Elke Hattingen

Summary

Country: Germany

Publications

  1. ncbi request reprint An unusual intraventricular haemangiopericytoma: MRI and spectroscopy
    E Hattingen
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Neuroradiology 45:386-9. 2003
  2. ncbi request reprint MR imaging in neuroborreliosis of the cervical spinal cord
    Elke Hattingen
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Eur Radiol 14:2072-5. 2004
  3. ncbi request reprint Brain surface reformatted images for fast and easy localization of perirolandic lesions
    Elke Hattingen
    Institute of Neuroradiology, Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 102:302-10. 2005
  4. ncbi request reprint Postictal spectroscopy and imaging findings mimicking brain tumor recurrence
    Elke Hattingen
    Institute of Neuroradiology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    J Magn Reson Imaging 24:226-30. 2006
  5. ncbi request reprint Human motor corpus callosum: topography, somatotopy, and link between microstructure and function
    Mathias Wahl
    Department of Neurology, Johann Wolfgang Goethe University of Frankfurt, D 60528 Frankfurt am Main, Germany
    J Neurosci 27:12132-8. 2007
  6. doi request reprint Stripe-like increase of rCBV beyond the visible border of glioblastomas: site of tumor infiltration growing after neurosurgery
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    J Neurooncol 103:575-84. 2011
  7. doi request reprint Diagnostic value of proton magnetic resonance spectroscopy in the noninvasive grading of solid gliomas: comparison of maximum and mean choline values
    Christian Senft
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt, Germany
    Neurosurgery 65:908-13; discussion 913. 2009
  8. pmc Quantitative T2 mapping of recurrent glioblastoma under bevacizumab improves monitoring for non-enhancing tumor progression and predicts overall survival
    Elke Hattingen
    Corresponding Author Elke Hattingen, MD, Goethe University Hospital Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    Neuro Oncol 15:1395-404. 2013
  9. doi request reprint Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Neuroradiology 54:753-64. 2012
  10. pmc Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: a 31P/1H MRSI and quantitative magnetic resonance imaging study
    Elke Hattingen
    Goethe University Frankfurt, Institute of Neuroradiology, Schleusenweg 2 16 Haus 95, 60528 Frankfurt M, Germany
    Neuro Oncol 13:1349-63. 2011

Collaborators

Detail Information

Publications73

  1. ncbi request reprint An unusual intraventricular haemangiopericytoma: MRI and spectroscopy
    E Hattingen
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Neuroradiology 45:386-9. 2003
    ..1)H MR spectroscopy demonstrated an increased choline peak, suggesting a malignant form of meningioma. Histologically a haemangiopericytoma was found, an exceptionally rare tumour at this site...
  2. ncbi request reprint MR imaging in neuroborreliosis of the cervical spinal cord
    Elke Hattingen
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Eur Radiol 14:2072-5. 2004
    ..These imaging patterns of borrelia-associated radiculitis have not been reported before. Knowledge of these imaging features may help to diagnose neuroborreliosis, which presents with non-specific symptoms...
  3. ncbi request reprint Brain surface reformatted images for fast and easy localization of perirolandic lesions
    Elke Hattingen
    Institute of Neuroradiology, Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 102:302-10. 2005
    ....
  4. ncbi request reprint Postictal spectroscopy and imaging findings mimicking brain tumor recurrence
    Elke Hattingen
    Institute of Neuroradiology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    J Magn Reson Imaging 24:226-30. 2006
    ..In conclusion, postictal neurological deficits with a temporary increase in TMA and tCr were diagnosed. This is the first report of seizure-induced MRS abnormalities mimicking tumor recurrence...
  5. ncbi request reprint Human motor corpus callosum: topography, somatotopy, and link between microstructure and function
    Mathias Wahl
    Department of Neurology, Johann Wolfgang Goethe University of Frankfurt, D 60528 Frankfurt am Main, Germany
    J Neurosci 27:12132-8. 2007
    ....
  6. doi request reprint Stripe-like increase of rCBV beyond the visible border of glioblastomas: site of tumor infiltration growing after neurosurgery
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    J Neurooncol 103:575-84. 2011
    ..De-novo CE appeared within the SS in all patients (96% of all slices). This implies that the SS might indicate the site of future CE tumor, which represents the area of tumor growth after neurosurgery...
  7. doi request reprint Diagnostic value of proton magnetic resonance spectroscopy in the noninvasive grading of solid gliomas: comparison of maximum and mean choline values
    Christian Senft
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt, Germany
    Neurosurgery 65:908-13; discussion 913. 2009
    ..The aim of this study was to compare normalized mean and maximum levels of Cho as single parameters in the noninvasive grading of gliomas...
  8. pmc Quantitative T2 mapping of recurrent glioblastoma under bevacizumab improves monitoring for non-enhancing tumor progression and predicts overall survival
    Elke Hattingen
    Corresponding Author Elke Hattingen, MD, Goethe University Hospital Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    Neuro Oncol 15:1395-404. 2013
    ..Thus, the importance of T2-weighted imaging is increasing. We therefore quantified T2 relaxation times, which are the basis for the image contrast on T2-weighted images...
  9. doi request reprint Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Neuroradiology 54:753-64. 2012
    ..We aimed to specify these pathological metabolite changes by combining both methods with additional focus on the neuronal metabolites glutamate (Glu) and N-acetyl-l-aspartate (NAA)...
  10. pmc Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: a 31P/1H MRSI and quantitative magnetic resonance imaging study
    Elke Hattingen
    Goethe University Frankfurt, Institute of Neuroradiology, Schleusenweg 2 16 Haus 95, 60528 Frankfurt M, Germany
    Neuro Oncol 13:1349-63. 2011
    ..The antiangiogenic effect of bevacizumab is predictive of better outcome and seems to induce antitumoral activity in the responding GBMs...
  11. doi request reprint Proton magnetic resonance spectroscopic imaging in pediatric low-grade gliomas
    Luciana Porto
    Neuroradiology Department, Institut für Neuroradiologie, Klinikum der Johann Wolfgang Goethe Universitat, Schleusenweg 2 16, D 60528, Frankfurt am Main, Germany
    Brain Tumor Pathol 27:65-70. 2010
    ..Our results suggest that tCr concentrations combined with lactate will be helpful in the differential diagnosis of PA and DA in children...
  12. doi request reprint Heterogeneity in malignant gliomas: a magnetic resonance analysis of spatial distribution of metabolite changes and regional blood volume
    Marlies Wagner
    Institute of Neuroradiology, Goethe University, Frankfurt am Main, Germany
    J Neurooncol 103:663-72. 2011
    ....
  13. doi request reprint Prognostic value of choline and creatine in WHO grade II gliomas
    Elke Hattingen
    Institute of Neuroradiology, Johann Wolfgang Goethe University of Frankfurt Main, Frankfurt Main, Germany
    Neuroradiology 50:759-67. 2008
    ..The purpose of this study was to evaluate whether proton magnetic resonance spectroscopy ((1)H-MRS) predicts survival time, tumor progression, and malignant transformation in patients with WHO grade II gliomas...
  14. doi request reprint Elevated peritumoural rCBV values as a mean to differentiate metastases from high-grade gliomas
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, Frankfurt, 60528, Germany
    Acta Neurochir (Wien) 152:1893-9. 2010
    ..Supposing that peritumoural rCBV is not increased in metastases, we aimed to evaluate whether rCBV values of the whole peritumoural area are accurate to differentiate solitary metastasis from GBM irrespective of the peritumoural oedema...
  15. doi request reprint Within-lesion differences in quantitative MRI parameters predict contrast enhancement in multiple sclerosis
    Alina Jurcoane
    Institute of Neuroradiology, Goethe University, Frankfurt am Main, Germany
    J Magn Reson Imaging 38:1454-61. 2013
    ..We compared maps of T1 relaxation time, proton density (PD), and magnetization transfer ratio (MTR) between lesions with and without contrast enhancement as quantified by the amount of T1 shortening postcontrast agent (CA)...
  16. pmc Phospholipid metabolites in recurrent glioblastoma: in vivo markers detect different tumor phenotypes before and under antiangiogenic therapy
    Elke Hattingen
    Institute of Neuroradiology, Goethe University Hospital Frankfurt, Frankfurt, Germany
    PLoS ONE 8:e56439. 2013
    ....
  17. doi request reprint Morphometry and diffusion MR imaging years after childhood traumatic brain injury
    Luciana Porto
    Neuroradiology, Klinikum Johann Wolfgang Goethe Universität, Schleusenweg 2 16, D 60528 Frankfurt, Germany
    Eur J Paediatr Neurol 15:493-501. 2011
    ..Our goal was to detect possible unrecognized injury in cerebral white matter (WM) in adult survivors of traumatic brain injury (TBI) during childhood, who showed no detectable axonal injury or chronic contusion on late conventional MRI...
  18. doi request reprint T2'- and PASL-based perfusion mapping at 3 Tesla: influence of oxygen-ventilation on cerebral autoregulation
    Marlies Wagner
    Institute of Neuroradiology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    J Magn Reson Imaging 36:1347-52. 2012
    ....
  19. doi request reprint MR perfusion in and around the contrast-enhancement of primary CNS lymphomas
    Stella Blasel
    Institute of Neuroradiology, Goethe University Hospital Frankfurt, University of Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    J Neurooncol 114:127-34. 2013
    ..PCNSL can be differentiated from glioblastomas through their significantly lower rCBV and shoulder-like signal intensity changes inside the enhancing area...
  20. doi request reprint Stereotactic biopsy in gliomas guided by 3-tesla 1H-chemical-shift imaging of choline
    Elvis J Hermann
    Department of Neurosurgery, Medical School Hannover, Hannover, Germany
    Stereotact Funct Neurosurg 86:300-7. 2008
    ..To investigate chemical-shift imaging (CSI) to guide stereotactic biopsy of the choline 'hot spot' in cerebral lesions suggestive of low-grade glioma...
  21. doi request reprint Spectroscopy of untreated pilocytic astrocytomas: do children and adults share some metabolic features in addition to their morphologic similarities?
    Luciana Porto
    Neuroradiology Department, Goethe Universitat, Frankfurt am Main, Germany
    Childs Nerv Syst 26:801-6. 2010
    ..Using magnetic resonance (MR) spectroscopy, we assessed if pilocytic astrocytomas show increased choline (tCho), classically related to proliferation and malignancy of gliomas...
  22. doi request reprint Cerebral gliomas: diffusional kurtosis imaging analysis of microstructural differences
    Peter Raab
    Institute of Neuroradiology and Department of Neurosurgery, Goethe University Frankfurt, Frankfurt am Main, Germany
    Radiology 254:876-81. 2010
    ..To characterize the non-Gaussian diffusion patterns of cerebral glioma microstructure with respect to the different glioma grades by using a new method called diffusional kurtosis (DK) imaging...
  23. doi request reprint Recanalization results after intracranial stenting of atherosclerotic stenoses
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    Cardiovasc Intervent Radiol 33:914-20. 2010
    ..Suboptimal recanalization results were frequently detected and may be the source of neurological complications in individual cases...
  24. doi request reprint Quantitative T2, T2*, and T2' MR imaging in patients with ischemic leukoaraiosis might detect microstructural changes and cortical hypoxia
    Marlies Wagner
    Institute of Neuroradiology, University Hospital, Goethe University, Schleusenweg 2 16, D 60528, Frankfurt am Main, Frankfurt, Germany
    Neuroradiology 57:1023-30. 2015
    ..Measurements were complemented by the assessment of the cerebral blood flow (CBF) and the degree of GM and WM atrophy...
  25. doi request reprint Benefit of tumor resection for recurrent glioblastoma
    Johanna Quick
    Department of Neurosurgery, University Hospital Frankfurt, Goethe University, Frankfurt, Germany
    J Neurooncol 117:365-72. 2014
    ..In the event of tumor recurrence, patients in good clinical condition with recurrent GBM amenable to complete resection should thus not be withheld second surgery as a treatment option. ..
  26. doi request reprint Motor cortex evaluation by nTMS after surgery of central region tumors: a feasibility study
    Marie Thérèse Forster
    Department of Neurosurgery, Goethe University Hospital, Schleusenweg 2 16, 60528, Frankfurt am Main, Germany
    Acta Neurochir (Wien) 154:1351-9. 2012
    ..We therefore aimed to investigate cortical motor representation after resection of perirolandic WHO grade II and III gliomas using navigated transcranial magnetic stimulation (nTMS)...
  27. doi request reprint T2' imaging within perfusion-restricted tissue in high-grade occlusive carotid disease
    Alexander Seiler
    Department of Neurology, Goethe University, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    Stroke 43:1831-6. 2012
    ..We investigated quantitative T2' imaging in patients with high-grade stenoses of brain-supplying arteries and hypothesized that T2' values are lower in perfusion-restricted areas as compared with normally perfused tissue...
  28. doi request reprint Quantitative T*2-mapping based on multi-slice multiple gradient echo flash imaging: retrospective correction for subject motion effects
    Joerg Magerkurth
    Brain Imaging Center, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Magn Reson Med 66:989-97. 2011
    ..Experimental results show that the method works well for sparse motion, but fails for strong motion affecting the same k-space lines in both acquisitions...
  29. doi request reprint Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Department of Anaesthesia, Schleusenweg 2 16, 60528, Frankfurt, Germany
    J Neurol 258:113-22. 2011
    ..35, range 0.92-1.73). Tumefactive autoimmune inflammatory demyelinating lesions not only have imaging appearance of gliomas but may also imitate marked increase of rCBV and Cho in WHO grade II-III gliomas...
  30. doi request reprint 1H MR spectroscopic imaging with short and long echo time to discriminate glycine in glial tumours
    Elke Hattingen
    Institute of Neuroradiology, University of Frankfurt Main, Frankfurt, Germany
    MAGMA 22:33-41. 2009
    ..56 ppm, but due to strong coupling the MI signal dephases more rapidly. Therefore, their contribution to the 3.56 ppm signal should be distinguishable comparing MRSI data acquired at short and long TE...
  31. doi request reprint A standardised evaluation of pre-surgical imaging of the corticospinal tract: where to place the seed ROI
    Elke Hattingen
    Institute of Neuroradiology, J W Goethe University, Schleusenweg 2 16, Frankfurt Main 60528, Germany
    Neurosurg Rev 32:445-56. 2009
    ..Hence, upward FT of the CST should be preferred in patients with space-occupying lesions. Downward FT should be performed if upward FT fails...
  32. doi request reprint Erythropoietin prevents delayed hemodynamic dysfunction after subarachnoid hemorrhage in a randomized controlled experimental setting
    Erdem Güresir
    Department of Neurosurgery and Institute for Neuroradiology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurol Sci 332:128-35. 2013
    ..The aim of the present investigation was, therefore, to characterize these effects on prevention of delayed proximal cerebral vasospasm (CVS), impaired microcirculation and cerebral blood flow (CBF) after experimental SAH...
  33. doi request reprint Confounding factors in diagnostics of MGMT promoter methylation status in glioblastomas in stereotactic biopsies
    Lutz M Weise
    Department of Neurosurgery, Goethe University Frankfurt, Frankfurt Main, Germany
    Stereotact Funct Neurosurg 92:129-39. 2014
    ..The analysis of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation adds prognostic and predictive information...
  34. ncbi request reprint Myo-inositol: a marker of reactive astrogliosis in glial tumors?
    Elke Hattingen
    Institute of Neuroradiology, Johann Wolfgang Goethe University of Frankfurt Main, Germany
    NMR Biomed 21:233-41. 2008
    ..As increased MI and tCr concentrations were found in gliomatosis and other cerebral diseases associated with marked astrogliosis, this process may also be responsible for the observed changes in MI in other glial tumors...
  35. ncbi request reprint Evaluation of optimal echo time for 1H-spectroscopic imaging of brain tumors at 3 Tesla
    Elke Hattingen
    Institute of Neuroradiology, Johann Wolfgang Goethe University of Frankfurt Main, Frankfurt, Germany
    J Magn Reson Imaging 26:427-31. 2007
    ..To compare the spectral quality of short echo time (TE) MR spectroscopic imaging (MRSI, TE = 30 msec) with long-TE MRSI (TE = 144 msec) at 3 Tesla in normal brain and tumor tissue...
  36. doi request reprint Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease
    Elke Hattingen
    Institute of Neuroradiology, J W Goethe University Schleusenweg 2 16, 60528 Frankfurt Main, Germany
    Brain 132:3285-97. 2009
    ....
  37. doi request reprint MR angiography in patients with subarachnoid hemorrhage: adequate to evaluate vasospasm-induced vascular narrowing?
    Elke Hattingen
    Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt M, Germany
    Neurosurg Rev 33:431-9. 2010
    ..The multifocal arterial stenoses in CVS may induce severe changes in blood flow dynamics, which compromise the diagnostic accuracy of the TOF-MRA...
  38. doi request reprint Intraoperative motor evoked potential alteration in intracranial tumor surgery and its relation to signal alteration in postoperative magnetic resonance imaging
    Andrea Szelenyi
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt, Germany
    Neurosurgery 67:302-13. 2010
    ....
  39. doi request reprint The striate sign: peritumoural perfusion pattern of infiltrative primary and recurrent gliomas
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Frankfurt, Germany
    Neurosurg Rev 33:193-203; discussion 203-4. 2010
    ..These differences might be due to post-therapeutic changes of the tumour-associated microvasculature by radiochemotherapy. Spectroscopic and susceptibility-weighted MR imaging may provide further insights into the tumour biology...
  40. doi request reprint Spectroscopic Characterization of Gliosarcomas-Do They Differ From Glioblastomas and Metastases?
    Peter Raab
    From the Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover Institute of Neuroradiology, Johann Wolfgang Goethe University, Frankfurt Main Department of Neuroradiology, Clinic of Radiology, University Bonn, Bonn Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt Main and Department of Neurosurgery, Hannover Medical School, Hannover, Germany
    J Comput Assist Tomogr 40:815-9. 2016
    ..To evaluate the spectroscopic pattern of gliosarcomas for differentiation from glioblastomas or metastases...
  41. doi request reprint Combination of Intraoperative Magnetic Resonance Imaging and Intraoperative Fluorescence to Enhance the Resection of Contrast Enhancing Gliomas
    Florian Gessler
    Department of Neurosurgery, Goethe University, Frankfurt, Germany Institute of Neurology Edinger Institute, Goethe University, Frankfurt, Germany Institute of Neuroradiology, Goethe University, Frankfurt, Germany
    Neurosurgery 77:16-22; discussion 22. 2015
    ..Recent studies have displayed the importance of intraoperative magnetic resonance imaging (iMRI) with 5-aminolevulinic acid (5-ALA) fluorescence-guidance in order to maximize EOR...
  42. doi request reprint Anti-tissue factor (TF9-10H10) treatment reduces tumor cell invasiveness in a novel migratory glioma model
    Patrick N Harter
    Edinger Institute, Institute of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany
    Neuropathology 33:515-25. 2013
    ..Thus, targeting the TF pathway might be a promising treatment strategy for future glioblastoma therapies, by affecting both invading tumor cells and tumor vasculature. ..
  43. doi request reprint Navigated transcranial magnetic stimulation and functional magnetic resonance imaging: advanced adjuncts in preoperative planning for central region tumors
    Marie Thérèse Forster
    Department of Neurosurgery, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany
    Neurosurgery 68:1317-24; discussion 1324-5. 2011
    ..Navigated transcranial magnetic stimulation (nTMS) is comparable to DCS in activating cortical pyramidal neurons...
  44. doi request reprint Combined (1)H and (31)P spectroscopy provides new insights into the pathobiochemistry of brain damage in multiple sclerosis
    Elke Hattingen
    Institute of Neuroradiology, Goethe University, Frankfurt am Main, Germany
    NMR Biomed 24:536-46. 2011
    ..A significant total choline increase was mainly a result of choline components not visible by (31)P MRS. The origin of this residual choline fraction remains to be investigated...
  45. doi request reprint Reduction of susceptibility-induced signal losses in multi-gradient-echo images: application to improved visualization of the subthalamic nucleus
    Steffen Volz
    Brain Imaging Center, University Frankfurt, University Hospital, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Neuroimage 45:1135-43. 2009
    ....
  46. doi request reprint The combination of semi-sitting position and intraoperative MRI--first report on feasibility
    Thomas Gasser
    Department of Neurosurgery, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Acta Neurochir (Wien) 152:947-51. 2010
    ..The technological advancement continuously extends the spectrum of iMRI, leading to an increasing number of installations. Yet, procedures in which a semi-sitting position would be advantageous were beyond the reach of iMRI...
  47. doi request reprint Perfusion MRI in the Evaluation of Suspected Glioblastoma Recurrence
    Stella Blasel
    Institute of Neuroradiology, Goethe University Hospital Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    J Neuroimaging 26:116-23. 2016
    ..Therefore, we aimed to evaluate if rCBV can differentiate between TRC and tumor progression irrespective of preceding therapies and number of tumor progressions...
  48. doi request reprint Brain surface reformatted imaging (BSRI) for intraoperative neuronavigation in brain tumor surgery
    Marie Thérèse Forster
    Department of Neurosurgery, Goethe University Hospital, Schleusenweg 2 16, 60528, Frankfurt am Main, Germany
    Acta Neurochir (Wien) 157:265-74; discussion 274. 2015
    ....
  49. doi request reprint MR volumetric changes after diagnostic CSF removal in normal pressure hydrocephalus
    Oliver C Singer
    Department of Neurology, Goethe University Frankfurt, Schleusenweg 2 16, 60528, Frankfurt Main, Germany
    J Neurol 259:2440-6. 2012
    ..In particular, we report evidence that CSF removal results in a change of the brain volume rather than only a change of the brain's shape...
  50. doi request reprint Development of biomarkers for multiple sclerosis as a neurodegenerative disorder
    Ulf Ziemann
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Prog Neurobiol 95:670-85. 2011
    ..This paper compiles an up-to-date critical review of the available knowledge of candidate biomarkers of neurodegenerative processes in MS...
  51. doi request reprint Contrast-enhanced MR myelography in spontaneous intracranial hypotension: description of an artefact imitating CSF leakage
    Elke Hattingen
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    Eur Radiol 19:1799-808. 2009
    ..Selective water excitation technique as well as periradicular and epidural contrast collections may be helpful to discriminate between real pathological findings and artefacts...
  52. doi request reprint Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity
    Christian Senft
    Department of Neurosurgery ZNN, Johann Wolfgang Goethe University Clinics, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Neurosurg Rev 31:231-6. 2008
    ..Thus, treatment options including surgery, radiation therapy, and chemotherapy remain controversial. We recommend surgical removal of PPTID, preferably in toto whenever the size of the tumor permits that kind of excision...
  53. doi request reprint Bevacizumab-induced diffusion-restricted lesions in malignant glioma patients
    Johannes Rieger
    Dr Senckenberg Institute of Neurooncology, Goethe University Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    J Neurooncol 99:49-56. 2010
    ..Within the tumor bed, bevacizumab induces diffusion-restricted lesions in the presence of reduced rCBF and rCBV. The cause of these alterations is unclear but may involve atypical necrosis and chronic hypoxia...
  54. doi request reprint Perfusion-weighted MRI to evaluate cerebral autoregulation in aneurysmal subarachnoid haemorrhage
    Elke Hattingen
    Institute of Neuroradiology, University of Frankfurt, Frankfurt, Germany
    Neuroradiology 50:929-38. 2008
    ..For this purpose, regional cerebral blood flow and volume (rCVF and rCBV) were measured in relation to different degrees of angiographically visible cerebral vasospasm (CVS)...
  55. doi request reprint Diffusion tensor imaging in patients with adult chronic idiopathic hydrocephalus
    Elke Hattingen
    Institute of Neuroradiology, Goethe University, Frankfurt am Main, Germany
    Neurosurgery 66:917-24. 2010
    ..Diffusion tensor imaging (DTI) parameters were investigated in patients with chronic idiopathic hydrocephalus to evaluate microstructural changes of brain tissue caused by chronic ventricular dilatation...
  56. ncbi request reprint Functional magnetic resonance imaging-integrated neuronavigation: correlation between lesion-to-motor cortex distance and outcome
    Rene Krishnan
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurgery 55:904-14; discusssion 914-5. 2004
    ..However, the clinical value remains to be defined. In this study, we investigated the correlation between the lesion-to-fMRI activation distance and the occurrence of a new postoperative deficit...
  57. pmc Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A 1H-Magnetic Resonance Spectroscopy Study
    Eike Steidl
    Dr Senckenberg Institute of Neurooncology, Center for Neurology and Neurosurgery, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    PLoS ONE 11:e0168113. 2016
    ..Since Bevacizumab markedly reduces tumor edema and influences the tumor microenvironment, we investigated whether the MI concentration in the tumor changes during therapy...
  58. doi request reprint Prospective evaluation of serum glial fibrillary acidic protein (GFAP) as a diagnostic marker for glioblastoma
    Julia Tichy
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    J Neurooncol 126:361-9. 2016
    ..Serum GFAP levels in GBM patients were positively correlated with tumor volume and histopathological tumor characteristics...
  59. pmc Differential expression of vascular endothelial growth factor A, its receptors VEGFR-1, -2, and -3 and co-receptors neuropilin-1 and -2 does not predict bevacizumab response in human astrocytomas
    Peter Baumgarten
    Institute of Neurology Edinger Institute, Goethe University, Frankfurt, Germany P B, A E B, M D, P Z, K H, L M, K H P, P N H, M Mi Department of Neurosurgery, Goethe University, Frankfurt, Germany K F, V S Dr Senckenberg Institute of Neurooncology, University of Frankfurt am Main, Frankfurt am Main, Germany K F, O B, J P S Department of Neuroradiology, University of Frankfurt am Main, Frankfurt am Main, Germany E H Department of Neurosurgery, University Hospital, Freiburg, Germany M Ma Cancer Consortium DKTK, Heidelberg, Germany O B, J P S, K H P, P N H, M Mi German Cancer Research Center DKFZ, Heidelberg, Germany O B, J P S
    Neuro Oncol 18:173-83. 2016
    ..To date, it is unclear why antiangiogenic therapy fails in many glioblastoma patients, while a small subpopulation profits considerably from this treatment...
  60. doi request reprint Quantitative T1 and T2 mapping in recurrent glioblastomas under bevacizumab: earlier detection of tumor progression compared to conventional MRI
    Stephanie Lescher
    Institute of Neuroradiology, Hospital of Goethe University, Schleusenweg 2 16, Frankfurt am Main, Germany
    Neuroradiology 57:11-20. 2015
    ..This raised the question whether quantitative T1 mapping is more suitable to monitor treatment effects of bevacizumab...
  61. ncbi request reprint Radiologically typical pilocytic astrocytoma with histopathological signs of atypia
    Roshanak Daneshzadeh Tabrizi
    Institute of Neuroradiology, Department of Neurosurgery, Goethe University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany
    Childs Nerv Syst 28:1791-4. 2012
    ..The case illustrates that neuroimaging features may give very important clues for the definite diagnosis in histopathologically atypical PCA...
  62. doi request reprint Detectability of multiple sclerosis lesions with 3T MRI: a comparison of proton density-weighted and FLAIR sequences
    Christoph Schmidt
    Institute of Neuroradiology, Goethe University, Schleusenweg 2 16, 60528 Frankfurt, Germany
    J Neuroradiol 39:51-6. 2012
    ..For this reason, the aim of this study was to prospectively investigate the detectability of MS lesions at 3 T in PD-w compared with fluid-attenuated inversion recovery (FLAIR) sequences...
  63. pmc Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy
    Gabriele D Maurer
    Dr Senckenberg Institute of Neurooncology, Goethe University Hospital, Schleusenweg 2 16, 60528 Frankfurt, Germany
    BMC Cancer 11:315. 2011
    ..Under these conditions, ketone bodies are generated serving as an important energy source at least for non-transformed cells...
  64. doi request reprint Misleading FLAIR imaging pattern after glioma surgery with intraoperative MRI
    Stephanie Lescher
    Institute of Neuroradiology, Hospital of Goethe University, Schleusenweg 2 16, 60528, Frankfurt am Main, Germany
    Neurosurg Rev 39:79-85; disucssion 85-6. 2016
    ..The findings may result in a misdiagnosis of subarachnoid hemorrhage (SAH) in these patients...
  65. pmc Netrin-1 expression is an independent prognostic factor for poor patient survival in brain metastases
    Patrick N Harter
    Edinger Institute, Institute of Neurology, University of Frankfurt am Main, Frankfurt am Main, Germany German Cancer Consortium DKTK, Heidelberg, Germany German Cancer Research Center dkfz, Heidelberg, Germany
    PLoS ONE 9:e92311. 2014
    ..Furthermore, netrin-1 may constitute a promising target for future anti-cancer treatment approaches in brain metastases. ..
  66. doi request reprint Toxic leukoencephalopathy after heroin abuse without heroin vapor inhalation: MR imaging and clinical features in three patients
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Frankfurt, Germany
    Clin Neuroradiol 20:48-53. 2010
    ..In context with the reviewed literature, a series of another three cases with toxic leukoencephalopathy after heroin abuse other than vapor inhalation is presented...
  67. doi request reprint Feasibility of intraventricular nicardipine prolonged release implants in patients following aneurysmal subarachnoid haemorrhage
    Martin Barth
    Department of Neurosurgery, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Germany
    Br J Neurosurg 25:677-83. 2011
    ..By comparison with an historical control group, an estimation of their effectivity in regard to angiographic vasospasm and the development of cerebral infarction has been performed...
  68. doi request reprint Changes of pH and energy state in subacute human ischemia assessed by multinuclear magnetic resonance spectroscopy
    Johann Philipp Zöllner
    From the Department of Neurology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany J P Z, O C S and Institute of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany E H, U P
    Stroke 46:441-6. 2015
    ..Our goal was to study pH changes in subacute ischemic stroke and their relation to energy metabolism, which, unlike acidosis in acute stroke, are not yet well understood...
  69. pmc Proton 1H- and Phosphorus 31P-MR spectroscopy (MRS) in asymptomatic HIV-positive patients
    Gundolf Schuettfort
    University Hospital Frankfurt, Infectious Diseases ZIM II, Frankfurt am Main, Germany
    J Int AIDS Soc 17:19577. 2014
    ....
  70. doi request reprint Rare mimicry of meningioma: angioleiomyoma of the falx
    Stephanie Lescher
    Institut für Neuroradiologie, Uniklinikum Frankfurt, Frankfurt am Main, Frankfurt, Germany
    J Neurol Surg A Cent Eur Neurosurg 75:403-6. 2014
    ..Intracranial ALMs are exceedingly rare with 12 reported cases to date presenting as extracerebral masses that mimic cerebral cavernous malformation or meningiomas...
  71. doi request reprint Accuracy of 3D fluoroscopy in cranial stereotactic surgery: a comparative study in phantoms and patients
    Lutz M Weise
    Department of Neurosurgery, Goethe University Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    Acta Neurochir (Wien) 156:581-8. 2014
    ..To assess the precision and accuracy of 3D fluoroscopy (XT) in phantoms and patients compared to computed tomography (CT) in localizing stereotactic probes...
  72. doi request reprint Evaluation of angiographic and technical aspects of carotid stenting with diffusion-weighted magnetic resonance imaging
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    Cardiovasc Intervent Radiol 32:666-71. 2009
    ..Single-center DWI studies with a moderate number of cases are inadequate for proper assessment of the embolic risk of technical- or material-related risk factors in carotid stenting. Larger multicenter studies with more cases are needed...
  73. ncbi request reprint Correlation between amplification of the gene for the epidermal growth factor receptor (EGFR), data from preoperative proton-MR-spectroscopy (1HMRS) and histomorphometric data of glioblastomas
    Reinhold Nafe
    Department of Neuroradiology, Clinics of Johann Wolfgang Goethe University, Frankfurt, Germany
    Anal Quant Cytol Histol 29:199-207. 2007
    ..To investigate a correlation between preoperative data from proton-MR-spectroscopy (1HMRS), genomic alterations (epidermal growth growth factor receptor [EGFR] gene amplification) and histomorphometric data from glioblastomas...