Yohannes Hagos

Summary

Country: Germany

Publications

  1. pmc Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity
    Yohannes Hagos
    Abteilung Vegetative Physiologie and Pathophysiologie, Zentrum Physiologie and Pathophysiologie, Georg August Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Toxins (Basel) 2:2055-82. 2010
  2. ncbi request reprint Torasemide transport by organic anion transporters contributes to hyperuricemia
    Yohannes Hagos
    Abteilung Vegetative Physiologie und Pathophysiologie, Georg August Universitat, Gottingen, Germany
    J Am Soc Nephrol 18:3101-9. 2007
  3. ncbi request reprint Human renal organic anion transporter 4 operates as an asymmetric urate transporter
    Yohannes Hagos
    Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Am Soc Nephrol 18:430-9. 2007
  4. ncbi request reprint Functional roles of cationic amino acid residues in the sodium-dicarboxylate cotransporter 3 (NaDC-3) from winter flounder
    Yohannes Hagos
    Zentrum Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie Universität Göttingen, Humboldtallee 23, 37073 Gottingen, Germany
    Am J Physiol Renal Physiol 291:F1224-31. 2006
  5. doi request reprint Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias
    Yohannes Hagos
    Zentrum Physiologie und Pathophysiologie, Universitatsmedizin Gottingen, Humboldtallee 23, 37073, Gottingen, Germany
    Pflugers Arch 457:223-31. 2008
  6. ncbi request reprint Regulation of sodium-dicarboxylate cotransporter-3 from winter flounder kidney by protein kinase C
    Yohannes Hagos
    Zentrum Physiologie und Pathophysiologie, Abteilung Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Am J Physiol Renal Physiol 286:F86-93. 2004
  7. ncbi request reprint Regulation of steroid hormone biosynthesis enzymes and organic anion transporters by forskolin and DHEA-S treatment in adrenocortical cells
    Abdul R Asif
    Department of Nephrology, Universitat Gottingen, Humboldtallee 23, 37073 Goettingen, Germany
    Am J Physiol Endocrinol Metab 291:E1351-9. 2006
  8. ncbi request reprint Functional expression of pig renal organic anion transporter 3 (pOAT3)
    Yohannes Hagos
    Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie, Humboldtallee 23, 37073 Gottingen, Germany
    Biochimie 87:421-4. 2005
  9. doi request reprint Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3
    Marcel Kaufhold
    Abteilung Vegetative Physiologie und Pathophysiologie, Universitatsmedizin Gottingen, Gottingen, Germany
    Am J Physiol Renal Physiol 301:F1026-34. 2011
  10. doi request reprint Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives
    Yohannes Hagos
    Department of Systemic Physiology and Pathophysiology, University Medical Center Gottingen, Gottingen, Germany
    Am J Physiol Renal Physiol 304:F403-9. 2013

Collaborators

Detail Information

Publications33

  1. pmc Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity
    Yohannes Hagos
    Abteilung Vegetative Physiologie and Pathophysiologie, Zentrum Physiologie and Pathophysiologie, Georg August Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Toxins (Basel) 2:2055-82. 2010
    ....
  2. ncbi request reprint Torasemide transport by organic anion transporters contributes to hyperuricemia
    Yohannes Hagos
    Abteilung Vegetative Physiologie und Pathophysiologie, Georg August Universitat, Gottingen, Germany
    J Am Soc Nephrol 18:3101-9. 2007
  3. ncbi request reprint Human renal organic anion transporter 4 operates as an asymmetric urate transporter
    Yohannes Hagos
    Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Am Soc Nephrol 18:430-9. 2007
    ..hOAT4 facilitates substantial uptake of [(14)C]urate, which was elevated 2.6-fold by intracellular HCTZ. Thus, hOAT4 is the long-postulated, low-affinity apical urate anion exchanger that facilitates HCTZ-associated hyperuricemia...
  4. ncbi request reprint Functional roles of cationic amino acid residues in the sodium-dicarboxylate cotransporter 3 (NaDC-3) from winter flounder
    Yohannes Hagos
    Zentrum Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie Universität Göttingen, Humboldtallee 23, 37073 Gottingen, Germany
    Am J Physiol Renal Physiol 291:F1224-31. 2006
    ..These results suggest that a positively charged residue at position 114 is required for electrogenic sodium-dicarboxylate cotransport...
  5. doi request reprint Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias
    Yohannes Hagos
    Zentrum Physiologie und Pathophysiologie, Universitatsmedizin Gottingen, Humboldtallee 23, 37073, Gottingen, Germany
    Pflugers Arch 457:223-31. 2008
    ....
  6. ncbi request reprint Regulation of sodium-dicarboxylate cotransporter-3 from winter flounder kidney by protein kinase C
    Yohannes Hagos
    Zentrum Physiologie und Pathophysiologie, Abteilung Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Am J Physiol Renal Physiol 286:F86-93. 2004
    ..In conclusion, fNaDC-3 expressed in oocytes is downregulated by PMA through endocytosis. PKC consensus sites appear not to be important for this process...
  7. ncbi request reprint Regulation of steroid hormone biosynthesis enzymes and organic anion transporters by forskolin and DHEA-S treatment in adrenocortical cells
    Abdul R Asif
    Department of Nephrology, Universitat Gottingen, Humboldtallee 23, 37073 Goettingen, Germany
    Am J Physiol Endocrinol Metab 291:E1351-9. 2006
    ..We conclude that the increased cortisol release of adrenocortical cells by DHEA-S and forskolin stimulation is probably due to high expression of the key enzymes of steroid biosynthesis and hOAT3...
  8. ncbi request reprint Functional expression of pig renal organic anion transporter 3 (pOAT3)
    Yohannes Hagos
    Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie, Humboldtallee 23, 37073 Gottingen, Germany
    Biochimie 87:421-4. 2005
    ..8 +/- 1.3 microM. Moreover, pOAT3 mediated [3H]estrone sulfate uptake was almost abolished by 0.5 mM of glutarate, dehydroepiandosterone sulfate, or probenecid consistent with the hallmarks of OAT3 function...
  9. doi request reprint Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3
    Marcel Kaufhold
    Abteilung Vegetative Physiologie und Pathophysiologie, Universitatsmedizin Gottingen, Gottingen, Germany
    Am J Physiol Renal Physiol 301:F1026-34. 2011
    ..The data 1) reveal α-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3 and 2) suggest potentially similar molecular structures of the binding sites in OAT1 and OAT3 for dicarboxylates...
  10. doi request reprint Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives
    Yohannes Hagos
    Department of Systemic Physiology and Pathophysiology, University Medical Center Gottingen, Gottingen, Germany
    Am J Physiol Renal Physiol 304:F403-9. 2013
    ..Taken together, human OAT3 and OAT1 cannot be involved in renal GSH extraction from the blood. However, OAT1 could support intracellular GSH synthesis by taking up cysteinyl glycine...
  11. ncbi request reprint Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells
    Abdul R Asif
    Abt Nephrologie und Rheumatologie, Georg August Universitat Gottingen, Gottingen, Germany
    Pflugers Arch 450:88-95. 2005
    ..Likewise, [3H]PAH uptake was cis-inhibited by estrone sulphate and trans-stimulated by preloading the cells with PAH, glutarate or cortisol, indicating functional expression of OATs in the plasma membrane of NCI-H295R cells...
  12. ncbi request reprint α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4)
    Yohannes Hagos
    Department of Systemic Physiology and Pathophysiology, University Medical Center Gottingen, Humboldtallee 23, 37073, Gottingen, Germany
    Pflugers Arch 464:367-74. 2012
    ..The data suggest that OAT1 is involved in the uptake of NOG and PDCA across the basolateral membrane of proximal tubule cells, whereas OAT4 may release these compounds into the primary urine...
  13. ncbi request reprint Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites
    Andrew Bahn
    Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Am J Physiol Cell Physiol 289:C1075-84. 2005
    ..Consequently, they are crucial for the regulation of central nervous system tryptophan metabolite concentration...
  14. ncbi request reprint Expression studies and functional characterization of renal human organic anion transporter 1 isoforms
    Andrew Bahn
    Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Drug Metab Dispos 32:424-30. 2004
    ....
  15. ncbi request reprint Mutation of amino acid 475 of rat organic cation transporter 2 (rOCT2) impairs organic cation transport
    Andrew Bahn
    Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Biochimie 86:133-6. 2004
    ..These data indicate that rOCT2 transports both ASP(+) and TEA and that aspartate at position 475 of rOCT2 plays a critical role in transport function...
  16. doi request reprint Human organic cation transporter 1 is expressed in lymphoma cells and increases susceptibility to irinotecan and paclitaxel
    Shivangi Gupta
    Abteilung Vegetative Physiologie und Pathophysiologie, Universitätmedizin Göttingen, Gottingen, Germany
    J Pharmacol Exp Ther 341:16-23. 2012
    ..In the future, an expression analysis of the transporters and the application of transporter-specific antineoplastic agents could help to tailor cancer therapy...
  17. doi request reprint Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)
    Andrew Bahn
    Zentrum Physiologie und Pathophysiologie, Abteilung Vegetative Physiologie und Pathophysiologie, Humboldtallee 23, 37073 Gottingen, Germany
    J Biol Chem 283:16332-41. 2008
    ..Uricosurics, diuretics, and cyclosporine A showed substantial interactions with hOAT10, of which cyclosporine A enhanced [(14)C]urate uptake, providing the first molecular evidence for cyclosporine A-induced hyperuricemia...
  18. pmc Torsemide renal clearance and genetic variation in luminal and basolateral organic anion transporters
    Stefan v Vormfelde
    Centre of Physiology and Pathophysiology, Georg August University Gottingen, Gottingen, Germany
    Br J Clin Pharmacol 62:323-35. 2006
    ..To investigate the association between torsemide renal clearance and genetic variation in the basolaterally expressed renal organic anion transporters OAT1 and OAT3 and in the luminally situated OAT4...
  19. doi request reprint Interaction of human multidrug and toxin extrusion 1 (MATE1) transporter with antineoplastic agents
    Julia Grottker
    Department of Physiology and Pathophysiology, Georg August University, Gottingen, Germany
    Drug Metabol Drug Interact 26:181-9. 2011
    ..MATE1 is highly expressed in the kidney, liver, skeletal muscle and also in adrenal glands, testes and heart. MATE1 exchanges organic cations against protons both in influx as well as in efflux modes...
  20. ncbi request reprint Cloning of the pig renal organic anion transporter 1 (pOAT1)
    Yohannes Hagos
    Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Biochimie 84:1221-4. 2002
    ..One splice form (pOAT1) showed typical functional characteristics of organic anion transporter 1, whereas the second form appears not to transport PAH...
  21. doi request reprint Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine
    Volodymyr Shnitsar
    Abteilung Vegetative Physiologie und Pathophysiologie, Georg August Universitat, Gottingen, Germany
    Cancer Res 69:1494-501. 2009
    ..Thus, our data support the hypothesis that the sensitivity of tumor cells to chemotherapeutic treatment depends on the expression of transporter proteins mediating specific drug accumulation into target cells...
  22. ncbi request reprint Localization of the sulfate/anion exchanger in the rat liver
    Fabio Quondamatteo
    Abteilung Histologie, Georg August Universitat Gottingen, Humboldtallee 23, Gottingen 37073, Germany
    Am J Physiol Gastrointest Liver Physiol 290:G1075-81. 2006
    ..Sat-1 may be responsible for the uptake of inorganic sulfate from the blood into hepatocytes to enable sulfation reactions. In hepatocytes and endothelial cells, sat-1 may also supply sulfate for proteoglycan synthesis...
  23. doi request reprint Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function
    Maja Henjakovic
    Institute of Systemic Physiology and Pathophysiology, University Medical Center Gottingen, Gottingen, Germany
    Am J Physiol Renal Physiol 309:F843-51. 2015
    ..These experiments suggest that OAT2-mediated cGMP uptake does not occur via exchange with monocarboxylates, dicarboxylates, and hydroxyl ions. The counter anion for electroneutral cGMP uptake remains to be identified...
  24. doi request reprint Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds
    Venkata V V R Marada
    Institut für Vegetative Physiologie und Pathophysiologie, Universitatsmedizin Gottingen, Humboldtallee 23, 37073 Gottingen, Germany Electronic address
    Eur J Med Chem 92:723-31. 2015
    ..6 μM, 1.8 μM and 13.5 μM, respectively. We report several novel interactions of the transporter proteins OATP1B1 and OATP1B3 highlighting the need to investigate their role in drug-drug interactions and cancer chemotherapy. ..
  25. doi request reprint Transporters involved in renal excretion of N-carbamoylglutamate, an orphan drug to treat inborn n-acetylglutamate synthase deficiency
    Elisabeth Schwob
    Institute of Systemic Physiology and Pathophysiology, University Medical Center Gottingen, Gottingen, Germany
    Am J Physiol Renal Physiol 307:F1373-9. 2014
    ..Efflux of NCG across the luminal membrane into the tubular lumen probably occurs by OAT4 completing renal secretion of this drug. ..
  26. ncbi request reprint Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3)
    Birgitta C Burckhardt
    Institute of Systemic Physiology and Pathophysiology, University Medical Center Gottingen, Humboldtallee 23, 37073, Gottingen, Germany
    Pflugers Arch 468:1909-1918. 2016
    ....
  27. doi request reprint SLC22 transporter family proteins as targets for cytostatic uptake into tumor cells
    Shivangi Gupta
    Abteilung Vegetative Physiologie und Pathophysiologie, Georg August Universitat, Humboldallee 23, Gottingen, Germany
    Biol Chem 392:117-24. 2011
    ..In this review, we focus on the interaction of SLC22 transporters with cytostatics, the expression of these transporters in tumor cells as well as their impact on the chemosensitivity of cancer cells...
  28. pmc The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes
    Christian Schnell
    Center for Nanoscale Microscopy and Molecular Physiology of the Brain CNMPB, Gottingen, Germany
    Brain Struct Funct 220:193-203. 2015
    ....
  29. pmc Active sulforhodamine 101 uptake into hippocampal astrocytes
    Christian Schnell
    Abt Neurophysiologie und Zelluläre Biophysik, Zentrum Physiologie und Pathophysiologie, Georg August Universitat, Gottingen, Germany
    PLoS ONE 7:e49398. 2012
    ....
  30. doi request reprint Interaction of human organic anion transporter 2 (OAT2) and sodium taurocholate cotransporting polypeptide (NTCP) with antineoplastic drugs
    Venkata V V R Marada
    Institut für Vegetative Physiologie und Pathophysiologie, Universitätmedizin Göttingen, Humboldtallee 23, 37073 Gottingen, Germany Electronic address
    Pharmacol Res 91:78-87. 2015
    ..The accumulation was diminished in the presence of cGMP, the substrate we used to functionally characterize OAT2, suggesting specificity of this uptake and the fact that OAT2 mediates uptake of irinotecan. ..
  31. doi request reprint Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes
    Nils Brökers
    Department of Cardiovascular Physiology, Georg August University Gottingen, Gottingen, Germany
    Cancer Sci 101:129-36. 2010
    ..Taken together, our data indicate that PHD inhibitors might increase chemoresistance of tumor cells in a HIF-1-dependent manner...
  32. ncbi request reprint Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition
    Marija Ljubojevic
    Unit of Molecular Toxicology, Institute for Medical Research and Occupational Health, HR 10001 Zagreb, Croatia
    Am J Physiol Renal Physiol 287:F124-38. 2004
    ....
  33. ncbi request reprint RT-PCR-based evidence for the in vivo stimulation of renal tubularp-aminohippurate (PAH) transport by triiodothyronine (T3) or dexamethasone (DEXA) in kidney tissue of immature and adult rats
    Andrew Bahn
    Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, Germany
    Exp Toxicol Pathol 54:367-73. 2003
    ..Thus, this is the first evidence that T3 and DEXA pre-treatment induces the expression of OAT1...