Jens W Fischer

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc Esophageal Squamous Cell Carcinoma Cells Modulate Chemokine Expression and Hyaluronan Synthesis in Fibroblasts
    Inga Kretschmer
    From the Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum der Heinrich Heine Universität, Moorenstrasse 5, 40225 Dusseldorf, Germany and
    J Biol Chem 291:4091-106. 2016
  2. pmc The impact of the receptor of hyaluronan-mediated motility (RHAMM) on human urothelial transitional cell cancer of the bladder
    Christian Niedworok
    Department of Urology, Essen Medical School, University Duisburg Essen, Essen, Germany
    PLoS ONE 8:e75681. 2013
  3. pmc Inhibitory role of the small leucine-rich proteoglycan biglycan in bladder cancer
    Christian Niedworok
    Department of Urology, Essen Medical School, University Duisburg Essen, Essen, Germany
    PLoS ONE 8:e80084. 2013
  4. ncbi request reprint Regulation of hyaluronan synthesis by vasodilatory prostaglandins. Implications for atherosclerosis
    Jens W Fischer
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Dusseldorf, Germany
    Thromb Haemost 98:287-95. 2007
  5. pmc Pharmacologic inhibition of nitric oxide synthases and cyclooxygenases enhances intimal hyperplasia in balloon-injured rat carotid arteries
    Jens W Fischer
    Molekulare Pharmakologie, Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Germany
    J Vasc Surg 40:115-22. 2004
  6. pmc Estradiol protects dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes
    Katharina Röck
    Institut für Pharmakologie and Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat Dusseldorf, Germany
    J Biol Chem 287:20056-69. 2012
  7. doi request reprint A novel function of FoxO transcription factors in thrombin-stimulated vascular smooth muscle cell proliferation
    Shailaja G Mahajan
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Thromb Haemost 108:148-58. 2012
  8. doi request reprint Thrombin receptors in vascular smooth muscle cells - function and regulation by vasodilatory prostaglandins
    Karsten Schror
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Universitatsstrasse 1, Gebäude 22 21, 40225 Dusseldorf, Germany
    Thromb Haemost 103:884-90. 2010
  9. pmc Collagen fragments inhibit hyaluronan synthesis in skin fibroblasts in response to ultraviolet B (UVB): new insights into mechanisms of matrix remodeling
    Katharina Röck
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, 40225 Dusseldorf, Germany
    J Biol Chem 286:18268-76. 2011
  10. doi request reprint Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions
    Bernhard H Rauch
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Germany
    Arterioscler Thromb Vasc Biol 30:2434-42. 2010

Collaborators

Detail Information

Publications42

  1. pmc Esophageal Squamous Cell Carcinoma Cells Modulate Chemokine Expression and Hyaluronan Synthesis in Fibroblasts
    Inga Kretschmer
    From the Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum der Heinrich Heine Universität, Moorenstrasse 5, 40225 Dusseldorf, Germany and
    J Biol Chem 291:4091-106. 2016
    ....
  2. pmc The impact of the receptor of hyaluronan-mediated motility (RHAMM) on human urothelial transitional cell cancer of the bladder
    Christian Niedworok
    Department of Urology, Essen Medical School, University Duisburg Essen, Essen, Germany
    PLoS ONE 8:e75681. 2013
    ..The present study addressed the role of HA matrix for progression and prognosis of human bladder cancer by studying the expression and function of HA-related genes...
  3. pmc Inhibitory role of the small leucine-rich proteoglycan biglycan in bladder cancer
    Christian Niedworok
    Department of Urology, Essen Medical School, University Duisburg Essen, Essen, Germany
    PLoS ONE 8:e80084. 2013
    ..Therefore, aim of the present study was to assess the possible implication of the small leucine-rich proteoglycan biglycan in progression of human urothelial bladder cancer...
  4. ncbi request reprint Regulation of hyaluronan synthesis by vasodilatory prostaglandins. Implications for atherosclerosis
    Jens W Fischer
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Dusseldorf, Germany
    Thromb Haemost 98:287-95. 2007
    ..This review discusses the regulation of HA-synthesis by prostaglandins and the evidence for a central role of cyclooxygenase-2/PGE2 in regulation of HA-synthesis during atherogenesis...
  5. pmc Pharmacologic inhibition of nitric oxide synthases and cyclooxygenases enhances intimal hyperplasia in balloon-injured rat carotid arteries
    Jens W Fischer
    Molekulare Pharmakologie, Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Germany
    J Vasc Surg 40:115-22. 2004
    ..The purpose of the present study was to test the hypothesis that endogenously generated nitric oxide (NO) and prostaglandins act synergistically to limit the extent of neointimal hyperplasia...
  6. pmc Estradiol protects dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes
    Katharina Röck
    Institut für Pharmakologie and Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat Dusseldorf, Germany
    J Biol Chem 287:20056-69. 2012
    ....
  7. doi request reprint A novel function of FoxO transcription factors in thrombin-stimulated vascular smooth muscle cell proliferation
    Shailaja G Mahajan
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Thromb Haemost 108:148-58. 2012
    ..This may contribute to remodelling and failure of saphenous vein bypass grafts...
  8. doi request reprint Thrombin receptors in vascular smooth muscle cells - function and regulation by vasodilatory prostaglandins
    Karsten Schror
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Universitatsstrasse 1, Gebäude 22 21, 40225 Dusseldorf, Germany
    Thromb Haemost 103:884-90. 2010
    ....
  9. pmc Collagen fragments inhibit hyaluronan synthesis in skin fibroblasts in response to ultraviolet B (UVB): new insights into mechanisms of matrix remodeling
    Katharina Röck
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, 40225 Dusseldorf, Germany
    J Biol Chem 286:18268-76. 2011
    ..Therefore, a novel mechanism is presented how proteolytic collagen cleavage may inhibit HA synthesis in dermal fibroblasts during extrinsic skin aging...
  10. doi request reprint Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions
    Bernhard H Rauch
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Germany
    Arterioscler Thromb Vasc Biol 30:2434-42. 2010
    ..This study is the first to describe increased transcriptional expression of a functionally active P2Y12 in response to thrombin in human vascular smooth muscle cells (SMC)...
  11. doi request reprint Estradiol inhibits hyaluronic acid synthase 1 expression in human vascular smooth muscle cells
    Till Freudenberger
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Basic Res Cardiol 106:1099-109. 2011
    ..For the first time this study provides strong evidence that HAS1-driven HA-synthesis is a target of E(2) in human VSMC and that E(2) mediates part of its anti-proliferative effects through an ERα-dependent inhibition of HA-synthesis...
  12. doi request reprint Inactivation of CD73 promotes atherogenesis in apolipoprotein E-deficient mice
    Anja Buchheiser
    Department of Cardiovascular Physiology, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Cardiovasc Res 92:338-47. 2011
    ..This study therefore explored the role of CD73-derived adenosine in a model of chronic vascular inflammation such as atherogenesis...
  13. doi request reprint Thrombin receptor protease-activated receptor 4 is a key regulator of exaggerated intimal thickening in diabetes mellitus
    Goran Pavic
    From the Institut für Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat, Dusseldorf, Germany G P, M G, K J, K S, J W F, A C F Institute of Molecular and Translational Therapeutic Strategies, Medizinische Hochschule, Hannover, Germany S D Institut für Pharmakologie, Ernst Moritz Arndt Universitat, Greifswald, Germany B H R Klinikum der J W Goethe Universität, Institut fur Allgemeine Pharmakologie und Toxikologie, Frankfurt Main, Germany A D Klinik für Gefäß und Endovaskularchirurgie A O and Klinik für Kardiovaskuläre Chirurgie P A, Klinikum der Heinrich Heine Universität Düsseldorf, Dusseldorf, Germany
    Circulation 130:1700-11. 2014
    ....
  14. pmc Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis
    Sören Twarock
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Mol Cancer 10:30. 2011
    ....
  15. ncbi request reprint Rapid release of active tissue factor from human arterial smooth muscle cells under flow conditions
    Jan Julius Stampfuss
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Germany
    Arterioscler Thromb Vasc Biol 26:e34-7. 2006
    ....
  16. ncbi request reprint Cholesterol enhances thrombin-induced release of fibroblast growth factor-2 in human vascular smooth muscle cells
    Bernhard H Rauch
    Universitatsklinikum Dusseldorf, Institut fur Pharmakologie und Klinische Pharmakologie, Universiäts str 1, 40225 Dusseldorf, Germany
    Arterioscler Thromb Vasc Biol 27:e20-5. 2007
    ..The present study investigates possible effects of cholesterol enrichment and depletion, which have been shown to influence FGF-2-dependent signaling and SMC mitogenesis, on thrombin-induced FGF-2 release...
  17. doi request reprint Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis
    Maria Grandoch
    From the Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum der Heinrich Heine Universität Düsseldorf, Dusseldorf, Germany M G, C K, A M B, K F, S H, J M, L S K, F S, N N, J W F Cardiovascular Research Institute Düsseldorf CARID, Universitätsklinikum der Heinrich Heine Universität Düsseldorf, Dusseldorf, Germany M G, C K, A M B, K F, S H, J M, L S K, F S, N N, A P, J W F Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum der Heinrich Heine Universität Düsseldorf, Dusseldorf, Germany A P Pharmazentrum Frankfurt, Institut für Allgemeine Pharmakologie und Toxikologie ZAFES, Klinikum der Goethe Universität, Maryland
    Arterioscler Thromb Vasc Biol 36:e41-50. 2016
    ..Here, the question was addressed whether the small leucine-rich proteoglycan biglycan acts as an endogenous thrombin inhibitor in atherosclerosis through activation of heparin cofactor II...
  18. pmc Impact of eNOS-Dependent Oxidative Stress on Endothelial Function and Neointima Formation
    Tatsiana Suvorava
    1 Institute for Pharmacology and Clinical Pharmacology, Heinrich Heine University, Dusseldorf, Germany
    Antioxid Redox Signal 23:711-23. 2015
    ..We investigated the impact of eNOS-dependent vascular oxidative stress on endothelial function and on neointimal hyperplasia...
  19. doi request reprint miR-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging
    Katharina Röck
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitätsklinikum der Heinrich Heine Universität, Dusseldorf, Germany
    J Invest Dermatol 135:369-77. 2015
    ..Taken together, these findings appear to link miR-23a-3p and the HA microenvironment as effector mechanisms in both dermal aging and senescence. ..
  20. ncbi request reprint Syndecan-4 is required for thrombin-induced migration and proliferation in human vascular smooth muscle cells
    Bernhard H Rauch
    University of Washington School of Medicine, Department of Surgery, Seattle, Washington 98195 6410, USA
    J Biol Chem 280:17507-11. 2005
    ..We conclude that thrombin-released bFGF binds to syndecan-4 and FGFR-1, which is required for thrombin-induced mitogenesis and migration...
  21. doi request reprint Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction
    Julia Muller
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitätsklinikum der Heinrich Heine Universität Düsseldorf, Moorenstr 5, 40225, Dusseldorf, Germany
    Basic Res Cardiol 109:440. 2014
    ....
  22. pmc Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases
    Guang Dai
    Molekulare Pharmakologie, Institut für Pharmakologie and Klinische Pharmakologie, Universitätsklinkum Düsseldorf, Dusseldorf, Germany
    Am J Pathol 171:1451-61. 2007
    ..In conclusion, chronic UVB irradiation induces loss of HA from the dermis, thereby contributing to the quiescent phenotype of dermal fibroblasts...
  23. doi request reprint Noninvasive Imaging of Early Venous Thrombosis by 19F Magnetic Resonance Imaging With Targeted Perfluorocarbon Nanoemulsions
    Sebastian Temme
    From Institut für Molekulare Kardiologie S T, C Q, C J, Z D, C O, J S, U F, Institut für Pharmakologie und klinische Pharmakologie M G, J W F, and Cardiovascular Research Institute Düsseldorf J W F, J S, U F, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany Institut für Pharmazeutische Technologie und Biopharmazie, Albert Ludwigs Universitat, Freiburg, Germany C G, F M, R S and Klinik für Kardiologie, Pneumologie und Angiologie, Universitatsklinikum Dusseldorf, Dusseldorf, Germany C Q, C J, U F
    Circulation 131:1405-14. 2015
    ..Noninvasive detection of deep venous thrombi and subsequent pulmonary thromboembolism is a serious medical challenge, since both incidences are difficult to identify by conventional ultrasound techniques...
  24. doi request reprint The hallmarks of fibroblast ageing
    Julia Tigges
    Leibniz Research Institute for Environmental Medicine IUF, Dusseldorf, Germany
    Mech Ageing Dev 138:26-44. 2014
    ..iv) The ageing process of dermal fibroblasts in their physiological tissue environment has only been partially elucidated, although these cells have been a preferred model of cell ageing in vitro for decades. ..
  25. doi request reprint Overexpression of prostaglandin EP3 receptors activates calcineurin and promotes hypertrophy in the murine heart
    Jutta Meyer-Kirchrath
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum, Heinrich Heine Universitat, Moorenstr 5, D 40225 Dusseldorf, Germany
    Cardiovasc Res 81:310-8. 2009
    ..This study focuses on the EP(3)-mediated hypertrophic action and investigates intracellular signalling pathways of the EP(3)-receptor subtype in the murine heart...
  26. ncbi request reprint Regulation of thrombomodulin expression in human vascular smooth muscle cells by COX-2-derived prostaglandins
    Kerstin Rabausch
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Germany
    Circ Res 96:e1-6. 2005
    ..The full text of this article is available online at http://circres.ahajournals.org...
  27. pmc Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype
    Ariane Melchior-Becker
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Heinrich Heine Universität Düsseldorf 40225, Germany
    J Biol Chem 286:17365-75. 2011
    ..Collectively, the data suggest that bgn deficiency promotes myofibroblast differentiation and proliferation in vitro and in vivo likely due to increased responses to TGF-β and SMAD2 signaling...
  28. doi request reprint Redox regulation of human protease-activated receptor-2 by activated factor X
    Klaus Jobi
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    Free Radic Biol Med 51:1758-64. 2011
    ..Thus FXa induces functional expression of PAR-2 but not of PAR-1 in human SMCs, independent of thrombin formation, via a mechanism involving NOX-1-containing NADPH oxidase, H(2)O(2), NF-κB, and HuR...
  29. ncbi request reprint Decorin promotes aortic smooth muscle cell calcification and colocalizes to calcified regions in human atherosclerotic lesions
    Jens W Fischer
    Molekulare Pharmakologie, Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat Dusseldorf, Germany
    Arterioscler Thromb Vasc Biol 24:2391-6. 2004
    ..In the present study, it was investigated whether decorin, a small leucine-rich proteoglycan expressed in bone and atherosclerotic plaque, is involved in arterial calcification...
  30. doi request reprint Regulation of vascular guanylyl cyclase by endothelial nitric oxide-dependent posttranslational modification
    Marc Oppermann
    Institute for Pharmacology and Clinical Pharmacology, Heinrich Heine University, Moorenstrasse 5, Dusseldorf, Germany
    Basic Res Cardiol 106:539-49. 2011
    ..Because this mechanism can compensate for reduction in vascular NO bioavailability, it may mask the development of endothelial dysfunction...
  31. pmc RHAMM splice variants confer radiosensitivity in human breast cancer cell lines
    Alexandra Schütze
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitätsklinikum der Heinrich Heine Universität, Dusseldorf, Germany
    Oncotarget 7:21428-40. 2016
    ..Additionally, our studies raise the possibility that the response to radiotherapy in selected cohorts may be improved by pharmaceutical strategies against RHAMM and its ligand hyaluronan. ..
  32. pmc Circulating NOS3 modulates left ventricular remodeling following reperfused myocardial infarction
    Simone Gorressen
    Medical Faculty, Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 10:e0120961. 2015
    ..In the current study we hypothesized that circulating NOS3 also affects remodeling of the left ventricle following reperfused MI...
  33. ncbi request reprint Tenascin-C: a key molecule in graft stenosis
    Jens W Fischer
    Cardiovasc Res 74:335-6. 2007
  34. ncbi request reprint Retrovirally mediated overexpression of versican v3 by arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointima after vascular injury
    Mervyn J Merrilees
    Department of Anatomy with Radiology, The University of Auckland, Auckland, New Zealand
    Circ Res 90:481-7. 2002
    ..These results indicate that a variant of versican is involved in elastic fiber assembly and may represent a novel therapeutic approach to facilitate the formation of elastic fibers...
  35. pmc Accumulation and loss of extracellular matrix during shear stress-mediated intimal growth and regression in baboon vascular grafts
    Richard D Kenagy
    Department of Vascular Surgery, University of Washington, 1959 N E Pacific St Box 356410, Seattle, WA 98195 6410, USA
    J Histochem Cytochem 53:131-40. 2005
    ..Neointimal atrophy occurs with an apparent loss of proteoglycans and evidence of versican degradation...
  36. ncbi request reprint Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells
    Wen Bin Chen
    Research Unit Molecular Oncology, Clinic for General Surgery and Thoracic Surgery, Christian Albrechts University, D 24105 Kiel, Germany
    J Biol Chem 277:36118-28. 2002
    ....
  37. ncbi request reprint Angiotensin II AT(1)-receptor induces biglycan in neonatal cardiac fibroblasts via autocrine release of TGFbeta in vitro
    Karen Tiede
    Institute of Pharmacology, Christian Albrechts University, Kiel, Germany
    Cardiovasc Res 60:538-46. 2003
    ..The aim of the present study was therefore to analyse in cultured cardiac fibroblasts the expression and secretion of the SLRP biglycan in response to AngII...
  38. ncbi request reprint Smooth muscle cell biglycan overexpression results in increased lipoprotein retention on extracellular matrix: implications for the retention of lipoproteins in atherosclerosis
    Kevin D O'Brien
    Division of Cardiology, Box 356422, Department of Medicine, University of Washington, 1959N E Pacific St, Seattle, WA 98195 6422, USA
    Atherosclerosis 177:29-35. 2004
    ..These results are consistent with the hypothesis that biglycan, through its glycosaminoglycan side chains, may mediate lipoprotein retention on atherosclerotic plaque ECM...
  39. ncbi request reprint Increased plasmin and serine proteinase activity during flow-induced intimal atrophy in baboon PTFE grafts
    Richard D Kenagy
    Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle 98195 6410, USA
    Arterioscler Thromb Vasc Biol 22:400-4. 2002
    ..These data suggest that serine proteinases, including plasmin, may be largely responsible for extracellular matrix degradation in this primate model of flow-induced intimal atrophy...
  40. ncbi request reprint Integrin-mediated transcriptional activation of inhibitor of apoptosis proteins protects smooth muscle cells against apoptosis induced by degraded collagen
    Karin von Wnuck Lipinski
    Institute of Pathophysiology, Center of Internal Medicine, University Hospital, Essen, Germany
    Circ Res 98:1490-7. 2006
    ..This may constitute a novel antiapoptotic pathway ensuring SMC survival in settings of enhanced ECM degradation such as cell migration, vascular remodeling, and atherosclerotic plaque rupture...
  41. ncbi request reprint Human vascular smooth muscle cells express functionally active endothelial cell protein C receptor
    Ellen Bretschneider
    Institut für Vaskuläre Medizin, Klinikum der Friedrich Schiller Universitat Jena, Germany
    Circ Res 100:255-62. 2007
    ..The present data demonstrate functionally active EPCR in SMCs and suggest that EPCR-bound APC might modulate PAR-1-mediated responses of SMCs to vascular injury...
  42. doi request reprint Complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosis
    Jan Julius Stampfuss
    Institut fur Pharmakologie, Universitat Duisburg Essen, Universitatsklinikum Essen, Hufelandstr 55, D 45122 Essen, Germany
    Arterioscler Thromb Vasc Biol 28:1375-8. 2008
    ..We have studied systematically the regulation of PSGL-1 expression and function in apoptotic monocytic cells...