Volkmar Gross

Summary

Country: Germany

Publications

  1. pmc NO-dependent blood pressure regulation in RGS2-deficient mice
    Michael Obst
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R1012-9. 2006
  2. ncbi request reprint Adapting renal and cardiovascular physiology to the genetically hypertensive mouse
    Volkmar Gross
    Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Semin Nephrol 22:172-9. 2002
  3. ncbi request reprint Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice
    Jens Tank
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Auton Neurosci 136:52-7. 2007
  4. ncbi request reprint Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice
    Hantz C Hercule
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Exp Physiol 92:1014-22. 2007
  5. doi request reprint Cardiovascular autonomic regulation in Non-Obese Diabetic (NOD) mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Auton Neurosci 138:108-13. 2008
  6. ncbi request reprint Autonomic nervous system and blood pressure regulation in RGS2-deficient mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 288:R1134-42. 2005
  7. doi request reprint Role of the multidomain protein spinophilin in blood pressure and cardiac function regulation
    Andrey C da Costa-Goncalves
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 52:702-7. 2008
  8. doi request reprint Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction
    Andrey C da Costa Goncalves
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Hypertension 53:387-92. 2009
  9. doi request reprint Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice
    Hantz C Hercule
    Charite Campus Buch, Franz Volhard Clinic ECRC, Berlin, Germany
    Arterioscler Thromb Vasc Biol 29:54-60. 2009
  10. ncbi request reprint Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation
    Jens Tank
    Department of Nephrology and Hypertension, Franz Volhard Clinic, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 43:1042-7. 2004

Collaborators

Detail Information

Publications32

  1. pmc NO-dependent blood pressure regulation in RGS2-deficient mice
    Michael Obst
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R1012-9. 2006
    ..The MAP increases during the active phase in RGS2(-/-) mice may be related to central sympathetic activation and increased vascular adrenergic responsiveness...
  2. ncbi request reprint Adapting renal and cardiovascular physiology to the genetically hypertensive mouse
    Volkmar Gross
    Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Semin Nephrol 22:172-9. 2002
    ..Imaging techniques for the mouse including ultrasound and magnetic resonance imaging are currently feasible. Thus, we will be able to characterize the physiology of any hypertensive mouse model that may become available...
  3. ncbi request reprint Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice
    Jens Tank
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Auton Neurosci 136:52-7. 2007
    ..This observation may depend on altered coupling between electrical nerve activity and norepinephrine release and/or a changed norepinephrine uptake in RGS2-/- mice...
  4. ncbi request reprint Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice
    Hantz C Hercule
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Exp Physiol 92:1014-22. 2007
    ..Our findings suggest that RGS2 deletion promotes Ang II-dependent hypertension primarily through an increase of myogenic tone and vasoreactivity, probably by sensitization of AT(1) receptors...
  5. doi request reprint Cardiovascular autonomic regulation in Non-Obese Diabetic (NOD) mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Auton Neurosci 138:108-13. 2008
    ..In conclusion the use of diabetic NOD mice as a functional model for human diabetes may be questioned...
  6. ncbi request reprint Autonomic nervous system and blood pressure regulation in RGS2-deficient mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 288:R1134-42. 2005
    ..A central nervous system mechanism might be implicated by an increased sympathetic tone. This state of affairs could lead to a baroreceptor-HR reflex resetting, while BRS remains unimpaired...
  7. doi request reprint Role of the multidomain protein spinophilin in blood pressure and cardiac function regulation
    Andrey C da Costa-Goncalves
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 52:702-7. 2008
    ..The elevated blood pressure in SPL(-/-) mice was associated with attenuated baroreflex sensitivity and decreased parasympathetic activity. Our study is the first to show a role for the spinophilin gene in blood pressure regulation...
  8. doi request reprint Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction
    Andrey C da Costa Goncalves
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Hypertension 53:387-92. 2009
    ..Our data suggest that db/db mice exhibit features found in humans with type 2 diabetic autonomic neuropathy and could serve as a model for this complication...
  9. doi request reprint Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice
    Hantz C Hercule
    Charite Campus Buch, Franz Volhard Clinic ECRC, Berlin, Germany
    Arterioscler Thromb Vasc Biol 29:54-60. 2009
    ..We identified a novel interaction between EETs and endothelial NO release using soluble epoxide hydrolase (sEH) -/- and +/+ mice...
  10. ncbi request reprint Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation
    Jens Tank
    Department of Nephrology and Hypertension, Franz Volhard Clinic, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 43:1042-7. 2004
    ..The effect of clonidine on baroreflex HR regulation is mediated by the parasympathetic nervous system. These murine data fit well with recent human observations regarding parasympathetic activation via alpha-2 adrenoceptors...
  11. doi request reprint Estrogen receptor-beta signals left ventricular hypertrophy sex differences in normotensive deoxycorticosterone acetate-salt mice
    Dennis Gürgen
    Department of Nephrology and Intensive Care Medicine Campus Virchow Klinikum, Center forCardiovascular Research Medical Faculty, Charite Berlin, Berlin, Germany
    Hypertension 57:648-54. 2011
    ..Our findings address the possibility of sex-specific cardiovascular therapies...
  12. doi request reprint Spinophilin regulates central angiotensin II-mediated effect on blood pressure
    Andrey C da Costa Goncalves
    Leibniz Institute for Molecular Pharmacology, Berlin, Germany
    J Mol Med (Berl) 89:1219-29. 2011
    ..SPL is a hitherto unrecognized molecule with regard to central blood pressure control and may pave the way to novel strategies for the treatment of hypertension...
  13. ncbi request reprint Nitric oxide synthase expression in AT2 receptor-deficient mice after DOCA-salt
    Michael Obst
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Kidney Int 65:2268-78. 2004
    ..The mice were challenged with deoxycorticosterone acetate (DOCA)-salt to stimulate NO generation...
  14. doi request reprint Increased blood pressure and water intake in transgenic mice expressing rat tonin in the brain
    Cibele C Cardoso
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Biol Chem 391:435-41. 2010
    ..In conclusion, tonin in the brain may represent an alternative pathway for angiotensin II generation with effects on the cardiovascular system...
  15. ncbi request reprint Cardiac hypertrophy and fibrosis in chronic L-NAME-treated AT2 receptor-deficient mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Hypertens 22:997-1005. 2004
    ..The availability of AT2 receptor-deficient mice (AT2 -/y) makes it possible to study the effects of AT1 receptors without the confounding influence of AT2 receptor activity...
  16. doi request reprint Endothelial dysfunction and elevated blood pressure in MAS gene-deleted mice
    Ping Xu
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin Buch, Germany
    Hypertension 51:574-80. 2008
    ....
  17. ncbi request reprint Heart rate variability and baroreflex function in AT2 receptor-disrupted mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Germany
    Hypertension 40:207-13. 2002
    ..We conclude that activation of the AT2 receptor impairs arterial baroreceptor reflex function, probably by a central action. These data support the existence of an inhibitory central effect of the AT2 receptor on baroreflex function...
  18. doi request reprint Deoxycorticosterone acetate-salt mice exhibit blood pressure-independent sexual dimorphism
    Aysun Karatas
    Department of Nephrology and Intensive Care, Medicine Campus, Virchow Klinikum, Berlin, Germany
    Hypertension 51:1177-83. 2008
    ..We suggest that sex-specific calcineurin activation determines the maladaptive cardiac and renal hypertrophic responses and accompanying organ injury in male mice...
  19. ncbi request reprint Systemic hemodynamics in non-anesthetized L-NAME- and DOCA-salt-treated mice
    Michael Obst
    Max Delbruck Center MDC for Molecular Medicine, Berlin, Germany
    J Hypertens 22:1889-94. 2004
    ..Long-term cardiac output measurements in non-anesthetized mice are now possible. We used this technology to study two different hypertensive models in mice...
  20. doi request reprint Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension
    Petra Gratze
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic, Berlin, Germany
    Circulation 117:2645-56. 2008
    ..We tested the hypothesis that an alteration in the number and quality of circulating blood cells caused by Id2 deletion would ameliorate Ang II-induced target-organ damage...
  21. ncbi request reprint Pressure natriuresis in AT(2) receptor-deficient mice with L-NAME hypertension
    Michael Obst
    Max Delbruck Center MDC for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    J Am Soc Nephrol 14:303-10. 2003
    ..Changes in RBF, GFR, and tubular sodium and water reabsorption are involved and may be also responsible for the greater BP increase in L-NAME-treated AT(2) -/- mice...
  22. doi request reprint Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
    Jan Monti
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Nat Genet 40:529-37. 2008
    ..We further demonstrated differential regulation of EPHX2 in human heart failure, suggesting a cross-species role for Ephx2 in this complex disease...
  23. ncbi request reprint Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress
    Stefan Donath
    Department of Cardiology, Campus Virchow Clinic, Charite, Humboldt University, HELIOS GmbH, Berlin, Germany
    Circulation 113:1203-12. 2006
    ..In this study we attempted to elucidate the physiological role of ARC and to understand pathophysiological consequences resulting from its deletion...
  24. doi request reprint Spinophilin is required for normal morphology, Ca(2+) homeostasis and contraction but dispensable for β-adrenergic stimulation of adult cardiomyocytes
    Daria Petzhold
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Str 10, 13092, Berlin, Germany
    J Muscle Res Cell Motil 32:243-8. 2011
    ..Our data suggest that spinophilin is an upstream regulator required for normal growth and excitation-contraction coupling, but is dispensable for β-adrenergic stimulation of adult cardiomyocytes...
  25. ncbi request reprint Dysfunction of dysferlin-deficient hearts
    Katrin Wenzel
    Department of Cardiology, Franz Volhard Clinic, Helios Clinic and Campus Virchow Clinic, Charite, Berlin, Germany
    J Mol Med (Berl) 85:1203-14. 2007
    ..Our data suggest that disturbances in dysferlin as well as Z-line proteins and transcription factors particularly under mechanical stress cause cardiomyopathy...
  26. ncbi request reprint Exercising restraint in measuring blood pressure in conscious mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 41:879-81. 2003
  27. ncbi request reprint Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice
    Sebastian Bachmann
    Medical Faculty of the Charite, Department of Anatomy, Franz Volhard Clinic, HELIOS Clinics and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Am J Physiol Renal Physiol 288:F559-67. 2005
    ..Our data raise the hypothesis that THP plays an important regulatory role in the kidney...
  28. ncbi request reprint Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotension
    Cecile Cayla
    Max Delbruck Center for Molecular Medicine, D 13092 Berlin Buch, Germany
    FASEB J 21:1689-98. 2007
    ..These results clearly demonstrate a pivotal role of kinins and their receptors in hypotension induced by endotoxemia in mice...
  29. ncbi request reprint Fine tuning of blood pressure by the regulator of G protein signaling (RGS) 2
    Andrey Ch da Costa Goncalves
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Am Soc Hypertens 2:403-9. 2008
    ..Interactions between GPCRs and RGS2 represent a regulatory mechanism for fine-tuning of BP which may be important for hypertension and may be considered as a potentially novel drug target...
  30. ncbi request reprint Angiotensin II modulates renal sympathetic neurotransmission through nitric oxide in AT2 receptor knockout mice
    Johannes Stegbauer
    Department of Nephrology, Marienhospital Herne, Ruhr University Bochum, Hölkeskampring 40, D 44625 Herne, Germany
    J Hypertens 23:1691-8. 2005
    ..The present study investigates whether Ang II-mediated modulation of sympathetic neurotransmission is dependent on NO production in the kidney. AT2 -/y receptor-deficient mice are used to identify the Ang II receptor subtype involved...
  31. ncbi request reprint Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+ channel
    Han Si
    Department of Internal Medicine Nephrology, Philipps University, Marburg, Germany
    Circ Res 99:537-44. 2006
    ..These results indicate that the endothelial K(Ca)3.1 is a fundamental determinant of endothelial hyperpolarization and EDHF signaling and, thereby, a crucial determinant in the control of vascular tone and overall circulatory regulation...
  32. pmc Increased vascular smooth muscle contractility in TRPC6-/- mice
    Alexander Dietrich
    Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Germany
    Mol Cell Biol 25:6980-9. 2005
    ..Thus, TRPC6 has distinct nonredundant roles in the control of vascular smooth muscle tone...