Steffen Hauptmann

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi Adhesion and migration of HRT-18 colorectal carcinoma cells on extracellular matrix components typical for the desmoplastic stroma of colorectal adenocarcinomas
    Steffen Hauptmann
    Institutes of Pathology, Charité Hospital Berlin, Berlin, Germany
    Oncology 65:174-81. 2003
  2. ncbi Fatal atypical T-cell proliferation associated with Epstein-Barr virus infection
    S Hauptmann
    Institute of Pathology and Department of Rheumatology, Charité Hospital Berlin, and Institute of Pathology, University Erlangen, Erlangen, Germany
    Br J Haematol 112:377-80. 2001
  3. ncbi Regulation of cell growth and the expression of extracellular matrix proteins in colorectal adenocarcinoma: a fibroblast-tumor cell coculture model to study tumor-host interactions in vitro
    Steffen Hauptmann
    Institute of Pathology, Charité Hospital Berlin, Berlin, Germany
    Eur J Cell Biol 82:1-8. 2003
  4. ncbi Serous tumors of low malignant potential of the ovary-molecular pathology: part 2
    S Hauptmann
    Institute of Pathology, Charite Hospital, Humboldt University Berlin, Germany
    Virchows Arch 438:539-51. 2001
  5. ncbi Uterine tumor resembling ovarian sex-cord tumor--a case report and review of the literature
    S Hauptmann
    Institute of Pathology, Charité Hospital Berlin, Germany
    Virchows Arch 439:97-101. 2001
  6. ncbi A thermodynamic interpretation of malignancy: do the genes come later?
    S Hauptmann
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Med Hypotheses 58:144-7. 2002
  7. ncbi Cytokine-suppressive anti-inflammatory drugs (CSAIDs) inhibit invasion and MMP-1 production of ovarian carcinoma cells
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    Cancer Lett 195:101-9. 2003
  8. ncbi Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression
    Carsten Denkert
    Institute of Pathology and Department of Gynecology and Obstetrics, Charite Hospital, Berlin, Germany
    Cancer Res 64:189-95. 2004
  9. ncbi Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Clin Cancer Res 10:5580-6. 2004
  10. ncbi Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
    Frank Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Halle Saale, Germany
    Int J Cancer 117:469-75. 2005

Detail Information

Publications73

  1. ncbi Adhesion and migration of HRT-18 colorectal carcinoma cells on extracellular matrix components typical for the desmoplastic stroma of colorectal adenocarcinomas
    Steffen Hauptmann
    Institutes of Pathology, Charité Hospital Berlin, Berlin, Germany
    Oncology 65:174-81. 2003
    ..g. at the tumor-host interface of colorectal carcinomas, can be attributed to environmental modifications...
  2. ncbi Fatal atypical T-cell proliferation associated with Epstein-Barr virus infection
    S Hauptmann
    Institute of Pathology and Department of Rheumatology, Charité Hospital Berlin, and Institute of Pathology, University Erlangen, Erlangen, Germany
    Br J Haematol 112:377-80. 2001
    ..The remarkable features of this case are (i) the occurrence in a Caucasian patient, (ii) the absence of detectable immunodeficiency, and (iii) the myocardial destruction by EBV-infected monoclonal T cells...
  3. ncbi Regulation of cell growth and the expression of extracellular matrix proteins in colorectal adenocarcinoma: a fibroblast-tumor cell coculture model to study tumor-host interactions in vitro
    Steffen Hauptmann
    Institute of Pathology, Charité Hospital Berlin, Berlin, Germany
    Eur J Cell Biol 82:1-8. 2003
    ..The analogies with ECM components expressed in cocultures and colorectal adenocarcinoma samples suggest that the coculture model used in this study is useful to study tumor cell-fibroblast interactions...
  4. ncbi Serous tumors of low malignant potential of the ovary-molecular pathology: part 2
    S Hauptmann
    Institute of Pathology, Charite Hospital, Humboldt University Berlin, Germany
    Virchows Arch 438:539-51. 2001
    ..In questionable cases, the loss of N-cadherin would argue for the presence of a carcinoma whereas the coexpression of p21 and MDM2 is rather characteristic for SLMP tumors...
  5. ncbi Uterine tumor resembling ovarian sex-cord tumor--a case report and review of the literature
    S Hauptmann
    Institute of Pathology, Charité Hospital Berlin, Germany
    Virchows Arch 439:97-101. 2001
    ..It is thus questionable whether the same prognostic criteria apply for these tumors as for endometrial stromal sarcomas. However, in the so-called mixed UTROSCT, the endometrial stromal sarcoma component determines the outcome...
  6. ncbi A thermodynamic interpretation of malignancy: do the genes come later?
    S Hauptmann
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Med Hypotheses 58:144-7. 2002
    ..Cancer could be seen as a reaction of a cell to entrap energy which reduces entropy, or, in other words, cancer may best be regarded as entropic devolution...
  7. ncbi Cytokine-suppressive anti-inflammatory drugs (CSAIDs) inhibit invasion and MMP-1 production of ovarian carcinoma cells
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    Cancer Lett 195:101-9. 2003
    ..Further studies are required to investigate whether inhibition of cytokine-induced signal transduction may be of value in therapy of ovarian carcinomas in-vivo...
  8. ncbi Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression
    Carsten Denkert
    Institute of Pathology and Department of Gynecology and Obstetrics, Charite Hospital, Berlin, Germany
    Cancer Res 64:189-95. 2004
    ..In addition, it would be interesting to investigate the prognostic role of increased cytoplasmic expression of HuR in prospective studies...
  9. ncbi Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Clin Cancer Res 10:5580-6. 2004
    ..Cell culture studies have shown that the mRNA of cyclooxygenase (COX)-2 can be stabilized by HuR...
  10. ncbi Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
    Frank Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Halle Saale, Germany
    Int J Cancer 117:469-75. 2005
    ..In summary, our data indicate that both the overexpression of the HDMX-S transcript as well as HDMX gene amplification are important prognostic markers for STS...
  11. ncbi Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Int J Cancer 102:507-13. 2002
    ..Further studies are needed to determine whether MKP-1 expression is a clinically useful marker to estimate patient prognosis as well as the response to chemotherapy...
  12. ncbi Hepsin is highly over expressed in and a new candidate for a prognostic indicator in prostate cancer
    Carsten Stephan
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    J Urol 171:187-91. 2004
    ..We quantitatively analyzed hepsin gene expression with real-time polymerase chain reaction and calculated its relationships with clinicopathological parameters in a large cohort of samples...
  13. doi Association of HDM2 transcript levels with age of onset and prognosis in soft tissue sarcomas
    Helge Taubert
    Institute of Pathology, Faculty of Medicine, University Halle Wittenberg, Magdeburger Strasse 14, D 06097 Halle Saale, Germany
    Mol Cancer Res 6:1575-81. 2008
    ....
  14. ncbi Influence of various cytokines on adhesion and migration of the colorectal adenocarcinoma cell line HRT-18
    Martin Köbel
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Oncology 68:33-9. 2005
    ..Therefore, different degrees of invasiveness at the tumor-host interface are not necessarily related to specific genetic alterations but might be related to different environmental conditions as well...
  15. ncbi Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference
    Carsten Denkert
    1Institute of Pathology, Charite Hospital, Humboldt University, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    Oncogene 22:8653-61. 2003
    ..Furthermore, our results suggest that cell cycle arrest is one of the primary mechanisms responsible for the antiproliferative effects of NS-398 on ovarian carcinoma cells...
  16. ncbi Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Cancer 97:2978-87. 2003
    ....
  17. pmc CD24 is expressed in ovarian cancer and is a new independent prognostic marker of patient survival
    Glen Kristiansen
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Am J Pathol 161:1215-21. 2002
    ..Our data suggest that the expression of CD24 as detected by immunohistochemistry is a new independent molecular marker for shortened survival time of patients with epithelial ovarian carcinomas...
  18. ncbi An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Clin Exp Metastasis 19:79-85. 2002
    ..Inhibitors of p38MAPK may be promising substances to interfere with a signaling cascade associated with invasion of malignant tumor cells...
  19. ncbi Ribozyme to TGF-beta1 mRNA abrogates immunosuppressive effects of human colorectal adenocarcinoma HRT-18 cells in vitro and in vivo
    Wolfgang Daniel Schmitt
    Institute of Pathology, Martin Luther University, 06097 Halle, Germany
    Int J Oncol 35:901-8. 2009
    ..Thus, a gene-therapeutic approach using anti-TGF-beta1 ribozyme in combination with established anti-tumor agents is of great promise...
  20. ncbi Epithelial hyaluronic acid and CD44v6 are mutually involved in invasion of colorectal adenocarcinomas and linked to patient prognosis
    Martin Köbel
    Institute of Pathology, Martin Luther University Halle Wittenberg, Magdeburger Strasse 14, 06097 Halle, Germany
    Virchows Arch 445:456-64. 2004
    ..This stimulation was partly reversed by an anti-CD44v6 antibody. Our findings suggest that the adverse prognostic effect of CD44v6 in colorectal adenocarcinoma might be restricted to those tumors that have pericellular HA...
  21. ncbi Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas
    Martin Köbel
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Mod Pathol 19:581-7. 2006
    ..0-5.4, P = 0.047). Hence, elevated ezrin expression is a new independent prognostic marker in FIGO stage I endometrioid carcinoma, and thus provides further evidence for an important role of ezrin in tumor progression...
  22. ncbi Quantitative analysis of kallikrein 15 gene expression in prostate tissue
    Carsten Stephan
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    J Urol 169:361-4. 2003
    ..We quantitatively measured and compared gene expression of KLK15 in malignant and benign prostate tissues...
  23. ncbi Genetic alterations in epithelial ovarian tumors analyzed by comparative genomic hybridization
    Steffen Hauptmann
    Institute of Pathology and Department of Gynecology and Obstetrics, Charité Hospital Berlin, Germany
    Hum Pathol 33:632-41. 2002
    ..On the other hand, there are common genetic abnormalities in serous and nonserous carcinomas, suggesting that they have very early lesions in common but take different paths of further development...
  24. ncbi Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis
    Wilko Weichert
    Institute of Pathology, Charite Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Int J Oncol 23:633-9. 2003
    ..The findings of this study, together with data from functional studies by other groups suggest that alteration of PKC isoform expression may be involved in progression of ovarian carcinomas...
  25. pmc Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma
    Carsten Denkert
    Department of Gynecology and Obstetrics, Charite Hospital, Berlin, Germany
    Am J Pathol 160:893-903. 2002
    ..Based on the results of this study, it would be interesting to investigate whether ovarian carcinoma patients with tumors positive for COX-2 would benefit from treatment with selective COX-2 inhibitors...
  26. ncbi An artificial neural network considerably improves the diagnostic power of percent free prostate-specific antigen in prostate cancer diagnosis: results of a 5-year investigation
    Carsten Stephan
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    Int J Cancer 99:466-73. 2002
    ..For PSA 4-10 ng/mL, we recommend a first-time biopsy based on the ANN at the 90% sensitivity level. Use of an ANN enhances the %fPSA performance to further reduce the number of unnecessary biopsies within the PSA range 2-10 ng/ml...
  27. ncbi Prognostic impact of cyclooxygenase-2 in breast cancer
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Clin Breast Cancer 4:428-33. 2004
    ..These investigations provide the basis for further evaluation of a possible therapeutic effect of COX inhibitors in therapy of breast cancer...
  28. ncbi Glucose transporter GLUT1 in colorectal adenocarcinoma cell lines is inversely correlated with tumour cell proliferation
    Steffen Hauptmann
    Institute of Pathology, Martin Luther University Halle Wittenberg, Magdeburger Str 14, D 06097 Halle Saale, Germany
    Anticancer Res 25:3431-6. 2005
    ..These data suggest that the protein synthesis of tumour cells is much more glucose-consuming than proliferation and that both processes are inversely related...
  29. ncbi Small polydispersed circular DNA contains strains of mobile genetic elements and occurs more frequently in permanent cell lines of malignant tumors than in normal lymphocytes
    Hannelore Schmidt
    Institute of Pathology, University of Halle Wittenberg, D 06097 Halle Saale, Germany
    Oncol Rep 22:393-400. 2009
    ..We suggest that the whole spcDNA including retrotranspositional elements and telomeric sequences may play a role for chromosomal rearrangements and genomic instability...
  30. doi Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival
    Frank Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Halle Saale, Germany
    Clin Cancer Res 14:89-96. 2008
    ..Although p53 is one of the most studied genes/proteins in ovarian carcinomas, the predictive value of p53 alterations is still ambiguous...
  31. ncbi Elevated expression of survivin-splice variants predicts a poor outcome for soft-tissue sarcomas patients
    Helge Taubert
    Institute of Pathology, Faculty of Medicine, University Halle Wittenberg, Magdeburger Strasse 14, D 06097 Halle Saale, Germany
    Oncogene 24:5258-61. 2005
    ....
  32. doi Inverse expression of cystein-rich 61 (Cyr61/CCN1) and connective tissue growth factor (CTGF/CCN2) in borderline tumors and carcinomas of the ovary
    Frank Bartel
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Int J Gynecol Pathol 31:405-15. 2012
    ..8; P=0.050) and disease-free (relative risk 2.3; P=0.031) survival. Cyr61 and CTGF are inversely expressed in BOTs and IOCs, and loss of CTGF independently indicates poor prognosis in IOCs...
  33. ncbi In-vivo repopularization of a tissue-engineered heart valve in a human subject
    Pascal M Dohmen
    Department of Cardiovascular Surgery, Charite Hospital, Medical University Berlin, Berlin, Germany
    J Heart Valve Dis 16:447-9. 2007
    ..The postoperative course was uneventful, and the patient rapidly recovered. After six years, he remains in excellent health...
  34. pmc Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy
    Isrid Sturm
    University Medical Center Charite, Campus Virchow Klinikum, Department of Hematology and Oncology, 13353 Berlin, Germany
    BMC Cancer 6:124. 2006
    ..e. 5-fluorouracil (5-FU), ionising gamma-radiation (IR) and heat shock/hyperthermia...
  35. ncbi Interferon-gamma treatment induces granulomatous tissue reaction in a case of localized cutaneous leishmaniasis
    Norbert Haas
    Department of Dermatology and Allergy, Charite, Humboldt University Berlin, Berlin, Germany
    Am J Dermatopathol 24:319-23. 2002
    ..In conclusion, IFNgamma therapy compensates for the parasite-dependent major histocompatibility complex class II downregulation and induces healing of chronic cutaneous leishmaniasis...
  36. pmc Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma
    W Weichert
    Institute of Pathology, Charite Hospital, Humboldt University, Schumannstrasse 20 21, Berlin 10117, Germany
    Br J Cancer 90:815-21. 2004
    ..Furthermore, this study suggests that PLK1 is a novel independent prognostic marker in ovarian carcinomas...
  37. ncbi Molecular forms of prostate-specific antigen in malignant and benign prostatic tissue: biochemical and diagnostic implications
    K Jung
    Department of Urology, University Hospital Charite, Humboldt University, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Clin Chem 46:47-54. 2000
    ..The patterns of the intracellular PSA isoforms in malignant and benign prostatic tissue have been studied as potential molecular reasons for this phenomenon...
  38. ncbi Primary chemotherapy with gemcitabine as prolonged infusion, non-pegylated liposomal doxorubicin and docetaxel in patients with early breast cancer: final results of a phase II trial
    P Schmid
    Medizinische Klinik mit Schwerpunkt Onkologie und Hämatologie, Charite Campus Mitte, Humboldt Universitat zu Berlin, Berlin
    Ann Oncol 16:1624-31. 2005
    ..Gemcitabine was given 72 h after NPLD and docetaxel as a prolonged infusion over 4 h in order to optimize synergistic effects and accumulation of active metabolites...
  39. ncbi Expression of cyclooxygenase 2 in human malignant melanoma
    C Denkert
    Institute of Pathology, , Berlin, Germany
    Cancer Res 61:303-8. 2001
    ..It remains to be investigated whether selective inhibitors of COX-2 might be useful for prevention or treatment of malignant melanoma...
  40. ncbi Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology
    M Dietel
    Institute of Pathology, Charite Hospital, Humboldt University Berlin, Germany
    Virchows Arch 436:403-12. 2000
    ..The concepts of molecular pathology of SLMP will be discussed in part 2 of this serial paper.)..
  41. ncbi Development of a flow cytometric method to determine DNA ploidy of oesophageal cancer cells obtained by forceps biopsy samples during oesophago-gastro-duodenoscopy
    S Rickes
    Department of Internal Medicine, University Hospital Charite, Campus Mitte, Humboldt University of Berlin, Germany
    Onkologie 26:32-7. 2003
    ....
  42. ncbi Molecular forms of prostate-specific antigen in serum with concentrations of total prostate-specific antigen <4 microg/L: are they useful tools for early detection and screening of prostate cancer?
    K Jung
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    Int J Cancer 93:759-65. 2001
    ..The ratios could be useful in assessing the risk of PCa in the individual and therefore in deciding on prostate biopsy for final diagnosis...
  43. ncbi Ratio of free or complexed prostate-specific antigen (PSA) to total PSA: which ratio improves differentiation between benign prostatic hyperplasia and prostate cancer?
    K Jung
    Department of Urology, University Hospital Charite, Humboldt University, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Clin Chem 46:55-62. 2000
    ....
  44. ncbi Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation
    G Riemekasten
    Department of Rheumatology and Clinical Immunology, Humboldt University of Berlin, Germany
    Lupus 11:204-7. 2002
    ..Immune complex 'independent' and other mechanisms of vascular injury and states of hypercoagulability will be discussed...
  45. ncbi Matrix-metalloproteinases and their inhibitors in plasma and tumor tissue of patients with renal cell carcinoma
    M Lein
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    Int J Cancer 85:801-4. 2000
    ..In plasma, MMP-9 concentrations were significantly higher in RCC patients than in healthy controls, MMP-2 and TIMP-2 concentrations were higher in healthy controls and TIMP-1 concentrations were not different...
  46. ncbi Interleukin-10 in serous ovarian carcinoma cell lines
    S Berger
    Institute of Pathology, Charité Hospital Berlin, Germany
    Cancer Immunol Immunother 50:328-33. 2001
    ..Our data on the regulation of IL-10 production in OVCAR-3 indicate that ovarian carcinoma cells share some, but not all, of the regulatory features typical for the monocytic IL-10 secretion...
  47. pmc Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion
    A Siegert
    Institute of Pathology, Charite Hospital, Humboldt University, Schumannstr 20 21, D 10117 Berlin, Germany
    Br J Cancer 86:1310-5. 2002
    ..Therefore, the production of nitric oxide and secretion of pro-inflammatory cytokines by tumour-associated macrophages, which in turn induce nitric oxide synthase II isoform in tumour cells, promotes tumour cell invasiveness...
  48. doi Specialized pathology review in patients with ovarian cancer: results from a prospective study
    Stefan Kommoss
    Universitats Frauenklinik Tubingen, Germany AGO Study Group, Wiesbaden, Germany Philipps Universität Marburg, Koordinierungszentrum für Klinische Studien, Marburg, Germany Luzerner Kantonsspital, Institute of Pathology, Luzern, Switzerland Institute of Pathology, Dueren, Germany Horst Schmidt Kliniken HSK, Wiesbaden, Germany Institute of Pathology, Mannheim, Germany Gynecologic Oncology Center, Kiel, Germany and Department Gynecology and Gynecologic Oncology, Kliniken Essen Mitte, Essen, Germany
    Int J Gynecol Cancer 23:1376-82. 2013
    ..Finally, clinical trials may be biased through unintended disregard of histological inclusion criteria...
  49. ncbi Cathepsins B, H, and L activities in urine of patients with transitional cell carcinoma of the bladder
    Andrea Staack
    Department of Urology, University Hospital Charite, Humboldt University Berlin, Berlin, Germany
    Urology 59:308-12. 2002
    ..The imbalance between proteinases and their inhibitors is believed to correlate with tumor progression and shortened patient survival. In transitional cell carcinoma (TCC) only limited data have been published...
  50. ncbi Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma
    M Kobel
    Department of Medicine, Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Oncogene 26:7584-9. 2007
    ..Reduced proliferation was associated with decreased c-myc mRNA half-life, suggesting IMP1 as an oncogenic factor that is involved in promoting elevated proliferation by stabilizing the c-myc mRNA in ovarian carcinoma cells...
  51. doi The Value of Serum CA125 in the Diagnosis of Borderline Tumors of the Ovary: A Subanalysis of the Prospective Multicenter ROBOT Study
    Christina Fotopoulou
    Department of Gynecology Charité, Campus Virchow Klinikum, Berlin, Germany Imperial College London, London, United Kingdom Gynäkologie and Gynäkologische Onkologie, Dr Horst Schmidt Klinik, Wiesbaden Frauenklinik Universitätsklinikum Ulm, Ulm Coordinating Center for Clinical Trials, University Marburg, Marburg Klinik und Poliklinik für Gynäkologie, Universitatsklinikum Hamburg Eppendorf, Hamburg Referenzzentrum für Gynäkopathologie, Institut fur Pathologie, Mannheim Frauen und Poliklinik, Klinikum der Technischen Universität, Muenchen Frauenklinik Universitätsklinikum Tuebingen, Tuebingen Frauenheilkunde und Geburtshilfe, Klinikum der J W Goethe Universitat, Frankfurt Klinik für Frauenheilkunde und Geburtshilfe der Universität Duisburg Essen, Essen Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Technische Universitat Dresden, Dresden Zentrum für Gynäkologische Onkologie, Kiel Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen Universitätsklinik und Poliklinik für Gynäkologie, Universitatsklinikum, Halle and Gynäkologie and Gynäkologische Onkologie, Kliniken Essen Mitte, Essen, Germany
    Int J Gynecol Cancer 25:1248-52. 2015
    ..The aim of the present project was to identify the predictive value of CA125 for stage and relapse...
  52. ncbi Transposable elements--is there a link between evolution and cancer?
    Steffen Hauptmann
    Institute of Pathology, Martin Luther University Halle Wittenberg, Magdeburger Strasse 14, D 06097 Halle Saale, Germany
    Med Hypotheses 66:580-91. 2006
    ..As part of the reformatting process of the cancer cell genome, activation of oncogenes and inactivation of tumor suppressor genes are not stochastic events but the result of an unlucky genomic composition...
  53. pmc Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis
    S Niesporek
    Institute of Pathology, Charite University Hospital, Campus Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Br J Cancer 92:1729-36. 2005
    ..In addition, LPAAT-beta expression is a predictor of a worse prognosis in patients younger than 60 years. Further studies are needed to investigate if LPAAT-beta may serve as a therapeutic target for certain subgroups of patients...
  54. ncbi Integrin expression on colorectal tumor cells growing as monolayers, as multicellular tumor spheroids, or in nude mice
    S Hauptmann
    Institute of Pathology, Technical University Aachen RWTH, Germany
    Int J Cancer 61:819-25. 1995
    ..These data indicate that integrin expression of tumor cells depends upon the culture system and that integrin expression in multicellular tumor spheroids is more similar to the in vivo situation in nude mouse tumors...
  55. ncbi Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability
    A Mrozek
    1Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, Humboldt University, Berlin, Germany
    Cell Death Differ 10:461-7. 2003
    ..Thus, we show for the first time that the combined mutation of p53 and Bax, two key regulators of the mitochondrial apoptosis pathway, results in an extremely aggressive tumor biology and poor clinical prognosis...
  56. ncbi Differential expression of matrix metalloproteinases and their tissue inhibitors in human primary cultured prostatic cells and malignant prostate cell lines
    Ju Zhang
    Department of Urology, University Hospital Charite, Humboldt University Berlin, Berlin, Germany
    Prostate 50:38-45. 2002
    ..The aim was to investigate the expression of matrix metalloproteinases (MMPs), membrane type MMPs (MT-MMPs), and their inhibitors (TIMPs) in human primary cultured prostatic cells and malignant prostate cell lines...
  57. ncbi Comparison of protein expression profiles between monolayer and spheroid cell culture of HT-29 cells revealed fragmentation of CK18 in three-dimensional cell culture
    Julia Poland
    Institute of Laboratory Medicine and Pathobiochemistry Charité Hospital Berlin, Berlin, Germany
    Electrophoresis 23:1174-84. 2002
    ..Some of these proteins have already been linked to chemoresistance and apoptotic phenomena...
  58. ncbi Excretion of matrix metalloproteinases 2 and 9 in urine is associated with a high stage and grade of bladder carcinoma
    S Gerhards
    Department of Urology, , Humboldt University Berlin, Berlin, Germany
    Urology 57:675-9. 2001
    ..CONCLUSIONS: Urinary excretion of MMP-2 and MMP-9 is associated with a high stage and grade of bladder cancer, and they may serve as indicators of tumor progression and recurrence in the future...
  59. ncbi Cardiac death after autologous stem cell transplantation (ASCT) for treatment of systemic sclerosis (SSc): no evidence for cyclophosphamide-induced cardiomyopathy
    O Rosen
    Department of Oncology/Haematology, , Berlin, Germany
    Bone Marrow Transplant 27:657-8. 2001
    ..We conclude that in selected patients with SSc, biopsies should be performed to reduce mortality after ASCT...
  60. ncbi Ezrin promotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis in ovarian carcinoma
    Martin Köbel
    Department of Pathology, Martin Luther University Halle Wittenberg, and Department of Gynecology, St Elisabeth Hospital, Halle, Germany
    Int J Gynecol Pathol 25:121-30. 2006
    ..These data imply that ezrin is necessary for tumor cell invasion, and the better prognosis of ovarian carcinomas lacking ezrin is probably related to their impaired invasion...
  61. pmc Reliability and validity of needle biopsy evaluation of breast-abnormalities using the B-categorization--design and objectives of the Diagnosis Optimisation Study (DIOS)
    Alexander Kluttig
    Clinical Epidemiology Unit, Institute of Medical Epidemiology, Biometry and Informatics, University Halle Wittenberg, Halle Saale, Germany
    BMC Cancer 7:100. 2007
    ..This paper describes the design and objectives of the DIOS Study...
  62. ncbi Disparities between male and female patients with thyroid cancers: sex difference or gender divide?
    Andreas Machens
    Departments of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Saale, Germany
    Clin Endocrinol (Oxf) 65:500-5. 2006
    ..This investigation was undertaken to quantify histopathological disparities between male and female patients with sporadic and hereditary thyroid cancers, which may reflect a biological 'sex difference' or a behavioural 'gender divide'...
  63. pmc Nucleolin as activator of human papillomavirus type 18 oncogene transcription in cervical cancer
    Edgar Grinstein
    Institut für Transplantationsdiagnostik und Zelltherapeutika, Heinrich Heine Universitat Dusseldorf, Germany
    J Exp Med 196:1067-78. 2002
    ..Thus, the host cell protein nucleolin is directly linked to HPV18-induced cervical carcinogenesis...
  64. ncbi Multigene analysis of Rb pathway and apoptosis control in esophageal squamous cell carcinoma identifies patients with good prognosis
    Dilek Güner
    Department of Radiation Oncology, University Medical Center Charite, Humboldt University, Lindenberger Weg 80, 13125 Berlin Buch, Germany
    Int J Cancer 103:445-54. 2003
    ..e., low cyclin D1 and high Rb, p21(CIP/WAF-1), p16(INK4a) and Bax protein expression. These results show that multigene analyses based on limited sets of functionally linked genes reliably identify patients with good vs. poor prognosis...
  65. ncbi Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy
    Beate Rau
    Charite Medical School, Campus Berlin Buch, Humboldt University, Department of Surgery and Surgical Oncology, Robert Roessle Klinik, Lindenberger Weg 80, 13125 Berlin, Germany
    J Clin Oncol 21:3391-401. 2003
    ..The focus of this study was on the dynamics of these genetic markers in a longitudinal study-that is, before and after radiochemotherapy...
  66. ncbi Locoregional recurrence and death from medullary thyroid carcinoma in a contemporaneous series: 5-year results
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Eur J Endocrinol 157:85-93. 2007
    ..This study was designed to investigate cancer-specific event rates after initial neck resection in contemporaneous patients recruited within less than a decade...
  67. ncbi Increased risk of lymph node metastasis in multifocal hereditary and sporadic medullary thyroid cancer
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06097, Halle Saale, Germany
    World J Surg 31:1960-5. 2007
    ..In sporadic and hereditary medullary thyroid cancer, tumor multifocality may constitute an independent risk factor of lymph node metastasis on top of primary tumor size when the diameter of the largest primary tumor is the same...
  68. ncbi Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: a multivariate analysis
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Arch Surg 142:289-93; discussion 294. 2007
    ..Medullary thyroid cancer cells are capable of secreting carcinoembyronic antigen (CEA). An abnormal preoperative CEA level may have important implications for the management of this condition...
  69. doi Primary lymph node gastrinoma or occult duodenal microgastrinoma with lymph node metastases in a MEN1 patient: the need for a systematic search for the primary tumor
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 32:1101-5. 2008
    ..It is concluded that duodenal gastrinomas that give rise to lymph node metastases may be so tiny that they are easily overlooked in a routine examination and that systematic tissue monitoring is required to identify them...
  70. doi Perspectives for improved and more accurate classification of thyroid epithelial tumors
    Markus Eszlinger
    Third Medical Department, University of Leipzig, D 04103 Leipzig, Germany
    J Clin Endocrinol Metab 93:3286-94. 2008
    ....
  71. ncbi mRNA expression profile of matrix metalloproteinases and their tissue inhibitors in malignant and non-malignant prostatic tissue
    Ralf Lichtinghagen
    Department of Clinical Chemistry, University Medical School, Hannover, Germany
    Anticancer Res 23:2617-24. 2003
    ..Increased expression of matrix metalloproteinases (MMPs) was found in various carcinomas. The aim of this study was to present a comprehensive mRNA expression profile of MMPs in benign and malignant prostatic tissue...
  72. pmc Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor
    Martin Köbel
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Pathol 167:879-85. 2005
    ..In contrast, neither compound had any effect on normal extravillous trophoblastic cells or JEG-3 cells. In conclusion, our findings demonstrate a functional role of MAPK activation in the motility and invasion of PSTT...
  73. ncbi Different mRNA and protein expression of matrix metalloproteinases 2 and 9 and tissue inhibitor of metalloproteinases 1 in benign and malignant prostate tissue
    Ralf Lichtinghagen
    Department of Clinical Chemistry, University Medical School, Hannover, Germany
    Eur Urol 42:398-406. 2002
    ..The aim of this study was to assess the behavior of the matrix metalloproteinases (MMPs) 2 and 9 and the tissue inhibitor of metalloproteinases 1 (TIMP-1) in human prostate cancer...