- Isolated bronchi of patients with COPD show decreased histamine responsiveness compared to smokers with normal lung functionChristian Taube
Pulmonary Research Institute, Centre for Pneumology and Thoracic Surgery, D 22927 Grosshansdorf, Germany
COPD 3:25-31. 2006..This suggests that in vivo hyperresponsiveness is based on other mechanisms than alterations in smooth muscle physiology...
- Physical activity is the strongest predictor of all-cause mortality in patients with COPD: a prospective cohort studyBenjamin Waschki
Pulmonary Research Institute at Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Grosshansdorf, Germany
Chest 140:331-42. 2011....
- Assessing airway inflammation in clinical practice - experience with spontaneous sputum analysisOlaf Holz
Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, 22927 Grosshansdorf, Germany
BMC Pulm Med 8:5. 2008..Sampling of spontaneous sputum is a well-known, simple, economic and non-invasive method to derive a qualitative cytology of airway cells and here we aimed to assess today's value of spontaneous sputum cytology in clinical practice...
- In contrast to lung fibroblasts--no signs of senescence in skin fibroblasts of patients with emphysemaKai Christian Müller
Hospital Grosshansdorf, Centre for Pneumology and Thoracic Surgery, Woehrendamm 80, 22927 Grosshansdorf, Germany
Exp Gerontol 43:623-8. 2008..05, each). These results suggest that the induction of a senescent fibroblast phenotype by cigarette smoke, as observed in emphysema, primarily occurs in the lung...
- Validation of the human ozone challenge model as a tool for assessing anti-inflammatory drugs in early developmentOlaf Holz
Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Wohrendamm 80, D 22927 Grosshansdorf, Germany
J Clin Pharmacol 45:498-503. 2005..The authors conclude that an optimized ozone challenge model (including ozone responders and ensuring adequate drug levels during exposure) may be useful for testing novel anti-inflammatory compounds in early development...
- The metabolic syndrome in patients with chronic bronchitis and COPD: frequency and associated consequences for systemic inflammation and physical inactivityHenrik Watz
Pulmonary Research Institute, Center for Pneumology and Thoracic Surgery, Hospital Grosshansdorf, Woehrendamm 80, D 22927 Grosshansdorf, Germany
Chest 136:1039-46. 2009..Here, we studied the following: (1) the frequency of the coexisting metabolic syndrome in patients with chronic bronchitis (CB) and COPD of different severities; and (2) its association with systemic inflammation and physical inactivity...
- Spatial interactions between dendritic cells and sensory nerves in allergic airway inflammationTibor Z Veres
Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
Am J Respir Cell Mol Biol 37:553-61. 2007..These results provide morphologic evidence of the interactions between dendritic cells and the neural network of the airways at multiple anatomical sites...
- Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysemaStephen I Rennard
University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, 985125 Nebraska Medical Center, Omaha, NE 98198 5125, USA
Proc Am Thorac Soc 3:703-8. 2006....
- Effect of cetirizine dihydrochloride on the airway response to hypertonic saline aerosol in patients with chronic obstructive pulmonary disease (COPD)Lars Grönke
Pulmonary Research Institute, Grosshansdorf, Germany
Respir Med 99:1241-8. 2005..In view of the mechanisms involved, it is an open question whether stronger effects can be elicited with higher doses and whether such effects would translate into clinical benefits, e.g. during exacerbations...
- Exhaled nitric oxide: independent effects of atopy, smoking, respiratory tract infection, gender and heightHolger Dressel
Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munchen, Germany
Respir Med 102:962-9. 2008..Thus, circumstances such as smoking and respiratory tract infection do not appear to affect the usefulness of exhaled nitric oxide, provided that appropriate factors for adjustment are applied...
- Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanismsShinsaku Togo
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Am J Respir Crit Care Med 178:248-60. 2008..Alterations in fibroblast functional capacity, therefore, could play a role in the pathogenesis of pulmonary emphysema, which is characterized by inadequate maintenance of tissue structure...