Affiliation: German Cancer Research Center
- Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1)M Bottner
Department of Neuroanatomy, University of Heidelberg, Germany
Gene 237:105-11. 1999..Deletion analysis suggests that a 350 bp region upstream of the start of the open reading frame appears to be the most important for regulation of transcription...
- Expression of growth differentiation factor-15/ macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in the perinatal, adult, and injured rat brainA Schober
Neuroanatomy and Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, D 69120 Heidelberg, Germany
J Comp Neurol 439:32-45. 2001..Finally, GDF-15/MIC-1 may also act within the antiinflammatory cytokine network activated in CNS lesions...
- Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivoJ Strelau
Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
J Neurosci 20:8597-603. 2000..Thus, GDF-15/MIC-1 is a novel neurotrophic factor with prominent effects on DAergic and serotonergic neurons. GDF-15/MIC-1 may therefore have a potential for the treatment of Parkinson's disease and disorders of the serotonergic system...
- Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervationA Roosen
Department of Neuroanatomy and Interdisciplinary Center for Neuroscience, University of Heidelberg, D 69120 Heidelberg, Germany
J Neurosci 21:3073-84. 2001..Impairment of synaptic connectivity may consequently reduce impulse flow, causing a reduction in transmitter synthesis in postganglionic neurons...