Ulrich Martin

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. doi request reprint Methods for studying stem cells: adult stem cells for lung repair
    Ulrich Martin
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Methods 45:121-32. 2008
  2. pmc Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis?
    Ulrich Martin
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Mol Cell Pediatr 2:15. 2015
  3. ncbi request reprint Absence of PERV specific humoral immune response in baboons after transplantation of porcine cells or organs
    Ulrich Martin
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Podbielskistrasse 380, 30659 Hannover, Germany
    Transpl Int 15:361-8. 2002
  4. ncbi request reprint Type II pneumocyte-restricted green fluorescent protein expression after lentiviral transduction of lung epithelial cells
    Stephanie Wunderlich
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, 30659 Hannover, Germany
    Hum Gene Ther 19:39-52. 2008
  5. doi request reprint Induced pluripotent stem cell (iPSC)-derived Flk-1 progenitor cells engraft, differentiate, and improve heart function in a mouse model of acute myocardial infarction
    Christina Mauritz
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery, Rebirth Cluster of Excellence, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 32:2634-41. 2011
  6. doi request reprint Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro
    George Kensah
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Cluster of Excellence REBIRTH, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 34:1134-46. 2013
  7. doi request reprint Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering
    Julia Dahlmann
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Rebirth Cluster of Excellence, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Biomaterials 34:940-51. 2013
  8. pmc Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors
    Susann Hartung
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Stem Cells Dev 22:1112-25. 2013
  9. doi request reprint Generation of induced pluripotent stem cells from human cord blood
    Alexandra Haase
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Cell Stem Cell 5:434-41. 2009
  10. doi request reprint Serum-free differentiation of murine embryonic stem cells into alveolar type II epithelial cells
    Monica E Winkler
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Hannover, Germany
    Cloning Stem Cells 10:49-64. 2008

Detail Information

Publications59

  1. doi request reprint Methods for studying stem cells: adult stem cells for lung repair
    Ulrich Martin
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Methods 45:121-32. 2008
    ....
  2. pmc Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis?
    Ulrich Martin
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Mol Cell Pediatr 2:15. 2015
    ..In the near future, genetically engineered induced pluripotent stem cells will provide an excellent basis for personalized organotypic models of CF disease and biological screens for identification of CFTR potentiators and correctors. ..
  3. ncbi request reprint Absence of PERV specific humoral immune response in baboons after transplantation of porcine cells or organs
    Ulrich Martin
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Podbielskistrasse 380, 30659 Hannover, Germany
    Transpl Int 15:361-8. 2002
    ..Our data suggest that no productive PERV infection and no continuous PERV release takes place in the nonhuman primates analyzed in this study...
  4. ncbi request reprint Type II pneumocyte-restricted green fluorescent protein expression after lentiviral transduction of lung epithelial cells
    Stephanie Wunderlich
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, 30659 Hannover, Germany
    Hum Gene Ther 19:39-52. 2008
    ..In particular, the generated vector should facilitate local alveolar gene therapy and investigation of alveolar regeneration and stem cell differentiation...
  5. doi request reprint Induced pluripotent stem cell (iPSC)-derived Flk-1 progenitor cells engraft, differentiate, and improve heart function in a mouse model of acute myocardial infarction
    Christina Mauritz
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery, Rebirth Cluster of Excellence, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 32:2634-41. 2011
    ....
  6. doi request reprint Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro
    George Kensah
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Cluster of Excellence REBIRTH, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 34:1134-46. 2013
    ....
  7. doi request reprint Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering
    Julia Dahlmann
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Rebirth Cluster of Excellence, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Biomaterials 34:940-51. 2013
    ....
  8. pmc Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors
    Susann Hartung
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Stem Cells Dev 22:1112-25. 2013
    ..In summary, this is the first report on TF-induced cardiomyogenesis of hPSCs applying a transient, nonintegrating method of cell transfection...
  9. doi request reprint Generation of induced pluripotent stem cells from human cord blood
    Alexandra Haase
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Cell Stem Cell 5:434-41. 2009
    ..CB could readily become available for pediatric patients and, in particular, for newborns with genetic diseases or congenital malformations...
  10. doi request reprint Serum-free differentiation of murine embryonic stem cells into alveolar type II epithelial cells
    Monica E Winkler
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Hannover, Germany
    Cloning Stem Cells 10:49-64. 2008
    ..The established serum-free differentiation protocol will facilitate the identification of key differentiation factors leading to a more specific and effective generation of AT2-like cells from ESCs...
  11. ncbi request reprint Human CMV immediate-early enhancer: a useful tool to enhance cell-type-specific expression from lentiviral vectors
    Ina Gruh
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Hannover, Germany
    J Gene Med 10:21-32. 2008
    ..While restriction of gene expression to specific cell populations is of particular importance, highly efficient cell-type-specific gene expression after viral gene transfer so far has been hampered by low levels of transgene expression...
  12. pmc Transplantation Effectiveness of Induced Pluripotent Stem Cells Is Improved by a Fibrinogen Biomatrix in an Experimental Model of Ischemic Heart Failure
    Sebastian V Rojas
    1 Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Tissue Eng Part A 21:1991-2000. 2015
    ..The aim of this study was to investigate whether a fibrinogen biomatrix improves the transplantation effectiveness of induced pluripotent stem cells (iPSCs) in a model of myocardial infarction...
  13. doi request reprint Generation of functional murine cardiac myocytes from induced pluripotent stem cells
    Christina Mauritz
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Circulation 118:507-17. 2008
    ..The aim of this study was to characterize the cardiac differentiation potential of a murine iPS cell clone in comparison to a well-established murine ES cell line...
  14. doi request reprint The use of agarose microwells for scalable embryoid body formation and cardiac differentiation of human and murine pluripotent stem cells
    Julia Dahlmann
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, 30625 Hannover, Rebirth Cluster of Excellence, Germany
    Biomaterials 34:2463-71. 2013
    ..Moreover, it might be useful for different cell types in any application that requires scalable and highly standardized aggregation...
  15. pmc Suspension culture of human pluripotent stem cells in controlled, stirred bioreactors
    Ruth Olmer
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover, Germany
    Tissue Eng Part C Methods 18:772-84. 2012
    ....
  16. ncbi request reprint Generation and characterization of functional cardiomyocytes from rhesus monkey embryonic stem cells
    Kristin Schwanke
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover, Germany
    Stem Cells 24:1423-32. 2006
    ..In contrast to hESCs, rESCs allow for establishment of pre-clinical allogeneic transplantation models. Moreover, rESC-derived CMs represent a cell source for the development of high-throughput assays for cardiac safety pharmacology...
  17. ncbi request reprint No evidence of transdifferentiation of human endothelial progenitor cells into cardiomyocytes after coculture with neonatal rat cardiomyocytes
    Ina Gruh
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, Hannover, Germany
    Circulation 113:1326-34. 2006
    ..This study investigates whether, when cocultured, neonatal rat cardiomyocytes (NRCMs) can induce transdifferentiation of huEPCs into cardiomyocytes...
  18. doi request reprint Bronchoalveolar sublineage specification of pluripotent stem cells: effect of dexamethasone plus cAMP-elevating agents and keratinocyte growth factor
    Katherina Katsirntaki
    1 Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Tissue Eng Part A 21:669-82. 2015
    ..The targeted in vitro generation of Clara cells with their important function in airway protection and regeneration will enable the evaluation of innovative cellular therapies in animal models of lung diseases. ..
  19. doi request reprint Substantial early loss of induced pluripotent stem cells following transplantation in myocardial infarction
    Andreas Martens
    Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Artif Organs 38:978-84. 2014
    ..Therefore, we recommend applying tissue engineering techniques for cardiac stem cell transplantations in order to improve cardiac retention and limit biodistribution...
  20. doi request reprint Keratinocyte growth factor and dexamethasone plus elevated cAMP levels synergistically support pluripotent stem cell differentiation into alveolar epithelial type II cells
    Sabrina Schmeckebier
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Tissue Eng Part A 19:938-51. 2013
    ..Combined application of these factors will facilitate more efficient generation of stem cell-derived ATII cells for future basic research and potential therapeutic application...
  21. pmc Induction of pluripotent stem cells from a cynomolgus monkey using a polycistronic simian immunodeficiency virus-based vector, differentiation toward functional cardiomyocytes, and generation of stably expressing reporter lines
    Stephanie Wunderlich
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany
    Cell Reprogram 14:471-84. 2012
    ..In conclusion, our data indicate that cyiPSCs represent a valuable cell source for establishment of macaque-based allogeneic and autologous preclinical cell transplantation models for various fields of regenerative medicine...
  22. pmc Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
    Henning Kempf
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery HTTG, Hannover Medical School, 30625 Hannover, Germany
    Nat Commun 7:13602. 2016
    ..Furthermore, these findings have profound consequences for inter-experimental comparability, reproducibility, bioprocess optimization and scale-up...
  23. doi request reprint Higher frequencies of BCRP+ cardiac resident cells in ischaemic human myocardium
    Maximilian Y Emmert
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, LEBAO and Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Cluster of Excellence REBIRTH, Carl Neuberg Str 1, Hannover 30625, Germany
    Eur Heart J 34:2830-8. 2013
    ..Several cardiac resident progenitor cell types have been reported for the adult mammalian heart. Here we characterize their frequencies and distribution pattern in non-ischaemic human myocardial tissue and after ischaemic events...
  24. pmc Fast and efficient multitransgenic modification of human pluripotent stem cells
    Kristin Schwanke
    1 Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, 30625 Hannover, Germany
    Hum Gene Ther Methods 25:136-53. 2014
    ..Practical applicability of the method is demonstrated for antibiotic-based lineage enrichment in vitro and for sodium iodide symporter transgene-based in situ cell imaging after intramyocardial cell infusion into explanted pig hearts...
  25. doi request reprint Primate iPS cells as tools for evolutionary analyses
    Stephanie Wunderlich
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany REBIRTH Cluster of Excellence, Germany
    Stem Cell Res 12:622-9. 2014
    ..Hence, primate iPSCs reveal insights into general primate gene expression evolution and should provide a rich source to identify conserved and species-specific gene expression patterns for cellular phenotypes. ..
  26. doi request reprint Rhesus monkey cardiosphere-derived cells for myocardial restoration
    Andreas Martens
    Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Cytotherapy 13:864-72. 2011
    ..However, their usefulness for myocardial restoration remains controversial. We aimed to determine the survival, differentiation and functional effects of Rhesus monkey CDC (RhCDC) in a mouse model of myocardial infarction...
  27. doi request reprint A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells
    Jiri Palecek
    Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167, Hannover, Germany
    Org Biomol Chem 9:5503-10. 2011
    ..Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells...
  28. pmc Efficient designer nuclease-based homologous recombination enables direct PCR screening for footprintless targeted human pluripotent stem cells
    Sylvia Merkert
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiac, Thoracic, Transplant and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany REBIRTH Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany
    Stem Cell Reports 2:107-18. 2014
    ....
  29. pmc Macroscopic fluorescence imaging: a novel technique to monitor retention and distribution of injected microspheres in an experimental model of ischemic heart failure
    Andreas Martens
    Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, Hannover, Germany
    PLoS ONE 9:e101775. 2014
    ..For this purpose, our main hypothesis was that macroscopic fluorescence imaging could adequately serve as a detection method for intramyocardial injections...
  30. doi request reprint Induced pluripotent stem cells: characteristics and perspectives
    Tobias Cantz
    Junior Research Group Stem Cell Biology, Excellence Cluster REBIRTH, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Adv Biochem Eng Biotechnol 123:107-26. 2010
    ....
  31. doi request reprint Reduced thrombocyte adhesion to endothelialized poly 4-methyl-1-pentene gas exchange membranes—a first step toward bioartificial lung development
    Christian Hess
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Tissue Eng Part A 16:3043-53. 2010
    ....
  32. pmc A novel miniaturized multimodal bioreactor for continuous in situ assessment of bioartificial cardiac tissue during stimulation and maturation
    George Kensah
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Tissue Eng Part C Methods 17:463-73. 2011
    ..Thus, this bioreactor represents a valuable tool for monitoring tissue development and, ultimately, the optimization of stem cell-based tissue replacement strategies in regenerative medicine...
  33. doi request reprint Multimodal Imaging for In Vivo Evaluation of Induced Pluripotent Stem Cells in a Murine Model of Heart Failure
    Sebastian V Rojas
    Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School
    Artif Organs . 2016
    ..9 ± 0.9%) compared to infarct controls (24.0 ± 2.1%; P < 0.05). The combination of MRI and BLI assesses stem cell fate in vivo, enabling cardiac graft localization with evaluation of LV function in myocardial infarction...
  34. pmc Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors
    Christina Kropp
    Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover, Germany REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany
    Stem Cells Transl Med 5:1289-1301. 2016
    ..This study paves the way toward more efficient GMP-compliant cell production and underscores the enormous process development potential of hPSCs in suspension culture...
  35. pmc EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival
    Monica Jara-Avaca
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery, Rebirth Cluster of Excellence, Hannover Medical School, Carl Neuberg Strase 1, 30625 Hannover, Germany
    Stem Cell Reports . 2017
    ....
  36. ncbi request reprint Adhesive functions of both chains of VLA-integrins are not fully conserved across the human-porcine species barrier: implications for xenotransplantation
    Andre R Simon
    Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Xenotransplantation 12:473-80. 2005
    ....
  37. ncbi request reprint In vivo echocardiographic imaging of transplanted human adult stem cells in the myocardium labeled with clinically applicable CliniMACS nanoparticles
    Christoph Bara
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    J Am Soc Echocardiogr 19:563-8. 2006
    ..We present a clinically applicable technique using transesophageal echocardiography (TEE) of CliniMACS nanoparticle labeled transplanted CD133+ cells in ischemic hearts...
  38. doi request reprint Functional effects of cannabinoids during dopaminergic specification of human neural precursors derived from induced pluripotent stem cells
    Nancy Stanslowsky
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Addict Biol . 2016
    ..Our data suggest that there are concentration-dependent actions of cannabinoids on neuronal function in vitro indicating neurotoxic, dysfunctional effects of 10-μM AEA and THC during human neurogenesis...
  39. doi request reprint Striatal Transplantation of Human Dopaminergic Neurons Differentiated From Induced Pluripotent Stem Cells Derived From Umbilical Cord Blood Using Lentiviral Reprogramming
    Anna Effenberg
    Institute of Neuroanatomy, Hannover Medical School, Hannover, Germany
    Cell Transplant 24:2099-112. 2015
    ..In conclusion, BMP/TGF-β inhibition was more effective than FGF-2 signaling with regard to dopaminergic induction of hCBiPSCs in vitro and prevented graft overgrowth in vivo. ..
  40. doi request reprint Cardiac differentiation of human pluripotent stem cells in scalable suspension culture
    Henning Kempf
    1 Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany 2 REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany
    Nat Protoc 10:1345-61. 2015
    ..In bioreactors, the generation of 40-50 million CMs per differentiation batch at >80% purity without further lineage enrichment can been achieved within 24 d. ..
  41. doi request reprint Scalable expansion of human pluripotent stem cells in suspension culture
    Robert Zweigerdt
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Nat Protoc 6:689-700. 2011
    ..Importantly, hPSCs maintain pluripotency and karyotype stability for more than ten passages...
  42. ncbi request reprint [Differentiation potential of human stem cells--approaches to tissue engineering and to cell transplantation]
    Axel Haverich
    Leibniz Forschungslaboratorien für Biotechnologie und künstliche Organe, Medizinische Hochschule Hannover
    Z Arztl Fortbild Qualitatssich 96:440-8. 2002
    ..In the long term, tissue engineering offers an as yet incalculable potential for future medical applications and may finally allow the development and clinical transplantation of complex tissues or even whole organs...
  43. ncbi request reprint Stiff matrix induces switch to pure β-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes
    Natalie Weber
    Institute of Molecular and Cell Physiology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Basic Res Cardiol 111:68. 2016
    ....
  44. ncbi request reprint Nonhuman primates: embryonic stem cells and transgenesis
    Peter A Horn
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Cloning Stem Cells 8:124-9. 2006
  45. pmc Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture
    Henning Kempf
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation, and Vascular Surgery HTTG, Hannover Medical School, Carl Neuberg Straβe 1, 30625 Hannover, Germany REBIRTH Cluster of Excellence, Hannover Medical School, Carl Neuberg Straβe 1, 30625 Hannover, Germany
    Stem Cell Reports 3:1132-46. 2014
    ..In 100 ml bioreactors, the production of 40 million predominantly ventricular-like cardiomyocytes (up to 85% purity) was enabled that were directly applicable to bioartificial cardiac tissue formation...
  46. doi request reprint Transdifferentiation of stem cells: a critical view
    Ina Gruh
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Adv Biochem Eng Biotechnol 114:73-106. 2009
    ..This chapter will concentrate on these controversies and focus on selected examples demonstrating the technical aspects of stem cell transdifferentiation and the evaluation of the tools used to analyze these events...
  47. doi request reprint Your heart on a chip: iPSC-based modeling of Barth-syndrome-associated cardiomyopathy
    Robert Zweigerdt
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany REBIRTH Cluster of Excellence
    Cell Stem Cell 15:9-11. 2014
    ..2014) powerfully combines analysis of human iPSCs with genome editing and tissue engineering, in conjunction with biochemical and physiological assays, to provide insights into Barth-syndrome-associated cardiomyopathy. ..
  48. doi request reprint MicroRNA-24 regulates vascularity after myocardial infarction
    Jan Fiedler
    Hannover Medical School, Institute for Molecular and Translational Therapeutic Strategies, Hannover, Germany
    Circulation 124:720-30. 2011
    ..Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms of cardiac angiogenesis are mechanistically not well understood...
  49. doi request reprint Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium
    Ruth Olmer
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Stem Cell Res 5:51-64. 2010
    ..The ability to expand HES / hiPS cells in a scalable suspension culture represents a critical step towards standardized production in stirred bioreactors...
  50. ncbi request reprint Analysis of pig-to-human porcine endogenous retrovirus transmission in a triple-species kidney xenotransplantation model
    Monica E Winkler
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover, Germany
    Transpl Int 17:848-58. 2005
    ..PERV-specific immune response of recipients was analysed by Western blot. No evidence of PERV infection or PERV-specific immune response was detected...
  51. pmc Site-Specific Genome Engineering in Human Pluripotent Stem Cells
    Sylvia Merkert
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany
    Int J Mol Sci 17:. 2016
    ..By now, customized engineered nucleases provide excellent tools for targeted genome editing, opening new perspectives for biomedical research and cellular therapies. ..
  52. ncbi request reprint Shuttle system allowing simplified cloning of expression cassettes into advanced generation lentiviral vectors
    Ina Gruh
    Leibniz Research Laboratories, Hannover, Germany
    Biotechniques 38:530, 532, 534. 2005
  53. doi request reprint Targeted genome engineering using designer nucleases: State of the art and practical guidance for application in human pluripotent stem cells
    Sylvia Merkert
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany REBIRTH Cluster of Excellence, Hannover Medical School, Germany Biomedical Research in Endstage and Obstructive Lung Disease BREATH, Member of the German Center for Lung Research DZL, Germany
    Stem Cell Res 16:377-86. 2016
    ..We discuss experimental considerations, limitations and critical aspects which will guide the investigator for successful implementation of this technology. ..
  54. ncbi request reprint Intra-vital fluorescence microscopy for intra-myocardial graft detection following cell transplantation
    Arjang Ruhparwar
    The Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Int J Cardiovasc Imaging 21:569-74. 2005
    ..A major limitation of all clinical studies for myocardial restoration through cell transfer is the inability to track the fate of the transplanted cells...
  55. doi request reprint Molecular and functional analyses of motor neurons generated from human cord-blood-derived induced pluripotent stem cells
    Maximilian Naujock
    1 Department of Neurology, Hannover Medical School, Hannover, Germany
    Stem Cells Dev 23:3011-20. 2014
    ....
  56. ncbi request reprint No evidence for infection of human embryonic stem cells by feeder cell-derived murine leukemia viruses
    Michal Amit
    Department of Obstetrics and Gynecology, Rambam Medical Center, Faculty of Medicine, The Technion, Haifa, Israel
    Stem Cells 23:761-71. 2005
    ..Our results suggest that recently established hESC lines are free of MuLV infections despite long-term close contact with MEFs...
  57. ncbi request reprint Pig endogenous retroviruses and xenotransplantation
    Jürgen H Blusch
    Max von Pettenkofer Institute, Department of Virology, Ludwig Maximilians University, Munich, Germany
    Xenotransplantation 9:242-51. 2002
    ..Here, we compile available data on PERV biology and diagnostics, and discuss the significance of the results with regard to the safety of clinical xenotransplantation...
  58. pmc Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model
    Heinz R Redl
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Crit Care 9:R735-44. 2005
    ..In this study, therefore, the potential risks of anti-L-selectin antibody therapy were evaluated in a primate model of sepsis...
  59. ncbi request reprint Enrichment of cardiac pacemaker-like cells: neuregulin-1 and cyclic AMP increase I(f)-current density and connexin 40 mRNA levels in fetal cardiomyocytes
    Arjang Ruhparwar
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Med Biol Eng Comput 45:221-7. 2007
    ..This method may allow the development of a biological cardiac pacemaker system when applied to adult or embryonic stem cells...