Luka Cicin-Sain

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. pmc Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency
    Franziska Dağ
    Department for Vaccinology Immune Aging and Chronic Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS Pathog 10:e1003962. 2014
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
  3. pmc Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging
    Luka Cicin-Sain
    Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany
    PLoS Pathog 8:e1002849. 2012
  4. pmc Type I Interferon Released by Myeloid Dendritic Cells Reversibly Impairs Cytomegalovirus Replication by Inhibiting Immediate Early Gene Expression
    Julia Katharina Holzki
    Department for Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Virol 89:9886-95. 2015
  5. pmc Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections
    Thomas F Marandu
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research HZI, Braunschweig, Germany Dar es salaam University College of Education, Dar es Salaam, Tanzania
    J Virol 89:11715-7. 2015
  6. doi request reprint Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection
    Jennifer D Oduro
    1 Department of Vaccinology Immune Aging and Chronic Infections, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Gen Virol 97:185-95. 2016
  7. doi request reprint The context of gene expression defines the immunodominance hierarchy of cytomegalovirus antigens
    Iryna Dekhtiarenko
    Department of Vaccinology, Helmholtz Center for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3399-409. 2013
  8. pmc Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts
    Linda Ebermann
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS Pathog 8:e1003062. 2012
  9. doi request reprint Activated NKT cells imprint NK-cell differentiation, functionality and education
    Peggy Riese
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 45:1794-807. 2015
  10. doi request reprint Mouse CMV infection delays antibody class switch upon an unrelated virus challenge
    Thomas F Marandu
    Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany Dar es salaam University College of Education, Tanzania
    Exp Gerontol 54:101-8. 2014

Collaborators

  • Janko Nikolich-Zugich
  • Zsolt Ruzsics
  • Ramon Arens
  • Niels A W Lemmermann
  • Stefan Lienenklaus
  • Lars Dölken
  • Dagmar Wirth
  • Barbara Adler
  • Iryna Dekhtiarenko
  • Thomas F Marandu
  • Jennifer D Oduro
  • Peggy Riese
  • Franziska Dağ
  • Linda Ebermann
  • Tobias May
  • Stephanie Trittel
  • Julia Katharina Holzki
  • Anja Drabig
  • Andrea Kröger
  • Ulfert Rand
  • Martin Messerle
  • Rosaely Casalegno-Garduño
  • Carlos A Guzman
  • Rafael Solana
  • Dirk H Busch
  • Julia K Holzki
  • Anke Redeker
  • Jennifer L Uhrlaub
  • Lisa Borkner
  • Benedict J Chambers
  • Katja Finsterbusch
  • Siegfried Weiß
  • Johannes Schwerk
  • Mario Köster
  • Ianina Conte
  • Julia Holzki
  • Hansjorg Hauser
  • Robert Geffers
  • Colin Davenport
  • Adrien Weingärtner
  • Michael A Jarvis
  • Anis Larbi
  • Victor Appay
  • Carmen Campos
  • Maciej Zielinski
  • Daniela Frasca
  • George C Wang
  • Sara Ferrando-Martínez
  • Florian Kern
  • Graham Pawelec
  • Mikko Hurme
  • Natalie Riddell
  • Beatriz Sanchez-Correa
  • Jerrald L Rector
  • Sara Cantisán
  • Miguel Lopez-Botet
  • Ann Hill
  • Nico Van Rooijen
  • Andrea B Maier
  • Elissaveta Naumova
  • Rene van Lier
  • Paolo Sansoni
  • Alejandra Pera
  • Mark Beswick
  • Tamas Fulop
  • Sheila Govind
  • Evelyna Derhovanessian
  • Janet E McElhaney
  • Jos A Bosch
  • Delphine Sauce
  • Mark R Wills
  • Raquel Tarazona
  • Ulrich Koszinowski
  • Allison E Aiello
  • Paul Moss
  • Arne N Akbar
  • Beatrix Grubeck-Loebenstein

Detail Information

Publications11

  1. pmc Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency
    Franziska Dağ
    Department for Vaccinology Immune Aging and Chronic Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS Pathog 10:e1003962. 2014
    ....
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
    ..Here we summarize the major findings of this workshop...
  3. pmc Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging
    Luka Cicin-Sain
    Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany
    PLoS Pathog 8:e1002849. 2012
    ..Therefore, latent MCMV infection resulted in pronounced changes of the T-cell compartment consistent with impaired naïve T-cell function...
  4. pmc Type I Interferon Released by Myeloid Dendritic Cells Reversibly Impairs Cytomegalovirus Replication by Inhibiting Immediate Early Gene Expression
    Julia Katharina Holzki
    Department for Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Virol 89:9886-95. 2015
    ..In light of our recent observation that type I IFN is sufficient for the induction of latency immediately upon infection, our results imply that IFN secreted by mDC may play an important role in the establishment of CMV latency...
  5. pmc Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections
    Thomas F Marandu
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research HZI, Braunschweig, Germany Dar es salaam University College of Education, Dar es Salaam, Tanzania
    J Virol 89:11715-7. 2015
    ..Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients. ..
  6. doi request reprint Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection
    Jennifer D Oduro
    1 Department of Vaccinology Immune Aging and Chronic Infections, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Gen Virol 97:185-95. 2016
    ..In conclusion, we showed that intranasal but not intragastric infection of mice with MCMV represents a robust model to study the short- and long-term biology of CMV infection by a mucosal route. ..
  7. doi request reprint The context of gene expression defines the immunodominance hierarchy of cytomegalovirus antigens
    Iryna Dekhtiarenko
    Department of Vaccinology, Helmholtz Center for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3399-409. 2013
    ....
  8. pmc Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts
    Linda Ebermann
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS Pathog 8:e1003062. 2012
    ....
  9. doi request reprint Activated NKT cells imprint NK-cell differentiation, functionality and education
    Peggy Riese
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 45:1794-807. 2015
    ..Thus, our findings reveal new fundamental aspects of the NKT-NK cell axis that provide important hints for the manipulation of NK cells in clinical settings. ..
  10. doi request reprint Mouse CMV infection delays antibody class switch upon an unrelated virus challenge
    Thomas F Marandu
    Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany Dar es salaam University College of Education, Tanzania
    Exp Gerontol 54:101-8. 2014
    ..Therefore, our results argue that latent CMV infection impairs B-cell, but not T-cell responses to a challenge with VSV and delays antibody class-switch by a mechanism which may be independent of T-cell help. ..
  11. doi request reprint Use of recombinant approaches to construct human cytomegalovirus mutants
    Iryna Dekhtiarenko
    Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Methods Mol Biol 1119:59-79. 2014
    ..Here we describe the methods used for the generation of a CMV BAC, targeted mutagenesis of BAC clones, and transfection of human cells with CMV BAC DNA in order to reconstitute the viral infection process. ..