Affiliation: German Research Centre for Biotechnology
- Coping with kinetic and thermodynamic barriers: RMCE, an efficient strategy for the targeted integration of transgenesA Baer
Gesellschaft für Biotechnologische Forschung mbH GBF, German Research Institute for Biotechnology, RDIF Epigenetic Regulation, D 38124 Braunschweig, FRG, Mascheroder Weg 1, Braunschweig, Germany
Curr Opin Biotechnol 12:473-80. 2001..A recent improvement of this method, the recombinase-mediated cassette exchange procedure (RMCE), permits expression in the absence of any co-expressed selection marker gene...
- Functional characterization of transgene integration patterns by halo fluorescence in situ hybridization: electroporation versus retroviral infectionS Goetze
GBF German Research Center for Biotechnology Epigenetic Regulation, Mascheroder Weg 1, D 38124 Braunschweig, Germany
Biochemistry 42:7035-43. 2003..These results may be one key to explain recent consequences of gene therapy trials that have led to the deregulation of endogenous genes...