Christian Gieger

Summary

Country: Germany

Publications

  1. pmc PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-Cohort
    Bernd Stratmann
    Heart and Diabetes Center NRW, Ruhr University Bochum, Georgstr, 11, D 32545 Bad Oeynhausen, Germany
    Cardiovasc Diabetol 13:90. 2014
  2. pmc Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles
    Harish Dharuri
    Center for Human and Clinical Genetics, Leiden University Medical Center, S4 P, PO Box 9600, 2300, RC Leiden, Netherlands
    BMC Genomics 14:865. 2013
  3. pmc Differences between human plasma and serum metabolite profiles
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS ONE 6:e21230. 2011
  4. pmc Schizophrenia shows a unique metabolomics signature in plasma
    Y He
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Transl Psychiatry 2:e149. 2012
  5. pmc Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study
    Tao Xu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Ingolstädter Landstraße 1, Neuherberg 85764, Germany
    BMC Med 11:60. 2013
  6. pmc Novel biomarkers for pre-diabetes identified by metabolomics
    Rui Wang-Sattler
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Syst Biol 8:615. 2012
  7. pmc Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study
    Rui Wang-Sattler
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 3:e3863. 2008
  8. pmc Human gene expression sensitivity according to large scale meta-analysis
    Pei Hao
    Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    BMC Bioinformatics 10:S56. 2009
  9. doi request reprint PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes
    Janina S Ried
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
    Genet Epidemiol 36:244-52. 2012
  10. pmc Human serum metabolic profiles are age dependent
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Aging Cell 11:960-7. 2012

Detail Information

Publications63

  1. pmc PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-Cohort
    Bernd Stratmann
    Heart and Diabetes Center NRW, Ruhr University Bochum, Georgstr, 11, D 32545 Bad Oeynhausen, Germany
    Cardiovasc Diabetol 13:90. 2014
    ..Whether it is associated with mortality, HbA1c or platelet volume is tested prospectively in an epidemiological cohort...
  2. pmc Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles
    Harish Dharuri
    Center for Human and Clinical Genetics, Leiden University Medical Center, S4 P, PO Box 9600, 2300, RC Leiden, Netherlands
    BMC Genomics 14:865. 2013
    ..This paper explores the opportunities and challenges in the analysis of GWAS of metabolomic phenotypes and provides novel insights into the genetic basis of metabolic variation through the re-analysis of published GWAS datasets...
  3. pmc Differences between human plasma and serum metabolite profiles
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS ONE 6:e21230. 2011
    ..However, different collecting procedures and the coagulation cascade influence concentrations of both proteins and metabolites in these matrices. The effects on metabolite concentration profiles have not been fully characterized...
  4. pmc Schizophrenia shows a unique metabolomics signature in plasma
    Y He
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Transl Psychiatry 2:e149. 2012
    ..This study illustrated that the metabolic deviations detected in plasma may serve as potential biomarkers to aid diagnosis of schizophrenia...
  5. pmc Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study
    Tao Xu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Ingolstädter Landstraße 1, Neuherberg 85764, Germany
    BMC Med 11:60. 2013
    ..Here, we extend our metabolomics study with a large prospective study including female smokers and quitters...
  6. pmc Novel biomarkers for pre-diabetes identified by metabolomics
    Rui Wang-Sattler
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Syst Biol 8:615. 2012
    ..The expression levels of these enzymes correlate with changes in the metabolite concentrations linked to diabetes. Our results may help developing novel strategies to prevent T2D...
  7. pmc Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study
    Rui Wang-Sattler
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 3:e3863. 2008
    ..Our findings provide new insight into the pathophysiology of smoking addiction. Activation of the enzyme alkyl-DHAP by small molecules may provide novel routes for therapy...
  8. pmc Human gene expression sensitivity according to large scale meta-analysis
    Pei Hao
    Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    BMC Bioinformatics 10:S56. 2009
    ..Systematical study of this concept is required because of its important implications in microarray analysis etc. J.H. Ohn et al. first studied this gene property with yeast transcriptional profiling data...
  9. doi request reprint PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes
    Janina S Ried
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
    Genet Epidemiol 36:244-52. 2012
    ..Its flexible design enables both the use of prior knowledge and the generation of new knowledge on connection of multiple phenotypes. A software program for PSEA based on GWAS results is available upon request...
  10. pmc Human serum metabolic profiles are age dependent
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Aging Cell 11:960-7. 2012
    ..The use of metabolomics will increase our understanding of aging networks and may lead to discoveries that help enhance healthy aging...
  11. pmc Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index
    Cornelia Huth
    Institute of Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Ann Med 41:128-38. 2009
    ..Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results...
  12. pmc The Human Blood Metabolome-Transcriptome Interface
    Jörg Bartel
    Institute of Computational Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS Genet 11:e1005274. 2015
    ..Overall, our results demonstrate the utility of a multi-omics integrative approach to understand the molecular mechanisms underlying both normal physiology and disease. ..
  13. pmc A genome-wide perspective of genetic variation in human metabolism
    Thomas Illig
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 42:137-41. 2010
    ..5 x 10(-179). These loci explained 5.6%-36.3% of the observed variance in metabolite concentrations. For several loci, associations with clinically relevant parameters have been reported previously...
  14. doi request reprint DYT16 revisited: exome sequencing identifies PRKRA mutations in a European dystonia family
    Michael Zech
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    Mov Disord 29:1504-10. 2014
    ..Our study provides the first independent replication of the DYT16 locus at 2q31.2 and strongly confirms the causal contribution of the PRKRA gene to DYT16. Our data suggest worldwide involvement of PRKRA in dystonia...
  15. pmc Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information
    Jan Krumsiek
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS Genet 8:e1003005. 2012
    ..Our approach is generic in nature and can be directly transferred to metabolomics data from different experimental platforms...
  16. pmc Body fat free mass is associated with the serum metabolite profile in a population-based study
    Carolin Jourdan
    Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 7:e40009. 2012
    ..To characterise the influence of the fat free mass on the metabolite profile in serum samples from participants of the population-based KORA (Cooperative Health Research in the Region of Augsburg) S4 study...
  17. pmc Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome
    Eva C Schulte
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS ONE 9:e98092. 2014
    ..42). Although a similar approach has been used successfully with regard to other complex diseases, we were unable to identify new genetic susceptibility factor for RLS by adding this novel level of functional assessment to RLS GWAS data...
  18. doi request reprint Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions
    Iris M Heid
    Institute of Epidemiology, Helmholtz Center, Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Circ Cardiovasc Genet 1:10-20. 2008
    ..We aimed to identify gene regions that influence HDLC levels by a genome-wide association analysis in the population-based KORA (Cooperative Health Research in the Region of Augsburg) study...
  19. doi request reprint Association of atopic dermatitis with cardiovascular risk factors and diseases
    Marie Standl
    Institute of Epidemiology I, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    J Invest Dermatol . 2016
    ..Relevant associations of AD with CVRFs reported in US-populations could not be confirmed. Likewise, AD patients did not have increased genetic risk factors for CVD...
  20. pmc The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study
    Elisabeth Altmaier
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    PLoS ONE 11:e0153163. 2016
    ..Since so far ACE activity measurement is substrate specific due to the usage of only one oligopeptide, taking several dipeptides as potential products of ACE into account may provide a broader picture of the ACE activity. ..
  21. pmc Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data
    Susanne Vogt
    Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Int J Epidemiol 45:1469-1481. 2016
    ....
  22. pmc Tobacco smoking leads to extensive genome-wide changes in DNA methylation
    Sonja Zeilinger
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 8:e63812. 2013
    ..The results of our study confirm the broad effect of tobacco smoking on the human organism, but also show that quitting tobacco smoking presumably allows regaining the DNA methylation state of never smokers...
  23. pmc Recessive mutations in the α3 (VI) collagen gene COL6A3 cause early-onset isolated dystonia
    Michael Zech
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany Department of Neurology and Neurological Sciences and Center for Sleep Sciences and Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA Institut für Humangenetik, Helmholtz Zentrum Munchen, 85764 Munich, Germany
    Am J Hum Genet 96:883-93. 2015
    ....
  24. doi request reprint Rare sequence variants in ANO3 and GNAL in a primary torsion dystonia series and controls
    Michael Zech
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    Mov Disord 29:143-7. 2014
    ..Rare autosomal-dominant mutations in ANO3 and GNAL have been recently shown to represent novel genetic factors underlying primary torsion dystonia (PTD) with predominantly craniocervical involvement...
  25. pmc Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism
    Elisabeth Altmaier
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764, Neuherberg, Germany
    Eur J Epidemiol 29:325-36. 2014
    ..Taken together, our results provide a basis for a deeper functional understanding of the action and side-effects of antihypertensive and lipid-lowering drugs in the general population...
  26. pmc Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    Christian Gieger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 4:e1000282. 2008
    ..These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge...
  27. doi request reprint Genetic associations with lipoprotein subfractions provide information on their biological nature
    Ann Kristin Petersen
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg 85764, Germany
    Hum Mol Genet 21:1433-43. 2012
    ..Future clinical studies are now needed to investigate their biomedical relevance...
  28. pmc On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies
    Ann Kristin Petersen
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    BMC Bioinformatics 13:120. 2012
    ..So far, only a rule of thumb was applied to determine the significance of the p-gain...
  29. doi request reprint Systematic TOR1A non-c.907_909delGAG variant analysis in isolated dystonia and controls
    Michael Zech
    Klinik und Poliklinik fur Neurologie, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Neurogenomik, Helmholtz Zentrum Munchen, Munich, Germany
    Parkinsonism Relat Disord 31:119-123. 2016
    ..Only recently, DYT1 genotype-phenotype correlations have been proposed, awaiting further elucidation in independent cohorts...
  30. doi request reprint Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes
    Tao Xu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany Institute of Epidemiology II, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Diabetes Care 38:1858-67. 2015
    ..Metformin is used as a first-line oral treatment for type 2 diabetes (T2D). However, the underlying mechanism is not fully understood. Here, we aimed to comprehensively investigate the pleiotropic effects of metformin...
  31. pmc Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality
    Johannes Raffler
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 11:e1005487. 2015
    ..By establishing connections from gene to disease via metabolic traits our results provide novel hypotheses about molecular mechanisms involved in the etiology of diseases. ..
  32. pmc Rare variants in PLXNA4 and Parkinson's disease
    Eva C Schulte
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat, Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS ONE 8:e79145. 2013
    ....
  33. pmc Discovery of sexual dimorphisms in metabolic and genetic biomarkers
    Kirstin Mittelstrass
    Unit of Molecular Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 7:e1002215. 2011
    ..Our study provides new important insights into sex-specific differences of cell regulatory processes and underscores that studies should consider sex-specific effects in design and interpretation...
  34. doi request reprint Multi-omic signature of body weight change: results from a population-based cohort study
    Simone Wahl
    Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    BMC Med 13:282. 2015
    ..Here, we pursued a multi-omic approach to comprehensively study metabolic consequences of body weight change during a seven-year follow-up in a large prospective study...
  35. pmc A genome-wide association study identifies three loci associated with mean platelet volume
    Christa Meisinger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Am J Hum Genet 84:66-71. 2009
    ..These findings may not only enhance our understanding of platelet activation and function, but may also provide a focus for several novel research avenues...
  36. pmc Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome
    Eva C Schulte
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, 85764 Munich, Germany
    Am J Hum Genet 95:85-95. 2014
    ....
  37. pmc Metabolomic markers reveal novel pathways of ageing and early development in human populations
    Cristina Menni
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK, Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany, Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany, Institute of Epidemiology I, Helmholtz Zentrum Munchen, Neuherberg, Germany, Pfizer Research Laboratories, Groton, CT, USA, Worldwide R and D, Pfizer Inc, Cambridge, MA, USA, School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, Metabolon Inc, 617 Davis Drive, Durham, NC 27713, USA Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, National University of Singapore
    Int J Epidemiol 42:1111-9. 2013
    ..Human ageing is a complex, multifactorial process and early developmental factors affect health outcomes in old age...
  38. pmc Mapping the genetic architecture of gene regulation in whole blood
    Katharina Schramm
    Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany Institute of Human Genetics, Technical University Munich, Munchen, Germany
    PLoS ONE 9:e93844. 2014
    ..We aimed to assess whether whole blood expression quantitative trait loci (eQTLs) with effects in cis and trans are robust and can be used to identify regulatory pathways affecting disease susceptibility...
  39. pmc Association between DNA Methylation in Whole Blood and Measures of Glucose Metabolism: KORA F4 Study
    Jennifer Kriebel
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 11:e0152314. 2016
    ..Furthermore, the interaction of ABCG1 with glucose metabolism is modulated by epigenetic processes...
  40. doi request reprint Large-scale TUBB4A mutational screening in isolated dystonia and controls
    Michael Zech
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Neurogenomik, Helmholtz Zentrum Munchen, Munich, Germany
    Parkinsonism Relat Disord 21:1278-81. 2015
    ..While several follow-up studies confirmed the importance of TUBB4A mutations in the development of H-ABC, their contribution to isolated dystonia remains uncertain...
  41. pmc Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 5:e13953. 2010
    ....
  42. pmc On the potential of models for location and scale for genome-wide DNA methylation data
    Simone Wahl
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    BMC Bioinformatics 15:232. 2014
    ....
  43. pmc Niemann-Pick C disease gene mutations and age-related neurodegenerative disorders
    Michael Zech
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS ONE 8:e82879. 2013
    ..Misdiagnosed NPC patients were not present in our samples. However, further assessment of NPC disease genes in age-related neurodegeneration is warranted...
  44. doi request reprint Genetic variation in metabolic phenotypes: study designs and applications
    Karsten Suhre
    Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO Box 24144, Doha, Qatar
    Nat Rev Genet 13:759-69. 2012
    ..We discuss such design considerations and applications in this Review...
  45. doi request reprint Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
    Simone Wahl
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Neuherberg, Germany
    Nature . 2016
    ..Our results provide new insights into the biologic pathways influenced by adiposity, and may enable development of new strategies for prediction and prevention of type 2 diabetes and other adverse clinical consequences of obesity...
  46. pmc Genetics of human metabolism: an update
    Gabi Kastenmüller
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany, German Center for Diabetes Research, Neuherberg, Germany and
    Hum Mol Genet 24:R93-R101. 2015
    ..We then discuss new approaches of integrating and exploring mGWAS results and finish by presenting selected applications of GIMs in recent studies...
  47. pmc An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker
    Gregory Livshits
    aDepartment of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom bDepartment of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel cNorwich Medical School, University of East Anglia, Norwich, United Kingdom dInstitute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany eInstitute of Health Informatics, University College London UCL, London, United Kingdom fResearch Unit Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany gInstitute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany hGerman Center for Diabetes Research, Neuherberg, Germany iInstitute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Pain 156:1845-51. 2015
    ..This study suggests that steroid hormone abnormalities result from pain rather than causing it, and EAS may provide a biomarker that identifies subgroups at risk of CWP...
  48. pmc Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood
    Divya Mehta
    Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Eur J Hum Genet 21:48-54. 2013
    ..Our data demonstrate that eQTLs in whole blood are highly robust and reproducible across studies and highlight the relevance of whole-blood eQTL mapping in prioritization of GWAS candidate genes in humans...
  49. pmc Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study
    Karl Heinz Ladwig
    Institute of Epidemiology II, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 8:e64762. 2013
    ..We analysed the impact of Posttraumatic Stress Disorder (PTSD) on TL in the general population and postulated a dose-dependent TL association in subjects suffering from partial PTSD compared to full PTSD...
  50. doi request reprint SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
    Angela Doring
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Nat Genet 40:430-6. 2008
    ..The proportion of the variance of serum uric acid concentrations explained by genotypes was about 1.2% in men and 6% in women, and the percentage accounted for by expression levels was 3.5% in men and 15% in women...
  51. doi request reprint A genome-wide association study of metabolic traits in human urine
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 43:565-9. 2011
    ..Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper-β-aminoisobutyric aciduria...
  52. pmc Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues
    Carola Marzi
    Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health Neuherberg, Germany
    PLoS ONE 11:e0166015. 2016
    ..Epigenetic studies on CRP might discover molecular mechanisms underlying CRP regulation. We aimed to identify DNA methylation sites related to CRP concentrations in cells and tissues regulating low-grade inflammation...
  53. ncbi request reprint Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues
    Jonathan Adam
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Diabetes 65:3776-3785. 2016
    ..The translational data derived from multiple murine tissues corroborated and complemented the findings from the human cohort...
  54. pmc Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures
    Manja Koch
    Institute of Epidemiology, Christian Albrechts University Kiel, Kiel, Germany
    J Invest Dermatol 135:1283-93. 2015
    ..Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct. ..
  55. doi request reprint Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function
    Rajesh Rawal
    Institute of Genetic Epidemiology, Helmholtz Zentrum Mu nchen, 85764 Neuherberg, Germany
    Hum Mol Genet 21:3275-82. 2012
    ..Together, these four quantitative trait loci accounted for ∼3.3% of the variance in TSH serum levels. These results contribute to our understanding of genetic factors and physiological mechanisms mediating thyroid function...
  56. doi request reprint The role of SCARB2 as susceptibility factor in Parkinson's disease
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Mov Disord 28:538-40. 2013
    ..An association between the common SNP rs6812193, upstream of SCARB2, and PD has been reported previously. The role of exonic variants in the SCARB2 gene in PD has not been examined...
  57. pmc Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Zentrum Munchen, National Research Center for Environment and Health, Neuherberg, Germany
    PLoS Genet 5:e1000504. 2009
    ..In addition, these findings strongly support the hypothesis that transport proteins are key in regulating serum uric acid levels...
  58. pmc Human metabolic individuality in biomedical and pharmaceutical research
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    Nature 477:54-60. 2011
    ..The study advances our knowledge of the genetic basis of metabolic individuality in humans and generates many new hypotheses for biomedical and pharmaceutical research...
  59. pmc New gene functions in megakaryopoiesis and platelet formation
    Christian Gieger
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Nature 480:201-8. 2011
    ..Taken together, our findings advance understanding of novel gene functions controlling fate-determining events during megakaryopoiesis and platelet formation, providing a new example of successful translation of GWAS to function...
  60. pmc Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A
    Carola Marzi
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 6:e1001213. 2010
    ..5-p13 region in the regulation of baseline A-SAA levels and provide confirmative evidence of the importance of the 1p31 region for inflammatory processes and the close interplay between A-SAA, leptin, and other acute-phase proteins...
  61. pmc Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon
    Derek Spieler
    Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Genome Res 24:592-603. 2014
    ..Thus, in vivo and in vitro analysis of a common SNP with small effect size showed allele-dependent function in the prospective basal ganglia representing the first neurodevelopmental region implicated in RLS. ..
  62. ncbi request reprint IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  63. pmc Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies
    Harald Grallert
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Eur Heart J 33:238-51. 2012
    ..We searched for genetic loci related to Lp-PLA2 mass or activity by a genome-wide association study as part of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium...