M Bremer

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Fanconi's anemia and clinical radiosensitivity report on two adult patients with locally advanced solid tumors treated by radiotherapy
    Michael Bremer
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Strahlenther Onkol 179:748-53. 2003
  2. pmc Low-dose splenic irradiation in symptomatic congestive splenomegaly: report of five cases with literature data
    Frank Bruns
    Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany
    Radiat Oncol 9:86. 2014
  3. pmc Distress, anxiety and depression in patients with brain metastases before and after radiotherapy
    Marie Christine Cordes
    Department of Radiation Oncology, Medical School Hannover, Carl Neuberg Str, 1, 30625 Hannover, Germany
    BMC Cancer 14:731. 2014
  4. pmc Hypofractionated stereotactic radiotherapy of limited brain metastases: a single-centre individualized treatment approach
    Bettina Märtens
    Radiation Oncology, Medical School Hannover, Carl Neuberg Str, 1, Hannover, 30625, Germany
    BMC Cancer 12:497. 2012
  5. pmc TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study
    Magda A Blaut
    Clinics of Obstetrics and Gynaecology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Negat Results Biomed 9:9. 2010
  6. pmc Mutation analysis of the MDM4 gene in German breast cancer patients
    Scarlett Reincke
    Department of Gynaecology and Obstetrics, Hannover Medical School, Carl Neuberg Str, 1, 30625 Hannover, Germany
    BMC Cancer 8:52. 2008
  7. ncbi request reprint Palliative radiotherapy of malignant melanoma with reactor fission neutron therapy (RENT): a prospective study
    M Bremer
    Department of Radiation Oncology, Technical University Munich, Germany
    Radiat Oncol Investig 7:118-24. 1999
  8. ncbi request reprint [Spermatocytic seminoma. Report of 2 personal cases and review of the literature]
    M Bremer
    Abteilung Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover
    Urologe A 41:60-3. 2002
  9. ncbi request reprint Effectiveness of hypofractionated radiotherapy in painful bone metastases. Two prospective studies with 1 x 4 Gy and 4 x 4 Gy
    M Bremer
    Department of Radiation Oncology, Medical School Hannover, Germany
    Strahlenther Onkol 175:382-6. 1999
  10. ncbi request reprint [Bilateral breast carcinoma and local recurrence: prevalence of BRCA-1 and BRCA-2 gene mutations in an unselected patient sample]
    M Bremer
    Abteilung für Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover
    Strahlenther Onkol 177:325-9. 2001

Detail Information

Publications47

  1. ncbi request reprint Fanconi's anemia and clinical radiosensitivity report on two adult patients with locally advanced solid tumors treated by radiotherapy
    Michael Bremer
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Strahlenther Onkol 179:748-53. 2003
    ..We report on two cases to underline the possible challenges in the radiotherapy of FA patients...
  2. pmc Low-dose splenic irradiation in symptomatic congestive splenomegaly: report of five cases with literature data
    Frank Bruns
    Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany
    Radiat Oncol 9:86. 2014
    ..To show effectiveness of low-dose splenic irradiation in symptomatic congestive splenomegaly...
  3. pmc Distress, anxiety and depression in patients with brain metastases before and after radiotherapy
    Marie Christine Cordes
    Department of Radiation Oncology, Medical School Hannover, Carl Neuberg Str, 1, 30625 Hannover, Germany
    BMC Cancer 14:731. 2014
    ..In this exploratory study we prospectively assessed distress, anxiety and depression in patients with brain metastases from different solid primary tumour treated with radiotherapy to the brain...
  4. pmc Hypofractionated stereotactic radiotherapy of limited brain metastases: a single-centre individualized treatment approach
    Bettina Märtens
    Radiation Oncology, Medical School Hannover, Carl Neuberg Str, 1, Hannover, 30625, Germany
    BMC Cancer 12:497. 2012
    ..Our aim was to find the most effective and safe dose concept...
  5. pmc TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study
    Magda A Blaut
    Clinics of Obstetrics and Gynaecology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Negat Results Biomed 9:9. 2010
    ..004). We conclude that there is no evidence for the TOPBP1*Arg309Cys variant to confer an increased risk for breast cancer in the German population...
  6. pmc Mutation analysis of the MDM4 gene in German breast cancer patients
    Scarlett Reincke
    Department of Gynaecology and Obstetrics, Hannover Medical School, Carl Neuberg Str, 1, 30625 Hannover, Germany
    BMC Cancer 8:52. 2008
    ..MDM4 is a negative regulator of p53 and cooperates with MDM2 in the cellular response to DNA damage. It is unknown, however, whether MDM4 gene alterations play some role in the inherited component of breast cancer susceptibility...
  7. ncbi request reprint Palliative radiotherapy of malignant melanoma with reactor fission neutron therapy (RENT): a prospective study
    M Bremer
    Department of Radiation Oncology, Technical University Munich, Germany
    Radiat Oncol Investig 7:118-24. 1999
    ..Because melanoma lesions of small size (< or = 6 cm3) tend to respond completely, neutron beam should be performed at an early stage...
  8. ncbi request reprint [Spermatocytic seminoma. Report of 2 personal cases and review of the literature]
    M Bremer
    Abteilung Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover
    Urologe A 41:60-3. 2002
    ..With only one case of relapse confirmed in the literature, in these patients postoperative treatment can safely be omitted in favor of surveillance. In case of spermatocytic seminoma diagnosis should be confirmed by a second pathologist...
  9. ncbi request reprint Effectiveness of hypofractionated radiotherapy in painful bone metastases. Two prospective studies with 1 x 4 Gy and 4 x 4 Gy
    M Bremer
    Department of Radiation Oncology, Medical School Hannover, Germany
    Strahlenther Onkol 175:382-6. 1999
    ....
  10. ncbi request reprint [Bilateral breast carcinoma and local recurrence: prevalence of BRCA-1 and BRCA-2 gene mutations in an unselected patient sample]
    M Bremer
    Abteilung für Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover
    Strahlenther Onkol 177:325-9. 2001
    ....
  11. pmc Mutations of the BRCA1 and BRCA2 genes in patients with bilateral breast cancer
    D Steinmann
    Department of Radiation Oncology, Institute of Human Genetics, Medical School Hannover, Hannover, Germany
    Br J Cancer 85:850-8. 2001
    ..The high frequency of bilateral disease in multi-case breast cancer families may be due to a familial aggregation of additional susceptibility factors modifying the penetrance of BRCA1 and BRCA2 mutations...
  12. ncbi request reprint Prognostic significance of the time of developing motor deficits before radiation therapy in metastatic spinal cord compression: one-year results of a prospective trial
    D Rades
    Department of Radiation Oncology, Hannover Medical University, Hannover, Germany
    Int J Radiat Oncol Biol Phys 48:1403-8. 2000
    ..To investigate prospectively the prognostic value of the time of developing motor deficits before radiation therapy (RT) for post-treatment functional outcome in metastatic spinal cord compression...
  13. ncbi request reprint Application of a new verification technique allowing craniospinal irradiation in supine position
    D Rades
    Department of Radiation Oncology, Hannover Medical University, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany
    Radiother Oncol 58:215-7. 2001
    ..We present clinical experiences with a new verification technique with all three fields exposed on one single film...
  14. doi request reprint Preoperative paclitaxel/carboplatin radiochemotherapy for stage III/IV resectable oral and oropharyngeal cancer: seven-year follow-up of a phase II trial
    A Eckardt
    Departmentsof Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany
    Oncology 73:198-203. 2007
    ..6%, whereas the local recurrence-free probability was still 84.2%. These results confirm the excellent local control and high survival rates of preoperative radiochemotherapy with the combination of paclitaxel/carboplatin...
  15. ncbi request reprint Metastatic spinal cord compression. Influence of time between onset of motoric deficits and start of irradiation on therapeutic effect
    D Rades
    Department of Radiation Oncology, Medical School, Hanover, Germany
    Strahlenther Onkol 175:378-81. 1999
    ..In a retrospective analysis we investigated the prognostic significance of the interval between first appearance of motoric deficits and the beginning of radiation therapy (RT) with regard to posttreatment motoric function...
  16. doi request reprint Partial-volume segmentation for dose optimization in whole-breast radiotherapy: a comparative dosimetric and clinical analysis
    Elisabeth Tromm
    Department of Radiotherapy and Special Oncology, Hannover Medical School, Hannover, Germany
    Strahlenther Onkol 186:40-5. 2010
    ..To analyze the dosimetric and clinical benefit of a forward planned technique to optimize dose distribution in whole-breast irradation (WBI) using additional partial-volume segments (PVSeg)...
  17. doi request reprint Postoperative periclavicular radiotherapy in breast cancer patients with 1-3 positive axillary lymph nodes. Outcome and morbidity
    A Biancosino
    Clinic of Radiation Oncology, Medical School Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Strahlenther Onkol 188:417-23. 2012
    ..The goal of this work was to examine the possible influence of periclavicular irradiation on outcome of breast cancer patients with 1-3 positive lymph nodes with special emphasis on late toxicity rates...
  18. ncbi request reprint Re-irradiation of head and neck cancer-impact of total dose on outcome
    S Janssen
    Department of Radiation Oncology, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Anticancer Res 30:3781-6. 2010
    ..To evaluate the outcome of re-irradiation and to define favourable pre-treatment characteristics...
  19. ncbi request reprint Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients
    T Dork
    Department of Biochemistry and Tumour Biology, Clinic of Obstetrics and Gynecology, Medical School Hannover, D 30659 Hannover, Germany
    Cancer Res 61:7608-15. 2001
    ..Screening for frequent A-T mutations such as the 1066-6-->G splice site substitution can be effective to prospectively identify A-T heterozygotes in an unselected cancer patient population...
  20. doi request reprint Complete remission of a lymphoma-associated chylothorax by radiotherapy of the celiac trunk and thoracic duct
    Johanna Gerstein
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Strahlenther Onkol 184:484-7. 2008
    ..A chylothorax is a rare complication of mostly advanced malignant lymphomas. A case of a refractory chylothorax unresponsive to chemotherapy and successfully treated with radiotherapy is reported...
  21. ncbi request reprint Nijmegen Breakage Syndrome mutations and risk of breast cancer
    Natalia Bogdanova
    Gynecology Research Unit, Hannover Medical School, Hannover, Germany
    Int J Cancer 122:802-6. 2008
    ..1; 95%CI 1.4-6.6) and indicate that the 657del5 deletion and perhaps the R215W substitution contribute to inherited breast cancer susceptibility in Central and Eastern Europe...
  22. doi request reprint TGFB1 gene polymorphism Leu10Pro (c.29T>C), prostate cancer incidence and quality of life in patients treated with brachytherapy
    Andreas Meyer
    Clinics of Radiation Oncology, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany
    World J Urol 27:371-7. 2009
    ..We investigated whether prevalence of this polymorphism is increased in prostate cancer patients and whether carriers are at increased risk for treatment-related side effects...
  23. ncbi request reprint Prediction of prognosis regarding fractionation schedule and survival in patients with whole-brain radiotherapy for metastatic disease
    Andreas Meyer
    Department of Radiation Oncology, Medical School Hannover, 30625 Hannover, Germany
    Anticancer Res 28:3965-9. 2008
    ..To look at differences between fractionation schedules regarding established prognostic factors in patients treated with whole-brain radiotherapy (WBRT) for metastasis and actual survival...
  24. doi request reprint Anal cancer treated with radio-chemotherapy: correlation between length of treatment interruption and outcome
    Stefan Janssen
    Department of Radiation Oncology, Medical School Hannover, Hannover, Germany
    Int J Colorectal Dis 24:1421-8. 2009
    ..The purpose of this study was the evaluation of the feasibility and outcome of definitive radio-chemotherapy without split-course technique but with individualised short treatment interruption in anal cancer patients...
  25. doi request reprint Chemoradiotherapy with weekly cisplatin 40 mg/m(2) in 103 head-and-neck cancer patients: a cumulative dose-effect analysis
    Diana Steinmann
    Department of Radiation Oncology, Medical School Hannover, Hannover, Germany
    Strahlenther Onkol 185:682-8. 2009
    ..Several treatment schedules are accepted with a cumulative cisplatin dose of 200 mg/m(2) (CisCD200) given during radiotherapy. The aim of this analysis was to investigate feasibility and efficacy of a weekly cisplatin 40 mg/m(2) regimen...
  26. ncbi request reprint Association of two mutations in the CHEK2 gene with breast cancer
    Natalia Bogdanova
    Gynecology Research Unit, Hannover Medical School, Hannover, Germany
    Int J Cancer 116:263-6. 2005
    ..Family history of breast cancer did not differ between carriers and noncarriers. Our data indicate that the I157T allele, and possibly the IVS2+1G > A allele, of the CHEK2 gene contribute to inherited breast cancer susceptibility...
  27. ncbi request reprint Current status of selenium and other treatments for secondary lymphedema
    Frank Bruns
    Department of Radiotherapy, Hannover Medical School, Hannover, Germany
    J Support Oncol 1:121-30. 2003
    ..The very low toxicity profile of selenium and its cost effectiveness are further arguments for its use in lymphedema treatment...
  28. ncbi request reprint Falsely low serum prolactin in two cases of invasive macroprolactinoma
    Christof Schofl
    Department of Clinical Endocrinology, Hannover Medical School, 30623 Hannover, Germany
    Pituitary 5:261-5. 2002
    ..This avoids unnecessary aggressive and dangerous treatment like surgery or radiotherapy in cases where pharmacological treatment may be the choice...
  29. ncbi request reprint Adjuvant radiotherapy in stage I seminoma: is there a role for further reduction of treatment volume?
    Frank Bruns
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Acta Oncol 44:142-8. 2005
    ..This approach is recommended in analogy to the surgical approach in NSGCT to further minimize the risk of radiation-related late effects...
  30. doi request reprint Association of chromosomal locus 8q24 and risk of prostate cancer: a hospital-based study of German patients treated with brachytherapy
    Andreas Meyer
    Hannover Prostate Cancer Study Group, Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Urol Oncol 27:373-6. 2009
    ..Polymorphic loci on chromosome 8q24 have emerged as possible risk factors for breast and prostate cancer from genome-wide association studies...
  31. ncbi request reprint Time of developing motor deficits before radiotherapy as a new and relevant prognostic factor in metastatic spinal cord compression: final results of a retrospective analysis
    D Rades
    Department of Radiation Oncology, Hannover Medical University, Hannover, Germany
    Eur Neurol 45:266-9. 2001
    ..001). A slower development of motor deficits predicts a better functional outcome. Time of developing motor deficits before RT is a relevant prognostic factor in metastatic spinal cord compression...
  32. ncbi request reprint Spondylodiscitis in patients with spinal cord compression: a possible pitfall in radiation oncology
    D Rades
    Department of Radiation Oncology, Hannover Medical University, Carl-Neuberg-Str 1, D-30625, Hannover, Germany
    Radiother Oncol 59:307-9. 2001
    ..If there is any doubt about metastatic disease as the cause for spinal cord compression a spinal MRI has to be demanded, even beyond regular operating hours...
  33. ncbi request reprint Radiation recall pneumonitis induced by gemcitabine
    Sebastian Schwarte
    Department of Radiation Oncology, Medical School Hannover, Hannover, Germany
    Strahlenther Onkol 183:215-7. 2007
    ..Radiation recall pneumonitis describes a very rare reaction in a previously irradiated area of pulmonary tissue after application of pharmacological agents. A case of recall pneumonitis induced by gemcitabine is reported...
  34. ncbi request reprint NBS1 variant I171V and breast cancer risk
    Natalia Bogdanova
    Department of Gynaecology and Obstetrics, Gynaecology Research Unit, Hannover Medical School, OE 6411, Carl Neuberg Str 1, 30625, Hannover, Germany
    Breast Cancer Res Treat 112:75-9. 2008
    ..05; 95%CI: 0.64-1.74, P=0.9). We conclude that the I171V substitution is unlikely to constitute a strong risk factor for breast cancer in our study populations...
  35. doi request reprint A new era of thoracic oncology? Ex-vivo stereotactic ablative radiosurgery within Ex-vivo Lung Treatment System as a hybrid therapy for unresectable locally advanced pulmonary malignancies
    C Henkenberens
    Department of Radiation Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany Electronic address
    Med Hypotheses 92:31-4. 2016
    ..The proposed - highly complex - technique consists of surgical lung explantation, followed by stereotactic radiotherapy during ex-vivo perfusion followed by surgical re-implantation. ..
  36. pmc Inhalative steroids as an individual treatment in symptomatic lung cancer patients with radiation pneumonitis grade II after radiotherapy - a single-centre experience
    C Henkenberens
    Department of Radiation Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Radiat Oncol 11:12. 2016
    ..To assess efficacy of our single-centre experience with inhalative steroids (IS) in lung cancer patients with symptomatic radiation pneumonitis (RP) grade II...
  37. ncbi request reprint Breast cancer in patients carrying a germ-line CHEK2 mutation: Outcome after breast conserving surgery and adjuvant radiotherapy
    Andreas Meyer
    Department of Radiation Oncology, Hannover Medical School, Germany
    Radiother Oncol 82:349-53. 2007
    ..Women carrying mutations in the CHEK2 gene are at an increased breast cancer risk. Data about outcome and prognosis for these patients after standard multimodality treatment are scarce at present...
  38. ncbi request reprint Chemoradiotherapy in patients with anal cancer: impact of length of unplanned treatment interruption on outcome
    Andreas Meyer
    Department of Radiation Oncology, Medical School Hannover, Hannover, Germany
    Acta Oncol 45:728-35. 2006
    ..762), respectively. Chemoradiotherapy with short individualised treatment interruptions seems to be feasible with acceptable acute or late toxicities. Treatment is highly effective in terms of local control and colostomy-free survival...
  39. ncbi request reprint Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute or late effects
    Michael Bremer
    Department of Radiation Oncology, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Radiother Oncol 69:155-60. 2003
    ..The impact of ataxia-telangiectasia (A-T) heterozygosity on clinical radiosensitivity remains a matter of debate while clinical data are scarce...
  40. ncbi request reprint Breast cancer in female carriers of ATM gene alterations: outcome of adjuvant radiotherapy
    Andreas Meyer
    Department of Radiation Oncology, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Radiother Oncol 72:319-23. 2004
    ....
  41. doi request reprint Outcome of moderately dosed radiosurgery for limited brain metastases. Report of a single-center experience
    Johanna Meisner
    Department of Radiation Oncology, Medical School Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Strahlenther Onkol 186:76-81. 2010
    ..Efficacy and safety of the own single-center experience with moderately dosed radiosurgery (SRS) for limited (one to four) brain metastases were analyzed and correlated with patient- and treatment-related variables...
  42. doi request reprint Long-term renal toxicity in children following fractionated total-body irradiation (TBI) before allogeneic stem cell transplantation (SCT)
    Johanna Gerstein
    Department of Radiation Oncology, Medical School Hannover, Hannover, Germany
    Strahlenther Onkol 185:751-5. 2009
    ..To retrospectively assess the incidence and time course of renal dysfunction in children (< or = 16 years) following total- body irradiation (TBI) before allogeneic stem cell transplantation (SCT)...
  43. ncbi request reprint Radiation protocols determine acute graft-versus-host disease incidence after allogeneic bone marrow transplantation in murine models
    Sebastian Schwarte
    Department of Radiation Oncology, Medical School of Hannover, Hannover, Germany
    Int J Radiat Biol 83:625-36. 2007
    ..Effects of radiation sources used for total body irradiation (TBI) on Graft-versus-Host Disease (GvHD) induction were examined...
  44. ncbi request reprint ATM missense variant P1054R predisposes to prostate cancer
    Andreas Meyer
    Department of Radiation Oncology, Hannover Medical School, Germany
    Radiother Oncol 83:283-8. 2007
    ..We investigated whether the prevalence of the ATM missense substitution P1054R is increased in a hospital-based series of prostate cancer patients and whether carriers are at increased risk for treatment-related side effects...
  45. ncbi request reprint Functional consequences of ATM sequence variants for chromosomal radiosensitivity
    Sara Gutierrez-Enriquez
    DNA Repair Group, International Agency for Research on Cancer, Lyon, France
    Genes Chromosomes Cancer 40:109-19. 2004
    ....
  46. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...
  47. ncbi request reprint Radiosensitivity of ataxia telangiectasia and Nijmegen breakage syndrome homozygotes and heterozygotes as determined by three-color FISH chromosome painting
    Susann Neubauer
    Clinic of Radiotherapy, University Erlangen Nurnberg, Germany
    Radiat Res 157:312-21. 2002
    ..Thus the three-color painting technique presented here proved to be well suited as a supplement to conventional cytogenetic techniques for the detection of heterozygous carriers of these diseases, and may be superior method...