Olaf Holz

Summary

Country: Germany

Publications

  1. ncbi request reprint Isolated bronchi of patients with COPD show decreased histamine responsiveness compared to smokers with normal lung function
    Christian Taube
    Pulmonary Research Institute, Centre for Pneumology and Thoracic Surgery, D 22927 Grosshansdorf, Germany
    COPD 3:25-31. 2006
  2. doi request reprint Physical activity is the strongest predictor of all-cause mortality in patients with COPD: a prospective cohort study
    Benjamin Waschki
    Pulmonary Research Institute at Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Grosshansdorf, Germany
    Chest 140:331-42. 2011
  3. pmc Assessing airway inflammation in clinical practice - experience with spontaneous sputum analysis
    Olaf Holz
    Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, 22927 Grosshansdorf, Germany
    BMC Pulm Med 8:5. 2008
  4. doi request reprint In contrast to lung fibroblasts--no signs of senescence in skin fibroblasts of patients with emphysema
    Kai Christian Müller
    Hospital Grosshansdorf, Centre for Pneumology and Thoracic Surgery, Woehrendamm 80, 22927 Grosshansdorf, Germany
    Exp Gerontol 43:623-8. 2008
  5. ncbi request reprint Validation of the human ozone challenge model as a tool for assessing anti-inflammatory drugs in early development
    Olaf Holz
    Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Wohrendamm 80, D 22927 Grosshansdorf, Germany
    J Clin Pharmacol 45:498-503. 2005
  6. doi request reprint The metabolic syndrome in patients with chronic bronchitis and COPD: frequency and associated consequences for systemic inflammation and physical inactivity
    Henrik Watz
    Pulmonary Research Institute, Center for Pneumology and Thoracic Surgery, Hospital Grosshansdorf, Woehrendamm 80, D 22927 Grosshansdorf, Germany
    Chest 136:1039-46. 2009
  7. ncbi request reprint Spatial interactions between dendritic cells and sensory nerves in allergic airway inflammation
    Tibor Z Veres
    Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Am J Respir Cell Mol Biol 37:553-61. 2007
  8. pmc Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysema
    Stephen I Rennard
    University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, 985125 Nebraska Medical Center, Omaha, NE 98198 5125, USA
    Proc Am Thorac Soc 3:703-8. 2006
  9. ncbi request reprint Effect of cetirizine dihydrochloride on the airway response to hypertonic saline aerosol in patients with chronic obstructive pulmonary disease (COPD)
    Lars Grönke
    Pulmonary Research Institute, Grosshansdorf, Germany
    Respir Med 99:1241-8. 2005
  10. doi request reprint Exhaled nitric oxide: independent effects of atopy, smoking, respiratory tract infection, gender and height
    Holger Dressel
    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munchen, Germany
    Respir Med 102:962-9. 2008

Collaborators

  • Helgo Magnussen
  • Henrik Watz
  • Kai Richter
  • Frank Kanniess
  • Dennis Nowak
  • S Rennard
  • Holger Dressel
  • Armin Braun
  • Lutz Welker
  • Kai Christian Müller
  • Rudolf A Jörres
  • Benjamin Waschki
  • Shinsaku Togo
  • Tibor Z Veres
  • Detlev Branscheid
  • Christian Taube
  • Lars Grönke
  • Anne Kirsten
  • Thorsten Meyer
  • Beke Feindt
  • Youngsoo Ahn
  • Masaki Nakashima
  • Hisatoshi Sugiura
  • Koichiro Kamio
  • Detlef Branscheid
  • Shin Kawasaki
  • Xiangqi Wang
  • Kirsten Paasch
  • Michael Weise
  • C Magnus Skold
  • Karin Fredriksson
  • Xiangde Liu
  • Ralph A Schmid
  • Kai Christian Mueller
  • Meike Muller
  • Barbara Fuchs
  • Sabine Rochlitzer
  • Christina Nassenstein
  • Norbert Krug
  • Marina Shevchenko
  • Axel Fischer
  • Frauke Prenzler
  • Martin Einhaus
  • Jens Schlenker
  • Theo A Out

Detail Information

Publications11

  1. ncbi request reprint Isolated bronchi of patients with COPD show decreased histamine responsiveness compared to smokers with normal lung function
    Christian Taube
    Pulmonary Research Institute, Centre for Pneumology and Thoracic Surgery, D 22927 Grosshansdorf, Germany
    COPD 3:25-31. 2006
    ..This suggests that in vivo hyperresponsiveness is based on other mechanisms than alterations in smooth muscle physiology...
  2. doi request reprint Physical activity is the strongest predictor of all-cause mortality in patients with COPD: a prospective cohort study
    Benjamin Waschki
    Pulmonary Research Institute at Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Grosshansdorf, Germany
    Chest 140:331-42. 2011
    ....
  3. pmc Assessing airway inflammation in clinical practice - experience with spontaneous sputum analysis
    Olaf Holz
    Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, 22927 Grosshansdorf, Germany
    BMC Pulm Med 8:5. 2008
    ..Sampling of spontaneous sputum is a well-known, simple, economic and non-invasive method to derive a qualitative cytology of airway cells and here we aimed to assess today's value of spontaneous sputum cytology in clinical practice...
  4. doi request reprint In contrast to lung fibroblasts--no signs of senescence in skin fibroblasts of patients with emphysema
    Kai Christian Müller
    Hospital Grosshansdorf, Centre for Pneumology and Thoracic Surgery, Woehrendamm 80, 22927 Grosshansdorf, Germany
    Exp Gerontol 43:623-8. 2008
    ..05, each). These results suggest that the induction of a senescent fibroblast phenotype by cigarette smoke, as observed in emphysema, primarily occurs in the lung...
  5. ncbi request reprint Validation of the human ozone challenge model as a tool for assessing anti-inflammatory drugs in early development
    Olaf Holz
    Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Wohrendamm 80, D 22927 Grosshansdorf, Germany
    J Clin Pharmacol 45:498-503. 2005
    ..The authors conclude that an optimized ozone challenge model (including ozone responders and ensuring adequate drug levels during exposure) may be useful for testing novel anti-inflammatory compounds in early development...
  6. doi request reprint The metabolic syndrome in patients with chronic bronchitis and COPD: frequency and associated consequences for systemic inflammation and physical inactivity
    Henrik Watz
    Pulmonary Research Institute, Center for Pneumology and Thoracic Surgery, Hospital Grosshansdorf, Woehrendamm 80, D 22927 Grosshansdorf, Germany
    Chest 136:1039-46. 2009
    ..Here, we studied the following: (1) the frequency of the coexisting metabolic syndrome in patients with chronic bronchitis (CB) and COPD of different severities; and (2) its association with systemic inflammation and physical inactivity...
  7. ncbi request reprint Spatial interactions between dendritic cells and sensory nerves in allergic airway inflammation
    Tibor Z Veres
    Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Am J Respir Cell Mol Biol 37:553-61. 2007
    ..These results provide morphologic evidence of the interactions between dendritic cells and the neural network of the airways at multiple anatomical sites...
  8. pmc Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysema
    Stephen I Rennard
    University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, 985125 Nebraska Medical Center, Omaha, NE 98198 5125, USA
    Proc Am Thorac Soc 3:703-8. 2006
    ....
  9. ncbi request reprint Effect of cetirizine dihydrochloride on the airway response to hypertonic saline aerosol in patients with chronic obstructive pulmonary disease (COPD)
    Lars Grönke
    Pulmonary Research Institute, Grosshansdorf, Germany
    Respir Med 99:1241-8. 2005
    ..In view of the mechanisms involved, it is an open question whether stronger effects can be elicited with higher doses and whether such effects would translate into clinical benefits, e.g. during exacerbations...
  10. doi request reprint Exhaled nitric oxide: independent effects of atopy, smoking, respiratory tract infection, gender and height
    Holger Dressel
    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munchen, Germany
    Respir Med 102:962-9. 2008
    ..Thus, circumstances such as smoking and respiratory tract infection do not appear to affect the usefulness of exhaled nitric oxide, provided that appropriate factors for adjustment are applied...
  11. pmc Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms
    Shinsaku Togo
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Crit Care Med 178:248-60. 2008
    ..Alterations in fibroblast functional capacity, therefore, could play a role in the pathogenesis of pulmonary emphysema, which is characterized by inadequate maintenance of tissue structure...