C Trautwein

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation
    Leif E Sander
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    J Immunol 181:3586-94. 2008
  2. pmc Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Arthritis Res Ther 8:R32. 2006
  3. ncbi request reprint [Treatment of hepatitis B and C virus infection]
    C Trautwein
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Zentrum Innere Medizin, Medizinische Hochschule Hannover, Hannover
    Dtsch Med Wochenschr 128:S87-9. 2003
  4. ncbi request reprint Mechanisms of hepatitis B virus graft reinfection and graft damage after liver transplantation
    Christian Trautwein
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Hepatol 41:362-9. 2004
  5. pmc Concanavalin A-induced liver injury triggers hepatocyte proliferation
    C Trautwein
    Department of Gastroenterology and Hepatology, Medical Hochschule Hannover, 30625 Hannover, Germany
    J Clin Invest 101:1960-9. 1998
  6. ncbi request reprint Ras adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy
    T Ludde
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Oncogene 20:5264-78. 2001
  7. ncbi request reprint Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3
    M Niehof
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Biol Chem 276:9016-27. 2001
  8. ncbi request reprint Lamivudine and low-dose hepatitis B immune globulin for prophylaxis of hepatitis B reinfection after liver transplantation possible role of mutations in the YMDD motif prior to transplantation as a risk factor for reinfection
    J Rosenau
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    J Hepatol 34:895-902. 2001
  9. ncbi request reprint p53 represses CAAT enhancer-binding protein (C/EBP)-dependent transcription of the albumin gene. A molecular mechanism involved in viral liver infection with implications for hepatocarcinogenesis
    S Kubicka
    Department of Gastroenterology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Biol Chem 274:32137-44. 1999
  10. doi request reprint Late hepatitis B virus relapse in patients co-infected with hepatitis B virus and hepatitis C virus after antiviral treatment with pegylated interferon-a2b and ribavirin
    A Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Scand J Gastroenterol 44:1487-90. 2009

Detail Information

Publications91

  1. ncbi request reprint Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation
    Leif E Sander
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    J Immunol 181:3586-94. 2008
    ..We provide evidence that IL-6 cytokines acting via gp130 are required in the acute stages of intestinal inflammation by modulating the dynamics of innate immune cell recruitment and activation...
  2. pmc Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Arthritis Res Ther 8:R32. 2006
    ....
  3. ncbi request reprint [Treatment of hepatitis B and C virus infection]
    C Trautwein
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Zentrum Innere Medizin, Medizinische Hochschule Hannover, Hannover
    Dtsch Med Wochenschr 128:S87-9. 2003
  4. ncbi request reprint Mechanisms of hepatitis B virus graft reinfection and graft damage after liver transplantation
    Christian Trautwein
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Hepatol 41:362-9. 2004
  5. pmc Concanavalin A-induced liver injury triggers hepatocyte proliferation
    C Trautwein
    Department of Gastroenterology and Hepatology, Medical Hochschule Hannover, 30625 Hannover, Germany
    J Clin Invest 101:1960-9. 1998
    ..This study demonstrates that after Con A injection, TNF- and IL-6- dependent signals trigger nuclear events regulating hepatocyte apoptosis and proliferation during liver injury...
  6. ncbi request reprint Ras adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy
    T Ludde
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Oncogene 20:5264-78. 2001
    ..These mechanisms result in an earlier activation of an active CDK2/Cyclin E complex which, in turn, triggers DNA synthesis...
  7. ncbi request reprint Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3
    M Niehof
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Biol Chem 276:9016-27. 2001
    ..Our analysis describes a new mechanism by which STAT3 controls gene transcription and which has direct implication for the acute phase response in liver cells...
  8. ncbi request reprint Lamivudine and low-dose hepatitis B immune globulin for prophylaxis of hepatitis B reinfection after liver transplantation possible role of mutations in the YMDD motif prior to transplantation as a risk factor for reinfection
    J Rosenau
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    J Hepatol 34:895-902. 2001
    ..However, pretransplantation lamivudine resistance is a risk factor for reinfection. Low dose HBIG maintenance therapy individualized according to anti-HBs-titers appears to be tenable...
  9. ncbi request reprint p53 represses CAAT enhancer-binding protein (C/EBP)-dependent transcription of the albumin gene. A molecular mechanism involved in viral liver infection with implications for hepatocarcinogenesis
    S Kubicka
    Department of Gastroenterology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Biol Chem 274:32137-44. 1999
    ..Additionally, as overexpression of p53 mutants is frequently found in undifferentiated hepatocellular carcinomas, the same mechanisms may contribute to the lack of liver-specific gene transcription in these tumors...
  10. doi request reprint Late hepatitis B virus relapse in patients co-infected with hepatitis B virus and hepatitis C virus after antiviral treatment with pegylated interferon-a2b and ribavirin
    A Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Scand J Gastroenterol 44:1487-90. 2009
    ..In contrast, a sustained response concerning HCV is durable. We recommend long-term monitoring of HBV/HCV-co-infected patients after IFN a-based therapies...
  11. ncbi request reprint Dissection of the intracellular pathways in hepatocytes suggests a role for Jun kinase and IFN regulatory factor-1 in Con A-induced liver failure
    K Streetz
    Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    J Immunol 167:514-23. 2001
    ..Therefore, our experiments indicate that 11418690..
  12. ncbi request reprint Mediators of inflammation and acute phase response in the liver
    K L Streetz
    Dept. of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    Cell Mol Biol (Noisy-le-grand) 47:661-73. 2001
    ..Both cytokines contribute in concert to a cellular balance during these pathophysiological conditions...
  13. ncbi request reprint Severe exacerbation of chronic hepatitis B after emergence of lamivudine resistance in a cirrhotic patient: immediate switch to adefovir dipivoxil appears to be indicated
    J Wiegand
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Z Gastroenterol 42:15-8. 2004
    ..The recently FDA approved nucleoside analogue adefovir dipivoxil has potent antiviral activity against lamivudine-resistant mutants and can prevent viral replication effectively...
  14. pmc Low frequency of HLA-DRB1*11 in hepatitis C virus induced end stage liver disease
    H L Tillmann
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    Gut 48:714-8. 2001
    ..Our results show that the presence of HLA-DRB1*11 and HLA-DQB1*03 alleles is associated with a reduced risk for the development of HCV induced end stage liver disease...
  15. ncbi request reprint Autoregulation enables different pathways to control CCAAT/enhancer binding protein beta (C/EBP beta) transcription
    M Niehof
    Department of Gastroenterology and Hepatology, Medizinische Hochschule, Cal-Neuberg-Str. 1, D30625 Hannover, Germany
    J Mol Biol 309:855-68. 2001
    ....
  16. ncbi request reprint Treatment of acute hepatitis C with interferon alfa-2b
    E Jaeckel
    Medizinische Hochschule Hannover, Germany
    N Engl J Med 345:1452-7. 2001
    ..2 weeks of treatment. Therapy was well tolerated in all but one patient, who stopped therapy after 12 weeks because of side effects. CONCLUSIONS: Treatment of acute hepatitis C with interferon alfa-2b prevents chronic infection...
  17. pmc Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake
    B Mundt
    Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, Carl Neubergstrasse 1, 30625 Hannover, Germany
    Gut 54:1590-6. 2005
    ..As there is evidence that TRAIL is also essential for apoptosis in animal models of liver injury, we investigated the role of TRAIL in viral hepatitis and after alcohol consumption...
  18. ncbi request reprint Risk factors and prevalence of hepatitis E in German immigrants from the former Soviet Union
    C Trautwein
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    J Med Virol 45:429-34. 1995
    ..Exposure to HBV is surprisingly high, and the number of hepatitis C virus (HCV)-positive individuals was also higher than those reported from Western European areas...
  19. pmc CREB/PKA sensitive signalling pathways activate and maintain expression levels of the hepatitis B virus pre-S2/S promoter
    F Tacke
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Gut 54:1309-17. 2005
    ..We aimed to test if CREB activation impacts on HBsAg expression...
  20. ncbi request reprint Tissue factor and thrombomodulin levels are correlated with stage of cirrhosis in patients with liver disease
    F Tacke
    Department of Haematology and Oncology, Hannover Medical School, Hannover, Germany
    Blood Coagul Fibrinolysis 12:539-45. 2001
    ..Further studies are warranted to clarify the underlying mechanisms that raise TM and TF plasma levels in liver disease with possible clinical consequences...
  21. ncbi request reprint Analysis of factors contributing to higher erythropoietin levels in patients with chronic liver disease
    F Tacke
    Dept of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Scand J Gastroenterol 39:259-66. 2004
    ..We aimed to identify the factors contributing to EPO regulation in patients with CLD...
  22. doi request reprint Value of magnifying endoscopy in classifying colorectal polyps based on vascular pattern
    J J W Tischendorf
    Department of Gastroenterology, Hepatology and Metabolic Diseases, University Hospital Aachen, D 52074 Aachen, Germany
    Endoscopy 42:22-7. 2010
    ..The aim of this study was to evaluate the diagnostic accuracy of NBI endoscopy with and without high magnification for the differentiation of neoplastic from non-neoplastic colorectal polyps...
  23. ncbi request reprint Structural organization of the hepatitis B virus minichromosome
    C T Bock
    Department of Gastroenterology and Hepatology, Medical School Hannover, Hannover, Germany
    J Mol Biol 307:183-96. 2001
    ....
  24. pmc Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1
    T Gebhardt
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Germany
    Gut 54:928-34. 2005
    ..Here, we asked whether human intestinal mast cells (MC) might also be subject to immunoregulation by TGF-beta1...
  25. ncbi request reprint [Therapy of chronic hepatitis B infection]
    C Trautwein
    Abteilung Gastroenterologie Hepatologie and Endokrinologie, Zentrum Innere Medizin, Medizinische Hochschule Hannover
    Praxis (Bern 1994) 91:970-6. 2002
    ..In this review these questions will be addressed and a special focus will be the use of lamivudine. Additionally future treatment options will be discussed...
  26. ncbi request reprint Steroid treatment for severe acute cryptogenic hepatitis
    A Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Z Gastroenterol 45:15-9. 2007
    ..Acute cryptogenic hepatitis may represent both a self-limited disease as well as the onset of chronic hepatitis. The aim of this analysis was to evaluate the effect of steroid treatment in patients with acute cryptogenic hepatitis...
  27. ncbi request reprint [Encoding of diagnosis by medical documentation assistant or ward physician. Influence on the mapping of Diagnostic Related Group (DRG) performance]
    J J Tischendorf
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 129:1731-5. 2004
    ..Additionally, the effect of introducing a completely changed organizational process was tested...
  28. ncbi request reprint [Severe drug hepatitis caused by Chelidonium]
    K Rifai
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Hannover
    Internist (Berl) 47:749-51. 2006
    ..As no autoantibodies were detectable, an idiosyncratic reaction as the cause of drug-induced hepatitis is probable. In cases of unknown hepatitis, herbal medications should be taken into account as a possible cause...
  29. ncbi request reprint Cholangioscopic characterization of dominant bile duct stenoses in patients with primary sclerosing cholangitis
    J J W Tischendorf
    Department of Gastroenterology, Hepatology and Endocrinology, Hanover Medical School, Hanover, Germany
    Endoscopy 38:665-9. 2006
    ..The aim of the present study was to assess the value of cholangioscopy for distinguishing between benign and malignant dominant stenoses in PSC patients...
  30. ncbi request reprint A liver nodule in a patient transplanted for primary sclerosing cholangitis: an interdisciplinary diagnostic approach
    S H Loosen
    Department of Gastroenterology, Digestive Diseases and Intensive Care Medicine Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
    Z Gastroenterol . 2016
    ..On the other hand, it shows that the acceptance of organs from elderly donors in times of organ shortage might be linked to an increased risk of donor transmitted malignancies...
  31. ncbi request reprint A patient with autoimmune hepatitis type I, Addison's disease, atrophic thyroiditis, atrophic gastritis, exocrine pancreatic insufficiency, and heterozygous alpha1-antitrypsin deficiency
    C Bergwitz
    Abteilung Klinische Endokrinologie und Abteilung für Gastroenterologie der Medizinischen Hochschule, Hannover, Germany
    Am J Gastroenterol 97:1050-2. 2002
    ....
  32. ncbi request reprint Recognition of uridine diphosphate glucuronosyl transferases by LKM-3 antibodies in chronic hepatitis D
    T Philipp
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    Lancet 344:578-81. 1994
    ..Sera from patients who had hepatitis B only did not react with UGT proteins. The UGT proteins are part of the phase II enzymes of drug metabolism and are the first such enzymes to be identified as human autoantigens...
  33. ncbi request reprint Lack of gp130 expression results in more bacterial infection and higher mortality during chronic cholestasis in mice
    Torsten Wuestefeld
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 42:1082-90. 2005
    ..Activation of gp130-dependent pathways after BDL is essential and appears to be a therapeutic target during cholestasis...
  34. ncbi request reprint Interferon-alpha enhances TRAIL-mediated apoptosis by up-regulating caspase-8 transcription in human hepatoma cells
    Christian Liedtke
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Hepatol 44:342-9. 2006
    ..The exact mechanisms underlying the antiviral and antitumor effects of IFNalpha are not completely understood. In this study, we investigated if the pro-apoptotic factor caspase-8 is a target gene of IFNalpha signalling...
  35. ncbi request reprint JunD attenuates phenylephrine-mediated cardiomyocyte hypertrophy by negatively regulating AP-1 transcriptional activity
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cardiovasc Res 71:108-17. 2006
    ..In the present study we analyzed the mechanistic role of JunD in cardiomyocyte hypertrophy in vitro in response to alpha-adrenergic agonist phenylephrine (PE)...
  36. ncbi request reprint Report of the monothematic EASL conference on liver transplantation for viral hepatitis (Paris, France, January 12-14, 2006)
    Didier Samuel
    HepatoBiliary Centre, Inserm Paris XI U 785, Paul Brousse Hospital, APHP, Villejuif, France
    J Hepatol 45:127-43. 2006
  37. pmc The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury
    Christian Klein
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Clin Invest 115:860-9. 2005
    ..Additionally, we identified the IL-6-gp130-STAT3-dependent proteins KC and SAA2 as new candidates for therapeutic targets in liver diseases...
  38. pmc Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury
    Tom Luedde
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Clin Invest 115:849-59. 2005
    ....
  39. ncbi request reprint The role of oxidative stress and antioxidant treatment in liver surgery and transplantation
    Tom Luedde
    Liver Transpl 12:1733-5. 2006
  40. doi request reprint Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration
    Uta Dierssen
    Internal Medicine III, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, Aachen, Germany
    J Biol Chem 283:9886-95. 2008
    ..In summary, gp130-dependent STAT3 activation and concomitant SOCS3 during liver regeneration is involved in timing of DNA synthesis and protects hepatocyte proliferation during stress conditions...
  41. ncbi request reprint The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection
    Hermann E Wasmuth
    Medical Department III, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Hepatol 48:208-15. 2008
    ..The chemokine receptor CX3CR1 and its specific ligand fractalkine (CX3CL1) are known to modulate inflammatory and fibroproliferative diseases. Here we investigate the role of CX3CR1/fractalkine in HCV-induced liver fibrosis...
  42. ncbi request reprint Molecular mechanism of Mitomycin C-dependent caspase-8 regulation: implications for apoptosis and synergism with interferon-alpha signalling
    Christian Liedtke
    Department of Medicine III, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany
    Apoptosis 12:2259-70. 2007
    ..MMC-induced up-regulation of caspase-8 triggers apoptosis in target cells which can be further enhanced by IFNalpha. Therefore these findings also provide a potential new therapeutic approach to treat cancer cells...
  43. ncbi request reprint Sustained HCV-RNA response and hepatitis Bs seroconversion after individualized antiviral therapy with pegylated interferon alpha plus ribavirin and active vaccination in a hepatitis C virus/hepatitis B virus-coinfected patient
    Andrej Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Eur J Gastroenterol Hepatol 19:906-9. 2007
    ..Monitoring of HBsAg levels can be useful in individualizing optimal treatment duration in HBV-infected patients...
  44. ncbi request reprint Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course
    Frank Tacke
    Medical Clinic III, University Hospital Aachen, Aachen, Germany
    J Gastroenterol Hepatol 22:1256-64. 2007
    ..The aim of this study was to analyze the role of eotaxin in chronic liver disease...
  45. ncbi request reprint Contribution of interleukin-6/gp 130 signaling in hepatocytes to the inflammatory response in mice infected with Streptococcus pyogenes
    Christian Klein
    Medizinische Klinik III, University Hospital Aachen, Rheinisch Westfalisch Techniche Hochschule Aachen, Aachen, Germany
    J Infect Dis 196:755-62. 2007
    ..Here, we investigated whether blockage of the transducer gp130, a receptor involved in the regulation of the inflammatory response, might be useful in the treatment of experimental gram-positive sepsis...
  46. pmc Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man
    Maren Luchtefeld
    Abteilung fur Kardiologie und Angiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Exp Med 204:1935-44. 2007
    ..Thus, the acute phase reaction should be considered an important target for future drug development in the management of CAD...
  47. ncbi request reprint Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha
    Christoph G Dietrich
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, University Hospital Aachen, Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Am J Physiol Gastrointest Liver Physiol 293:G585-90. 2007
    ..We conclude that upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway...
  48. ncbi request reprint Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury
    Naiara Beraza
    Medizinische Klinik III, University Hospital, RWTH Aachen, Aachen, Germany
    Gastroenterology 132:2504-17. 2007
    ..NEMO knockout mice die during embryogenesis due to massive hepatocyte apoptosis. Here we investigated the role of NEMO-dependent signaling in hepatocytes during acute liver injury...
  49. ncbi request reprint Acute hepatitis B virus infection by genotype F despite successful vaccination in an immune-competent German patient
    Frank Tacke
    Medical Clinic III, RWTH University Hospital Aachen, Aachen, Germany
    J Clin Virol 38:353-7. 2007
    ..Hepatitis B Virus (HBV) infection is a leading cause of chronic hepatitis and liver cirrhosis worldwide, and efficient protection can usually be achieved by vaccination that is based on recombinant HBsAg protein from HBV genotype A and D...
  50. ncbi request reprint The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver
    Rinke Stienstra
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Hepatol 46:869-77. 2007
    ..The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver...
  51. ncbi request reprint Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
    Tom Luedde
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Cancer Cell 11:119-32. 2007
    ....
  52. ncbi request reprint Maid (GCIP) is involved in cell cycle control of hepatocytes
    Eva Sonnenberg-Riethmacher
    ZMNH Centre for Molecular Neurobiology University of Hamburg, Hamburg, Germany
    Hepatology 45:404-11. 2007
    ..Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally...
  53. ncbi request reprint STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico Via del Pozzo 71, 41100 Modena, Italy
    Gastroenterology 132:294-300. 2007
    ..To clarify the molecular pathways involved in hepcidin activation by IL-6, we used different mice strains in which the main IL-6/gp130 signaling pathways have been genetically disrupted...
  54. ncbi request reprint Intracellular survival pathways in the liver
    Tom Luedde
    EMBL Mouse Biology Program, Monterotondo, Italy
    Liver Int 26:1163-74. 2006
    ..Moreover, the role of the interleukin-6 pathway and its possible protective function in the context of liver failure will be summarized...
  55. ncbi request reprint NFkappaB-mediated upregulation of bcl-xl restrains TRAIL-mediated apoptosis in murine viral hepatitis
    Lars Zender
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Germany
    Hepatology 41:280-8. 2005
    ..In conclusion, inhibition of NFkappaB or bcl-xl during TRAIL therapy may harbor a risk of liver damage in patients with viral hepatitis...
  56. ncbi request reprint Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes
    Kai C Wollert
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Hannover, Germany
    Hypertension 39:87-92. 2002
    ..Adenoviral gene transfer of PKG I selectively enhances the antihypertrophic effects of NO without increasing the susceptibility to apoptosis...
  57. ncbi request reprint Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases
    Konrad L Streetz
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 38:218-29. 2003
    ..Hepatology 2003;38:218-229)...
  58. pmc Caspase 8 small interfering RNA prevents acute liver failure in mice
    Lars Zender
    Department of Gastroenterology, Medical School Hannover, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 100:7797-802. 2003
    ..Consequently, our data raise hope for future successful application of siRNA in patients with acute liver failure...
  59. ncbi request reprint Relevance of hepatitis B core gene deletions in patients after kidney transplantation
    C Thomas Bock
    Department of Gastroenterology, Hepatology and Oncology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Gastroenterology 124:1809-20. 2003
    ..The selection pressure on the HBV genome in these patients is reduced. The aim was to analyze and characterize variations in the HBV core gene after organ transplantation and their impact for prognosis...
  60. ncbi request reprint Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis
    Marieke H Schoemaker
    Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, PO Box 30 001, 9700 RB, Groningen, The Netherlands
    J Hepatol 36:742-50. 2002
    ..In the present study the relationship between NF-kappaB activation and apoptosis has been investigated in hepatocytes...
  61. ncbi request reprint p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver
    Tom Luedde
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 37:833-41. 2003
    ..Additionally we provide evidence that timing and strength of DNA synthesis in hepatocytes after PH is regulated tightly through the collaboration of different cell cycle inhibitors...
  62. ncbi request reprint Successful treatment of fibrosing cholestatic hepatitis using adefovir dipivoxil in a patient with cirrhosis and renal insufficiency
    Hans L Tillmann
    Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Liver Transpl 9:191-6. 2003
    ..Adefovir dipivoxil resulted in significant clinical improvement in this patient with hepatitis B virus-induced fibrosing cholestatic hepatitis, despite the presence of renal impairment and lamivudine resistance...
  63. ncbi request reprint Losing balance: cytokine signaling and cell death in the context of hepatocyte injury and hepatic failure
    Tom Luedde
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Germany
    Eur Cytokine Netw 13:377-83. 2002
    ....
  64. ncbi request reprint Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration
    Torsten Wuestefeld
    Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Biol Chem 278:11281-8. 2003
    ..Thus our results suggest that the role of gp130-dependent signaling is not a direct influence on cell cycle progression after partial hepatectomy but is to activate protective pathways important to enable hepatocyte proliferation...
  65. ncbi request reprint Involvement of TRAIL and its receptors in viral hepatitis
    Bettina Mundt
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    FASEB J 17:94-6. 2003
    ..Our results suggest that TRAIL might be used not only for cancer therapy but also for therapy of patients with viral hepatitis to selectively eliminate infected hepatocytes and limit viral replication...
  66. ncbi request reprint Imbalanced intrahepatic expression of interleukin 12, interferon gamma, and interleukin 10 in fulminant hepatitis B
    Ludger Leifeld
    Department of Internal Medicine I, University of Bonn, Germany
    Hepatology 36:1001-8. 2002
    ..This cytokine imbalance may play an important role in promoting inflammatory reactions leading to massive liver damage in fulminant hepatitis B...
  67. ncbi request reprint Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells
    Christian Liedtke
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Hannover Germany
    Hepatology 36:315-25. 2002
    ....
  68. ncbi request reprint Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA
    Christian Klein
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Germany
    Gastroenterology 125:9-18. 2003
    ..Animal models to study new treatment options in vivo have several drawbacks. Therefore, we were interested to establish a new small animal model in which HBV replication and especially new treatment options can be studied easily...
  69. ncbi request reprint Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration
    Heike Steiling
    Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Oncogene 22:4380-8. 2003
    ..These data demonstrate a key role of FGFR signalling in repair after liver injury...
  70. ncbi request reprint ME3738 protects from concanavalin A-induced liver failure via an IL-6-dependent mechanism
    Christian Klein
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Eur J Immunol 33:2251-61. 2003
    ..Therefore, we demonstrate that ME3738 triggers IL-6 expression, which activates pathways that are relevant to protect from Con A-induced liver failure...
  71. ncbi request reprint Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis
    Bernhard Schieffer
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Circulation 110:3493-500. 2004
    ..Mediators of inflammation, ie, interleukin (IL)-6, are elevated in patients with acute coronary syndromes and may contribute to the exacerbation of atherosclerosis...
  72. ncbi request reprint Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplantation
    C Thomas Bock
    Department of Gastroenterology and Hepatology, Medical School of Hannover, FRG
    Gastroenterology 122:264-73. 2002
    ..However, we observed a severe clinical course of hepatitis B infection in several liver transplant recipients after the emergence of lamivudine resistance. This was associated with high viral load in the blood...
  73. ncbi request reprint C/EBP beta isoforms LIP and LAP modulate progression of the cell cycle in the regenerating mouse liver
    Tom Luedde
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 40:356-65. 2004
    ..In the context of previous studies, our results demonstrate that LAP, through a dose-dependent effect, withholds a dual activating and inhibiting role on hepatocyte proliferation in vivo...
  74. pmc Basal core promoter and precore mutations in the hepatitis B virus genome enhance replication efficacy of Lamivudine-resistant mutants
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Virol 78:8524-35. 2004
    ..Adefovir may be an effective treatment when combinations of core and polymerase mutations occur...
  75. pmc Met provides essential signals for liver regeneration
    Malgorzata Borowiak
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 101:10608-13. 2004
    ..Our data demonstrate that the HGF/SF/Met signaling system is essential not only during liver development but also for the regeneration of the organ in the adult...
  76. ncbi request reprint The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis
    Xu Ping Wang
    Department of Dermatology, University of Kiel, Germany
    J Invest Dermatol 123:124-31. 2004
    ..Our results indicate that the IL-6 cytokine system, particularly transsignalling via the soluble IL-6R, is critically involved in barrier repair after skin injury...
  77. ncbi request reprint Quantification of hepatic thrombopoietin mRNA transcripts in patients with chronic liver diseases shows maintained gene expression in different etiologies of liver cirrhosis
    Frank Tacke
    Department of Gastroenterology and Hepatology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Liver 22:205-12. 2002
    ....
  78. ncbi request reprint Lamivudine transiently reduces viral load and improves liver function in liver transplant recipients with fibrosing cholestatic hepatitis
    Hans L Tillmann
    Am J Gastroenterol 97:777-8. 2002
  79. ncbi request reprint Expression of tissue factor pathway inhibitor-2 in murine and human liver regulation during inflammation
    Toru Hisaka
    GREF, INSERM E 362 and IFR 66, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Thromb Haemost 91:569-75. 2004
    ..The large difference in the level of liver expression of human and murine TFPI-2 suggests that despite significant sequence similarities, these proteins presumably have different functions in the two species...
  80. ncbi request reprint Thrombopoietin serum levels are elevated in patients with hepatitis B/C infection compared to other causes of chronic liver disease
    Patrick Schoffski
    Department of Hematology Oncology, Hannover Medical School, Carl Neuberg Strasse 1, Germany
    Liver 22:114-20. 2002
    ..Thrombocytopenia in patients with advanced liver disease may stem from a deficient hepatic thrombopoietin production...
  81. ncbi request reprint Plasma P-selectin levels are elevated in patients with chronic liver disease
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Blood Coagul Fibrinolysis 14:319-25. 2003
    ..In line with its role in acute liver damage, P-selectin elevation in chronic liver disease may suggest a possible pathogenetic role in the course of liver cirrhosis...
  82. ncbi request reprint Lack of gp130 expression in hepatocytes promotes liver injury
    Konrad L Streetz
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Gastroenterology 125:532-43. 2003
    ..To define the IL-6-dependent intracellular pathways more specifically, we generated a hepatocyte-specific gp130 knockout mouse...
  83. doi request reprint Hepatocyte-specific inhibitor-of-kappaB-kinase deletion triggers the innate immune response and promotes earlier cell proliferation during liver regeneration
    Yann Malato
    Medical Clinic III, University Hospital Aachen RWTH, Aachen, Germany
    Hepatology 47:2036-50. 2008
    ..Interestingly, despite faster G(1)/S progression, IKK2DeltaLPC mice exhibited an enduring mitosis phase, because mitotic bodies were still observed at later stages after PH...
  84. ncbi request reprint Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target
    Soazig Le Lay
    INSERM Unité 465, Centre de Recherches Biomedicales des Cordeliers, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    J Biol Chem 277:35625-34. 2002
    ..Thus, some of the effects of insulin and/or SREBP-1c in mature fat cells might require C/EBPbeta or C/EBPdelta as transcriptional relays...
  85. ncbi request reprint Ghrelin in chronic liver disease
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Hepatol 38:447-54. 2003
    ..We investigated the role of ghrelin and insulin-like growth factor-1 (IGF-1), the mediator of the GH axis, in patients with chronic liver diseases (CLD)...
  86. ncbi request reprint Hepatic gas gangrene following liver transplantation
    Johannes Hadem
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Liver Transpl 13:468-9. 2007
  87. ncbi request reprint The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism
    Christian Liedtke
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, D 30625 Hannover, Germany
    J Biol Chem 278:27593-604. 2003
    ..In summary, our study contributes to the understanding of the transcriptional regulation of the caspase-8 gene by basal (SP1- and ETS-dependent) and inducible (p53-dependent) mechanisms...
  88. ncbi request reprint Tumor-specific adenoviral gene therapy: transcriptional repression of gene expression by utilizing p53-signal transduction pathways
    Florian Kuhnel
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cancer Gene Ther 11:28-40. 2004
    ..Controlled gene expression from CMVgal promoters by transcriptional repression utilizing functional p53 signalling thus provides a very effective tool for tumor-specific adenoviral gene therapy...
  89. ncbi request reprint Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis
    Eray Yagmur
    Institute of Clinical Chemistry and Pathobiochemistry, University Hospital Aachen UKA, Aachen University RWTH, Pauwelsstrasse 30, 52074 Aachen, Germany
    Clin Biochem 39:39-45. 2006
    ..Nepsilon-(carboxymethyl)lysine (CML)-modified advanced glycation end products (AGEs) in patients with CLD could reflect the degree of severity of the disease...
  90. ncbi request reprint Influence of mutations in the hepatitis B virus genome on virus replication and drug resistance--implications for novel antiviral strategies
    Frank Tacke
    Dept of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, Germany
    Curr Med Chem 11:2667-77. 2004
    ..This review summarises the impact of clinically relevant mutations in the HBV genome on viral replication and drug sensitivity, the current status of therapy and promising future perspectives on novel drug regimens...
  91. pmc Functional cooperation between CCAAT/enhancer-binding proteins and the vitamin D receptor in regulation of 25-hydroxyvitamin D3 24-hydroxylase
    Puneet Dhawan
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Mol Cell Biol 25:472-87. 2005
    ..These findings also indicate a novel role for C/EBPbeta in the cross talk between PTH and 1,25(OH)(2)D(3) that involves the regulation of VDR transcription...