Aurelio A Teleman

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. doi Metabolism meets development at Wiston House
    Aurelio A Teleman
    German Cancer Research Center DKFZ, Heidelberg 69120, Germany
    Development 143:3045-9. 2016
  2. doi Role for Torsin in Lipid Metabolism
    Aurelio A Teleman
    German Cancer Research Center DKFZ, 69120 Heidelberg, Germany Electronic address
    Dev Cell 38:223-4. 2016
  3. pmc Wnt6 is required for maxillary palp formation in Drosophila
    Nikolaos Doumpas
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Biol 11:104. 2013
  4. doi Drosophila: a model for understanding obesity and diabetic complications
    A A Teleman
    German Cancer Research Center, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 120:184-5. 2012
  5. doi Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Aurelio A Teleman
    German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem J 425:13-26. 2009
  6. doi Tissue-specific coupling between insulin/IGF and TORC1 signaling via PRAS40 in Drosophila
    Cristina Pallares-Cartes
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Dev Cell 22:172-82. 2012
  7. doi Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP
    Katrin Straßburger
    German Cancer Research Center, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Dev Biol 367:187-96. 2012
  8. doi MAP4K3 regulates body size and metabolism in Drosophila
    Boris Bryk
    European Molecular Biology Laboratory, Meyerhofstr 1, Heidelberg, Germany
    Dev Biol 344:150-7. 2010
  9. doi PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation
    Katrin Hahn
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cell Metab 11:438-44. 2010
  10. pmc eIF4A inactivates TORC1 in response to amino acid starvation
    Foivos Filippos Tsokanos
    Division of Signal Transduction in Cancer and Metabolism, German Cancer Research Center DKFZ, Heidelberg, Germany
    EMBO J 35:1058-76. 2016

Collaborators

Detail Information

Publications27

  1. doi Metabolism meets development at Wiston House
    Aurelio A Teleman
    German Cancer Research Center DKFZ, Heidelberg 69120, Germany
    Development 143:3045-9. 2016
    ..This Meeting Review discusses examples of talks that illustrated this principle. ..
  2. doi Role for Torsin in Lipid Metabolism
    Aurelio A Teleman
    German Cancer Research Center DKFZ, 69120 Heidelberg, Germany Electronic address
    Dev Cell 38:223-4. 2016
    ..In this issue of Developmental Cell, Grillet et al. (2016) use Drosophila to discover that TorsinA regulates lipid metabolism, opening up future directions of research into the causes of this disease. ..
  3. pmc Wnt6 is required for maxillary palp formation in Drosophila
    Nikolaos Doumpas
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Biol 11:104. 2013
    ..To test whether Wnt6 also contributes towards wing size regulation, we generated Wnt6 knockout flies...
  4. doi Drosophila: a model for understanding obesity and diabetic complications
    A A Teleman
    German Cancer Research Center, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 120:184-5. 2012
    ..Drosophila has become a popular model organism for studying a variety of human diseases. We discuss here emerging Drosophila models of obesity and diabetic complications...
  5. doi Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Aurelio A Teleman
    German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem J 425:13-26. 2009
    ..I discuss both the intracellular signalling network, as well as the communication between organs in the fly...
  6. doi Tissue-specific coupling between insulin/IGF and TORC1 signaling via PRAS40 in Drosophila
    Cristina Pallares-Cartes
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Dev Cell 22:172-82. 2012
    ..Finally, this work sheds some light on the question of whether TORC1 activity is coupled to IIS in vivo...
  7. doi Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP
    Katrin Straßburger
    German Cancer Research Center, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Dev Biol 367:187-96. 2012
    ..Interestingly, we also find the converse--that Yorkie signaling activates components of the insulin/TOR pathway. In sum, this crosstalk between IIS and Yorkie leads to coordinated regulation of these two oncogenic pathways...
  8. doi MAP4K3 regulates body size and metabolism in Drosophila
    Boris Bryk
    European Molecular Biology Laboratory, Meyerhofstr 1, Heidelberg, Germany
    Dev Biol 344:150-7. 2010
    ..Lastly, we show physical interaction between MAP4K3 and the Rag GTPases raising the possibility they might be acting in one signaling pathway...
  9. doi PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation
    Katrin Hahn
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cell Metab 11:438-44. 2010
    ..Since S6K affects development of cancer and metabolic disease, our data identify PPP2R5C as a novel factor of potential medical relevance...
  10. pmc eIF4A inactivates TORC1 in response to amino acid starvation
    Foivos Filippos Tsokanos
    Division of Signal Transduction in Cancer and Metabolism, German Cancer Research Center DKFZ, Heidelberg, Germany
    EMBO J 35:1058-76. 2016
    ..This effect is specific for eIF4F and not a general consequence of blocked translation. This study identifies specific components of the translation machinery as important mediators of TORC1 inactivation upon amino acid removal. ..
  11. pmc Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth
    Sibylle Schleich
    German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 4:e6305. 2009
    ..This shows that phosphorylation of the Tsc1/2 complex by Akt is not required for Akt to activate TORC1 and to promote tissue growth in Drosophila...
  12. doi dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling
    Víctor A Francis
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, Germany
    Curr Biol 20:1799-808. 2010
    ..Because no DOR loss-of-function mammalian models are available, we analyze here the in vivo function of DOR by studying flies mutant for Drosophila DOR (dDOR)...
  13. pmc Insulin signaling regulates fatty acid catabolism at the level of CoA activation
    Xiaojun Xu
    German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS Genet 8:e1002478. 2012
    ..In sum, we identify fatty acid activation onto CoA as an important, regulated step in triglyceride catabolism, and we identify a mechanistic link through which insulin regulates lipid homeostasis...
  14. pmc Brk regulates wing disc growth in part via repression of Myc expression
    Nikolaos Doumpas
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg 69120, Germany
    EMBO Rep 14:261-8. 2013
    ..This work sheds light on the effector mechanisms by which Dpp signalling controls tissue growth...
  15. doi Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila
    Aurelio A Teleman
    EMBL, Meyerhofstrasse 1, Heidelberg, Germany
    Cell Metab 7:21-32. 2008
    ..This study uncovers a network of convergent regulation of protein biosynthesis by the FOXO and TOR branches of the nutrient-sensing pathway...
  16. pmc REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1
    Marcel Tiebe
    German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Dev Cell 33:272-84. 2015
    ..In vivo functional analysis using knockout flies reveals that REPTOR and REPTOR-BP play critical roles in maintaining energy homeostasis and promoting animal survival upon nutrient restriction...
  17. pmc Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
    Constantinos Demetriades
    German Cancer Research Center DKFZ, 69120 Heidelberg, Germany Electronic address
    Cell 156:786-99. 2014
    ..These data suggest that regulation of TSC2 subcellular localization may be a general mechanism to control its activity and place TSC2 in the amino-acid-sensing pathway to TORC1...
  18. pmc THADA Regulates the Organismal Balance between Energy Storage and Heat Production
    Alexandra Moraru
    German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Dev Cell 41:72-81.e6. 2017
    ..In sum, this identifies THADA as a regulator of the balance between energy consumption and energy storage, which was selected during human evolution...
  19. pmc DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth
    Sibylle Schleich
    1 German Cancer Research Center DKFZ, 69120 Heidelberg, Germany 2 Center for Molecular Neurobiology ZMNH, University Medical Center Hamburg Eppendorf UKE, Falkenried 94, 20251 Hamburg, Germany
    Nature 512:208-12. 2014
    ..Collectively, our data reveal that cells have a previously unappreciated translational control system with a key role in supporting proliferation and tissue growth. ..
  20. pmc Lysosomal recruitment of TSC2 is a universal response to cellular stress
    Constantinos Demetriades
    Division of Signal Transduction in Cancer and Metabolism, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Nat Commun 7:10662. 2016
    ..Our findings indicate that lysosomal recruitment of TSC2 is a universal response to stimuli that inactivate mTORC1, and that the presence of any single stress is sufficient to cause TSC2 lysosomal localization. ..
  21. doi In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis
    Simone C Albrecht
    Division of Redox Regulation, DKFZ ZMBH Alliance, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cell Metab 14:819-29. 2011
    ..Midgut enterocytes are identified as prominent sites of age-dependent cytosolic H(2)O(2) accumulation. A longer life span correlated with increased formation of oxidants in the gut, rather than a decrease...
  22. pmc Isolation of microRNA targets by miRNP immunopurification
    George Easow
    European Molecular Biology Laboratory, Heidelberg, Germany
    RNA 13:1198-204. 2007
    ..This approach provides a means to identify functional miRNA targets based on their physical interaction in vivo...
  23. pmc PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis
    Yong Sheng Cheng
    German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS Genet 11:e1005561. 2015
    ..In sum, our data suggest that hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state. ..
  24. pmc 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth
    Aurelio A Teleman
    European Molecular Biology Laboratory, Heidelberg, Germany
    Genes Dev 19:1844-8. 2005
    ..We suggest that 4E-BP works as a metabolic brake that is activated under conditions of environmental stress to control fat metabolism. 4E-BP mutants lack this regulation, reducing their ability to survive under unfavorable conditions...
  25. ncbi Protocols to Study Growth and Metabolism in Drosophila
    Katrin Strassburger
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
    Methods Mol Biol 1478:279-290. 2016
    ..It then provides protocols for measuring tissue growth, cell size, and metabolic parameters such as stored lipids and glycogen, and circulating sugars...
  26. pmc TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1
    Monika Plescher
    Division of Signal Transduction in Cancer and Metabolism, German Cancer Research Center DKFZ, 69120, Heidelberg, Germany
    Sci Rep 5:13828. 2015
    ..This work puts together a signaling pathway whereby hyperosmotic stress inactivates mTORC1. ..
  27. pmc Regulation of mitochondrial morphology and function by stearoylation of TFR1
    Deniz Senyilmaz
    German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Nature 525:124-8. 2015
    ..This work identifies the metabolite C18:0 as a signalling molecule regulating mitochondrial function in response to diet. ..