onset insulin-requiring PTDM could be an important prognostic factor for patient survival after oLT. Further investigations are necessary to evaluate the prognostic meaning of PTDM and the pathophysiologic mechanisms...
  55. ncbi request reprint Diabetes mellitus is no independent risk factor for perioperative mortality following hepatic resection
    O Guckelberger
    Charite Campus Virchow Klinikum, Department of General, Visceral and Transplantation Surgery, Berlin, Germany
    Exp Clin Endocrinol Diabetes 114:257-61. 2006
    ....
  56. ncbi request reprint Liver transplantation for recurrent hepatocellular carcinoma in Europe
    S Jonas
    Department of General, Visceral and Transplantation Surgery, , Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    J Hepatobiliary Pancreat Surg 8:422-6. 2001
    ..Adult living donor liver transplantation is one way to overcome graft shortage. Other strategies, for example, salvage transplantation, are presented...
  57. ncbi request reprint Cyclosporine-based quadruple induction therapy versus tacrolimus-based dual immunosuppression after liver transplantation: ten-year follow-up
    S Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Transplant Proc 34:1504-6. 2002
  58. ncbi request reprint Combination prophylaxis with Hepatitis B immunoglobulin and lamivudine after liver transplantation minimizes HBV recurrence rates unless evolution of pretransplant lamivudine resistance
    D Seehofer
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow, Humboldt University of Berlin, Germany
    Z Gastroenterol 40:795-9. 2002
    ..Due to viral escape mutations recurrence still occurs, but recently a combination prophylaxis with hepatitis B immunoglobuline plus lamivudine is evaluated in transplant centers in terms of a further reduction of recurrence rates...
  59. doi request reprint Liver resection for metastatic gastric cancer
    A Thelen
    Departmant of General, Visceral and Transplantation Surgery, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Eur J Surg Oncol 34:1328-34. 2008
    ..This study was conducted to evaluate the safety and effectiveness of liver resection in these conditions and to identify criteria for the selection of suitable patients...
  60. ncbi request reprint Early cellular markers for the prediction of chronic graft deterioration in a retransplantation model
    S G Tullius
    Department of General and Transplantation Surgery, Charite, Virchow Clinic, Berlin, Germany
    Transplant Proc 34:2357-8. 2002
  61. ncbi request reprint Review article: liver transplantation for hepatocellular carcinoma
    T Steinmuller
    Department of Visceral and Transplantation Surgery, Charite, Campus Virchow Klinikum, Berlin, Germany
    Aliment Pharmacol Ther 17:138-44. 2003
    ..Other selection criteria are under investigation. Studies on multimodal therapy are also underway but have not yet demonstrated a clear benefit...
  62. ncbi request reprint Changes in serum levels of growth factors in healthy individuals after living related liver donation
    E A Efimova
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow Clinic, University Medicine, Berlin, Germany
    Transplant Proc 37:1074-5. 2005
    ....
  63. ncbi request reprint Contribution of prolonged ischemia and donor age to chronic renal allograft dysfunction
    S G Tullius
    Department of Surgery, Charite Virchow Clinic, Berlin, Germany
    J Am Soc Nephrol 11:1317-24. 2000
    ..Donor age and duration of ischemia act in a synergistic manner in our model. Brief ischemic times seem of particular relevance when grafts from older donors are being used...
  64. ncbi request reprint Transabdominal ligation of the thoracic duct as treatment of choice for postoperative chylothorax after esophagectomy
    G Schumacher
    Department of General, Visceral, and Transplantation Surgery, Humboldt University, Charite Campus Virchow Klinikum, Berlin, Germany
    Dis Esophagus 20:19-23. 2007
    ..Discharge from hospital, after ligation of the thoracic duct, was possible after a median time of 18 days (11-52). Ligation of the thoracic duct via relaparotomy appeared to be a simple and safe method to treat postoperative chylothorax...
  65. ncbi request reprint Magnetic resonance imaging including magnetic resonance cholangiopancreatography for tumor localization and therapy planning in malignant hilar obstructions
    E L Hanninen
    Department of Radiology, Charite Medical University Center, Campus Virchow Clinic, Berlin, Germany
    Acta Radiol 46:462-70. 2005
    ..To assess image quality and overall accuracy of magnetic resonance imaging (MRI), including two magnetic cholangiopancreatography (MRCP) techniques, for the diagnostics and preoperative work-up of malignant hilar obstructions...
  66. ncbi request reprint Brain death activates donor organs and is associated with a worse I/R injury after liver transplantation
    S Weiss
    Department of Surgery, Charite, Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
    Am J Transplant 7:1584-93. 2007
    ..Based on our clinical data, we demonstrate that brain death and the events that precede it are associated with a significant upregulation of inflammatory cytokines and lead to a worse ischemia/reperfusion injury after transplantation...
  67. ncbi request reprint Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD)
    S H K Oertel
    University Medicine of Berlin, Charite Campus Virchow Clinic, Department of Internal Medicine, Berlin, Germany
    Am J Transplant 5:2901-6. 2005
    ..Two patients relapsed, at intervals 3 and 5 months after obtaining complete remission. Rituximab proved to be well tolerated and effective in the treatment of PTLD...
  68. ncbi request reprint Complication rate of pancreas retransplantation after simultaneous pancreas-kidney transplantation compared with pancreas after kidney transplantation
    P Fellmer
    Klinik f Allgemein, Visceral und Transplantationschirurgie, Charité Berlin Campus Virchow Klinikum, Berlin, Germany
    Transplant Proc 39:563-4. 2007
    ..The study despite the small number of cases shows a high complication rate after pancreas retransplantation. Nevertheless, pancreatic retransplantation should be considered in selected patients...
  69. ncbi request reprint Liver resection for metastases from renal cell carcinoma
    Armin Thelen
    Departmant of General, Visceral and Transplantation Surgery, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Berlin, Germany
    World J Surg 31:802-7. 2007
    ..This study was conducted to evaluate the safety and efficacy of liver resection in patients with hepatic metastases from renal cell carcinoma and to identify selection criteria for patients suitable for resection...
  70. ncbi request reprint Living related liver transplantation: preoperative magnetic resonance imaging for assessment of hepatic vasculature of donor candidates
    F Streitparth
    Department of Radiology, Charite Medical University Center, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Acta Radiol 48:20-6. 2007
    ..To evaluate the accuracy of magnetic resonance angiography (MRA) for preoperative assessment of hepatic vascular anatomy in liver donors before living related liver transplantation...
  71. ncbi request reprint Adult living donor liver transplantation: living donation of the right liver lobe
    J Mittler
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Langenbecks Arch Surg 392:657-62. 2007
    ..In European and North American countries, LDLT for adult recipients is mainly performed with right lobe grafts. Indications, when compared to deceased donor liver transplantation, are controversial...
  72. ncbi request reprint Repeat liver resection for recurrent liver metastases from colorectal cancer
    A Thelen
    Departmant of General, Visceral and Transplantation Surgery, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Surg Oncol 33:324-8. 2007
    ..This study was conducted to clarify safety and effectiveness of this treatment and to identify prognostic factors of a favourable outcome after repeat hepatectomy...
  73. ncbi request reprint [Resection and reconstruction of the retrohepatic vena cava in combination with liver resections]
    U Settmacher
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Campus Virchow Klinikum, Charite, Humboldt Universitat zu Berlin
    Zentralbl Chir 130:104-8. 2005
    ..We were able to achieve a long-term survival for surgically treated patients even in cases with advanced tumor stages...
  74. doi request reprint Management of esophageal perforations
    Sven Christian Schmidt
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Surg Endosc 24:2809-13. 2010
    ..Esophageal perforations remain a life-threatening event requiring rapid diagnosis and treatment. Surgical repair and interventional endoscopic or conservative treatment are the common treatment methods...
  75. ncbi request reprint Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth
    G Schumacher
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Transplant Proc 34:1392-3. 2002
  76. ncbi request reprint Surgical treatment of a leiomyosarcoma of the inferior vena cava involving the hepatic and renal veins confluences: technical aspects
    A Spinelli
    Department of General, Visceral and Transplantation Surgery, Charite Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Surg Oncol 34:831-5. 2008
  77. ncbi request reprint Significant reduction of proinflammatory cytokines by treatment of the brain-dead donor
    O Kuecuek
    Deutsche Stiftung Organtransplantation, DSO Berlin Brandenburg, Berlin, Germany
    Transplant Proc 37:387-8. 2005
    ..Furthermore, it is unknown whether donor treatment can reduce the up-regulation of proinflammatory cytokines and thereby optimize organ quality...
  78. doi request reprint CD44 and CXCL9 serum protein levels predict the risk of clinically significant allograft rejection after liver transplantation
    Nathanael Raschzok
    General, Visceral, and Transplantation Surgery, Experimental Surgery and Regenerative Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Liver Transpl 21:1195-207. 2015
    ..Our results suggest that CD44 and CXCL9 may serve as predictive biomarkers to identify liver allograft recipients at risk for clinically significant ACR...
  79. pmc Independent effects of sham laparotomy and anesthesia on hepatic microRNA expression in rats
    Wiebke Werner
    General, Visceral, and Transplantation Surgery, Experimental Surgery and Regenerative Medicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    BMC Res Notes 7:702. 2014
    ..As control groups, non-treated rats and rats undergoing anesthesia only were used...
  80. ncbi request reprint Liver transplantation for treatment of intrahepatic Osler's disease: first experiences
    R Pfitzmann
    Department of General, Visceral, and Transplantation Surgery, , Campus Virchow-Klinikum, Humboldt-University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Transplantation 72:237-41. 2001
    ..Our therapeutic regimen of early liver transplantation in the case of intrahepatic Osler's disease in four patients has promising results...
  81. ncbi request reprint Liver transplantation in patients with advanced Budd-Chiari syndrome
    F Ulrich
    Department of General, Visceral and Transplantation Surgery, Charite, Virchow Clinic, Humboldt University, Berlin, Germany
    Transplant Proc 34:2278. 2002
  82. pmc Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological surgery: a review and meta-analysis of published data
    Christian von Heymann
    Department of Anesthesiology and Intensive Care Medicine, Charite University Medicine Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Augustenburger Platz 1, 13353 Berlin, Germany
    Crit Care 12:R14. 2008
    ..The purpose of this study was to determine the role of recombinant activated factor VII (rFVIIa) in abdominal, vascular, and urological surgery...
  83. ncbi request reprint Identification of early antigen BZLF1/ZEBRA protein of Epstein-Barr virus can predict the effectiveness of antiviral treatment in patients with post-transplant lymphoproliferative disease
    Stephan H Oertel
    Hämatologie und Onkologie, Universitätsklinikum Charite Campus Virchow, Humboldt Universitat Berlin, Berlin, Germany
    Br J Haematol 118:1120-3. 2002
    ..Response of PTLD to antiviral treatment correlated with the expression of lytic phase antigen BZLF1/ZEBRA protein, an early antigen of lytic EBV-activity, in the biopsied PTLD specimens...
  84. ncbi request reprint Therapy of Caroli's disease by orthotopic liver transplantation
    F Ulrich
    Department of General, Visceral and Transplantation Surgery, Charite, Virchow Clinic, Humboldt University, Berlin, Germany
    Transplant Proc 34:2279-80. 2002
  85. ncbi request reprint Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation
    J Peter A Lodge
    St James s University Hospital, Leeds, UK
    Liver Transpl 11:973-9. 2005
    ..In conclusion, use of rFVIIa during OLT significantly reduced the number of patients requiring RBC transfusion. There was no increase in thromboembolic events with rFVIIa administration compared with placebo...
  86. ncbi request reprint Recombinant coagulation factor VIIa in major liver resection: a randomized, placebo-controlled, double-blind clinical trial
    J Peter A Lodge
    St James s University Hospital, Hospital Haute Pierre, Strasbourg, France
    Anesthesiology 102:269-75. 2005
    ..The authors conducted a randomized, placebo-controlled, double-blind trial to evaluate the hemostatic effect and safety of recombinant factor VIIa (rFVIIa) in major partial hepatectomy...
  87. ncbi request reprint The perspective of liver transplantation for cholangiocarcinoma
    Sven Jonas
    Liver Transpl 13:1358-61. 2007
  88. ncbi request reprint Outcomes of liver transplantation in 490 patients with hepatocellular carcinoma: validation of a uniform staging after surgical treatment
    Jean Nicolas Vauthey
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 204:1016-27; discussion 1027-8. 2007
    ....