Henry Fechner

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint A bidirectional Tet-dependent promotor construct regulating the expression of E1A for tight control of oncolytic adenovirus replication
    Henry Fechner
    Department of Cardiology and Pulmology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Biotechnol 127:560-74. 2007
  2. ncbi request reprint An improved Tet-On regulatable FasL-adenovirus vector system for lung cancer therapy
    Isaac Sipo
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin Germany
    J Mol Med (Berl) 84:215-25. 2006
  3. doi request reprint Inhibition of adenovirus infections by siRNA-mediated silencing of early and late adenoviral gene functions
    Anne Eckstein
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Antiviral Res 88:86-94. 2010
  4. doi request reprint Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor
    Sandra Pinkert
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite University Medicine Berlin, Hindenburgdamm 30, Berlin, Germany
    Circulation 120:2358-66. 2009
  5. ncbi request reprint Dimethyl sulfoxide enhances doxycycline-dependent protein expression in Tet-On cells
    Malte Oppermann
    Charite Universitatsmedizin Berlin, Berlin, Germany
    Biotechniques 42:304, 306, 308 passim. 2007
  6. doi request reprint Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy
    Henry Fechner
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Mol Med (Berl) 86:987-97. 2008
  7. doi request reprint Transactivation of human parvovirus B19 gene expression in endothelial cells by adenoviral helper functions
    Tanja Pozzuto
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite University Medicine Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Virology 411:50-64. 2011
  8. ncbi request reprint Viral and nonviral factors causing nonspecific replication of tumor- and tissue-specific promoter-dependent oncolytic adenoviruses
    Almudena Hurtado Picó
    Department of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Mol Ther 11:563-77. 2005
  9. pmc Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure
    Wolfgang Poller
    Department of Cardiology and Pneumology, Charité Centrum 11, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Cardiovasc Res 86:353-64. 2010
  10. pmc Antibody-mediated enhancement of parvovirus B19 uptake into endothelial cells mediated by a receptor for complement factor C1q
    Kristina von Kietzell
    Institute of Virology, Campus Benjamin Franklin, Charite University Medicine Berlin, Berlin, Germany
    J Virol 88:8102-15. 2014

Collaborators

Detail Information

Publications19

  1. ncbi request reprint A bidirectional Tet-dependent promotor construct regulating the expression of E1A for tight control of oncolytic adenovirus replication
    Henry Fechner
    Department of Cardiology and Pulmology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Biotechnol 127:560-74. 2007
    ..Future improvement of the Dox-dependent E1A regulation cassette should lead to the generation of an oAdV well suited to meet the demands for a highly regulated and efficient oncolytic virus for in vivo applications...
  2. ncbi request reprint An improved Tet-On regulatable FasL-adenovirus vector system for lung cancer therapy
    Isaac Sipo
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin Germany
    J Mol Med (Berl) 84:215-25. 2006
    ..These data show that the novel TRE-Tight1 promoter has a high potential for closely controlled and efficient expression of cytotoxic genes in AdV-based anti-cancer approaches...
  3. doi request reprint Inhibition of adenovirus infections by siRNA-mediated silencing of early and late adenoviral gene functions
    Anne Eckstein
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Antiviral Res 88:86-94. 2010
    ..Thus, an enhanced anti-adenoviral efficiency of RNAi-based inhibition strategies can be achieved by co-silencing of early and late adenoviral genes, with down regulation of the E1A as a crucial factor...
  4. doi request reprint Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor
    Sandra Pinkert
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite University Medicine Berlin, Hindenburgdamm 30, Berlin, Germany
    Circulation 120:2358-66. 2009
    ..Here, we analyze the therapeutic potential of a soluble (s) virus receptor molecule against CVB3 myocarditis using a gene therapy approach...
  5. ncbi request reprint Dimethyl sulfoxide enhances doxycycline-dependent protein expression in Tet-On cells
    Malte Oppermann
    Charite Universitatsmedizin Berlin, Berlin, Germany
    Biotechniques 42:304, 306, 308 passim. 2007
  6. doi request reprint Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy
    Henry Fechner
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Mol Med (Berl) 86:987-97. 2008
    ..5 vs. 16.2 +/- 1.1 ms (p < 0.01). The data show, for the first time, that intravenously injected AAV9 has the potential to target RNAi to the heart and suggest AAV9-shRNA vectors as a novel therapeutic approach for cardiac disorders...
  7. doi request reprint Transactivation of human parvovirus B19 gene expression in endothelial cells by adenoviral helper functions
    Tanja Pozzuto
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite University Medicine Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Virology 411:50-64. 2011
    ..Thus the almost complete block in B19V gene expression seen in endothelial cells can be abrogated by infection with other viruses...
  8. ncbi request reprint Viral and nonviral factors causing nonspecific replication of tumor- and tissue-specific promoter-dependent oncolytic adenoviruses
    Almudena Hurtado Picó
    Department of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Mol Ther 11:563-77. 2005
    ..Consideration of these factors may help optimize ttsP-dependent RRCA vectors and may thereby improve their safety...
  9. pmc Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure
    Wolfgang Poller
    Department of Cardiology and Pneumology, Charité Centrum 11, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Cardiovasc Res 86:353-64. 2010
    ..Recent years have witnessed parallel progress in the fields of gene-based and regulatory RNA-based therapies that are likely to significantly expand the cardiovascular therapeutic repertoire within the next decade...
  10. pmc Antibody-mediated enhancement of parvovirus B19 uptake into endothelial cells mediated by a receptor for complement factor C1q
    Kristina von Kietzell
    Institute of Virology, Campus Benjamin Franklin, Charite University Medicine Berlin, Berlin, Germany
    J Virol 88:8102-15. 2014
    ....
  11. ncbi request reprint Apoptosis pathways and oncolytic adenoviral vectors: promising targets and tools to overcome therapy resistance of malignant melanoma
    Jürgen Eberle
    Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Dermatol 17:1-11. 2008
    ..Proapoptotic genes may be employed in improved gene therapeutic strategies, based on conditional oncolytic adenoviral vectors...
  12. pmc Roles of E4orf6 and VA I RNA in adenovirus-mediated stimulation of human parvovirus B19 DNA replication and structural gene expression
    Kerstin Winter
    Institute of Virology, Campus Benjamin Franklin, Charite University Medicine Berlin, Berlin, Germany
    J Virol 86:5099-109. 2012
    ..These data show that the cellular pathways regulating B19V replication may be very similar to those governing the productive cycle of the helper-dependent parvoviruses, the adeno-associated viruses...
  13. doi request reprint Matricellular signaling molecule CCN1 attenuates experimental autoimmune myocarditis by acting as a novel immune cell migration modulator
    Madlen Rother
    Institute for Medical Immunology, Charite Campus, Berlin, Germany
    Circulation 122:2688-98. 2010
    ..Here, we provide evidence of a novel function of CCN1 as a modulator of immune cell migration...
  14. pmc Decreased cardiac SERCA2 expression, SR Ca uptake, and contractile function in hypothyroidism are attenuated in SERCA2 overexpressing transgenic rats
    Roland Vetter
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin
    Am J Physiol Heart Circ Physiol 300:H943-50. 2011
    ..However, SR Ca(2+) uptake and in vivo heart function were only partially rescued...
  15. ncbi request reprint Selective induction of apoptosis in melanoma cells by tyrosinase promoter-controlled CD95 ligand overexpression
    Lothar F Fecker
    Department of Dermatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 124:221-8. 2005
    ..Our investigations provide evidence that tyrosinase promoter CD95L constructs may be of value for selective induction of apoptosis in therapeutic strategies for melanoma...
  16. pmc Mismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38
    Mandar Ramesh Bhonde
    Department of Gastroenterology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Int J Cancer 126:2813-25. 2010
    ..These data show that the stabilization of the tetraploid G1 arrest in response to double strand breaks is a novel function of the MMR system that contributes to the lesser survival of MMR(+) cells...
  17. doi request reprint Description of a local cardiac adiponectin system and its deregulation in dilated cardiomyopathy
    Carsten Skurk
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite University Medicine Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur Heart J 29:1168-80. 2008
    ..This study was performed to identify possible new therapeutic targets in dilated cardiomyopathy (DCM)...
  18. pmc Gene therapy for gastric cancer: is it promising?
    Andreas P Sutter
    Department of Gastroenterology Infectious Diseases Rheumatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    World J Gastroenterol 12:380-7. 2006
    ..This review provides an update of the new developments in cancer gene therapy, new principles, techniques, strategies and vector systems, and shows how they may be applied in the treatment of gastric cancer...
  19. ncbi request reprint Regulation of human factor IX expression using doxycycline-inducible gene expression system
    Mahmoud A Srour
    Institute for Experimental Hematology and Transfusion Medicine, University Clinics Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Thromb Haemost 90:398-405. 2003
    ..Although hFIX expression showed a slow and gradual decrease over time in vivo with the Ad5.CMV.rtTA vector, it remained within the therapeutic range. To date, regulation of hFIX has not been described in this way...