Christian Geis

Summary

Country: Germany

Publications

  1. doi request reprint Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg, Germany
    J Neural Transm (Vienna) 119:981-5. 2012
  2. doi request reprint Stiff person syndrome associated anti-amphiphysin antibodies reduce GABA associated [Ca(2+)]i rise in embryonic motoneurons
    C Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Neurobiol Dis 36:191-9. 2009
  3. doi request reprint Lacosamide has protective disease modifying properties in experimental vincristine neuropathy
    Christian Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Neuropharmacology 61:600-7. 2011
  4. pmc Human stiff-person syndrome IgG induces anxious behavior in rats
    Christian Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e16775. 2011
  5. doi request reprint Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Brain 133:3166-80. 2010
  6. doi request reprint Human Stiff person syndrome IgG-containing high-titer anti-GAD65 autoantibodies induce motor dysfunction in rats
    Niels Hansen
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Exp Neurol 239:202-9. 2013
  7. doi request reprint Mild experimental autoimmune encephalitis as a tool to induce blood-brain barrier dysfunction
    Michael K Boettger
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    J Neural Transm (Vienna) 117:165-9. 2010
  8. doi request reprint Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation
    Eva Göb
    Department of Neurology, University Hospital Wurzburg, Wurzburg
    Ann Neurol 77:784-803. 2015
  9. ncbi request reprint Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat
    M Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Neurosci Lett 347:179-82. 2003
  10. doi request reprint Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro
    M Schäfers
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    Neuroscience 157:414-23. 2008

Collaborators

Detail Information

Publications22

  1. doi request reprint Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg, Germany
    J Neural Transm (Vienna) 119:981-5. 2012
    ..We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways...
  2. doi request reprint Stiff person syndrome associated anti-amphiphysin antibodies reduce GABA associated [Ca(2+)]i rise in embryonic motoneurons
    C Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Neurobiol Dis 36:191-9. 2009
    ..Thus, anti-amphiphysin antibodies exert a direct effect on GABA signaling, which is likely to contribute to the pathogenesis of SPS...
  3. doi request reprint Lacosamide has protective disease modifying properties in experimental vincristine neuropathy
    Christian Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Neuropharmacology 61:600-7. 2011
    ..Lacosamide may be a promising candidate for preventive treatment of CIPN in patients receiving chemotherapy with vinca alkaloids or platinum drugs...
  4. pmc Human stiff-person syndrome IgG induces anxious behavior in rats
    Christian Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e16775. 2011
    ..Most patients have high-titer antibodies against glutamate decarboxylase (GAD) 65. The pathogenic role of these autoantibodies is unclear...
  5. doi request reprint Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Brain 133:3166-80. 2010
    ....
  6. doi request reprint Human Stiff person syndrome IgG-containing high-titer anti-GAD65 autoantibodies induce motor dysfunction in rats
    Niels Hansen
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Exp Neurol 239:202-9. 2013
    ..GABAergic dysfunction in supraspinal motor pathways rather than in the spinal cord may lead to motor deficits observed in the rats contrasting observations made in SPS with amphiphysin antibodies...
  7. doi request reprint Mild experimental autoimmune encephalitis as a tool to induce blood-brain barrier dysfunction
    Michael K Boettger
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    J Neural Transm (Vienna) 117:165-9. 2010
    ..We show that large molecules can readily penetrate the BBB between days 3 and 7 after EAE-induction. This model may be valuable for studying putative pathogenic effects of immunoglobulins in the central nervous system...
  8. doi request reprint Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation
    Eva Göb
    Department of Neurology, University Hospital Wurzburg, Wurzburg
    Ann Neurol 77:784-803. 2015
    ..In addition, PK can activate coagulation factor XII, the origin of the intrinsic coagulation cascade. Thus, PK triggers 2 important pathological pathways of stroke formation, thrombosis and inflammation...
  9. ncbi request reprint Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat
    M Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Neurosci Lett 347:179-82. 2003
    ..TNFR upregulation in injured and adjacent uninjured DRG neurons may be essential for mediating enhanced TNF effects and thus contribute to the development of pain-related behavior...
  10. doi request reprint Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro
    M Schäfers
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    Neuroscience 157:414-23. 2008
    ..Importantly, the effects of individually applied R1 and R2 on injured and adjacent uninjured fibers imply that the role of TNFR2 in the excitation of sensory neurons increases after injury...
  11. ncbi request reprint Questionnaire on neuropathic pain: a European neurologist survey
    C Sommer
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080, Wurzburg, Germany
    Neurol Sci 28:136-41. 2007
    ..Antiepileptic and antidepressant drugs were by far the drug classes most used (73%), with 2/3 of the patients reaching at least moderate pain relief...
  12. doi request reprint Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition
    Christian Werner
    1 Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany 2 Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Brain 139:365-79. 2016
    ....
  13. pmc Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells
    Nils Offen
    Department of Neurosurgery, University of Wurzburg, Wurzburg, Germany
    Mol Med 19:399-408. 2013
    ..In differentiating cultures EPO facilitated neurodifferentiation as assessed by the increased number of β-III-tubulin positive neurons. Our results show that EPO inhibits iPS pNPC self-renewal and promotes neurogenesis. ..
  14. pmc Functional neuronal cells generated by human parthenogenetic stem cells
    Ruhel Ahmad
    Institute for Medical Radiation and Cell Research in the Center for Experimental Molecular Medicine, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 7:e42800. 2012
    ..Thus, hpESCs can serve as a model to study the role of maternal and paternal genomes in neural development and to better understand imprinting-associated brain diseases...
  15. pmc The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model
    Christian Geis
    Department of Neurology and Clinical Research Group for Multiple Sclerosis and Neuroimmunology, University of Wurzburg, 97080 Wurzburg, Germany Hans Berger Department of Neurology, Jena University Hospital, 07747 Jena, Germany The Integrated Research and Treatment Center for Sepsis Control and Care CSCC, Jena University Hospital, 07747 Jena, Germany Electronic address
    Exp Neurol 265:8-21. 2015
    ..These findings may be the experimental correlate of "penumbra-like" lesions recently reported in NMO patients adjacent to effector-mediated tissue damage. ..
  16. doi request reprint Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway
    Yong Chen
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 28:5836-45. 2008
    ..Thus, blocking TRPV1 might be a way to reduce morphine tolerance...
  17. pmc Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration
    Christoph Kleinschnitz
    Neurologische Klinik und Poliklinik, Universitat Wurzburg, Wurzburg, Germany
    PLoS Biol 8:. 2010
    ..NOX4 therefore represents a major source of oxidative stress and novel class of drug target for stroke therapy...
  18. pmc Acute tetraparesis secondary to bilateral precentral gyral cerebral ischemia: a case report
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Str, 11, Wuerzburg 97080, Germany
    J Med Case Rep 7:61. 2013
    ..Sudden tetraparesis represents a neurological emergency and is most often caused by traumatic spinal cord injury, spinal epidural bleeding or brainstem ischemia and less frequently by medial disc herniation or spinal ischemia...
  19. pmc Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation
    Friederike Langhauser
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Blood 120:4082-92. 2012
    ..Because KNG appears to be instrumental in pathologic thrombus formation and inflammation but dispensable for hemostasis, KNG inhibition may offer a selective and safe strategy for combating stroke and other thromboembolic diseases...
  20. pmc Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients
    Sven Jarius
    Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany
    J Neuroinflammation 9:14. 2012
    ..However, little is known so far about the clinical impact of AQP4-Ab seropositivity...
  21. ncbi request reprint Influence of female sex and fertile age on neuromyelitis optica spectrum disorders
    Nadja Borisow
    NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charite University Medicine Berlin, Berlin, Germany
    Mult Scler . 2016
    ..Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases...
  22. doi request reprint Enhanced spinal neuronal responses as a mechanism for the increased nociceptive sensitivity of interleukin-4 deficient mice
    Sören Lemmer
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 271:198-204. 2015
    ..An enhanced excitability in the first segment of the nociceptive pathway may contribute to the increased behavioral responsiveness to painful stimuli of young IL-4 ko mice...