Jochen Huehn

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. doi request reprint Epigenetic and transcriptional control of Foxp3+ regulatory T cells
    Jochen Huehn
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124 Braunschweig, Germany Electronic address
    Semin Immunol 27:10-8. 2015
  2. doi request reprint Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
    Jochen Huehn
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nat Rev Immunol 9:83-9. 2009
  3. doi request reprint Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    Aras Toker
    Helmholtz Centre for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3180-8. 2013
  4. doi request reprint Foxp3+ regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen
    Pedro Milanez-Almeida
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 45:153-66. 2015
  5. doi request reprint Induced and thymus-derived Foxp3⁺ regulatory T cells share a common niche
    Yi Ju Huang
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 44:460-8. 2014
  6. pmc The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling
    Lisa Schreiber
    Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 9:e88318. 2014
  7. doi request reprint To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms
    Aras Toker
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Sci Signal 4:pe4. 2011
  8. pmc Development of a unique epigenetic signature during in vivo Th17 differentiation
    Bi Huei Yang
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nucleic Acids Res 43:1537-48. 2015
  9. doi request reprint IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor
    Marc Schuster
    Systems oriented Immunology and Inflammation Research, Helmholtz Center for Infection Research, Braunschweig, Germany
    Immunity 37:998-1008. 2012
  10. pmc Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4+ T Cell Differentiation
    Joern Pezoldt
    Department Experimental Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
    Eur J Microbiol Immunol (Bp) 6:219-226. 2016

Collaborators

  • Michael Meyer-Hermann
  • Ingo Schmitz
  • Eva Medina
  • Andreas Beineke
  • Igor V Deyneko
  • Marc Beyer
  • Immo Prinz
  • Jorn Walter
  • Burkhart Schraven
  • Karsten Kretschmer
  • Siegfried Weiss
  • Shohei Hori
  • Stefan Floess
  • Aras Toker
  • Joern Pezoldt
  • Lisa Schreiber
  • Sahamoddin Khailaie
  • Tim Sparwasser
  • Julia K Polansky
  • Pedro Milanez-Almeida
  • Bi Huei Yang
  • Maria Pasztoi
  • Christina Tebartz
  • Yi Ju Huang
  • Lothar Jänsch
  • Marc Schuster
  • Sebastian König
  • Alf Hamann
  • Lothar Groebe
  • Georg Peters
  • Sarah Anita Horst
  • Stefanie Hagemann
  • Matthias Lochner
  • Verena Haist
  • Sebastian Suerbaum
  • Philippe A Robert
  • Beate Pietzsch
  • Carla Farah
  • Wolfgang Baumgartner
  • Lisa Föhse
  • Sven Olek
  • Sandra Düber
  • Robert Geffers
  • Garima Garg
  • Sonja Schallenberg
  • Pascal Giehr
  • Takahisa Miyao
  • Dirk Engelbert
  • Udo Baron
  • Andreas Jeron
  • Anja A Kuhl
  • Linda K Clayton
  • Tobias Reinl
  • Klaus Pfeffer
  • Rainer Glauben
  • Britta Siegmund
  • Michael Probst-Kepper
  • Klaus Schulze-Osthoff
  • Michaela Annemann
  • Carlos Plaza-Sirvent
  • Leif Ludwig
  • Melanie Krüger
  • Sascha Cording
  • Ria Baumgrass
  • Christoph Thelemann

Detail Information

Publications15

  1. doi request reprint Epigenetic and transcriptional control of Foxp3+ regulatory T cells
    Jochen Huehn
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124 Braunschweig, Germany Electronic address
    Semin Immunol 27:10-8. 2015
    ....
  2. doi request reprint Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
    Jochen Huehn
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nat Rev Immunol 9:83-9. 2009
    ....
  3. doi request reprint Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    Aras Toker
    Helmholtz Centre for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3180-8. 2013
    ..Together, our results demonstrate that initiating TSDR demethylation during early stages of thymic Treg development commences stabilization of Foxp3 expression and guarantees full functionality and long-term lineage stability of Tregs...
  4. doi request reprint Foxp3+ regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen
    Pedro Milanez-Almeida
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 45:153-66. 2015
    ..Hence, we provide the first estimation of the peripheral Treg-cell conversion rate and propose additional facets of Treg-cell-mediated immune regulation that may previously have escaped attention. ..
  5. doi request reprint Induced and thymus-derived Foxp3⁺ regulatory T cells share a common niche
    Yi Ju Huang
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 44:460-8. 2014
    ..However, when transferred together Nrp1⁺ tTreg cells outcompeted Nrp1⁻ iTreg cells and dominated the Treg-cell compartment. Taken together, our data suggest that tTreg cells and iTreg cells share a common peripheral niche...
  6. pmc The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling
    Lisa Schreiber
    Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 9:e88318. 2014
    ..In conclusion, we show that NF-κB signaling is not substantially involved in TSDR-mediated stabilization of Foxp3 expression in Tregs. ..
  7. doi request reprint To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms
    Aras Toker
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Sci Signal 4:pe4. 2011
    ....
  8. pmc Development of a unique epigenetic signature during in vivo Th17 differentiation
    Bi Huei Yang
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nucleic Acids Res 43:1537-48. 2015
    ....
  9. doi request reprint IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor
    Marc Schuster
    Systems oriented Immunology and Inflammation Research, Helmholtz Center for Infection Research, Braunschweig, Germany
    Immunity 37:998-1008. 2012
    ..Our results demonstrate that IκB(NS) critically regulates Treg cell development in the thymus and during gut inflammation, indicating that strategies targeting IκB(NS) could modulate the Treg cell compartment...
  10. pmc Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4+ T Cell Differentiation
    Joern Pezoldt
    Department Experimental Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
    Eur J Microbiol Immunol (Bp) 6:219-226. 2016
    ..Collectively, these findings identify further aspects of early T cell differentiation within skin-draining pLNs, which could be utilized to further develop tailored and highly specialized vaccination strategies...
  11. doi request reprint Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells
    Maria Pasztoi
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Prog Mol Biol Transl Sci 136:35-56. 2015
    ....
  12. doi request reprint A signal integration model of thymic selection and natural regulatory T cell commitment
    Sahamoddin Khailaie
    Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
    J Immunol 193:5983-96. 2014
    ..This study provides a mechanistic model showing that time integration of TCR-mediated signals, as opposed to single-cell interaction events, is needed to gain a full view on the properties emerging from thymic selection. ..
  13. doi request reprint A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection
    Christina Tebartz
    Infection Immunology Research Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
    J Immunol 194:1100-11. 2015
    ..In summary, our results indicate that expansion of MDSC and, to a minor degree, of regulatory T cells in S. aureus-infected mice may create an immunosuppressive environment that sustains chronic infection. ..
  14. pmc Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    Julia K Polansky
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124, Braunschweig, Germany
    J Mol Med (Berl) 88:1029-40. 2010
    ..We therefore propose that Ets-1 is part of a larger protein complex, which binds to the TSDR only in its demethylated state, thereby restricting stable Foxp3 expression to the Treg lineage...
  15. pmc First insight into the kinome of human regulatory T cells
    Sebastian König
    Department of Molecular Structural Biology, Helmholtz Zentrum für Infektionsforschung, Braunschweig, Germany
    PLoS ONE 7:e40896. 2012
    ....