Affiliation: Humboldt University
- Prospective study on the mismatch concept in acute stroke patients within the first 24 h after symptom onset - 1000Plus studyBenjamin Hotter
Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
BMC Neurol 9:60. 2009..Primary endpoint of the study is infarct growth determined by imaging, secondary endpoints are neurological deficit on day 5-7 and functional outcome after 3 months...
- Natural course of total mismatch and predictors for tissue infarctionBenjamin Hotter
From the Center for Stroke Research Berlin, Charite University Hospital Berlin, Germany
Neurology 85:770-5. 2015..We longitudinally assessed patients presenting with total mismatch and hypothesized that hypoperfusion intensity ratio (HIR), severity of stroke, and occlusion of blood vessel are predictors of tissue fate...
- Validity of negative high-resolution diffusion-weighted imaging in transient acute cerebrovascular eventsBenjamin Hotter
Department of Neurology, Charite University Hospital Berlin, Berlin, Germany
Stroke 44:2598-600. 2013..We attempted to quantify the rate of false-negative high-resolution (hr) DWI and to identify a valid screening tool to guide follow-up MRI to diagnose infarction initially not visible on hrDWI...
- Search for a map and threshold in perfusion MRI to accurately predict tissue fate: a protocol for assessing lesion growth in patients with persistent vessel occlusionIvana Galinovic
Center for Stroke Research Berlin CSB, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
Cerebrovasc Dis 32:186-93. 2011..The goal of our study was to find a minimally biased yet maximally useful perfusion postprocessing protocol which would offer the treating physician a useful estimate of tissue fate...
- The potential of microvessel density in prediction of infarct growth: a two-month experimental study in vessel size imagingChao Xu
Center for Stroke Research Berlin, Charite University Medicine Berlin, Berlin, Germany
Cerebrovasc Dis 33:303-9. 2012..As a follow-up study, we assessed these parameters for microscopic description of ischemic penumbra and their potentials in predicting lesion growth...
- Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI softwareIvana Galinovic
Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
BMC Med Imaging 12:16. 2012..The goal of our study was to compare the performances of these approaches...
- Relative FLAIR Signal Intensities over Time in Acute Ischemic Stroke: Comparison of Two MethodsAnn Christin Ostwaldt
Center for Stroke Research Berlin CSB, Charite Universitatsmedizin Berlin, Germany
J Neuroimaging 25:964-8. 2015..We compared two published methods for calculation of relative FLAIR signal intensities (rSI) regarding their association with time from symptom onset in a longitudinal fashion...
- Fully automated postprocessing carries a risk of substantial overestimation of perfusion deficits in acute stroke magnetic resonance imagingIvana Galinovic
Center for Stroke Research Berlin, Charite University Medicine Berlin, Germany
Cerebrovasc Dis 31:408-13. 2011..We tested the hypothesis that existing software solutions, on account of numerous artifacts, produce hypoperfused tissue even in a cohort of patients with no ischemia...
- Early time course of FLAIR signal intensity differs between acute ischemic stroke patients with and without hyperintense acute reperfusion markerAnn Christin Ostwaldt
Center for Stroke Research Berlin CSB, Charite Universitatsmedizin Berlin, Berlin, Germany
Cerebrovasc Dis 37:141-6. 2014..However, the time course of the leakage is unknown and difficult to study in human patients. Also, the association of HARM with signal intensities and enhancement in the parenchyma on FLAIR images has not been thoroughly researched...
- Reliability of Two Diameters Method in Determining Acute Infarct Size. Validation as New Imaging BiomarkerJochen B Fiebach
Center for Stroke Research Berlin CSB, Department of Neurology, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
PLoS ONE 10:e0140065. 2015..In this study, we compared volumetric measurements of DWI hyperintensity to a simple maximum orthogonal diameter approach to identify thresholds indicating infarct size >70 ml and >100 ml...
- Hyperintense acute reperfusion marker on FLAIR is not associated with early haemorrhagic transformation in the elderlyMichal Rozanski
Department of Neurology, Center for Stroke Research Berlin CSB, Charite, Universitatsmedizin Berlin, Berlin, Germany
Eur Radiol 20:2990-6. 2010..The hyperintense acute reperfusion marker (HARM) has been described as a predictor for haemorrhagic transformation (HT) in acute ischaemic stroke. We hypothesised that this phenomenon is not present in the elderly...
- Impact of selection criteria on recruitment in an interventional stroke trialBenjamin Hotter
Center for Stroke Research, Charite University Hospital Berlin, Berlin, Germany
Cerebrovasc Dis 36:344-50. 2013..We proposed that slight modifications to inclusion criteria might augment recruitment without causing selection bias...