Christian P Bacher
Affiliation: German Cancer Research Center
- 4-D single particle tracking of synthetic and proteinaceous microspheres reveals preferential movement of nuclear particles along chromatin - poor tracksChristian P Bacher
Division of Theoretical Bioinformatics, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
BMC Cell Biol 5:45. 2004..Typically, such studies generate a wealth of data that require novel methods in image analysis and computational tools to quantitatively track particle movement on the background of moving cells and shape changing nuclei...
- Nuclear body movement is determined by chromatin accessibility and dynamicsSabine M Görisch
Division of Molecular Genetics, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 101:13221-6. 2004..This finding suggests that the body mobility reflects the dynamics and accessibility of the chromatin environment, which might target bodies to specific nuclear subcompartments where they exert their biological function...
- Trichostatin A-induced histone acetylation causes decondensation of interphase chromatinKatalin Fejes Toth
Kirchhoff Institut für Physik, AG Molekulare Biophysik, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 227, 69120 Heidelberg, Germany
J Cell Sci 117:4277-87. 2004..An analysis by flow cytometry showed that the addition of TSA led to a significant arrest of cells in S phase and induced apoptosis. The concentration dependence of both processes was studied...
- A contractile nuclear actin network drives chromosome congression in oocytesPeter Lenart
Gene Expression and Cell Biology Biophysics Programmes, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Nature 436:812-8. 2005..We show that this mechanism is essential for preventing chromosome loss and aneuploidy of the egg--a leading cause of pregnancy loss and birth defects in humans...