Helmut Hanenberg

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Phenotypic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool
    Helmut Hanenberg
    Klinik für Pädiatrische Hämatologie und Onkologie, Zentrum fur Kinderheilkunde, Heinrich Heine Universitat, Dusseldorf, Germany
    Exp Hematol 30:410-20. 2002
  2. doi request reprint High expression of CD40 on B-cell precursor acute lymphoblastic leukemia blasts is an independent risk factor associated with improved survival and enhanced capacity to up-regulate the death receptor CD95
    Anja Troeger
    Clinic for Pediatric Oncology, Heinrich Heine University of Duesseldorf, Duesseldorf, Germany
    Blood 112:1028-34. 2008
  3. pmc Analysis of prototype foamy virus particle-host cell interaction with autofluorescent retroviral particles
    Kristin Stirnnagel
    Institut fur Virologie, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Retrovirology 7:45. 2010
  4. pmc Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents
    Andreas Palagyi
    Department of Medicine II, Ludwig Maximilians University, Campus Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    Mol Cancer 9:127. 2010
  5. ncbi request reprint Horizontal gene transfer from human endothelial cells to rat cardiomyocytes after intracoronary transplantation
    Sandra Burghoff
    Institute for Heart and Circulatory Physiology, Heinrich Heine University Duesseldorf, Universitaetsstr 1, 40225 Duesseldorf, Germany
    Cardiovasc Res 77:534-43. 2008
  6. ncbi request reprint High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor-acute lymphoblastic leukaemia
    Anja Troeger
    Clinic for Paediatric Haematology, Oncology and Immunology, Heinrich Heine University, Duesseldorf, Germany
    Br J Haematol 139:450-7. 2007
  7. ncbi request reprint Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia
    Anja Troeger
    Clinic for Pediatric Oncology, Hematology and Immunology, University of Duesseldorf, Duesseldorf, Germany
    Haematologica 92:1043-50. 2007
  8. pmc Human cytomegalovirus disrupts the major histocompatibility complex class I peptide-loading complex and inhibits tapasin gene transcription
    Anne Halenius
    Institute for Virology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    J Virol 85:3473-85. 2011
  9. ncbi request reprint Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells
    Cordula Leurs
    Klinik für Pädiatrische Hämatologie und Onkologie, Zentrum fur Kinderheilkunde, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Hum Gene Ther 14:509-19. 2003
  10. pmc Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells
    Niklas Feldhahn
    Laboratory for Molecular Stem Cell Biology, Institute for Transplantation Diagnostics and Cell Therapeutics, and Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 102:13266-71. 2005

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Phenotypic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool
    Helmut Hanenberg
    Klinik für Pädiatrische Hämatologie und Onkologie, Zentrum fur Kinderheilkunde, Heinrich Heine Universitat, Dusseldorf, Germany
    Exp Hematol 30:410-20. 2002
    ..The aim of this study was to develop a rapid laboratory procedure that is capable of subtyping Fanconi anemia (FA) complementation groups FA-A, FA-C, FA-G, and FA-nonACG patients from a small amount of peripheral blood...
  2. doi request reprint High expression of CD40 on B-cell precursor acute lymphoblastic leukemia blasts is an independent risk factor associated with improved survival and enhanced capacity to up-regulate the death receptor CD95
    Anja Troeger
    Clinic for Pediatric Oncology, Heinrich Heine University of Duesseldorf, Duesseldorf, Germany
    Blood 112:1028-34. 2008
    ..Thus very high expression of CD40 on BCP-ALL blasts is an independent prognostic marker indicative of superior relapse-free survival that may in part be due to CD40-dependent death receptor up-regulation...
  3. pmc Analysis of prototype foamy virus particle-host cell interaction with autofluorescent retroviral particles
    Kristin Stirnnagel
    Institut fur Virologie, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Retrovirology 7:45. 2010
    ..Second, the unusually broad host range of FV is thought to be due to use of a very common entry receptor present on host cell plasma membranes, because all cell lines tested in vitro so far are permissive...
  4. pmc Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents
    Andreas Palagyi
    Department of Medicine II, Ludwig Maximilians University, Campus Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    Mol Cancer 9:127. 2010
    ..Except for pancreatic cancer, however, the prevalence of FA defects in gastrointestinal (GI) tumors has not yet been systematically explored...
  5. ncbi request reprint Horizontal gene transfer from human endothelial cells to rat cardiomyocytes after intracoronary transplantation
    Sandra Burghoff
    Institute for Heart and Circulatory Physiology, Heinrich Heine University Duesseldorf, Universitaetsstr 1, 40225 Duesseldorf, Germany
    Cardiovasc Res 77:534-43. 2008
    ..To test the functional relevance of this observation, we examined the transdifferentiation potential of HUVECs in vivo after intracoronary cell application in Wistar rats...
  6. ncbi request reprint High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor-acute lymphoblastic leukaemia
    Anja Troeger
    Clinic for Paediatric Haematology, Oncology and Immunology, Heinrich Heine University, Duesseldorf, Germany
    Br J Haematol 139:450-7. 2007
    ..041). Thus, in this prospective analysis, high p75NTR expression was a strong prognostic marker that identified a group of paediatric ALL patients with favourable outcome...
  7. ncbi request reprint Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia
    Anja Troeger
    Clinic for Pediatric Oncology, Hematology and Immunology, University of Duesseldorf, Duesseldorf, Germany
    Haematologica 92:1043-50. 2007
    ..To date, however, there is no information available on the prognostic role of survivin in pediatric precursor B-cell acute lymphocytic leukemia (BCP-ALL), the most frequent malignancy in childhood...
  8. pmc Human cytomegalovirus disrupts the major histocompatibility complex class I peptide-loading complex and inhibits tapasin gene transcription
    Anne Halenius
    Institute for Virology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    J Virol 85:3473-85. 2011
    ..The data presented here document a two-pronged coordinated attack on tapasin function by HCMV...
  9. ncbi request reprint Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells
    Cordula Leurs
    Klinik für Pädiatrische Hämatologie und Onkologie, Zentrum fur Kinderheilkunde, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Hum Gene Ther 14:509-19. 2003
    ..These data demonstrate that vectors based on FVs warrant further investigation and development for medical use...
  10. pmc Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells
    Niklas Feldhahn
    Laboratory for Molecular Stem Cell Biology, Institute for Transplantation Diagnostics and Cell Therapeutics, and Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 102:13266-71. 2005
    ....
  11. ncbi request reprint A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint
    Brian W Freie
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 279:50986-93. 2004
    ....
  12. ncbi request reprint In vitro phenotypic correction of hematopoietic progenitors from Fanconi anemia group A knockout mice
    Paula Rio
    Hematopoietic Gene Therapy Program, Centro de Investigaciones Energeticas, Medioambientales y Tecnológicas CIEMAT Marcelino Botín Foundation, 22840 Madrid, Spain
    Blood 100:2032-9. 2002
    ..More significantly, transductions with FANCA vectors corrected both the MMC hypersensitivity as well as the impaired ex vivo expansion ability that characterized the BM progenitors of Fanca(-/-) mice...
  13. ncbi request reprint Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing
    Manfred Schmidt
    Department I of Internal Medicine, University of Freiburg, 79106 Freiburg, Germany
    Ann N Y Acad Sci 996:112-21. 2003
    ....
  14. ncbi request reprint Spectrum of sequence variation in the FANCG gene: an International Fanconi Anemia Registry (IFAR) study
    Arleen D Auerbach
    Laboratory of Human Genetics and Hematology, Rockefeller University, New York, New York 10021 6399, USA
    Hum Mutat 21:158-68. 2003
    ..Our data suggest that the Portuguese-Brazilian, French-Acadian, and Korean/Japanese mutations were likely to have been present in a founding member of each of these populations...
  15. ncbi request reprint A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients
    Saurabh Chandra
    Division of Experimental Hematology and Fanconi Anemia Comprehensive Care Center, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mol Ther 12:976-84. 2005
    ..This assay has now been established in a standardized fashion for complementation assignments in FA patients and the subsequent directing of rapid mutation analysis in those patients...
  16. pmc Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype
    Reinhard Kalb
    Department of Human Genetics, University of Wurzburg, Wurzburg, Germany
    Am J Hum Genet 80:895-910. 2007
    ..Although hypomorphic mutations arie involved, clinically, these patients have a relatively severe form of FA...
  17. pmc A comprehensive strategy for the subtyping of patients with Fanconi anaemia: conclusions from the Spanish Fanconi Anemia Research Network
    José Antonio Casado
    Spanish Fanconi Anemia Research Network and Centre for Biomedical Research on Rare Diseases CIBERER, Madrid, Spain
    J Med Genet 44:241-9. 2007
    ..Identifying the complementation group in patients with Fanconi anaemia constitutes a direct procedure to confirm the diagnosis of the disease and is required for the recruitment of these patients in gene therapy trials...
  18. ncbi request reprint Decreased platelet reactivity identified by whole blood flow cytometry in Fanconi anaemia patients
    Susanne Holzhauer
    University Children s Hospital, University of Wuerzburg, Germany
    Thromb Haemost 98:1291-7. 2007
    ..Our data show that FA is associated with reduced platelet reactivity, which may contribute to the high bleeding tendency in FA patients. Whole blood flow cytometry is a suitable method for analysis of platelet function in FA patients...
  19. pmc In vivo selection of hematopoietic stem cells transduced at a low multiplicity-of-infection with a foamy viral MGMT(P140K) vector
    Shanbao Cai
    Department of Pediatrics, James Whitcomb Riley Hospital for Children and Indiana University School of Medicine, Indianapolis, IN 46202 5525, USA
    Exp Hematol 36:283-92. 2008
    ....
  20. pmc Restriction of foamy viruses by primate Trim5alpha
    Melvyn W Yap
    Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    J Virol 82:5429-39. 2008
    ..This region most likely corresponds to the capsid of conventional retroviruses. Due to their unique replication strategy, FVs should provide a valuable new system to examine the mechanism of retroviral restriction by Trim5alpha...
  21. ncbi request reprint A 20-year perspective on the International Fanconi Anemia Registry (IFAR)
    David I Kutler
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Blood 101:1249-56. 2003
    ..The results of this study of patients registered in the IFAR over a 20-year period provide information that will enable better prediction of outcome and aid clinicians with decisions regarding major therapeutic modalities...
  22. pmc Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer
    Marianne Berwick
    Cancer Research and Treatment Center Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA
    Cancer Res 67:9591-6. 2007
    ..4; 95% CI, 1.1-5.2). Overall, there was no increased risk for cancer among FA heterozygotes in this study of Fanconi relatives, although there is some evidence that FANCC mutations are possibly breast cancer susceptibility alleles...
  23. ncbi request reprint The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival
    Leonid Schneider
    Institut für Biochemie und Molekularbiologie II, Universitätsklinikum der Heinrich Heine Universität, 40225 Dusseldorf, Germany
    J Biol Chem 282:29273-83. 2007
    ..Our findings therefore point to an essential role of TACC3 in spindle assembly and cellular survival and identify TACC3 as a potential therapeutic target in cancer cells...
  24. ncbi request reprint Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia
    Kenneth Offit
    Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 95:1548-51. 2003
    ..Individuals who carry a germline BRCA2 mutation and who plan to have children with a partner of Ashkenazi Jewish descent should consider undergoing genetic counseling...
  25. ncbi request reprint A common founder mutation in FANCA underlies the world's highest prevalence of Fanconi anemia in Gypsy families from Spain
    Elsa Callen
    Universitat Autònoma de Barcelona and the Hospital Meterno Infantil Vall d Hebron, Barcelona, Spain
    Blood 105:1946-9. 2005
    ..The high carrier frequency makes the Spanish Gypsies a population model to study FA heterozygote mutations in cancer...
  26. ncbi request reprint Peripheral myelin protein 22 kDa and protein zero: domain specific trans-interactions
    Birgit Hasse
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University, 40225 Dusseldorf, Germany
    Mol Cell Neurosci 27:370-8. 2004
    ..In addition, we demonstrate that disease-related point mutations of P0 resulted in a decreased adhesion capability correlating with the severity of the respective disease phenotype...
  27. ncbi request reprint Spectrum of sequence variations in the FANCA gene: an International Fanconi Anemia Registry (IFAR) study
    Orna Levran
    Laboratory of Human Genetics and Hematology, Rockefeller University, New York, New York 10021 6399, USA
    Hum Mutat 25:142-9. 2005
    ..In addition, a conserved SNP haplotype block spanning at least 60 kb of the FANCA gene was identified in individuals from various ethnic groups...
  28. ncbi request reprint The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
    Orna Levran
    Laboratory for Human Genetics and Hematology, The Rockefeller University, New York, New York, USA
    Nat Genet 37:931-3. 2005
    ..Using genetic mapping, mutation identification and western-blot data, we identify the defective protein in FA-J cells as BRIP1 (also called BACH1), a DNA helicase that is a binding partner of the breast cancer tumor suppressor BRCA1...
  29. ncbi request reprint GST genotype may modify clinical phenotype in patients with Fanconi anaemia
    Stella M Davies
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45329, USA
    Br J Haematol 131:118-22. 2005
    ..GSTM1 genotype significantly influenced time to bone marrow failure in complementation group FA-C, (median age 3.0 years vs. 7.0 years, P < 0.01). GSTP1 genotype did not influence FA phenotype...
  30. ncbi request reprint Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia
    John E Wagner
    Division of Pediatric Hematology, Oncology, and Blood Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA
    Blood 103:3226-9. 2004
    ..Our results suggest that BRCA2 testing should be considered in all patients with FA in whom the complementation group cannot be defined or in whom leukemia is diagnosed at or before 5 years of age...
  31. ncbi request reprint Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer
    Sarah Reid
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Nat Genet 39:162-4. 2007
    ....
  32. ncbi request reprint FANCI is a second monoubiquitinated member of the Fanconi anemia pathway
    Ashley E Sims
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    Nat Struct Mol Biol 14:564-7. 2007
    ..Biallelic mutations in the gene coding for this protein were found in cells from four FA patients, including an FA-I reference cell line...
  33. ncbi request reprint Delayed diagnosis and complications of Fanconi anaemia at advanced age--a paradigm
    Kirsten Huck
    Department of Paediatric Oncology, Haematology and Immunology, Children s Hospital UKD, Heinrich Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Br J Haematol 133:188-97. 2006
    ....