Manfred Gerlach

Summary

Country: Germany

Publications

  1. ncbi request reprint Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson's disease
    M Gerlach
    Clinical Neurochemistry, Clinic for Child and Youth Psychiatry, Julius Maximilians University, Wurzburg, Germany
    J Neural Transm Suppl . 2003
  2. ncbi request reprint Strategies for the protection of dopaminergic neurons against neurotoxicity
    M Gerlach
    Division of Clinical Neurochemistry, Department of Psychiatry and Psychotherapy, University of Wurzburg, D 97980 Würzburg, Fuchsleinstrasse 15, Germany
    Neurotox Res 2:99-114. 2000
  3. ncbi request reprint Potential sources of increased iron in the substantia nigra of parkinsonian patients
    M Gerlach
    Laboratory for Clinical Neurochemistry, Department of Child and Adolescence Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Neural Transm Suppl . 2006
  4. ncbi request reprint The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats
    M Gerlach
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm (Vienna) 108:189-204. 2001
  5. ncbi request reprint Different modes of action of catecholamine-O-methyltransferase inhibitors entacapone and tolcapone on adenylyl cyclase activity in vitro
    M Gerlach
    Clinical Neurochemistry, Department of Child and Youth Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm (Vienna) 109:789-95. 2002
  6. ncbi request reprint Current state of stem cell research for the treatment of Parkinson's disease
    M Gerlach
    Klinische Neurochemie, Universitätsklinik für Kinder und Jugendpsychiatrie und Psychotherapie, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    J Neurol 249:III/33-5. 2002
  7. ncbi request reprint [Current preclinical findings on substances against Parkinson's disease]
    M Gerlach
    Klinische Neurochemie, Universitatsklinik fur Psychiatrie und Psychotherapie, Wurzburg
    Nervenarzt 74:S2-6. 2003
  8. ncbi request reprint The relevance of preclinical studies for the treatment of Parkinson's disease
    M Gerlach
    Klinische Neurochemie, Universitätsklinik für Kinder und Jugendpsychiatrie und Psychotherapie, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    J Neurol 250:I31-4. 2003
  9. ncbi request reprint Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease
    Manfred Gerlach
    Clinical Neurochemistry, Department of Child and Youth Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, D 97080 Wurzburg, Germany
    Neurotox Res 5:35-44. 2003
  10. ncbi request reprint Dopamine receptor agonists in current clinical use: comparative dopamine receptor binding profiles defined in the human striatum
    M Gerlach
    Clinical Neurochemistry, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Neural Transm (Vienna) 110:1119-27. 2003

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson's disease
    M Gerlach
    Clinical Neurochemistry, Clinic for Child and Youth Psychiatry, Julius Maximilians University, Wurzburg, Germany
    J Neural Transm Suppl . 2003
    ..Preclinical approaches for demonstrating neuroprotective effects and their clinical relevance are also discussed...
  2. ncbi request reprint Strategies for the protection of dopaminergic neurons against neurotoxicity
    M Gerlach
    Division of Clinical Neurochemistry, Department of Psychiatry and Psychotherapy, University of Wurzburg, D 97980 Würzburg, Fuchsleinstrasse 15, Germany
    Neurotox Res 2:99-114. 2000
    ..The problems associated with carrying out clinical neuroprotective studies aimed to demonstrate neuroprotection in PD are also discussed...
  3. ncbi request reprint Potential sources of increased iron in the substantia nigra of parkinsonian patients
    M Gerlach
    Laboratory for Clinical Neurochemistry, Department of Child and Adolescence Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Neural Transm Suppl . 2006
    ..Additionally, upon neurodegeneration there is strong microglial activation which can be another source of high iron concentrations in the brain...
  4. ncbi request reprint The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats
    M Gerlach
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm (Vienna) 108:189-204. 2001
    ..We cannot, however, exclude the possibility that hydroxyl radicals are produced by tolcapone as a result of uncoupling mitochondrial oxidative phosphorylation...
  5. ncbi request reprint Different modes of action of catecholamine-O-methyltransferase inhibitors entacapone and tolcapone on adenylyl cyclase activity in vitro
    M Gerlach
    Clinical Neurochemistry, Department of Child and Youth Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm (Vienna) 109:789-95. 2002
    ..Entacapone enhanced the stimulatory effect of Gpp(NH)p/dopamine, whereas tolcapone attentuated this effect, suggesting that diarrhoea associated with tolcapone treatment is not caused by permanent activation of G(s) proteins...
  6. ncbi request reprint Current state of stem cell research for the treatment of Parkinson's disease
    M Gerlach
    Klinische Neurochemie, Universitätsklinik für Kinder und Jugendpsychiatrie und Psychotherapie, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    J Neurol 249:III/33-5. 2002
    ..The problem is controlling cell growth and differentiation. We will briefly review the current state of stem cell research and will critically discuss the potential of stem cells for the treatment of PD...
  7. ncbi request reprint [Current preclinical findings on substances against Parkinson's disease]
    M Gerlach
    Klinische Neurochemie, Universitatsklinik fur Psychiatrie und Psychotherapie, Wurzburg
    Nervenarzt 74:S2-6. 2003
    ..This article reviews new approaches for the treatment of PD and presents findings from our studies using a new experimental in vivo model of PD...
  8. ncbi request reprint The relevance of preclinical studies for the treatment of Parkinson's disease
    M Gerlach
    Klinische Neurochemie, Universitätsklinik für Kinder und Jugendpsychiatrie und Psychotherapie, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    J Neurol 250:I31-4. 2003
    ....
  9. ncbi request reprint Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease
    Manfred Gerlach
    Clinical Neurochemistry, Department of Child and Youth Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, D 97080 Wurzburg, Germany
    Neurotox Res 5:35-44. 2003
    ..The resultant radical-mediated cytotoxicity may contribute to cellular damage observed in PD...
  10. ncbi request reprint Dopamine receptor agonists in current clinical use: comparative dopamine receptor binding profiles defined in the human striatum
    M Gerlach
    Clinical Neurochemistry, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Neural Transm (Vienna) 110:1119-27. 2003
    ..97 nM). The present results thus support the hypothesis that the antiparkinsonian effect of dopamine receptor agonists is mediated by a more complex interactions with dopamine receptor subtypes than currently believed...
  11. ncbi request reprint Entacapone increases and prolongs the central effects of l-DOPA in the 6-hydroxydopamine-lesioned rat
    Manfred Gerlach
    Laboratory of Clinical Neurochemistry, Clinic for Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 370:388-94. 2004
    ....
  12. ncbi request reprint [Therapeutic drug monitoring in child and adolescent psychiatry--practical recommendations]
    Manfred Gerlach
    Klinik für Kinder und Jugendpsychiatrie und Psychotherapie der Universität Würzburg
    Z Kinder Jugendpsychiatr Psychother 34:5-13. 2006
    ..For a detailed treatment of TDM in psychiatry, the interested reader is referred to the AG-NP-TDM Expert Group Consensus Guidelines published earlier (Baumann et al., 2004)...
  13. ncbi request reprint [Therapy with lithium salts in child and adolescent psychiatry--clinical efficacy and practical recommendations]
    Manfred Gerlach
    Klinik für Kinder und Jugendpsychiatrie und Psychotherapie der Universität Würzburg
    Z Kinder Jugendpsychiatr Psychother 34:181-8; quiz 188-9. 2006
    ..5 mmol/l are dangerous. All potential side effects, with the exception of very infrequently occurring renal damage, are reversible by means of dose reduction or, if necessary, by discontinuation of medication with lithium...
  14. ncbi request reprint Therapeutic drug monitoring of quetiapine in adolescents with psychotic disorders
    M Gerlach
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Pharmacopsychiatry 40:72-6. 2007
    ....
  15. doi request reprint Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter
    Florian Palm
    Department of Neurology, University of Wurzburg, Neurologische Klinik der Universität, D 97080 Wurzburg, Germany
    Eur J Pain 12:790-7. 2008
    ..Human variants of the 5-HTT genotypes might be part of the factors determining the extent of nerve injury and hyperalgesia in inflammation...
  16. doi request reprint Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder
    Regina Taurines
    Hospital of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 12:104-8. 2011
    ....
  17. doi request reprint Effects of methylphenidate: the cellular point of view
    Jasmin Bartl
    Clinical Neurochemistry Laboratory, Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, University of Wurzburg, Germany
    Atten Defic Hyperact Disord 2:225-32. 2010
    ..These data point to diverse effects of MPH on cell metabolism independent of inhibiting DAT...
  18. pmc Human stiff-person syndrome IgG induces anxious behavior in rats
    Christian Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e16775. 2011
    ..Most patients have high-titer antibodies against glutamate decarboxylase (GAD) 65. The pathogenic role of these autoantibodies is unclear...
  19. doi request reprint A systematic review on olfaction in child and adolescent psychiatric disorders
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitatsstrasse 84, 93053, Regensburg, Germany
    J Neural Transm (Vienna) 120:121-30. 2013
    ..We further propose studies of thorough and elaborate methodological standards in combination with imaging techniques and the investigation of the influence of genetic variation on olfactory function...
  20. doi request reprint Biomarkers for attention-deficit/hyperactivity disorder (ADHD). A consensus report of the WFSBP task force on biological markers and the World Federation of ADHD
    Johannes Thome
    Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 13:379-400. 2012
    ..Thus, validated biomarkers, more directly linked to the underlying pathology, could constitute an objective measure for the condition...
  21. doi request reprint Neuromelanin-bound ferric iron as an experimental model of dopaminergic neurodegeneration in Parkinson's disease
    Manfred Gerlach
    University of Wurzburg, Department of Child and Adolescent Psychiatry and Psychotherapy, Laboratory for Clinical Neurobiology, Wurzburg, Germany
    Parkinsonism Relat Disord 14:S185-8. 2008
    ....
  22. ncbi request reprint Oxidative stress in the brain at early preclinical stages of mouse scrapie
    Seong Wook Yun
    Clinical Neurochemistry and NPF Center of Excellence Research Laboratories, Clinic of Psychiatry and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Exp Neurol 201:90-8. 2006
    ....
  23. doi request reprint No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapy
    Susanne Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080 Wuerzburg, Germany
    Toxicol Lett 184:38-43. 2009
    ..Furthermore, micronuclei were analyzed in a second tissue, buccal mucosa...
  24. doi request reprint Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia
    Regina Taurines
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Eur Child Adolesc Psychiatry 19:441-8. 2010
    ..Although further studies are necessary to test for the specificity of this marker, our findings point to the potential use of the mitochondrial complex I as a biomarker for schizophrenia...
  25. ncbi request reprint The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery
    Seong Wook Yun
    Institute of Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    J Neurovirol 13:328-37. 2007
    ..However, neither intraperitoneal nor intracerebroventricular delivery of the drug exerted any PrP(Sc) clearance effect in the CNS...
  26. doi request reprint The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms
    Manfred Gerlach
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm (Vienna) 120:31-6. 2013
    ..Clonidine blocked the effect of piribedil on AD, OD and FD. These data suggest a differential involvement of α(2) adrenergic receptors in the action of piribedil on different subclasses of L-DOPA-induced dyskinesias...
  27. ncbi request reprint The relevance of iron in the pathogenesis of Parkinson's disease
    Mario E Götz
    Department of Pharmacology and Toxicology, University of Wurzburg, Germany
    Ann N Y Acad Sci 1012:193-208. 2004
    ..There are indications that iron-mediated neuronal death in PD proceeds retrogradely. These results are also discussed with respect to their relevance for disease progression in relation to cytotoxic alpha-synuclein protofibril formation...
  28. doi request reprint Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy
    Niels Hansen
    Department of Neurology, University of Wurzburg, Josef Schneider Straße 11, 97080 Wurzburg, Germany
    Neurosci Lett 495:93-7. 2011
    ..Conversely, attenuation of mechanical allodynia in 5-HTT-/- mice may indicate reduced 5-HT-mediated facilitation in the central nervous system...
  29. pmc 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg 97080, Germany
    Mol Pain 7:21. 2011
    ..Previous work led to the hypothesis that 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, might by itself influence pain thresholds...
  30. pmc Biomarker candidates of neurodegeneration in Parkinson's disease for the evaluation of disease-modifying therapeutics
    Manfred Gerlach
    Department for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    J Neural Transm (Vienna) 119:39-52. 2012
    ..Almost all of the biomarker candidates were not investigated in relation to effects of treatment, validated in experimental models of PD and confirmed in independent studies...
  31. doi request reprint Role of dopamine D3 and serotonin 5-HT 1A receptors in L: -DOPA-induced dyskinesias and effects of sarizotan in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease
    Manfred Gerlach
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Laboratory for Clinical Neurobiology, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    J Neural Transm (Vienna) 118:1733-42. 2011
    ..This selective involvement is in contrast to the more general involvement of 5-HT(1A) receptors in the anti-dyskinetic effects of sarizotan...
  32. doi request reprint Flibanserin attenuates L: -DOPA-sensitized contraversive circling in the unilaterally 6-hydroxydopamine-lesioned rat model of Parkinson's disease
    Manfred Gerlach
    Laboratory for Clinical Neurobiology, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    J Neural Transm (Vienna) 118:1727-32. 2011
    ..The current preclinical findings further implicate the 5-HT(1A) receptor as a promising therapeutic target for the reduction of LID and predict a potential efficacy of flibanserin in the treatment of LID in PD...
  33. pmc Identification of L-ferritin in neuromelanin granules of the human substantia nigra: a targeted proteomics approach
    Florian Tribl
    Clinic and Polyclinic for Psychiatry and Psychotherapy, Julius Maximilians Universitat Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Mol Cell Proteomics 8:1832-8. 2009
    ..Thus our finding entails far reaching implications especially when considering etiopathogenetic aspects of Parkinson disease...
  34. doi request reprint Evaluation of the efficacy and effectiveness of a structured disorder tailored psychotherapy in ADHD in adults: study protocol of a randomized controlled multicentre trial
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Atten Defic Hyperact Disord 2:203-12. 2010
    ..The trial is funded by the German Federal Ministry of Research and Education (01GV0606) and is part of the German network for the treatment of ADHD in children and adults (ADHD-NET)...
  35. doi request reprint Oxytocin plasma concentrations in children and adolescents with autism spectrum disorder: correlation with autistic symptomatology
    Regina Taurines
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Füchsleinstraße 15, 97080, Wurzburg, Germany
    Atten Defic Hyperact Disord 6:231-9. 2014
    ....
  36. ncbi request reprint Comparison analysis of gene expression patterns between sporadic Alzheimer's and Parkinson's disease
    Edna Grunblatt
    Neurochemistry Laboratory, National Parkinson Foundation Centre of Excellence Laboratories, Clinic and Policlinic for Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Alzheimers Dis 12:291-311. 2007
    ..Knowledge of selective gene expression profile can lead to better understanding of disease pathology and development of specific diagnosis and effective therapy...
  37. pmc Neuromelanin is an immune stimulator for dendritic cells in vitro
    Uwe Oberländer
    University of Wurzburg, Institute of Virology and Immunobiology, Wurzburg, Germany
    BMC Neurosci 12:116. 2011
    ..This recognition of NM by DCs is a prerequisite to trigger an adaptive autoimmune response directed against NM-associated structures...
  38. doi request reprint Olfaction in child and adolescent anorexia nervosa
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University Regensburg, Universitätsstraße 84, 93053 Regensburg, Germany
    J Neural Transm (Vienna) 119:721-8. 2012
    ....
  39. doi request reprint Pharmacotherapy in depressed children and adolescents
    Regina Taurines
    Hospital of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 12:11-5. 2011
    ..In the following overview we address a general framework, therapeutic strategies and the issues of antidepressant pharmacotherapy for the treatment of unipolar depression in childhood and adolescence...
  40. ncbi request reprint Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease
    R Mossner
    Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
    Mol Psychiatry 6:350-2. 2001
    ..Thus, the 5HTTLPR but not the MAOA gene promoter-associated polymorphism may be a risk factor for depression in PD patients, while neither polymorphism increases the risk for development of Parkinson's disease itself...
  41. doi request reprint Relationship between clozapine dose, serum concentration, and clinical outcome in children and adolescents in clinical practice
    Christopher Wohkittel
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Wurzburg, Wurzburg, Germany
    J Neural Transm (Vienna) 123:1021-31. 2016
    ..However, regarding the limitations of this study results should be validated in larger studies with more standardized designs. ..
  42. doi request reprint Is the treatment with psychostimulants in children and adolescents with attention deficit hyperactivity disorder harmful for the dopaminergic system?
    Manfred Gerlach
    Department for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Atten Defic Hyperact Disord 5:71-81. 2013
    ....
  43. ncbi request reprint Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings
    Evelyn Braungart
    PIERIS Proteolab AG, Freising Weihenstephan, Wurzburg, Germany
    Neurodegener Dis 1:175-83. 2004
    ..elegans with a variety of pharmacologically active components used in PD treatment reduced the MPP+-induced defects. Our data suggest that the C. elegans MPTP/MPP+ model can be used for the quantitative evaluation of anti-PD drugs...
  44. ncbi request reprint beta-Amyloid deposition and prion infection in adult primary brain cell long-term culture model
    Seong Wook Yun
    Clinical Neurochemistry and NPF Center of Excellence Laboratories, Clinic of Psychiatry and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Biochem Biophys Res Commun 360:520-4. 2007
    ..After long-term culture of adult primary brain cells prepared from Alzheimer's disease and prion disease mouse models, we observed beta-amyloid deposition and prion infection in primary cell cultures in vitro...
  45. ncbi request reprint Relating mode of action to clinical practice: dopaminergic agents in Parkinson's disease
    Peter Riederer
    Klinische Neurochemie Universitätsklinik für Psychiatrie und Psychotherapie, Wurzburg, Germany
    Parkinsonism Relat Disord 13:466-79. 2007
    ..This article reviews the three main classes of dopaminergic PD therapy (levodopa, monoamine oxidase inhibitors and dopamine agonists)...
  46. ncbi request reprint Dopaminergic dysbalance in distinct basal ganglia neurocircuits: implications for the pathophysiology of Parkinson's disease, schizophrenia and attention deficit hyperactivity disorder
    C Mehler-Wex
    Department of Child and Adolescent Psychiatry and Psychotherapy, Julius Maximilians University, Wuerzburg, Germany
    Neurotox Res 10:167-79. 2006
    ..Finally, imaging studies demonstrated an increased density of DAT in the striatum of ADHD patients. Which system is disturbed and whether this system is hyper- or hypoactive is not unambiguously known yet...
  47. ncbi request reprint Differential effects of human neuromelanin and synthetic dopamine melanin on neuronal and glial cells
    Jie Li
    Clinical Neurochemistry and National Parkinson Foundation Center of Excellence Laboratories, Clinic and Policlinic for Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neurochem 95:599-608. 2005
    ..Our findings provide new evidence for a physiological role for neuromelanin in vivo and highlights the caution with which data based upon model systems should be interpreted...
  48. ncbi request reprint Unaltered susceptibility to scrapie in serotonin transporter deficient mice
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Neurochem Int 49:454-8. 2006
    ..These findings argue against a major role of the 5-HTT in the pathogenesis of prion diseases in mice...
  49. ncbi request reprint Preclinical versus clinical neuroprotection
    Edna Grunblatt
    Department of Neurochemistry, Clinic and Polyclinic of Psychiatry and Psychotherapy, Bayerische Julius Maximilians University of Würzburg, Wurzburg, Germany
    Adv Neurol 91:309-28. 2003
  50. doi request reprint Decreased anxiety in mice lacking the organic cation transporter 3
    Thomas Wultsch
    Section of Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm (Vienna) 116:689-97. 2009
    ....
  51. ncbi request reprint Increased mRNA levels of the mitochondrial complex I 75-kDa subunit. A potential peripheral marker of early onset schizophrenia?
    Claudia Mehler-Wex
    Dept of Child and Adolescent Psychiatry, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Child Adolesc Psychiatry 15:504-7. 2006
    ..Our preliminary findings suggest the mitochondrial complex I as a potential peripheral marker of schizophrenia and its involvement in the pathophysiology of this illness...
  52. doi request reprint Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system
    Susanne Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm (Vienna) 115:1071-8. 2008
    ..No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group...
  53. doi request reprint [The impact of attention deficit/hyperactivity disorder (ADHD) in mothers on the treatment of their ADHD children--review and summary of the study protocol of a randomized controlled multi-centre trial on parent training]
    Thomas Jans
    Klinik und Poliklinik für Kinder und Jugendpsychiatrie, Psychosomatik und Psychotherapie des Klinikums der Universität Würzburg, Fuchsleinstrasse 15, Wurzburg
    Z Kinder Jugendpsychiatr Psychother 36:335-43. 2008
    ..Treatment comparisons of the primary endpoint (externalizing symptoms in the children) will be performed within a linear regression model...
  54. doi request reprint Altered frontal and temporal brain function during olfactory stimulation in adult attention-deficit/hyperactivity disorder
    Martin Schecklmann
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wurzburg, University of Wurzburg, Wurzburg, Germany
    Neuropsychobiology 63:66-76. 2011
    ..Some investigations suggested alterations in olfactory processing (identification and sensitivity) in childhood and adult ADHD...
  55. ncbi request reprint Biochemical and pharmacological characterization of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline: a biologically relevant neurotoxin?
    Peter Riederer
    Clinical Neurochemistry, Department of Psychiatry, University of Wurzburg, Fuchsleinstrasse 15, Wurzburg, Germany
    Eur J Pharmacol 442:1-16. 2002
    ..The biochemical and pharmacological characteristics of TaClo and related compounds are thus reviewed here, and their potential significance for human neurodegenerative disease discussed...
  56. ncbi request reprint "Subcellular proteomics" of neuromelanin granules isolated from the human brain
    Florian Tribl
    Department of Clinical Neurochemistry, Clinic and Polyclinic for Psychiatry and Psychotherapy, and The National Parkinson Foundation Research Laboratories, Miami, Florida, USA
    Mol Cell Proteomics 4:945-57. 2005
    ....
  57. doi request reprint Improved odor sensitivity in attention-deficit/hyperactivity disorder
    Marcel Romanos
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinic of Wuerzburg, Wuerzburg, Germany
    Biol Psychiatry 64:938-40. 2008
    ..Because of the involvement of the dopamine system in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), olfactory function was investigated in children with the disorder...
  58. pmc Drug monitoring in child and adolescent psychiatry for improved efficacy and safety of psychopharmacotherapy
    Claudia Mehler-Wex
    Department of Child and Adolescent Psychiatry Psychotherapy, University of Ulm, Ulm, Germany
    Child Adolesc Psychiatry Ment Health 3:14. 2009
    ....
  59. doi request reprint Association of attention-deficit/hyperactivity disorder and atopic eczema modified by sleep disturbance in a large population-based sample
    Marcel Romanos
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinic of Wuerzburg, Fuechsleinstr 15, 97080 Wuerzburg, Germany
    J Epidemiol Community Health 64:269-73. 2010
    ....
  60. pmc Structural abnormality of the substantia nigra in children with attention-deficit hyperactivity disorder
    Marcel Romanos
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wuerzburg, Wuerzburg, Germany
    J Psychiatry Neurosci 35:55-8. 2010
    ..We investigated echogenicity of the substantia nigra as a potential structural marker for dysfunction of the nigrostriatal dopamine system in children with attention-deficit hyperactivity disorder (ADHD)...
  61. doi request reprint Genotoxicity of the neurotransmitter dopamine in vitro
    Helga Stopper
    Department of Toxicology, University of Wuerzburg, Versbacher Strasse 9, D 97078 Wuerzburg, Germany
    Toxicol In Vitro 23:640-6. 2009
    ....
  62. doi request reprint Does the treatment of maternal attention deficit and hyperactivity disorder (ADHD) enhance the efficacy of a behavioural parent training for the treatment of their children's ADHD? Study protocol of a randomized controlled multicentre trail
    Thomas Jans
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Wuerzburg, Germany
    Atten Defic Hyperact Disord 1:33-45. 2009
    ..Intention-to-treat analysis will be performed within a linear regression model (Current Controlled Trials ISRCTN73911400)...
  63. ncbi request reprint Amino acid specificity of glycation and protein-AGE crosslinking reactivities determined with a dipeptide SPOT library
    G Munch
    Department of Physiological Chemistry I, University of Wurzburg, Wurzburg, Germany
    Nat Biotechnol 17:1006-10. 1999
    ..Dipeptide SPOT libraries are excellent tools for comparing individual reactivities of amino acids for nonenzymatic modifications, and could be extended to other chemically reactive molecules...
  64. ncbi request reprint Chronic alcohol consumption and cerebral indices of oxidative stress: is there a link?
    M E Götz
    Departments of Psychiatry, Pharmacology and Toxicology, University of Wurzburg, Germany
    Alcohol Clin Exp Res 25:717-25. 2001
    ..It is still difficult to define the biochemical mechanisms that cause alterations in neuronal function and plasticity and neuronal cell loss in the brains of alcohol-dependent patients...
  65. ncbi request reprint Brain iron pathways and their relevance to Parkinson's disease
    D Berg
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Germany
    J Neurochem 79:225-36. 2001
    ..Because many neurodegenerative diseases show increased accumulation of iron at the site of neurodegeneration, it is believed that maintenance of cellular iron homeostasis is crucial for the viability of neurons...
  66. ncbi request reprint Increased hippocampal DNA oxidation in serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm (Vienna) 109:557-65. 2002
    ..Given the importance of the hippocampus in learning and memory, this may be the most important neurochemical consequence of the absence of the 5HTT...
  67. ncbi request reprint Quantitation of 5HT3 receptors in forebrain of serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    J Neural Transm (Vienna) 111:27-35. 2004
    ..The adaptive changes of 5HT3 receptor expression constitute a part of the complex regulatory pattern of 5HT receptors in 5HTT knockout mice...
  68. ncbi request reprint Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway
    S Walitza
    Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
    J Neural Transm (Vienna) 111:817-25. 2004
    ..We did not detect transmission disequilibrium of the investigated polymorphisms in OCD. Hence, these polymorphisms do not play a major role in the genetic predisposition to early onset OCD...
  69. ncbi request reprint Microarray analysis reveals distinct gene expression patterns in the mouse cortex following chronic neuroleptic and stimulant treatment: implications for body weight changes
    C Mehler-Wex
    Department of Child and Adolescent Psychiatry, University of Wurzburg, Germany
    J Neural Transm (Vienna) 113:1383-93. 2006
    ..g. insulin, mitochondrial uncoupling protein 1) that are implicated in the control of food intake and are differently expressed in the neuroleptic groups...
  70. ncbi request reprint Subcellular proteomics reveals neuromelanin granules to be a lysosome-related organelle
    F Tribl
    National Parkinson Foundation NPF Research Laboratory, Miami, FL, USA
    J Neural Transm (Vienna) 113:741-9. 2006
    ..Thereby, NM granules could be described as a 'lysosome-related organelle'. This indicates a genetic program underlying a biogenesis of NM rather than its autoxidative formation...
  71. ncbi request reprint Brief review of available evidence concerning the potential induction of genomic damage by methylphenidate
    H Stopper
    Department of Toxicology, University of Wuerzburg, Wuerzburg, Germany
    J Neural Transm (Vienna) 115:331-4. 2008
    ..In conclusion, changes in treatment strategies do not seem justified currently. Larger studies are under way and will hopefully eliminate any remaining doubt about potential genotoxic or carcinogenic consequences of MPH treatment...
  72. doi request reprint Allelic variants of SNAP25 in a family-based sample of ADHD
    T J Renner
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm (Vienna) 115:317-21. 2008
    ..In our German ADHD sample no preferential transmission of either variant could be observed. Further investigation considering sub-sample analysis regarding response to D-amphetamine could enlight the role of SNAP25 in ADHD...
  73. doi request reprint [Neurobiology of attention-deficit hyperactivity disorder]
    T J Renner
    Klinik und Poliklinik für Kinder und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Universitat Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg
    Nervenarzt 79:771-81. 2008
    ....
  74. doi request reprint Genomic aspects of sporadic Parkinson's disease
    P Riederer
    Institute of Clinical Neurochemistry, Clinic and Policlinic for Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, Wurzburg, Germany
    Parkinsonism Relat Disord 14:S88-91. 2008
    ..In this article, we discuss recent findings of gene expression in PD that may elucidate the usage of specific new biomarkers for sporadic PD and point to novel drug developments...
  75. doi request reprint Serum concentrations, therapeutic response and side effects in children and adolescents with impulsive-aggressive symptoms during risperidone therapy
    K Klampfl
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Pharmacopsychiatry 43:58-65. 2010
    ....
  76. ncbi request reprint Therapeutic drug monitoring as a measure of proactive pharmacovigilance in child and adolescent psychiatry
    Manfred Gerlach
    a Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Wurzburg, Wurzburg, Germany
    Expert Opin Drug Saf 15:1477-1482. 2016
    ..This approach could minimize the risk of exposing paediatric patients to ineffective treatments of uncertain or unknown risks...
  77. ncbi request reprint Postnatal brain development and psychotropic drugs. Effects on animals and animal models of depression and attention-deficit/hyperactivity disorder
    Nathalie Bock
    University of Goettingen, Germany, Department of Child and Adolescent Psychiatry, Von Siebold Str 5, 37075 Goettingen, Germany
    Curr Pharm Des 16:2474-83. 2010
    ....
  78. ncbi request reprint 5-HT2A promoter polymorphism -1438G/A in children and adolescents with obsessive-compulsive disorders
    S Walitza
    Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
    Mol Psychiatry 7:1054-7. 2002
    ..05) between individuals with OCD and controls. In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD...
  79. doi request reprint Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Brain 133:3166-80. 2010
    ....
  80. pmc Does methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder?
    Susanne Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Environ Health Perspect 115:936-40. 2007
    ..Assessment and treatment of patients were performed during inpatient or outpatient health care. The measure for genomic damage was the frequency of micronuclei, a subset of chromosomal aberrations, in peripheral lymphocytes...
  81. ncbi request reprint Expression, but not activity, of neuronal nitric oxide synthase is regionally increased in the alcoholic brain
    M Gerlach
    Division of Clinical Neurochemistry and Drug Dependence Unit, University Hospital for Psychiatry, , , Germany
    Alcohol Alcohol 36:65-9. 2001
    ....
  82. ncbi request reprint A highly sensitive method for the determination of protein bound 3,4-dihydroxyphenylalanine as a marker for post-translational protein hydroxylation in human tissues ex vivo
    R Harth
    University Clinic and Policlinic for Psychiatry and Psychotherapy, Clinical Neurochemistry, , Germany
    Free Radic Res 35:167-74. 2001
    ....
  83. ncbi request reprint Dopamine receptor agonists in the therapy of Parkinson's disease
    P Foley
    Clinical Neurochemistry, Clinic for Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Neural Transm 111:1375-446. 2004
    ....
  84. ncbi request reprint Absence of thermal hyperalgesia in serotonin transporter-deficient mice
    Carola Vogel
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 23:708-15. 2003
    ..In contrast, bilateral mechanical allodynia, a centrally mediated phenomenon, was associated with decreased spinal 5-HT concentrations in 5-HTT-/- mice and may possibly be caused by a lack of spinal inhibition...
  85. ncbi request reprint Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury
    Daniela Berg
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Arch Neurol 59:999-1005. 2002
    ..The same echo feature of the SN can be identified in 9% of healthy adults...
  86. ncbi request reprint Selegiline completely restores choline acetyltransferase activity deficits in simian immunodeficiency infection
    E Koutsilieri
    Clinical Neurochemistry, Department of Psychiatry, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Eur J Pharmacol 411:R1-R2. 2001
    ..We report now that selegiline, completely restores the reduced choline acetyltransferase activity which encourages for a meaningful anti-dementia therapeutic strategy...
  87. ncbi request reprint Iron-binding characteristics of neuromelanin of the human substantia nigra
    Kay L Double
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Biochem Pharmacol 66:489-94. 2003
    ..The interaction between NM and iron has implications for disorders such as Parkinson's disease where an increase in iron in the SN is associated with increased indices of oxidative stress...
  88. ncbi request reprint New developments in diagnosis and treatment of Parkinson's disease--from basic science to clinical applications
    Alexander Storch
    Technical University of Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany
    J Neurol 251:VI/33-8. 2004
    ..Furthermore, we discuss the major problems in the translation of results from preclinical research into successful clinical trials...
  89. ncbi request reprint Dolichol is the major lipid component of human substantia nigra neuromelanin
    Heidi Fedorow
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
    J Neurochem 92:990-5. 2005
    ..Furthermore, these studies identify a potential novel role for the isoprenoid pathway in the regulation of neuromelanin function and neurodegeneration within the SN...
  90. ncbi request reprint Levodopa in the treatment of Parkinson's disease: current controversies
    Manfred Gerlach
    Mov Disord 20:643; author reply 643-4. 2005
  91. ncbi request reprint In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage
    Luigi Zecca
    Institute of Biomedical Technologies CNR, Segrate Milano, Italy
    Mov Disord 20:1278-85. 2005
    ....
  92. ncbi request reprint ["Therapeutic drug monitoring", a strategy for improving drug safety in child and adolescent psychiatry and psychotherapy]
    Manfred Gerlach
    Z Kinder Jugendpsychiatr Psychother 33:157-8. 2005
  93. ncbi request reprint Multipotent neural stem cells from the adult tegmentum with dopaminergic potential develop essential properties of functional neurons
    Andreas Hermann
    Department of Neurology, University of Ulm, Germany
    Stem Cells 24:949-64. 2006
    ..Here, we demonstrate the existence of adult tNSCs with functional neurogenic and dopaminergic potential, a prerequisite for future endogenous cell replacement strategies in Parkinson's disease...
  94. ncbi request reprint Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cells
    Andreas Hermann
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    J Neurochem 98:629-40. 2006
    ..Our findings reinforce the emerging view that the differentiation capacity of adult hNPCs is critically influenced by non-neuronal mesodermal feeder cells...
  95. ncbi request reprint Brain dopamine and kinematics of graphomotor functions
    Klaus W Lange
    Department of Experimental Psychology, University of Regensburg, 93040 Regensburg, Germany
    Hum Mov Sci 25:492-509. 2006
    ..Central dopamine appears to be of particular importance with regard to the automatic execution of well-learned movements...
  96. ncbi request reprint Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling
    Javorina Milosevic
    Department of Neurology, University of Leipzig, 04103 Leipzig, Germany
    J Neurosci 27:412-21. 2007
    ..In conclusion, HIF-1alpha seems to be a transcription factor relevant to the development and survival of substantia nigra dopaminergic neurons involving VEGF signaling...
  97. ncbi request reprint Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder
    Andreas Lazar
    Department of Pharmacology, University of Cologne, Cologne, Germany
    Int J Neuropsychopharmacol 11:35-48. 2008
    ..Heterologous expression of mutant cDNA revealed a 40% decline of transport capacity for norepinephrine. Rare mutations in the EMT gene suggest a causative or modulating role in genetic subtypes of OCD...
  98. ncbi request reprint Glia protects neurons against extracellular human neuromelanin
    Candan Depboylu
    Experimental Neurology, Department of Neurology, Philipps University Marburg, Marburg, Germany
    Neurodegener Dis 4:218-26. 2007
    ....
  99. ncbi request reprint Neuroprotective strategies in Parkinson's disease : an update on progress
    Silvia Mandel
    Department of Pharmacology, Technion Faculty of Medicine, Eve Topf and US National Parkinson s Foundation Centers for Neurodegenerative Diseases, Bruce Rappaport Family Research Institute, Haifa, Israel
    CNS Drugs 17:729-62. 2003
    ..Even with the advent of powerful new tools such as genomics, proteomics, brain imaging, gene replacement therapy and knockout animal models, the desired end result of neuroprotection is still beyond our current capability...
  100. ncbi request reprint Neurorestoration in Parkinson's disease by cell replacement and endogenous regeneration
    Andreas Hermann
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Expert Opin Biol Ther 4:131-43. 2004
    ..However, one major problem is the control of growth and differentiation of these cells. This review discusses new data on stem cell technology in cell replacement strategies in PD as well as endogenous dopaminergic regeneration...
  101. ncbi request reprint GC/MS analysis of thermally degraded neuromelanin from the human substantia nigra
    Anna Dzierzega-Lecznar
    Department of Instrumental Analysis, Faculty of Pharmacy, Medical University of Silesia, Katowice, Poland
    J Am Soc Mass Spectrom 15:920-6. 2004
    ..The nigral pigment was also shown to be tightly associated with an isoprenoid-type compound...