Silke Jansen

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. doi request reprint Genotyping methods
    Burkhard Tummler
    Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany
    Methods Mol Biol 1149:33-47. 2014
  2. pmc Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection
    Yu Sing Tammy Bohn
    Klinische Forschergruppe, Medizinische Hochschule Hannover, Carl Neuberg Strasse, Hannover, Germany
    Mol Microbiol 71:730-47. 2009
  3. pmc Fitness of isogenic colony morphology variants of Pseudomonas aeruginosa in murine airway infection
    Elza Rakhimova
    Clinical Research Group, OE6710, Hanover Medical School, Hanover, Germany
    PLoS ONE 3:e1685. 2008
  4. pmc Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis
    Nina Cramer
    Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany
    PLoS ONE 7:e50731. 2012
  5. pmc Intraclonal genome diversity of Pseudomonas aeruginosa clones CHA and TB
    Oliver Ki Bezuidt
    Klinische Forschergruppe, Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Hannover D 30625, Germany
    BMC Genomics 14:416. 2013
  6. pmc Acute intratracheal Pseudomonas aeruginosa infection in cystic fibrosis mice is age-independent
    Antje Munder
    Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany
    Respir Res 12:148. 2011
  7. pmc An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    BMC Med Genet 12:62. 2011
  8. pmc The SeqWord Genome Browser: an online tool for the identification and visualization of atypical regions of bacterial genomes through oligonucleotide usage
    Hamilton Ganesan
    Dep of Biochemistry, Bioinformatics and Computational Biology Unit, University of Pretoria, Lynnwood Road, Hillcrest, Pretoria, 0002, South Africa
    BMC Bioinformatics 9:333. 2008
  9. pmc Global features of sequences of bacterial chromosomes, plasmids and phages revealed by analysis of oligonucleotide usage patterns
    Oleg N Reva
    Klinische Forschergruppe, OE6711, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hanover, Germany
    BMC Bioinformatics 5:90. 2004
  10. pmc Differentiation of regions with atypical oligonucleotide composition in bacterial genomes
    Oleg N Reva
    Klinische Forschergruppe, OE6711, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    BMC Bioinformatics 6:251. 2005

Detail Information

Publications60

  1. doi request reprint Genotyping methods
    Burkhard Tummler
    Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany
    Methods Mol Biol 1149:33-47. 2014
    ..The chapter provides a detailed step-by-step manual for SpeI genome fingerprinting of Pseudomonas chromosomes that has been optimized for SpeI fragment pattern analysis of P. aeruginosa...
  2. pmc Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection
    Yu Sing Tammy Bohn
    Klinische Forschergruppe, Medizinische Hochschule Hannover, Carl Neuberg Strasse, Hannover, Germany
    Mol Microbiol 71:730-47. 2009
    ..P. aeruginosa PilY1 is not an adhesin on the pilus tip, but assists in pilus biogenesis, twitching motility, secretion of secondary metabolites and in the control of cell density in the bacterial population...
  3. pmc Fitness of isogenic colony morphology variants of Pseudomonas aeruginosa in murine airway infection
    Elza Rakhimova
    Clinical Research Group, OE6710, Hanover Medical School, Hanover, Germany
    PLoS ONE 3:e1685. 2008
    ....
  4. pmc Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis
    Nina Cramer
    Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany
    PLoS ONE 7:e50731. 2012
    ....
  5. pmc Intraclonal genome diversity of Pseudomonas aeruginosa clones CHA and TB
    Oliver Ki Bezuidt
    Klinische Forschergruppe, Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Hannover D 30625, Germany
    BMC Genomics 14:416. 2013
    ..The outcome was compared with the intraclonal genome diversity between three more closely related isolates of another clonal complex...
  6. pmc Acute intratracheal Pseudomonas aeruginosa infection in cystic fibrosis mice is age-independent
    Antje Munder
    Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany
    Respir Res 12:148. 2011
    ..Age related changes regarding the course of disease and susceptibility towards pulmonary infections have been discussed in numerous studies...
  7. pmc An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    BMC Med Genet 12:62. 2011
    ....
  8. pmc The SeqWord Genome Browser: an online tool for the identification and visualization of atypical regions of bacterial genomes through oligonucleotide usage
    Hamilton Ganesan
    Dep of Biochemistry, Bioinformatics and Computational Biology Unit, University of Pretoria, Lynnwood Road, Hillcrest, Pretoria, 0002, South Africa
    BMC Bioinformatics 9:333. 2008
    ..The purpose of this research was to make OU statistical analysis available as a novel web-based tool for functional genomics and annotation. The tool is also available as a downloadable package...
  9. pmc Global features of sequences of bacterial chromosomes, plasmids and phages revealed by analysis of oligonucleotide usage patterns
    Oleg N Reva
    Klinische Forschergruppe, OE6711, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hanover, Germany
    BMC Bioinformatics 5:90. 2004
    ..In this paper we analyzed oligonucleotide usage (OU) biases in a comprehensive collection of 155 completely sequenced bacterial chromosomes, 316 plasmids and 104 phages...
  10. pmc Differentiation of regions with atypical oligonucleotide composition in bacterial genomes
    Oleg N Reva
    Klinische Forschergruppe, OE6711, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    BMC Bioinformatics 6:251. 2005
    ..We tested the usefulness of local oligonucleotide usage (OU) patterns to recognize and differentiate types of atypical oligonucleotide composition in DNA sequences of bacterial genomes...
  11. pmc Pyoverdine receptor: a case of positive Darwinian selection in Pseudomonas aeruginosa
    Burkhard Tummler
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, D 30623 Hannover, Germany
    J Bacteriol 187:3289-92. 2005
  12. ncbi request reprint Cystic fibrosis: an inherited susceptibility to bacterial respiratory infections
    B Tummler
    Klinische Forschergruppe, Zentrum Biochemie und Zentrum Kinderheilkunde, OE 6711, Medizinische Hochschule Hannover, D 30623 Hannover, Germany
    Mol Med Today 5:351-8. 1999
    ..Regular chemotherapy with aerosol and systemic antipseudomonal drugs has improved the course and prognosis of the disease, and research for effective vaccines is on the way...
  13. pmc Genome-wide transcriptional profiling of the steady-state response of Pseudomonas aeruginosa to hydrogen peroxide
    Prabhakar Salunkhe
    Clinical Reseach Group, OE 6710, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Bacteriol 187:2565-72. 2005
    ....
  14. ncbi request reprint Rescue of F508del CFTR: Commentary on "F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive"
    Burkhard Tummler
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Biochim Biophys Acta 1758:563-4. 2006
  15. ncbi request reprint [Molecular genetics principles in cystic fibrosis. An example of genetic illness in pneumology]
    B Tummler
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover
    Internist (Berl) 44:S7-15. 2003
    ....
  16. doi request reprint Transient correction of the basic defect in sweat glands in an individual with cystic fibrosis carrying the complex CFTR allele F508del-R553Q
    B Tummler
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Thorax 64:179-80. 2009
    ..R553Q caused a delay in diagnosis because of false negative sweat tests but was not a disease reverting suppressor mutation as had been inferred from cellular models...
  17. doi request reprint Functional analysis of F508del CFTR in native human colon
    Andrea van Barneveld
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Hannover, Germany
    Biochim Biophys Acta 1802:1062-9. 2010
    ..The finding that some F508del CFTR escapes the ER quality control in vivo substantiates the hope that the defective processing and trafficking of F508del CFTR can be corrected by pharmacological agents...
  18. pmc Very mild disease phenotype of congenic CftrTgH(neoim)Hgu cystic fibrosis mice
    Balazs Toth
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    BMC Genet 9:28. 2008
    ..Clinical and electrophysiological features of the two congenic strains were compared with those of CF/1-CftrTgH(neoim)Hgu and CF/3-CftrTgH(neoim)Hgu and wild type controls...
  19. pmc Expression analysis of a highly adherent and cytotoxic small colony variant of Pseudomonas aeruginosa isolated from a lung of a patient with cystic fibrosis
    Franz von Götz
    Institute of Medical Microbiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Bacteriol 186:3837-47. 2004
    ..Thus, the prevailing assumption that P. aeruginosa is subject to selection towards reduced cytotoxicity and attenuated virulence during chronic CF lung infection might not apply to all clonal variants...
  20. pmc Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Germany
    J Med Genet 48:24-31. 2011
    ..The cystic fibrosis (CF) basic defect, caused by dysfunction of the apical chloride channel CFTR in the gastrointestinal and respiratory tract epithelia, has not been employed so far to support the role of CF modifier genes...
  21. pmc Genome diversity of Pseudomonas aeruginosa PAO1 laboratory strains
    Jens Klockgether
    Klinische Forschergruppe, Medizinische Hochschule Hannover, Hannover, Germany
    J Bacteriol 192:1113-21. 2010
    ..High-throughput genome resequencing will resolve more cases and could become a proper quality control for strain collections...
  22. pmc Spontaneous rescue from cystic fibrosis in a mouse model
    Nikoletta Charizopoulou
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Genet 7:18. 2006
    ..In order to further investigate whether these genetic differences have an impact on the disease phenotype of cystic fibrosis we characterised the phenotype of the two inbred strains...
  23. ncbi request reprint In silico comparison of pKLC102-like genomic islands of Pseudomonas aeruginosa
    Dieco Würdemann
    Klinische Forschergruppe, OE 6711, Medizinische Hochschule Hannover, Hannover, Germany
    FEMS Microbiol Lett 275:244-9. 2007
    ..The conserved backbone has predilection sites for the uptake of island-specific gene cassettes. A major difference between the islands is the organization of the origin of replication oriV...
  24. ncbi request reprint CFTR protein analysis of splice site mutation 2789+5 G-A
    Andrea van Barneveld
    Department of Pediatric Pneumology and Neonatology, OE 6710, Medizinische Hochschule Hannover, D30625 Hannover, Germany
    J Cyst Fibros 7:165-7. 2008
    ....
  25. doi request reprint Microevolution of the major common Pseudomonas aeruginosa clones C and PA14 in cystic fibrosis lungs
    Nina Cramer
    Klinische Forschergruppe, Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Environ Microbiol 13:1690-704. 2011
    ..Late clone C and PA14 persistors in the CF lungs were compromised in growth and cytotoxicity, but their mutation frequency was normal even in mutL mutant clades...
  26. ncbi request reprint Functional genomics of Pseudomonas aeruginosa to identify habitat-specific determinants of pathogenicity
    Lutz Wiehlmann
    Klinische Forschergruppe, Abteilung Pädiatrische Pneumologie und Neonatologie, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Strass1, D 30625 Hannover, Germany
    Int J Med Microbiol 297:615-23. 2007
    ....
  27. doi request reprint Transcript profiling of the Pseudomonas aeruginosa genomic islands PAGI-2 and pKLC102
    Jens Klockgether
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Microbiology 154:1599-604. 2008
    ....
  28. doi request reprint Lung function and inflammation during murine Pseudomonas aeruginosa airway infection
    Florian Wölbeling
    Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Immunobiology 216:901-8. 2011
    ..Following any acute irritation lung function declines rapidly. Reasons for pulmonary deterioration in humans had been attributed to the action of either interleukin-6 or interleukin-8 in the lungs...
  29. doi request reprint Pseudomonas aeruginosa population biology in chronic obstructive pulmonary disease
    Elza Rakhimova
    Klinische Forschergruppe, Abteilung für Pädiatrische Pneumologie und Neonatologie, OE 6710, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    J Infect Dis 200:1928-35. 2009
    ..We report on the molecular epidemiology and population biology of P. aeruginosa in COPD...
  30. doi request reprint Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Hum Genet 127:383-94. 2010
    ....
  31. pmc Differential decay of parent-of-origin-specific genomic sharing in cystic fibrosis-affected sib pairs maps a paternally imprinted locus to 7q34
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Eur J Hum Genet 18:553-9. 2010
    ....
  32. ncbi request reprint GeneChip expression analysis of the VqsR regulon of Pseudomonas aeruginosa TB
    Mario Juhas
    Clinical Research Group OE 6711, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    FEMS Microbiol Lett 242:287-95. 2005
    ..The expression of a large group of metabolic genes, ECF sigma factors as well as of many quorum-sensing genes previously not assigned to VqsR-regulon was found to be affected by the disruption of vqsR...
  33. pmc Population structure of Pseudomonas aeruginosa
    Lutz Wiehlmann
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 104:8101-6. 2007
    ..Thus, the P. aeruginosa genome is made up of clone-typical segments in core and accessory genome and of blocks in the core with unrestricted gene flow in the population...
  34. pmc Diversity of the abundant pKLC102/PAGI-2 family of genomic islands in Pseudomonas aeruginosa
    Jens Klockgether
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Bacteriol 189:2443-59. 2007
    ..This evolutionarily ancient family of genomic islands retained its oligonucleotide signature during horizontal spread within and among taxa...
  35. doi request reprint Intestinal current measurement for diagnostic classification of patients with questionable cystic fibrosis: validation and reference data
    Nico Derichs
    Cystic Fibrosis Centre, Department of Pediatric Pulmonology and Neonatology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Thorax 65:594-9. 2010
    ..CF transmembrane conductance regulator (CFTR)-mediated ion transport can be studied ex vivo in rectal biopsies by intestinal current measurement (ICM)...
  36. doi request reprint Comparative genomics of green sulfur bacteria
    Colin Davenport
    Klinische Forschergruppe, Klinik für Pädiatrische Pneumologie und Neonatologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Photosynth Res 104:137-52. 2010
    ..The predicted proteins have a huge molecular weight of 10(6), and are probably instrumental for the bacteria to generate their own intimate (micro)environment...
  37. ncbi request reprint The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis
    Margit Ritzka
    Department of Pediatrics and Clinical CF Research Group, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Hum Genet 115:483-91. 2004
    ..The CLCA gene region was identified to encode mediators of DIDS-sensitive anion conductance in the human gastrointestinal tract that modulate the CF basic defect...
  38. ncbi request reprint Global features of the Alcanivorax borkumensis SK2 genome
    Oleg N Reva
    Klinische Forschergruppe, OE6711, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Environ Microbiol 10:614-25. 2008
    ....
  39. doi request reprint Pseudomonas putida KT2440 genome update by cDNA sequencing and microarray transcriptomics
    Sarah Frank
    Klinische Forschergruppe, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Environ Microbiol 13:1309-26. 2011
    ..The study demonstrates the power of next-generation cDNA sequencing for the quantitation of mRNA transcripts and the refinement of bacterial genome annotation...
  40. pmc Gene islands integrated into tRNA(Gly) genes confer genome diversity on a Pseudomonas aeruginosa clone
    Karen D Larbig
    Klinische Forschergruppe, Medizinische Hochschule Hannover, Hannover, Germany
    J Bacteriol 184:6665-80. 2002
    ....
  41. pmc Functional genomics of stress response in Pseudomonas putida KT2440
    Oleg N Reva
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30623 Hannover, Germany
    J Bacteriol 188:4079-92. 2006
    ..Adaptation of the membrane barrier, uptake of phosphate, maintenance of the intracellular pH and redox status, and translational control of metabolism are key mechanisms of the response of P. putida to abiotic stresses...
  42. doi request reprint Clonal epidemiology of Pseudomonas aeruginosa in cystic fibrosis
    Nina Cramer
    Klinik für Pädiatrische Pneumologie und Neonatologie, Medizinische Hochschule Hannover, Germany
    Int J Med Microbiol 300:526-33. 2010
    ..Highly transmissible epidemic strains, however, that emerge within a clonal lineage remain a major, still unresolved health threat for the CF community...
  43. ncbi request reprint An intragenic deletion in pilQ leads to nonpiliation of a Pseudomonas aeruginosa strain isolated from cystic fibrosis lung
    Yu Sing Tammy Chang
    Klinische Forschergruppe, Medizinische Hochschule Hannover, Hannover, Germany
    FEMS Microbiol Lett 270:201-6. 2007
    ..PAO1 suggests that close direct repeats framing the deletion site may have triggered this mutation. This type of mutation could play a role in the emergence of pathoadaptive mutations of P. aeruginosa in the CF lung habitat...
  44. ncbi request reprint Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated residual chloride secretion does not protect against early chronic Pseudomonas aeruginosa infection in F508del homozygous cystic fibrosis patients
    Nico Derichs
    Medizinische Hochschule Hannover, Department of Pediatrics, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Pediatr Res 55:69-75. 2004
    ..These results demonstrate the presence of some active F508del-CFTR in the apical cell membrane and imply that factors other than the CFTR-mediated residual Cl- secretion determine the age of onset of PA colonization...
  45. ncbi request reprint Murine pulmonary infection with Listeria monocytogenes: differential susceptibility of BALB/c, C57BL/6 and DBA/2 mice
    Antje Munder
    Clinical Research Group OE 6711, Center of Pediatrics, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Microbes Infect 7:600-11. 2005
    ..Dissemination from the lung into the deep organs started almost immediately after application, although a pulmonary bacterial reservoir remained during the first 4 days...
  46. doi request reprint Beneficial effects of TLR-2/6 ligation in pulmonary bacterial infection and immunization with Pseudomonas aeruginosa
    Tanja Kerber-Momot
    Institute of Functional and Applied Anatomy, Medical School Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Inflammation 33:58-64. 2010
    ..The MALP-2 enhanced immunization only resulted in a tendency to clinical improvement. In conclusion, local immunostimulation at the appropriate time can enhance the host defense against bacteria in the lung...
  47. ncbi request reprint The TNFalpha receptor TNFRSF1A and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in cystic fibrosis
    Frauke Stanke
    Department of Pediatrics, OE6711, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Hum Genet 119:331-43. 2006
    ....
  48. doi request reprint Visualization of Pseudomonas genomic structure by abundant 8-14mer oligonucleotides
    Colin F Davenport
    Klinische Forschergruppe, OE 6711, Medizinische Hochschule Hannover, Hanover, Germany
    Environ Microbiol 11:1092-104. 2009
    ..In the future of next-generation ultra-high throughput DNA sequencing, the composition of bacterial metagenomes may be quantified by scanning the primary sequence reads for these 8-14mer markers...
  49. ncbi request reprint Ex vivo biochemical analysis of CFTR in human rectal biopsies
    Andrea van Barneveld
    Klinische Forschergruppe, OE 6711, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Biochim Biophys Acta 1762:393-7. 2006
    ..Interestingly, maturation of CFTR increases substantially in tissue incubated at 26 degrees C. Our data provide a solid basis for future studies on the characterisation of CFTR in pathological cases...
  50. pmc Sequence analysis of the mobile genome island pKLC102 of Pseudomonas aeruginosa C
    Jens Klockgether
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    J Bacteriol 186:518-34. 2004
    ..The case of pKLC102 in P. aeruginosa clone C documents the intraclonal evolution of a genome island from a mobile ancestor via a reversibly integrated state to irreversible incorporation and dissipation in the chromosome...
  51. ncbi request reprint Highly adherent small-colony variants of Pseudomonas aeruginosa in cystic fibrosis lung infection
    Susanne Haussler
    Institute of Medical Microbiology, Hannover Medical School, Carl Neuberg Str 1, Germany
    J Med Microbiol 52:295-301. 2003
    ..The emergence of these highly adherent SCVs within the CF lung might play a key role in the pathogenesis of P. aeruginosa lung infection, where a biofilm mode of growth is thought to be responsible for persistent infection...
  52. pmc Inter- and intraclonal diversity of the Pseudomonas aeruginosa proteome manifests within the secretome
    Dirk Wehmhöner
    Institute of Medical Microbiology, Hannover Medical School, 30265 Hannover, Germany
    J Bacteriol 185:5807-14. 2003
    ..We concluded that the secretome expression is a sensitive measure of P. aeruginosa strain variation...
  53. pmc Abundant oligonucleotides common to most bacteria
    Colin F Davenport
    Pediatric Pneumology and Neonatology, Hanover Medical School, Hanover, Lower Saxony, Germany
    PLoS ONE 5:e9841. 2010
    ..We surveyed overrepresented mid-length oligomers across all prokaryotes and normalised for base composition and embedded oligomers using zero and second order Markov models...
  54. pmc Instability of the insertional mutation in CftrTgH(neoim)Hgu cystic fibrosis mouse model
    Nikoletta Charizopoulou
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Genet 5:6. 2004
    ....
  55. ncbi request reprint Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa
    Mario Juhas
    Clinical Research Group, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Microbiology 150:831-41. 2004
    ..The protein encoded by PA2591 regulates several traits of pathogenicity; hence, the name vqsR ('virulence and quorum-sensing regulator') was assigned to PA2591...
  56. pmc Initial interrogation, confirmation and fine mapping of modifying genes: STAT3, IL1B and IFNGR1 determine cystic fibrosis disease manifestation
    Heike Labenski
    Department of Pediatrics, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Eur J Hum Genet 19:1281-8. 2011
    ....
  57. ncbi request reprint Genes in the vicinity of CFTR modulate the cystic fibrosis phenotype in highly concordant or discordant F508del homozygous sib pairs
    Frauke Mekus
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Hum Genet 112:1-11. 2003
    ..We conclude that disease manifestation in CF is modulated by loci in the partially imprinted region 3' of CFTR that determine stature, food intake and energy homeostasis, such as the Silver-Russel-Syndrome candidate gene region and LEP...
  58. pmc EuroCareCF quality assessment of diagnostic microbiology of cystic fibrosis isolates
    Michael Hogardt
    Klinische Forschergruppe, Klinik für Pädiatrische Pneumologie und Neonatologie, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Str 1, Hannover D 30625, Germany
    J Clin Microbiol 47:3435-8. 2009
    ..The shortcomings in the diagnostics of rare and emerging pathogens point to the need for continuing education in CF microbiology and suggest the establishment of CF microbiology reference laboratories...
  59. ncbi request reprint Global features of the Pseudomonas putida KT2440 genome sequence
    Christian Weinel
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Environ Microbiol 4:809-18. 2002
    ....