A M Arafat

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint The role of insulin-like growth factor (IGF) binding protein-2 in the insulin-mediated decrease in IGF-I bioactivity
    Ayman M Arafat
    Department of Endocrinology, Diabetes, and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 94:5093-101. 2009
  2. doi request reprint The impact of insulin-independent, glucagon-induced suppression of total ghrelin on satiety in obesity and type 1 diabetes mellitus
    A M Arafat
    MD, Department of Endocrinology, Diabetes, and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    J Clin Endocrinol Metab 98:4133-42. 2013
  3. pmc Changes in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity
    Martin O Weickert
    Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Nutr Metab (Lond) 8:90. 2011
  4. doi request reprint Improved insulin sensitivity, preserved beta cell function and improved whole-body glucose metabolism after low-dose growth hormone replacement therapy in adults with severe growth hormone deficiency: a pilot study
    A M Arafat
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Diabetologia 53:1304-13. 2010
  5. doi request reprint Growth hormone response during oral glucose tolerance test: the impact of assay method on the estimation of reference values in patients with acromegaly and in healthy controls, and the role of gender, age, and body mass index
    Ayman M Arafat
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 93:1254-62. 2008
  6. ncbi request reprint Glucagon suppression of ghrelin secretion is exerted at hypothalamus-pituitary level
    A M Arafat
    Department of Endocrinology, Diabetes, and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 91:3528-33. 2006
  7. ncbi request reprint Glucagon inhibits ghrelin secretion in humans
    M A Arafat
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Charite University Berlin, Germany
    Eur J Endocrinol 153:397-402. 2005
  8. doi request reprint Levothyroxine medication is associated with adiposity independent of TSH
    S Ruhla
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Clin Endocrinol Diabetes 120:351-4. 2012
  9. doi request reprint T3/rT3-ratio is associated with insulin resistance independent of TSH
    S Ruhla
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 43:130-4. 2011
  10. doi request reprint Comparison of oral glucose tolerance test (OGTT) 100 g with OGTT 75 g for evaluation of acromegalic patients and the impact of gender on test reproducibility
    A M Arafat
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Clin Endocrinol (Oxf) 75:685-91. 2011

Detail Information

Publications13

  1. doi request reprint The role of insulin-like growth factor (IGF) binding protein-2 in the insulin-mediated decrease in IGF-I bioactivity
    Ayman M Arafat
    Department of Endocrinology, Diabetes, and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 94:5093-101. 2009
    ..This network is linked to metabolic syndrome and cardiovascular diseases...
  2. doi request reprint The impact of insulin-independent, glucagon-induced suppression of total ghrelin on satiety in obesity and type 1 diabetes mellitus
    A M Arafat
    MD, Department of Endocrinology, Diabetes, and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    J Clin Endocrinol Metab 98:4133-42. 2013
    ..We further aimed to identify a possible mechanistic impact of changes in endogenous insulin...
  3. pmc Changes in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity
    Martin O Weickert
    Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Nutr Metab (Lond) 8:90. 2011
    ..abstract:..
  4. doi request reprint Improved insulin sensitivity, preserved beta cell function and improved whole-body glucose metabolism after low-dose growth hormone replacement therapy in adults with severe growth hormone deficiency: a pilot study
    A M Arafat
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Diabetologia 53:1304-13. 2010
    ..We postulated that long-term low-dose growth hormone replacement, restoring IGF-1 to the low-normal range, might beneficially affect glucose metabolism...
  5. doi request reprint Growth hormone response during oral glucose tolerance test: the impact of assay method on the estimation of reference values in patients with acromegaly and in healthy controls, and the role of gender, age, and body mass index
    Ayman M Arafat
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 93:1254-62. 2008
    ..However, the development of highly sensitive and specific GH assays necessitates a critical reevaluation of criteria for diagnosis and follow-up of disease activity...
  6. ncbi request reprint Glucagon suppression of ghrelin secretion is exerted at hypothalamus-pituitary level
    A M Arafat
    Department of Endocrinology, Diabetes, and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 91:3528-33. 2006
    ..The mechanisms underlying the well-known glucagon-induced satiety effect are unclear. Recently, we showed that glucagon induces a remarkable decrease in the orexigenic hormone ghrelin that might be responsible for this effect...
  7. ncbi request reprint Glucagon inhibits ghrelin secretion in humans
    M A Arafat
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Charite University Berlin, Germany
    Eur J Endocrinol 153:397-402. 2005
    ..The aim of the present study was to investigate the role of ghrelin in mediating the stimulatory effects of glucagon and to evaluate the effect of glucagon on ghrelin secretion...
  8. doi request reprint Levothyroxine medication is associated with adiposity independent of TSH
    S Ruhla
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Clin Endocrinol Diabetes 120:351-4. 2012
    ..We therefore investigated the association between levothyroxine medication and BMI in a large cross-sectional study group...
  9. doi request reprint T3/rT3-ratio is associated with insulin resistance independent of TSH
    S Ruhla
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 43:130-4. 2011
    ..Here we show that the T3/rT3-ratio, which is supposed to reflect the tissue thyroid hormone metabolism, is significantly increased in insulin resistant subjects. This further supports a link between thyroid function and IR...
  10. doi request reprint Comparison of oral glucose tolerance test (OGTT) 100 g with OGTT 75 g for evaluation of acromegalic patients and the impact of gender on test reproducibility
    A M Arafat
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Clin Endocrinol (Oxf) 75:685-91. 2011
    ..Whether the tests are interchangeable concerning GH nadir and test interpretation is unclear. Furthermore, information on test reproducibility and the impact of gender is scarce...
  11. doi request reprint Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?
    A M Arafat
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Berlin, Germany
    Diabetologia 56:588-97. 2013
    ..Animal experiments have suggested a possible interaction between glucagon and FGF-21 however, the metabolic consequences of this crosstalk are not understood...
  12. ncbi request reprint Adipocyte fatty acid-binding protein is associated with markers of obesity, but is an unlikely link between obesity, insulin resistance, and hyperandrogenism in polycystic ovary syndrome women
    Matthias Mohlig
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, 12200 Berlin, Germany
    Eur J Endocrinol 157:195-200. 2007
    ..Thus, as observed with other adipose tissue derived factors, secreted A-FABP might be involved in the pathogenesis of obesity-associated disorders such as PCOS...
  13. ncbi request reprint Cereal fiber improves whole-body insulin sensitivity in overweight and obese women
    Martin O Weickert
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal 14558, Germany
    Diabetes Care 29:775-80. 2006
    ..The pathogenic background of this phenomenon is unknown. Based on recent findings, we hypothesized that intake of purified insoluble oat fiber may improve whole-body insulin sensitivity...