Alexander Strom

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. doi request reprint Spontaneous obesity-linked type 2 diabetes in the absence of islet amyloid in a cynomolgus monkey infected with bovine spongiform encephalopathy
    A Strom
    Institute for Clinical Diabetology, German Diabetes Center, Auf m Hennekamp 65, D 40225 Dusseldorf, Germany email
    Vet Pathol 50:909-13. 2013
  2. doi request reprint Cellular interferon-γ and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: action LADA 6
    Alexander Strom
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Dusseldorf, Germany
    Cytokine 58:148-51. 2012
  3. pmc Improved preservation of residual beta cell function by atorvastatin in patients with recent onset type 1 diabetes and high CRP levels (DIATOR trial)
    Alexander Strom
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 7:e33108. 2012
  4. doi request reprint Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Eur J Cell Biol 90:414-9. 2011
  5. doi request reprint Effect of Low-Energy Diets Differing in Fiber, Red Meat, and Coffee Intake on Cardiac Autonomic Function in Obese Individuals With Type 2 Diabetes
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany Department of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany German Center for Diabetes Research DZD, Partner Düsseldorf, Dusseldorf, Germany
    Diabetes Care 38:1750-7. 2015
  6. ncbi request reprint Impaired glucose tolerance in mice lacking cellular prion protein
    Alexander Strom
    Chronic Disease Program, Institute for Clinical Diabetology, German Diabetes Centre, Du sseldorf, Germany
    Pancreas 40:229-32. 2011
  7. ncbi request reprint Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Ottawa, ON, Canada
    Lab Invest 87:139-49. 2007
  8. doi request reprint Heme Oxygenase-1 Induction Prevents Autoimmune Diabetes in Association With Pancreatic Recruitment of M2-Like Macrophages, Mesenchymal Cells, and Fibrocytes
    Mahmoud Husseini
    Chronic Disease Program M H, G S W, C P, J A C, J A N, A s, F W S, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 and Departments of Biochemistry, Microbiology, and Immunology M H, C P, A J M, J A N, F W S and Medicine F W S, University of Ottawa, Ottawa, Ontario, Canada K1H 8L6 Food Directorate A J M, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada K1A 0K9
    Endocrinology 156:3937-49. 2015
  9. doi request reprint Adiponectin, markers of subclinical inflammation and nerve conduction in individuals with recently diagnosed type 1 and type 2 diabetes
    Imke Schamarek
    Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, GermanyGerman Center for Diabetes ResearchMünchen Neuherberg, GermanyInstitute for Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, GermanyGerman Center for Diabetes ResearchMünchen Neuherberg, GermanyInstitute for Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Eur J Endocrinol 174:433-43. 2016
  10. pmc Antibodies from a patient with type 1 diabetes and celiac disease bind to macrophages that express the scavenger receptor CD163
    Brigitte Sonier
    Chronic Disease Program, Ottowa Hospital Research Institute, Ottowa, Ontario
    Can J Gastroenterol 25:327-9. 2011

Collaborators

Detail Information

Publications21

  1. doi request reprint Spontaneous obesity-linked type 2 diabetes in the absence of islet amyloid in a cynomolgus monkey infected with bovine spongiform encephalopathy
    A Strom
    Institute for Clinical Diabetology, German Diabetes Center, Auf m Hennekamp 65, D 40225 Dusseldorf, Germany email
    Vet Pathol 50:909-13. 2013
    ..This unusual case of spontaneous T2D in the absence of islet amyloid deposits could have been due to early prion spread from the periphery to the endocrine system or could have occurred spontaneously. ..
  2. doi request reprint Cellular interferon-γ and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: action LADA 6
    Alexander Strom
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Dusseldorf, Germany
    Cytokine 58:148-51. 2012
    ..This study aimed to compare the pro-inflammatory (interferon-γ, IFN-γ) and anti-inflammatory (interleukin-13, IL-13) T-cell responses in humans with LADA and type 1 diabetes...
  3. pmc Improved preservation of residual beta cell function by atorvastatin in patients with recent onset type 1 diabetes and high CRP levels (DIATOR trial)
    Alexander Strom
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 7:e33108. 2012
    ..Aim of this secondary analysis was to identify patient subgroups which differ in the decline of beta cell function during treatment with atorvastatin...
  4. doi request reprint Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Eur J Cell Biol 90:414-9. 2011
    ..This study reveals new avenues for the elucidation of the physiological function of PrP(C) in endocrine and neuronal cells as well as the molecular mechanisms leading to prion diseases...
  5. doi request reprint Effect of Low-Energy Diets Differing in Fiber, Red Meat, and Coffee Intake on Cardiac Autonomic Function in Obese Individuals With Type 2 Diabetes
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany Department of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany German Center for Diabetes Research DZD, Partner Düsseldorf, Dusseldorf, Germany
    Diabetes Care 38:1750-7. 2015
    ..Thus, we sought to determine whether low-energy diets differing in fiber, red meat, and coffee intake exert differential effects on cardiac autonomic function...
  6. ncbi request reprint Impaired glucose tolerance in mice lacking cellular prion protein
    Alexander Strom
    Chronic Disease Program, Institute for Clinical Diabetology, German Diabetes Centre, Du sseldorf, Germany
    Pancreas 40:229-32. 2011
    ..To further characterize the function of PrPC in glucose homeostasis, we studied glucoregulation in PrPC knockout (PrPC KO) mice...
  7. ncbi request reprint Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Ottawa, ON, Canada
    Lab Invest 87:139-49. 2007
    ..These data suggest a potential dysfunction in beta-cells of diabetes-prone rats, and point to new avenues for the study of diabetes pathogenesis...
  8. doi request reprint Heme Oxygenase-1 Induction Prevents Autoimmune Diabetes in Association With Pancreatic Recruitment of M2-Like Macrophages, Mesenchymal Cells, and Fibrocytes
    Mahmoud Husseini
    Chronic Disease Program M H, G S W, C P, J A C, J A N, A s, F W S, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 and Departments of Biochemistry, Microbiology, and Immunology M H, C P, A J M, J A N, F W S and Medicine F W S, University of Ottawa, Ottawa, Ontario, Canada K1H 8L6 Food Directorate A J M, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada K1A 0K9
    Endocrinology 156:3937-49. 2015
    ..Thus, short-term induction of HO-1 promoted a protective M2-like milieu in the pancreas and recruited mesenchymal cells, M2 macrophages, and fibrocytes that imparted immunoregulatory and pro-repair effects, preventing T1D...
  9. doi request reprint Adiponectin, markers of subclinical inflammation and nerve conduction in individuals with recently diagnosed type 1 and type 2 diabetes
    Imke Schamarek
    Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, GermanyGerman Center for Diabetes ResearchMünchen Neuherberg, GermanyInstitute for Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, GermanyGerman Center for Diabetes ResearchMünchen Neuherberg, GermanyInstitute for Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Eur J Endocrinol 174:433-43. 2016
    ..Therefore, we aimed to investigate associations of biomarkers reflecting different aspects of subclinical inflammation with motor and sensory nerve conduction velocity (NCV) in individuals with diabetes...
  10. pmc Antibodies from a patient with type 1 diabetes and celiac disease bind to macrophages that express the scavenger receptor CD163
    Brigitte Sonier
    Chronic Disease Program, Ottowa Hospital Research Institute, Ottowa, Ontario
    Can J Gastroenterol 25:327-9. 2011
    ..The novel finding of putative autoantibodies against tolerogenic intestinal CD163⁺ macrophages suggests that regulatory macrophages were targeted in this patient with celiac disease and T1D...
  11. doi request reprint Overexpression of cutaneous mitochondrial superoxide dismutase in recent-onset type 2 diabetes
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Auf m Hennekamp 65, 40225, Dusseldorf, Germany
    Diabetologia 58:1621-5. 2015
    ..We hypothesised that patients with recently diagnosed type 2 diabetes would show an altered cutaneous expression of SOD2 and endothelial cell area...
  12. pmc Peripherin-reactive antibodies in mouse, rabbit, and human blood
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Proteome Res 9:1203-8. 2010
    ..These findings point to the need for a re-evaluation of PRPH as a T1D autoantigen in NOD mice and raise the question of the physiological relevance of such widespread immune reactivity against this peripheral nervous system protein...
  13. doi request reprint Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes
    Amanda J MacFarlane
    Nutrition Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON K1A0K9, Canada
    Mamm Genome 20:624-32. 2009
    ..Here we speculate on various candidate processes and molecules of the immune and endocrine systems that could modify risk for T1D through epigenetic regulation...
  14. pmc Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany Department of Endocrinology and Diabetology, University Hospital, Dusseldorf, Germany German Center for Diabetes Research DZD, Partner Düsseldorf, Dusseldorf, Germany
    PLoS ONE 10:e0124242. 2015
    ....
  15. pmc Foodborne transmission of bovine spongiform encephalopathy to non-human primates results in preclinical rapid-onset obesity
    Alexander Strom
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    PLoS ONE 9:e104343. 2014
    ..To our knowledge, this is the first experimental model which clearly demonstrates that foodborne pathogens can induce obesity. ..
  16. doi request reprint Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, GermanyDepartment of Endocrinology and Diabetology, University Hospital, Dusseldorf, Germany
    Diabetes 63:2454-63. 2014
    ..Concomitant NCS impairment points to an early parallel involvement of small and large fibers, but the precise temporal sequence should be clarified in prospective studies. ..
  17. doi request reprint Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Auf m Hennekamp 65, 40225, Dusseldorf, Germany
    Diabetologia 58:1118-28. 2015
    ..We aimed to determine the prevalence of, risk factors for and impact of CAND in glucose intolerance and diabetes...
  18. doi request reprint High prevalence of diagnosed and undiagnosed polyneuropathy in subjects with and without diabetes participating in a nationwide educational initiative (PROTECT study)
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany Department of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany Electronic address
    J Diabetes Complications 29:998-1002. 2015
    ..Since neuropathy screening may be underutilized in primary care practice, we conducted a nationwide educational initiative to determine the prevalence of diagnosed and previously undiagnosed polyneuropathy...
  19. doi request reprint Pronounced reduction of cutaneous Langerhans cell density in recently diagnosed type 2 diabetes
    Alexander Strom
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Diabetes 63:1148-53. 2014
    ....
  20. ncbi request reprint Dietary proteins as environmental modifiers of type 1 diabetes mellitus
    David E Lefebvre
    Molecular Medicine, Ottawa Health Research Institute, Ottawa, Ontario, K1H 8L6, Canada
    Annu Rev Nutr 26:175-202. 2006
    ..The key to diabetes pathogenesis, its prevention, and the ultimate success of beta-cell replacement therapies lies in understanding how the environment controls disease expression. Dietary proteins could be one of these keys...
  21. ncbi request reprint Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Lab N1, Box 221, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Proteomics 6:26-34. 2006
    ..Especially the application of this technique to investigate other neurodegenerative diseases is promising...