Josef Mautner

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. pmc Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy
    Dinesh Adhikary
    Clinical Cooperation Group, Institute for Clinical and Molecular Biology, GSF National Research Center for Environment and Health, Munich, Germany Children s Hospital, Hematology Oncology, University of Technology, Munich, Germany
    PLoS ONE 2:e583. 2007
  2. pmc Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins
    Dinesh Adhikary
    Clinical Cooperation Group, Institute for Clinical and Molecular Biology, GSF National Research Center for Environment and Health, Technical University Munich, 80804 Munich, Germany
    J Exp Med 203:995-1006. 2006
  3. ncbi request reprint Epstein-Barr virus nuclear antigen 1 evades direct immune recognition by CD4+ T helper cells
    Josef Mautner
    Clinical Cooperation Group, Institute for Clinical and Molecular Biology, GSF National Research Center for Environment and Health, Munich, Germany
    Eur J Immunol 34:2500-9. 2004
  4. ncbi request reprint Tumor-specific CD4+ T cells from a patient with renal cell carcinoma recognize diverse shared antigens
    Josef Mautner
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 115:752-9. 2005
  5. pmc Identification of major histocompatibility complex class II-restricted antigens and epitopes of the Epstein-Barr virus by a novel bacterial expression cloning approach
    Slavoljub Milosevic
    Children s Hospital, Technical University Munich, Kolner Platz 1, D 80804 Munich, Germany
    J Virol 80:10357-64. 2006
  6. ncbi request reprint Diverse CD8+ T-cell responses to renal cell carcinoma antigens in patients treated with an autologous granulocyte-macrophage colony-stimulating factor gene-transduced renal tumor cell vaccine
    Xianzheng Zhou
    Division of Immunology and Hematopoiesis, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Cancer Res 65:1079-88. 2005
  7. doi request reprint Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation
    Slavoljub Milosevic
    Clinical Cooperation Group, Helmholtz Zentrum Munchen, Munich, Germany
    Transplantation 90:1030-5. 2010
  8. ncbi request reprint Direct mapping of MHC class II epitopes
    Slavoljub Milosevic
    Clinical Cooperation Group, Children s Hospital, Hematology Oncology, Technical University Munich, Kolner Platz 1, D 80804 Munich, Germany
    J Immunol Methods 306:28-39. 2005
  9. ncbi request reprint Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy
    Falk Nimmerjahn
    Klinische Kooperationsgruppe, GSF Institut für Klinische Molekularbiologie, Munich, Germany
    Eur J Immunol 33:1250-9. 2003
  10. doi request reprint Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells
    Andreas Moosmann
    Clinical Cooperation Group Molecular Oncology, Helmholtz Zentrum München and Ludwig Maximilians Universität, Munich, Germany
    Blood 115:2960-70. 2010

Collaborators

Detail Information

Publications26

  1. pmc Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy
    Dinesh Adhikary
    Clinical Cooperation Group, Institute for Clinical and Molecular Biology, GSF National Research Center for Environment and Health, Munich, Germany Children s Hospital, Hematology Oncology, University of Technology, Munich, Germany
    PLoS ONE 2:e583. 2007
    ..Although patients receiving T cell preparations with a higher CD4+ T cell proportion show better clinical responses, the specificity of the infused CD4+ component has remained completely unknown...
  2. pmc Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins
    Dinesh Adhikary
    Clinical Cooperation Group, Institute for Clinical and Molecular Biology, GSF National Research Center for Environment and Health, Technical University Munich, 80804 Munich, Germany
    J Exp Med 203:995-1006. 2006
    ..These findings have implications for the treatment of diseases associated with EBV and potentially other coated viruses infecting MHC class II-positive cells...
  3. ncbi request reprint Epstein-Barr virus nuclear antigen 1 evades direct immune recognition by CD4+ T helper cells
    Josef Mautner
    Clinical Cooperation Group, Institute for Clinical and Molecular Biology, GSF National Research Center for Environment and Health, Munich, Germany
    Eur J Immunol 34:2500-9. 2004
    ..These findings have important implications for the design of immunotherapeutic approaches to target EBV-positive malignancies...
  4. ncbi request reprint Tumor-specific CD4+ T cells from a patient with renal cell carcinoma recognize diverse shared antigens
    Josef Mautner
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 115:752-9. 2005
    ..These experiments show that a dual Th1/Th2, MHC class II-restricted T-helper-cell response against diverse shared tumor antigens has been elicited in this patient...
  5. pmc Identification of major histocompatibility complex class II-restricted antigens and epitopes of the Epstein-Barr virus by a novel bacterial expression cloning approach
    Slavoljub Milosevic
    Children s Hospital, Technical University Munich, Kolner Platz 1, D 80804 Munich, Germany
    J Virol 80:10357-64. 2006
    ..Using this approach, the BALF4 and BNRF1 proteins were identified as targets of the EBV-specific T-helper-cell response, demonstrating that lytic cycle antigens are a relevant component of the EBV-specific TH-cell response...
  6. ncbi request reprint Diverse CD8+ T-cell responses to renal cell carcinoma antigens in patients treated with an autologous granulocyte-macrophage colony-stimulating factor gene-transduced renal tumor cell vaccine
    Xianzheng Zhou
    Division of Immunology and Hematopoiesis, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Cancer Res 65:1079-88. 2005
    ....
  7. doi request reprint Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation
    Slavoljub Milosevic
    Clinical Cooperation Group, Helmholtz Zentrum Munchen, Munich, Germany
    Transplantation 90:1030-5. 2010
    ..Thus, for increasing beneficial GVT and decreasing life-threatening GVHD responses, knowledge of the relevant mHags is required. Here, we sought to identify mHags recognized by CD4 T cells using a novel serologic approach...
  8. ncbi request reprint Direct mapping of MHC class II epitopes
    Slavoljub Milosevic
    Clinical Cooperation Group, Children s Hospital, Hematology Oncology, Technical University Munich, Kolner Platz 1, D 80804 Munich, Germany
    J Immunol Methods 306:28-39. 2005
    ..Thus, this method not only facilitates the identification of T cell epitopes, but also makes it possible to assess the role of individual amino acids for MHC binding or T cell recognition...
  9. ncbi request reprint Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy
    Falk Nimmerjahn
    Klinische Kooperationsgruppe, GSF Institut für Klinische Molekularbiologie, Munich, Germany
    Eur J Immunol 33:1250-9. 2003
    ..These results identify endosomes/lysosomes as the processing compartment for cytosolic antigens and furthermore link endogenous antigen presentation on MHC class II with the process of cellular protein turnover by autophagy...
  10. doi request reprint Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells
    Andreas Moosmann
    Clinical Cooperation Group Molecular Oncology, Helmholtz Zentrum München and Ludwig Maximilians Universität, Munich, Germany
    Blood 115:2960-70. 2010
    ..Thus, a rapid and sustained reconstitution of a protective EBV-specific T-cell memory occurred after the infusion of small numbers of directly isolated EBV-specific T cells...
  11. doi request reprint Targeting high-grade B cell lymphoma with CD19-specific T cells
    Frank M Lehmann
    Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany
    Int J Cancer 135:1153-64. 2014
    ..In conclusion, our data highlight CD19-specific CD4(+) T cells for adoptive T cell therapy of B cell lymphomas. ..
  12. pmc Standardized and highly efficient expansion of Epstein-Barr virus-specific CD4+ T cells by using virus-like particles
    Dinesh Adhikary
    Children s Hospital, University of Technology, Kolner Platz 1, D 80804 Munich, Germany
    J Virol 82:3903-11. 2008
    ..This strategy facilitated the specific and rapid expansion of EBV-specific CD4(+) T cells and, thus, might contribute to the development of standardized protocols for the generation of T-cell lines with improved clinical efficacy...
  13. pmc The infectious kiss: newly infected B cells deliver Epstein-Barr virus to epithelial cells
    Georg W Bornkamm
    Institute of Clinical Molecular Biology and Tumor Genetics, GSF National Research Center for Environment and Health, Marchioninistrasse 25, D 81377 Munich, Germany
    Proc Natl Acad Sci U S A 103:7201-2. 2006
  14. doi request reprint The role of virus-specific CD4+ T cells in the control of Epstein-Barr virus infection
    Josef Mautner
    Clinical Cooperation Group, Pediatric Tumor Immunology, Helmholtz Zentrum Munchen, Marchioninistrasse 25, Munich, Germany
    Eur J Cell Biol 91:31-5. 2012
    ..To this aim, we studied the poorly defined EBV-specific CD4+ T cell response during acute and chronic infection...
  15. pmc Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders
    Stefanie Linnerbauer
    Clinical Cooperation Group Pediatric Tumor Immunology, Children s Hospital, Technische Universitat Munchen, Munich, Germany Helmholtz Zentrum München, Munich, Germany German Centre for Infection Research DZIF, Munich, Germany
    PLoS Pathog 10:e1004068. 2014
    ..Moreover, the expression in several EBV-negative B-cell lymphoma cell lines implies that these putative autoantigen(s) might also qualify as targets for T-cell-based immunotherapy of virus-negative B cell malignancies. ..
  16. ncbi request reprint Efficient generation and expansion of antigen-specific CD4+ T cells by recombinant influenza viruses
    Falk Nimmerjahn
    Klinische Kooperationsgruppe, Pädiatrische Tumorimmunologie, Kinderklinik, Universitätsklinikum der Technischen Universität München, Munchen, Germany
    Eur J Immunol 33:3331-41. 2003
    ..These findings support the notion that recombinant influenza virus is a valuable tool for the expansion of antigen-specific CD4(+) T cells in vitro...
  17. ncbi request reprint Active NF-kappaB signalling is a prerequisite for influenza virus infection
    Falk Nimmerjahn
    Klinische Kooperationsgruppe, Pädiatrische Tumorimmunologie, Kinderklinik, Universitätsklinikum der Technischen Universität München, Marchioninistr 25, D 81377 Munchen, Germany
    J Gen Virol 85:2347-56. 2004
    ..These results might be of major importance for both the development of new antiviral therapies and the understanding of influenza virus biology...
  18. pmc Stringent doxycycline-dependent control of gene activities using an episomal one-vector system
    Georg W Bornkamm
    GSF Institut für Klinische Molekularbiologie und Tumorgenetik, Marchioninistrasse 25, D 81377 Munchen, Germany
    Nucleic Acids Res 33:e137. 2005
    ..Tight down regulation is achieved through binding of the silencer tTS(KRAB) to P(tet)bi-1 in the absence of Dox. Addition of Dox releases repression and via binding of rtTA2(S)-M2 activates P(tet)bi-1...
  19. pmc Presentation of an immunodominant immediate-early CD8+ T cell epitope resists human cytomegalovirus immunoevasion
    Stefanie Ameres
    Clinical Cooperation Group Immunooncology, Department of Medicine III, Klinikum der Universitat Munchen, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS Pathog 9:e1003383. 2013
    ..Our work identifies a T cell population that may be of particular efficiency in HCMV-specific immunotherapy...
  20. pmc Humanized c-Myc mouse
    Frank M Lehmann
    Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Center Munich, Munich, Germany
    PLoS ONE 7:e42021. 2012
    ..The aim of this work is to provide such a mouse strain for the human proto-oncogene product c-MYC...
  21. pmc Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing
    Takanobu Tagawa
    Research Unit Gene Vectors, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Partner Site Munich, Germany, D 81377 Munich, Germany German Centre for Infection Research DZIF, Partner Site Munich, Germany, D 81377 Munich, Germany
    J Exp Med 213:2065-80. 2016
    ....
  22. doi request reprint Polyubiquitination of lysine-48 is an essential but indirect signal for MHC class I antigen processing
    Benjamin M Fiebiger
    Clinical Cooperation Group Pediatric Tumor Immunology, Children s Hospital, Technische Universitat Munchen, Munich, Germany Helmholtz ZentrumMünchen, Munich, Germany German Centre for Infection Research DZIF, Germany
    Eur J Immunol 45:716-27. 2015
    ..Altogether, these findings show an important but indirect role of K48-polyubiquitination in preproteasomal antigen sampling. ..
  23. ncbi request reprint Epstein-Barr virus latent membrane protein 2A mimics B-cell receptor-dependent virus reactivation
    Eveline Schaadt
    GSF Research Center for Environment and Health, Institute for Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, D 81377 Munich, Germany
    J Gen Virol 86:551-9. 2005
    ..Our data reinforce the notion that LMP2A is a functional homologue of the B-cell receptor, not only with respect to B-cell survival but also with respect to regulation of the lytic cycle...
  24. pmc MYC overexpression imposes a nonimmunogenic phenotype on Epstein-Barr virus-infected B cells
    Martin S Staege
    Institut für Klinische Molekularbiologie und Tumorgenetik, GSF Forschungszentrum für Umwelt und Gesundheit, Marchioninistrasse 25, D 81377 Munchen, Germany
    Proc Natl Acad Sci U S A 99:4550-5. 2002
    ..Deregulation of c-myc, a step central to the development of uncontrolled BL cell growth in vivo, can thus impose a nonimmunogenic phenotype on proliferating human B cells in the absence of any immune pressure...
  25. doi request reprint Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear export
    Alexander Riedel
    Klinische Kooperationsgruppe, GSF Institut für Klinische Molekularbiologie und Tumorgenetik, Munchen, Germany
    Eur J Immunol 38:2090-5. 2008
    ..Thus, this endogenous presentation pathway broadens the spectrum of intracellular antigens surveyed by CD4(+) T cells by efficiently sampling cytoplasmic as well as nuclear antigens...
  26. ncbi request reprint Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries
    Uta Behrends
    Kinderklinik, Hämatologie Onkologie, Technische Universitat, Munchen, Germany
    Int J Cancer 106:244-51. 2003
    ..These findings indicate that the humoral immune response against medulloblastoma is directed against diverse antigens that may be useful as diagnostic markers or targets for immunotherapy...