Adelheid Cerwenka

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. doi request reprint Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells
    Nathalie Fiegler
    Innate Immunity Group, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Blood 122:684-93. 2013
  2. pmc New twist on the regulation of NKG2D ligand expression
    Adelheid Cerwenka
    Group of Innate Immunity, German Cancer Research Center, 69120 Heidelberg, Germany
    J Exp Med 206:265-8. 2009
  3. doi request reprint Regulatory T cells control macrophage accumulation and activation in lymphoma
    Ioanna E Galani
    Boveri junior research group of Innate Immunity, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 127:1131-40. 2010
  4. pmc Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells
    Norman Nausch
    Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    Blood 112:4080-9. 2008
  5. pmc Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes
    Kai Zanzinger
    German Cancer Research Centre DKFZ, Innate Immunity, 69120 Heidelberg, Germany
    Immunology 128:185-95. 2009
  6. doi request reprint Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells
    Nicole Schwinn
    Division of Clinical Cooperation Unit Dermato Oncology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 124:1594-604. 2009
  7. doi request reprint CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-γ production in response to mature dendritic cells
    Ana Stojanovic
    Innate Immunity Group, German Cancer Research Center, 69120 Heidelberg, Germany
    J Immunol 192:4184-91. 2014
  8. doi request reprint Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
    Eva Schlecker
    Innate Immunity, Research Program Tumor Immunology, German Cancer Research Center, Heidelberg D 69120, Germany
    J Immunol 189:5602-11. 2012
  9. doi request reprint Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer
    Sonja Textor
    Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 123:2343-53. 2008
  10. doi request reprint Antitumor vaccination by Newcastle Disease Virus Hemagglutinin-Neuraminidase plasmid DNA application: changes in tumor microenvironment and activation of innate anti-tumor immunity
    Jing Ni
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    Vaccine 29:1185-93. 2011

Collaborators

Detail Information

Publications38

  1. doi request reprint Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells
    Nathalie Fiegler
    Innate Immunity Group, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Blood 122:684-93. 2013
    ..Thus, we identified a novel mechanism that governs B7-H6 expression in tumor cells that has implications for potential cancer treatments combining immunotherapy with HDACi. ..
  2. pmc New twist on the regulation of NKG2D ligand expression
    Adelheid Cerwenka
    Group of Innate Immunity, German Cancer Research Center, 69120 Heidelberg, Germany
    J Exp Med 206:265-8. 2009
    ..Thus, targeting the ubiquitination machinery in cancer cells might increase the susceptibility of tumors to NK cell-mediated killing...
  3. doi request reprint Regulatory T cells control macrophage accumulation and activation in lymphoma
    Ioanna E Galani
    Boveri junior research group of Innate Immunity, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 127:1131-40. 2010
    ..In our study, high numbers of macrophages infiltrating RMA-S tumors in the absence of Treg correlated with tumor rejection suggesting that macrophages are additional targets for Treg-mediated immune suppression in cancer...
  4. pmc Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells
    Norman Nausch
    Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    Blood 112:4080-9. 2008
    ..Thus, our results have great impact on the design of immune therapies against cancer aiming at the manipulation of MDSCs...
  5. pmc Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes
    Kai Zanzinger
    German Cancer Research Centre DKFZ, Innate Immunity, 69120 Heidelberg, Germany
    Immunology 128:185-95. 2009
    ..Our study reveals differential regulation of TREM-1 expression on mouse monocyte subpopulations and improves our understanding of the biological role of TREM-1 during disease...
  6. doi request reprint Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells
    Nicole Schwinn
    Division of Clinical Cooperation Unit Dermato Oncology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 124:1594-604. 2009
    ..Our study suggests that IFN-gamma, by down-regulating ligand expression, might facilitate escape of MHC class I-negative melanoma cells from NKG2D-mediated killing by NK cells...
  7. doi request reprint CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-γ production in response to mature dendritic cells
    Ana Stojanovic
    Innate Immunity Group, German Cancer Research Center, 69120 Heidelberg, Germany
    J Immunol 192:4184-91. 2014
    ..Accordingly, our study might have implications for immunotherapy of cancer based on blocking anti-CTLA-4 mAbs. ..
  8. doi request reprint Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
    Eva Schlecker
    Innate Immunity, Research Program Tumor Immunology, German Cancer Research Center, Heidelberg D 69120, Germany
    J Immunol 189:5602-11. 2012
    ....
  9. doi request reprint Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer
    Sonja Textor
    Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 123:2343-53. 2008
    ....
  10. doi request reprint Antitumor vaccination by Newcastle Disease Virus Hemagglutinin-Neuraminidase plasmid DNA application: changes in tumor microenvironment and activation of innate anti-tumor immunity
    Jing Ni
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    Vaccine 29:1185-93. 2011
    ..This highlights thus the potential adjuvant activity of the HN gene in tumor therapy...
  11. doi request reprint Btk is a positive regulator in the TREM-1/DAP12 signaling pathway
    Tereza Ormsby
    German Cancer Research Center DKFZ, Innate Immunity, Heidelberg, Germany
    Blood 118:936-45. 2011
    ..In conclusion, our data identify Btk as a positive regulator in the ITAM-mediated TREM-1/DAP12 pathway and suggest its implication in inflammatory processes...
  12. doi request reprint Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2
    Sonja Textor
    Innate Immunity Group, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
    Cancer Res 71:5998-6009. 2011
    ..One implication of our work is that activating p53 after adoptive transfer of NK cells might constitute an effective combinatorial strategy of NK cell-based immunochemotherapy in cancers in which wild-type p53 function is preserved...
  13. doi request reprint The TREM-1/DAP12 pathway
    Anja S Tessarz
    German Cancer Research Center DKFZ, Division of Innate Immunity, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Immunol Lett 116:111-6. 2008
    ..Therefore, it is of great importance to get further insight into the signaling cascade downstream of TREM-1. This review summarizes the current understanding of the TREM-1/DAP12 pathway in monocytes and neutrophils...
  14. ncbi request reprint Identification of CLEC12B, an inhibitory receptor on myeloid cells
    Sabrina C Hoffmann
    Institute for Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    J Biol Chem 282:22370-5. 2007
    ....
  15. doi request reprint NF-κ B-dependent upregulation of ICAM-1 by HPV16-E6/E7 facilitates NK cell/target cell interaction
    Sonja Textor
    German Cancer Research Center, Research Group Innate Immunity, Heidelberg, Germany
    Int J Cancer 128:1104-13. 2011
    ..Moreover, levels of the adhesion molecule ICAM-1 are enhanced by HPV16-E6/E7. Therefore, strategies that aim at harnessing NK cells might be beneficial for the treatment of cervical carcinoma...
  16. pmc Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase
    Mostafa Jarahian
    German Cancer Research Center, Heidelberg, Germany
    J Virol 83:8108-21. 2009
    ..These results suggest that direct activation of NK cells contributes to the antitumor effects of NDV...
  17. pmc Modulation of NKp30- and NKp46-mediated natural killer cell responses by poxviral hemagglutinin
    Mostafa Jarahian
    Translational Immunology Research Unit, German Cancer Research Center, Heidelberg, Germany
    PLoS Pathog 7:e1002195. 2011
    ..We conclude that poxviral HA represents a conserved ligand of NCR, exerting a novel immune escape mechanism through its blocking effect on NKp30-mediated activation at a late stage of infection...
  18. ncbi request reprint The coincidence of chromosome 15 aberrations and beta2-microglobulin gene mutations is causative for the total loss of human leukocyte antigen class I expression in melanoma
    Annette Paschen
    Skin Cancer Unit of the German Cancer Research Center Heidelberg, University Clinics of Mannheim, Mannheim, Germany
    Clin Cancer Res 12:3297-305. 2006
    ..We asked whether abnormalities of chromosome 15, harboring the beta2m gene on 15q21, in addition to beta2m gene mutations, are causative for the HLA class I-negative phenotype of melanoma cells...
  19. pmc The proto-oncogene Myc drives expression of the NK cell-activating NKp30 ligand B7-H6 in tumor cells
    Sonja Textor
    Innate Immunity Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    Oncoimmunology 5:e1116674. 2016
    ..Thus, our data imply that Myc driven tumors could be targets for cancer immunotherapy exploiting the NKp30/B7-H6 axis. ..
  20. pmc HMGB1: The metabolic weapon in the arsenal of NK cells
    Adelheid Cerwenka
    German Cancer Research Center, Research Group Innate Immunity, Heidelberg, Germany
    Mol Cell Oncol 3:e1175538. 2016
    ..This opens up new perspectives for cancer immunotherapy. ..
  21. pmc Adoptively transferred natural killer cells maintain long-term antitumor activity by epigenetic imprinting and CD4+ T cell help
    Jing Ni
    German Cancer Research Center DKFZ, Research Group Innate Immunity, Heidelberg, Germany
    Oncoimmunology 5:e1219009. 2016
    ..In addition, our results support combination of cytokine-preactivated NK cells with CD4+ T cell activation upon lymphopenic conditioning to achieve long-term NK cell effector function for cancer immunotherapy...
  22. pmc Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors
    Jing Ni
    Junior Research Group Innate Immunity, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    J Exp Med 209:2351-65. 2012
    ..Moreover, our results reveal an essential role of CD4+ T cell help for sustained antitumor activity by NK cells linking adaptive and innate immunity...
  23. ncbi request reprint Non-T cell activation linker (NTAL) negatively regulates TREM-1/DAP12-induced inflammatory cytokine production in myeloid cells
    Anja S Tessarz
    German Cancer Research Center DKFZ, Division of Innate Immunity, Heidelberg, Germany, Europe
    J Immunol 178:1991-9. 2007
    ..Our results show that activation signals delivered via DAP12 can be counterbalanced by the adaptor NTAL, identifying NTAL as gatekeeper of TREM-1/DAP12-induced signaling in myeloid cells...
  24. doi request reprint Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands
    Marco Wendel
    Divisions of Innate Immunity and Immunogenetics, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 68:8437-45. 2008
    ..Exploiting strategies to augment NK cell accumulation in the tumor might lead to the development of effective antitumor therapies...
  25. pmc Highly efficient IL-21 and feeder cell-driven ex vivo expansion of human NK cells with therapeutic activity in a xenograft mouse model of melanoma
    Markus Granzin
    Innate Immunity Group, German Cancer Research Center, Heidelberg, Germany Miltenyi Biotec GmbH, Bergisch Gladbach, Germany
    Oncoimmunology 5:e1219007. 2016
    ..The expanded NK cells possess potent antitumor activity in vitro and in vivo and could be utilized at high numbers for adoptive immunotherapy in the clinic...
  26. doi request reprint CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection
    Alexander Rölle
    Clinical Cooperation Unit Applied Tumor Immunity, Antigen Presentation and T NK Cell Activation Group, German Cancer Research Center DKFZ D121, Heidelberg, Germany
    Eur J Immunol 46:2420-2425. 2016
    ....
  27. doi request reprint Natural killer cells and solid tumors
    Ana Stojanovic
    Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    J Innate Immun 3:355-64. 2011
    ..This review summarizes our current knowledge of NK cells in solid tumors. We will discuss the impact of novel insights into NK cell responses against tumors on the design of NK cell-based therapies...
  28. ncbi request reprint NK cells--from basic research to cancer therapy
    Adelheid Cerwenka
    Institute for Immunology, INF 305, 69120 Heidelberg, Germany
    Eur J Immunol 37:1161-4. 2007
    ..50 scientists recently met for the Hengstberger Symposium on NK cells in Heidelberg, Germany to discuss the regulation and function of these important immune cells...
  29. pmc Active but not inactive granulomatosis with polyangiitis is associated with decreased and phenotypically and functionally altered CD56(dim) natural killer cells
    Wolfgang Merkt
    Department of Hematology, Oncology and Rheumatology, Internal Medicine V, University Hospital of Heidelberg, Heidelberg, Germany
    Arthritis Res Ther 18:204. 2016
    ..The purpose of the current study was to further characterize NK cell subsets, phenotype and function in a second GPA cohort (cohort II)...
  30. doi request reprint Tricking the balance: NK cells in anti-cancer immunity
    Jens Pahl
    Innate Immunity Group, D080, German Cancer Research Center, DKFZ Im Neuenheimer Feld 280, 69221 Heidelberg, Germany Electronic address
    Immunobiology 222:11-20. 2017
    ..Finally, recent strategies that focus on exploiting NK cell anti-cancer responses for immunotherapeutic approaches are outlined...
  31. doi request reprint STAT5 Loss Awakens the Dark Force in Natural Killer Cells
    Jing Ni
    German Cancer Research Center DKFZ, Research Group Innate Immunity, Heidelberg, Germany
    Cancer Discov 6:347-9. 2016
    ..These unexpected findings shed new light on potential adverse effects of JAK-STAT inhibitors in the clinics...
  32. pmc The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration
    Georg Gdynia
    Institute of Pathology, Department of Surgical Pathology, University of Heidelberg, 69120 Heidelberg, Germany
    Nat Commun 7:10764. 2016
    ..Moreover, pharmaceutical inhibition of glutaminolysis sensitizes tumour cells to HMGB1 providing a basis for a therapeutic strategy for treating cancer. ..
  33. doi request reprint Exploiting natural killer cells for therapy of melanoma
    Oliver Hölsken
    Innate Immunity Group D080, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Dtsch Dermatol Ges 13:23-9. 2015
    ..Several novel approaches aim at harnessing NK cells to treat melanoma patients and to counteract existing tumor escape mechanisms. This review summarizes the most recent advances in the field. ..
  34. doi request reprint Chronic liver inflammation and hepatocellular carcinogenesis are independent of S100A9
    Aurora De Ponti
    Division of Signal Transduction and Growth Control, DKFZ ZMBH Alliance, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 136:2458-63. 2015
    ..Our data demonstrate that, although highly upregulated, calprotectin is dispensable in the onset and development of HCC, and in the maintenance of liver inflammation...
  35. doi request reprint Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke
    Arthur Liesz
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain 134:704-20. 2011
    ..Thus, targeting T lymphocyte-migration represents a promising therapeutic approach for ischaemic stroke...
  36. ncbi request reprint Cutting edge: the AP-1 subunit JunB determines NK cell-mediated target cell killing by regulation of the NKG2D-ligand RAE-1epsilon
    Norman Nausch
    Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    J Immunol 176:7-11. 2006
    ..Thus, up-regulated RAE-1epsilon expression due to low levels of JunB could alert immune cells to tumors and stressed cells...