Johann Bauersachs

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. doi request reprint Biogenesis and regulation of cardiovascular microRNAs
    Johann Bauersachs
    Hannover Medical School, Institute of Molecular and Translational Therapeutic Strategies, Carl Neuberg Strasse 1, Hannover, Germany
    Circ Res 109:334-47. 2011
  2. doi request reprint Regulation of myocardial fibrosis by MicroRNAs
    Johann Bauersachs
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat, Wurzburg, Germany
    J Cardiovasc Pharmacol 56:454-9. 2010
  3. ncbi request reprint Telmisartan improves vascular function and reduces platelet activation in rats with streptozotocin-induced diabetes mellitus
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Pharmacol Res 56:217-23. 2007
  4. pmc Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation
    Andreas Schafer
    Department of Internal Medicine I, University Hospital Wurzburg, Julius Maximilians University Würzburg, Wurzburg, Germany
    Diabetes 59:2001-9. 2010
  5. ncbi request reprint Ligand-dependent activation of ER{beta} lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats
    Virginija Jazbutyte
    Department of Medicine, University of Wurzburg, Josef Schneider Str 2, Wurzburg, Germany
    Cardiovasc Res 77:774-81. 2008
  6. doi request reprint Inhibition of platelet activation in rats with severe congestive heart failure by a novel endothelial nitric oxide synthase transcription enhancer
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Eur J Heart Fail 11:336-41. 2009
  7. pmc Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Wurzburg, Germany
    Am J Pathol 171:507-12. 2007
  8. ncbi request reprint Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I Kardiologie, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 92:4172-9. 2007
  9. doi request reprint Guanylyl cyclase activator ataciguat improves vascular function and reduces platelet activation in heart failure
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
    Pharmacol Res 62:432-8. 2010
  10. ncbi request reprint Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Diabetes 56:666-74. 2007

Detail Information

Publications75

  1. doi request reprint Biogenesis and regulation of cardiovascular microRNAs
    Johann Bauersachs
    Hannover Medical School, Institute of Molecular and Translational Therapeutic Strategies, Carl Neuberg Strasse 1, Hannover, Germany
    Circ Res 109:334-47. 2011
    ..Better knowledge about regulatory mechanisms of miRNAs in cardiovascular disease will probably lead to improved and novel miRNA-based therapeutic therapies...
  2. doi request reprint Regulation of myocardial fibrosis by MicroRNAs
    Johann Bauersachs
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat, Wurzburg, Germany
    J Cardiovasc Pharmacol 56:454-9. 2010
    ....
  3. ncbi request reprint Telmisartan improves vascular function and reduces platelet activation in rats with streptozotocin-induced diabetes mellitus
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Pharmacol Res 56:217-23. 2007
    ..Telmisartan normalizes vascular dysfunction and reduces platelet activation in diabetic rats. These effects may contribute to the reduction of cardiovascular events by angiotensin II receptor blockers in diabetic patients...
  4. pmc Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation
    Andreas Schafer
    Department of Internal Medicine I, University Hospital Wurzburg, Julius Maximilians University Würzburg, Wurzburg, Germany
    Diabetes 59:2001-9. 2010
    ..We investigated the mechanisms underlying vascular endothelial and contractile dysfunction in diabetes as well as the effect of HMR1766, a novel nitric oxide (NO)-independent activator of soluble guanylyl cyclase (sGC)...
  5. ncbi request reprint Ligand-dependent activation of ER{beta} lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats
    Virginija Jazbutyte
    Department of Medicine, University of Wurzburg, Josef Schneider Str 2, Wurzburg, Germany
    Cardiovasc Res 77:774-81. 2008
    ....
  6. doi request reprint Inhibition of platelet activation in rats with severe congestive heart failure by a novel endothelial nitric oxide synthase transcription enhancer
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Eur J Heart Fail 11:336-41. 2009
    ..We investigated whether treatment with a novel endothelial NO synthase (eNOS)-transcription enhancer positively modulates systemic NO bioavailability and reduces platelet activation in rats with CHF...
  7. pmc Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Wurzburg, Germany
    Am J Pathol 171:507-12. 2007
    ..Bone marrow transplantation experiments indicate that impaired NF-kappaB activation in p50 KO leukocytes attenuates cardiac damage...
  8. ncbi request reprint Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I Kardiologie, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 92:4172-9. 2007
    ..We investigated whether improved systemic NO bioavailability and increased levels of EPC after GH treatment are related and mediated by the IGF-I...
  9. doi request reprint Guanylyl cyclase activator ataciguat improves vascular function and reduces platelet activation in heart failure
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
    Pharmacol Res 62:432-8. 2010
    ..We investigated whether chronic activation of the NO target enzyme soluble guanylyl cyclase (sGC) would beneficially modulate vascular function and platelet activation in experimental CHF...
  10. ncbi request reprint Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Diabetes 56:666-74. 2007
    ..Subsequent reduction of EPC levels and impairment of EPC function likely contributes to the pathogenesis of vascular disease in diabetes...
  11. ncbi request reprint Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells
    Thomas Thum
    Medizinische Klinik I, Kardiologie, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 70:50-60. 2006
    ..However, potential underlying mechanisms have not yet been investigated...
  12. ncbi request reprint Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent
    Julian Widder
    Medizinische Klinik, Julius Maximilians Universitat, Wurzburg, Germany
    Cardiovasc Res 63:161-7. 2004
    ..The mitogen-activated protein (MAP) kinase system, especially the p38 MAP kinase, is activated in chronic heart failure (CHF). However, the role of vascular p38 MAP kinase in CHF has not been analyzed yet...
  13. ncbi request reprint Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction
    Daniela Fraccarollo
    Medizinische Klinik der Julius Maximilians Universität Würzburg, Wurzburg, Germany
    J Am Coll Cardiol 42:1666-73. 2003
    ....
  14. ncbi request reprint Mineralocorticoid receptor blockade improves vasomotor dysfunction and vascular oxidative stress early after myocardial infarction
    Carmem Luíza Sartório
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
    Hypertension 50:919-25. 2007
    ..Underlying mechanisms involve inhibition of vascular angiotensin-converting enzyme upregulation and improvement of endothelial NO synthase-derived NO bioavailability...
  15. ncbi request reprint ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
    Thromb Haemost 100:618-25. 2008
    ..PRI detected significantly more patients with impaired response than conventional platelet aggregation...
  16. ncbi request reprint Additive amelioration of left ventricular remodeling and molecular alterations by combined aldosterone and angiotensin receptor blockade after myocardial infarction
    Daniela Fraccarollo
    Medizinische Klinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Cardiovasc Res 67:97-105. 2005
    ..The mechanisms underlying the clinical benefits of mineralocorticoid receptor antagonism in patients with left ventricular (LV) dysfunction and heart failure (CHF) after myocardial infarction (MI) are poorly understood...
  17. doi request reprint Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction
    Daniela Fraccarollo
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Circulation 118:818-27. 2008
    ..In this study, we investigated whether the transcription enhancer of endothelial NO synthase (eNOS) AVE9488 improves cardiac remodeling and heart failure after experimental myocardial infarction (MI)...
  18. doi request reprint Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarction
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitatsklinikum Wurzburg, 97080, Wurzburg, Germany
    Basic Res Cardiol 103:485-92. 2008
    ..However, data regarding the function of TGF-beta after ischemic injury are inconclusive...
  19. ncbi request reprint Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress
    Thomas Thum
    Department of Cardiology, University of Wurzburg, University Hospital, Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 27:748-54. 2007
    ..Endothelial nitric oxide synthase (eNOS)-derived NO regulates EPC mobilization and function. Organic nitrates release NO, and therefore may favorably affect EPC biology...
  20. ncbi request reprint Improved endothelial function and reduced platelet activation by chronic HMG-CoA-reductase inhibition with rosuvastatin in rats with streptozotocin-induced diabetes mellitus
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Universitat Wurzburg, Germany
    Biochem Pharmacol 73:1367-75. 2007
    ..Therefore, rosuvastatin treatment normalizes endothelial function and reduces platelet activation in diabetic rats. These effects may contribute to the reduction of cardiovascular events by statins in diabetic patients...
  21. pmc Attenuation of angiotensin II-induced vascular dysfunction and hypertension by overexpression of Thioredoxin 2
    Julian D Widder
    Medizinische Klinik I, Universitatsklinikum, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Hypertension 54:338-44. 2009
    ..Thioredoxin 2 may represent an important therapeutic target for the prevention and treatment of hypertension and oxidative stress...
  22. doi request reprint Early determination of clopidogrel responsiveness by platelet reactivity indexidentifies patients at risk for cardiovascular events after myocardial infarction
    Andreas Schafer
    Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Thromb Haemost 106:141-8. 2011
    ..Pre-hospital clopidogrel loading was associated with impaired response and more adverse events challenging the concept of earliest oral clopidogrel loading in MI patients...
  23. ncbi request reprint Reduced basal nitric oxide bioavailability and platelet activation in young spontaneously hypertensive rats
    Andreas Schafer
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    Biochem Pharmacol 67:2273-9. 2004
    ..Phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) in platelets was used as a sensitive monitor of in vivo NO bioavailability...
  24. ncbi request reprint Soluble guanylyl cyclase activation with HMR1766 attenuates platelet activation in diabetic rats
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 26:2813-8. 2006
    ..Guanylyl cyclase activation enhances the reduced signaling via the NO/cGMP pathway. We investigated whether chronic guanylyl cyclase activation would beneficially modulate platelet activation in experimental diabetes mellitus...
  25. ncbi request reprint The CX3C chemokine fractalkine induces vascular dysfunction by generation of superoxide anions
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 27:55-62. 2007
    ..Expression of fractalkine and its receptor, CX3CR1, is elevated in coronary artery disease. We assessed the effects of fractalkine on vascular function in isolated rat aorta...
  26. doi request reprint Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease
    Christian Wolf
    Institut für Molekulare und Translationale Therapiestrategien IMTTS, Medizinische Hochschule, Hannover, Germany
    Int J Cardiol 156:289-94. 2012
    ..Unlike circulating ADMA, very little is known about urinary ADMA and DMA concentrations and a predictive value in CAD patients...
  27. doi request reprint Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response
    Daniela Fraccarollo
    Medizinische Klinik und Poliklinik I, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Hypertension 51:905-14. 2008
    ....
  28. doi request reprint Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction
    Daniela Fraccarollo
    Klinik fuer Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 123:400-8. 2011
    ....
  29. ncbi request reprint Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice
    Anna Adamek
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Germany
    Eur J Pharmacol 571:51-4. 2007
    ..In summary, inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response...
  30. pmc Angiopoietin-2 in adults with congenital heart disease and heart failure
    Alexander Lukasz
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e66861. 2013
    ..Their role in ACHD has not been studied...
  31. ncbi request reprint Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Universitat Wurzburg, Germany
    FASEB J 20:1918-20. 2006
    ..Therefore, we investigated left ventricular remodeling in mice with a targeted deletion of the NF-kappaB subunit p50/NF-kappaB1 after myocardial infarction...
  32. pmc 5-Lipoxygenase facilitates healing after myocardial infarction
    Nadja Blömer
    Department of Internal Medicine I, University Hospital Wurzburg, Wurzburg, Germany
    Basic Res Cardiol 108:367. 2013
    ..In conclusion, a lack or inhibition of 5-LOX increases mortality after MI because of healing defects. This is not mediated by a change in local blood flow, but through an altered inflammation and/or fibroblast function. ..
  33. ncbi request reprint Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1
    Thomas Thum
    Universitat Wurzburg, Medizinische Klinik I Kardiologie, Wurzburg, Germany
    Circ Res 100:434-43. 2007
    ..Growth hormone-mediated increase in IGF-1 reverses age-related EPC dysfunction and may be a novel therapeutic strategy against vascular disorders with impairment of EPC...
  34. doi request reprint MicroRNA-24 regulates vascularity after myocardial infarction
    Jan Fiedler
    Hannover Medical School, Institute for Molecular and Translational Therapeutic Strategies, Hannover, Germany
    Circulation 124:720-30. 2011
    ..Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms of cardiac angiogenesis are mechanistically not well understood...
  35. doi request reprint Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism
    Felix Fleissner
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    Circ Res 107:138-43. 2010
    ..The endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) is increased in patients with coronary artery disease and may regulate function of circulating angiogenic progenitor cells (APCs) by small regulatory RNAs...
  36. doi request reprint A collagen α2(I) mutation impairs healing after experimental myocardial infarction
    Ulrich Hofmann
    Department of Internal Medicine I, Comprehensive Heart Failure Center, University Clinic, University of Wurzburg, Wurzburg, Germany
    Am J Pathol 180:113-22. 2012
    ..Both structural alterations within pre-existing collagen matrix and impaired collagen de novo expression contribute to a high rate of early myocardial rupture after MI...
  37. ncbi request reprint Endothelial dysfunction in heart failure
    Johann Bauersachs
    Medizinische Klinik and Poliklinik I, Herz Kreislaufzentrum, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Josef Schneider 2, Wurzburg, Germany
    Pharmacol Rep 60:119-26. 2008
    ..AVE 9488, ACE or HMG-CoA reductase inhibition result in significant increases in EPC levels, and beneficial effects on bone marrow molecular alterations after myocardial infarction...
  38. pmc MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart
    Virginija Jazbutyte
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, IFB Tx, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Age (Dordr) 35:747-62. 2013
    ..Our results suggest an involvement of miR-22 in age-associated cardiac changes, such as cardiac fibrosis...
  39. doi request reprint Reverse epidemiology in systolic and nonsystolic heart failure: cumulative prognostic benefit of classical cardiovascular risk factors
    Gülmisal Güder
    Medizinische Klinik und Poliklinik I, University Hospital Wurzburg, Wurzburg, Germany
    Circ Heart Fail 2:563-71. 2009
    ..We estimated the prognostic role of these risk factors in unselected patients with heart failure...
  40. ncbi request reprint Late thrombosis of a drug-eluting stent during combined anti-platelet therapy in a clopidogrel nonresponsive diabetic patient: shall we routinely test platelet function?
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Thromb Haemost 97:862-5. 2007
  41. doi request reprint Impact of different bone marrow cell preparations on left ventricular remodelling after experimental myocardial infarction
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Germany
    Eur J Heart Fail 10:119-24. 2008
    ..Since the specific characteristics of different BM cell subsets could influence their therapeutic potential we determined the effect of different BM cell populations on left ventricular remodelling after MI...
  42. pmc Spike rate of multi-unit muscle sympathetic nerve fibers after catheter-based renal nerve ablation
    Jens Tank
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    J Am Soc Hypertens 9:794-801. 2015
    ..06; P = .369). Spike rate analysis of multi-unit MSNA neurograms further suggests that profound sympathetic inhibition is not a consistent finding after renal nerve ablation...
  43. ncbi request reprint Endothelial dysfunction in heart failure: mechanisms and therapeutic approaches
    Johann Bauersachs
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    Curr Vasc Pharmacol 2:115-24. 2004
    ..This article reviews the current knowledge of the pathophysiological events contributing to endothelial dysfunction in CHF as well as several treatment options to reverse those changes...
  44. ncbi request reprint Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibition
    Andreas Schafer
    Medizinische Universitatsklinik, Wurzburg, Germany
    Thromb Haemost 89:1024-30. 2003
    ..Increased nitric oxide bioavailability can only partially explain the reduced platelet activation by eplerenone and ACE inhibition...
  45. pmc Therapeutic plasma exchange decreases levels of routinely used cardiac and inflammatory biomarkers
    Oktay Tutarel
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e38573. 2012
    ..The effect of TPE on biomarkers used in the clinical routine has not been investigated...
  46. doi request reprint Novel therapeutic approaches to post-infarction remodelling
    Daniela Fraccarollo
    Klinik fuer Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Cardiovasc Res 94:293-303. 2012
    ..This review provides an overview of future and emerging therapies for cardiac wound healing and remodelling after MI...
  47. pmc Post-infarct remodelling: contribution of wound healing and inflammation
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 81:474-81. 2009
    ..Healing in the heart occurs in overlapping phases. Herein, we review the inflammatory phase as a trigger of tissue formation...
  48. doi request reprint [Clopidogrel--clinical use and potential therapeutic problems]
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Wurzburg
    Herz 33:280-6. 2008
    ..Further prospective studies are needed to determine the risk reduction by an individually adjusted antiplatelet therapy...
  49. doi request reprint MicroRNAs: novel regulators in cardiac development and disease
    Thomas Thum
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat, Josef Schneider Street 2, D 97080 Wurzburg, Germany
    Cardiovasc Res 79:562-70. 2008
    ..Finally, we focus on the development and use of miRNA antagonists (antagomirs) to target miRNAs in vivo, which may translate into novel therapeutic strategies for heart disease in the future...
  50. ncbi request reprint Angiotensin-converting enzyme inhibition and endothelin antagonism for endothelial dysfunction in heart failure: mono-or combination therapy
    Johann Bauersachs
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    J Cardiovasc Pharmacol 40:594-600. 2002
    ..Although monotherapy with the ACE inhibitor trandolapril and the ET receptor antagonist LU 135252 improved endothelial dysfunction in experimental CHF, combination therapy was more effective...
  51. doi request reprint The novel P2Y 12 antagonist AZD6140 rapidly and reversibly reduces platelet activation in diabetic rats
    Ulrike Flierl
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Germany
    Thromb Res 125:e93-9. 2010
    ..We investigated acute and chronic effects of AZD6140, a reversible oral rapid-onset P2Y(12) antagonist, on platelet reactivity in diabetic rats...
  52. doi request reprint Circulating miR-423_5p fails as a biomarker for systemic ventricular function in adults after atrial repair for transposition of the great arteries
    Oktay Tutarel
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Int J Cardiol 167:63-6. 2013
    ..Its role in patients with a systemic right ventricle and reduced ejection fraction after atrial repair for transposition of the great arteries has not been evaluated...
  53. ncbi request reprint Simvastatin improves left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects
    Johann Bauersachs
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Universitat Wurzburg, Germany
    Cardiovasc Res 72:438-46. 2006
    ..The aim of this study was to investigate the effects of hypercholesterolemia and statin treatment in rabbits with experimental MI...
  54. ncbi request reprint Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine
    Thomas Thum
    Bayerische Julius Maximilians Universität, Medizinische Klinik I, Wurzburg, Germany
    J Am Coll Cardiol 46:1693-701. 2005
    ..We tested the hypothesis that asymmetric dimethylarginine (ADMA) may be an endogenous inhibitor of endothelial progenitor cells (EPCs)...
  55. doi request reprint Pathologic endothelial response and impaired function of circulating angiogenic cells in patients with Fabry disease
    Johan M Lorenzen
    Hannover Medical School, Institute of Molecular and Translational Therapeutic Strategies, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Basic Res Cardiol 108:311. 2013
    ..Fabry patients show a dysfunction of CAC and a pathologic endothelial response. ERT improves CAC and endothelial function and thus may attenuate development of cardiovascular disease in the long term in this patient population...
  56. doi request reprint Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome
    Christian Widera
    Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany
    J Mol Cell Cardiol 51:872-5. 2011
    ..The present study tempers speculations about the potential usefulness of cardiomyocyte-enriched microRNAs as diagnostic or prognostic markers in ACS...
  57. doi request reprint Organic nitrates differentially modulate circulating endothelial progenitor cells and endothelial function in patients with symptomatic coronary artery disease
    Thomas Thum
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Antioxid Redox Signal 15:925-31. 2011
    ..Treatment of symptomatic CAD patients with PETN for 14 days significantly increased levels of circulating EPC and improved markers for EPC function, whereas ISDN was without effects on EPCs and worsened endothelial function...
  58. pmc Aminoethyl nitrate--the novel super nitrate?
    Johann Bauersachs
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Br J Pharmacol 158:507-9. 2009
    ..This work from Daiber's group is an important step forward in the understanding of nitrate bioactivation, tolerance phenomena and towards the development of better organic nitrates for clinical use...
  59. doi request reprint Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation
    Jan Marcus Daniel
    From the Department of Cardiology and Angiology J M D, J D, K S, J B, D G S, REBIRTH Excellence Cluster J M D, T T, J B, D G S, and Institute of Molecular and Translational Therapeutic Strategies IMTTS K S, T T, Hannover Medical School, Hannover, Germany Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany A P and National Heart and Lung Institute, Imperial College London, London, UK T T
    Arterioscler Thromb Vasc Biol 36:317-27. 2016
    ..In the present study, we investigated the effects of RGS5 on vascular SMC function in vitro and neointima formation after wire-induced injury in mice and determined the underlying mechanisms...
  60. ncbi request reprint Severe neutropenia under clopidogrel treatment three weeks after coronary stenting
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Thromb Haemost 97:317-8. 2007
  61. ncbi request reprint Improvement of endothelial dysfunction by selective estrogen receptor-alpha stimulation in ovariectomized SHR
    Julian Widder
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    Hypertension 42:991-6. 2003
    ..The novel selective ERalpha agonist Cpd1471 prevented these pathophysiological changes to a similar extent as E2. Thus, the pharmacological principle of selective ERalpha activation mediates positive vascular effects...
  62. doi request reprint Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice
    Ulrich Hofmann
    University of Wuerzburg, University Clinic, Comprehensive Heart Failure Center, Department of Internal Medicine I, Oberdürrbacherstraße 6, Wurzburg, Germany
    Circulation 125:1652-63. 2012
    ..Therefore, we studied whether CD4(+) T cells become activated and influence wound healing after experimental MI in mice...
  63. doi request reprint The H(2)-receptor antagonist ranitidine interferes with clopidogrel-mediated P2Y(12) inhibition in platelets
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Oberdürrbacher Str 6, 97080 Wurzburg, Germany
    Pharmacol Res 62:352-6. 2010
    ..We investigated whether ranitidine interacts with P2Y(12) inhibition on the platelet level...
  64. doi request reprint Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection
    Jan Horstkotte
    Medizinische Klinik und Poliklinik I, Munich Heart Alliance, Klinikum Grosshadern of the Ludwig Maximilians University, Munich, Germany
    Circulation 124:2892-902. 2011
    ..Here, we investigated whether mitochondrial thioredoxin reductase is protective against myocardial ischemia/reperfusion injury...
  65. ncbi request reprint Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease
    Dimitrios Tsikas
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:229-39. 2007
    ..17+/-4.2) being insignificantly lower (P=0.46). Between urinary DMA and ADMA there was a positive correlation (R=0.6655, P<0.0001) in coronary artery disease, but no correlation (R=0.27339) was found in end-stage liver disease...
  66. ncbi request reprint Toll-like receptor signaling in the ischemic heart
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Universitatsklinikum Wurzburg, Wurzburg, Germany
    Front Biosci 13:5772-9. 2008
    ..Herein we review the experimental and clinical evidence for the involvement of TLR and its downstream signaling molecules in cardiac ischemic injury...
  67. ncbi request reprint Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosis
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Wurzburg, Germany
    Curr Vasc Pharmacol 6:52-60. 2008
    ..Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis, the major complication of atherosclerosis triggering myocardial infarction and stroke...
  68. doi request reprint Clopidogrel improves endothelial function and NO bioavailability by sensitizing adenylyl cyclase in rats with congestive heart failure
    Andreas Schafer
    Klinik für Kardiologie und Angiologie, Zentrum Innere Medizin, Medizinische Hochschule Hannover, Germany
    Basic Res Cardiol 106:485-94. 2011
    ..Chronic P2Y(12)-blockade with clopidogrel improved adenylyl cyclase-mediated signaling including increased AKT- and eNOS-phosphorylation contributing to improved NO-mediated vasorelaxation...
  69. pmc Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans
    Thomas Thum
    Institut für Molekulare und Translationale Therapiestrategien, Medizinische Hochschule Hannover, Germany
    Eur Heart J 32:1275-86. 2011
    ..Bone marrow-derived endothelial progenitor cells (EPCs) play an important role in endothelial repair and vascular homeostasis. We hypothesized that hyperaldosteronism impairs EPC function and vascularization capacity in mice and humans...
  70. doi request reprint Mineralocorticoid receptor activation in myocardial infarction and failure: recent advances
    Paolo Galuppo
    Klinik fuer Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Eur J Clin Invest 42:1112-20. 2012
    ..This review addresses emerging preclinical studies as well as ongoing clinical trials regarding MR activation in MI and failure...
  71. pmc Asymmetrical dimethylarginine--more sensitive than NT-proBNP to diagnose heart failure in adults with congenital heart disease
    Oktay Tutarel
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e33795. 2012
    ..Asymmetrical dimethylarginine (ADMA) correlates with disease severity and independently predicts adverse clinical events in heart failure of non-congenital origin. Its role in ACHD has not been investigated...
  72. ncbi request reprint Microarray-based gene expression profiling to elucidate cellular responses to nitric oxide--a review from an analytical and biomedical point of view
    Thomas Thum
    Bayerische Julius Maximilians Universität, Universitatsklinikum, Medizinische Klinik und Poliklinik I, Kardiologie, Wurzburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:3-11. 2007
    ..We also point out the limitations of general microarray-based gene expression analyses and especially when investigating the effects of NO...
  73. ncbi request reprint MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure
    Thomas Thum
    University of Wurzburg, University Hospital, Department of Internal Medicine I, Cardiology, Wurzburg, Germany
    Circulation 116:258-67. 2007
    ..Here we provide evidence that cardiac microRNAs, recently discovered key regulators of gene expression, contribute to the transcriptional changes observed in heart failure...
  74. ncbi request reprint Mechanisms of disease: Toll-like receptors in cardiovascular disease
    Stefan Frantz
    Universitat Wurzburg, Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Wurzburg, Germany
    Nat Clin Pract Cardiovasc Med 4:444-54. 2007
    ..Here we review the rapid progress that has been made in this field, which has improved our understanding of vascular as well as myocardial TLR function in basic and clinical science...
  75. ncbi request reprint Collagen accumulation after myocardial infarction: effects of ETA receptor blockade and implications for early remodeling
    Daniela Fraccarollo
    Medizinische Klinik, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Cardiovasc Res 54:559-67. 2002
    ..We tested the hypothesis that inhibition of ETA receptors during the early phase of healing affects collagen synthesis and accumulation, and induces expansion of infarcted myocardium...