Alois Fürstner

Summary

Country: Germany

Publications

  1. ncbi request reprint Flexible synthesis of phenanthrenes by a PtCl(2)-catalyzed cycloisomerization reaction
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Org Chem 67:6264-7. 2002
  2. ncbi request reprint Stereoselective synthesis of enamides by a Peterson reaction manifold
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Org Lett 3:3955-7. 2001
  3. ncbi request reprint Ruthenium carbene complexes with N,N'-bis(mesityl)imidazol-2-ylidene ligands: RCM catalysts of extended scope
    - Furstner
    Max Planck Institut fur Kohlenforschung, Mulheim Ruhr, Germany
    J Org Chem 65:2204-7. 2000
  4. ncbi request reprint A "hard/soft" mismatch enables catalytic Friedel-Crafts acylations
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Org Lett 3:417-20. 2001
  5. ncbi request reprint Comparative investigation of ruthenium-based metathesis catalysts bearing N-heterocyclic carbene (NHC) ligands
    A Fürstner
    Max Planck Institut fur Kohlenforschung, Mulheim Ruhr, Germany
    Chemistry 7:3236-53. 2001
  6. ncbi request reprint Platinum-catalyzed cycloisomerization reactions of enynes
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 123:11863-9. 2001
  7. ncbi request reprint Alkyne metathesis: development of a novel molybdenum-based catalyst system and its application to the total synthesis of epothilone A and C
    A Fürstner
    Max Planck Institut fur Kohlenforschung, Mulheim Ruhr, Germany
    Chemistry 7:5299-317. 2001
  8. ncbi request reprint Preparation, structure and catalytic properties of a binuclear Pd(0) complex with bridging silylene ligands
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2001
  9. ncbi request reprint A chemo- and stereoselective reduction of cycloalkynes to (E)-cycloalkenes
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2002
  10. ncbi request reprint Carene terpenoids by gold-catalyzed cycloisomerization reactions
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2004

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Flexible synthesis of phenanthrenes by a PtCl(2)-catalyzed cycloisomerization reaction
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Org Chem 67:6264-7. 2002
    ..Moreover, the reaction is readily applied to the heterocyclic series as exemplified by the preparation of benzoindoles, naphthothiophenes as well as bridgehead nitrogen heterocycles...
  2. ncbi request reprint Stereoselective synthesis of enamides by a Peterson reaction manifold
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Org Lett 3:3955-7. 2001
    ..This method is distinguished by its wide applicability and stereoselective course. [reaction: see text]..
  3. ncbi request reprint Ruthenium carbene complexes with N,N'-bis(mesityl)imidazol-2-ylidene ligands: RCM catalysts of extended scope
    - Furstner
    Max Planck Institut fur Kohlenforschung, Mulheim Ruhr, Germany
    J Org Chem 65:2204-7. 2000
    ....
  4. ncbi request reprint A "hard/soft" mismatch enables catalytic Friedel-Crafts acylations
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Org Lett 3:417-20. 2001
    ..The nature of the catalytically relevant species formed from (PhCN)2PtCl2 and AgSbF6 and their interactions with the substrates are studied by NMR and ESI-MS...
  5. ncbi request reprint Comparative investigation of ruthenium-based metathesis catalysts bearing N-heterocyclic carbene (NHC) ligands
    A Fürstner
    Max Planck Institut fur Kohlenforschung, Mulheim Ruhr, Germany
    Chemistry 7:3236-53. 2001
    ..The search for the most reactive catalyst for a specific transformation is facilitated by IR thermography allowing a rapid and semi-quantitative ranking among a given set of catalysts...
  6. ncbi request reprint Platinum-catalyzed cycloisomerization reactions of enynes
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 123:11863-9. 2001
    ....
  7. ncbi request reprint Alkyne metathesis: development of a novel molybdenum-based catalyst system and its application to the total synthesis of epothilone A and C
    A Fürstner
    Max Planck Institut fur Kohlenforschung, Mulheim Ruhr, Germany
    Chemistry 7:5299-317. 2001
    ..Since this strategy opens a stereoselective entry into (Z)-alkene 115, the approach is inherently more efficient than previous syntheses based on conventional RCM...
  8. ncbi request reprint Preparation, structure and catalytic properties of a binuclear Pd(0) complex with bridging silylene ligands
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2001
    ..In contrast to the N-heterocyclic carbene (NHC) 1, the homologous N-heterocyclic silylene (NHS) 4 acts as a bridging ligand to Pd(0), giving rise to the dinuclear complex 5 which is catalytically active in Suzuki reactions...
  9. ncbi request reprint A chemo- and stereoselective reduction of cycloalkynes to (E)-cycloalkenes
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2002
    ....
  10. ncbi request reprint Carene terpenoids by gold-catalyzed cycloisomerization reactions
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2004
    ..Propargyl acetates in the presence of catalytic amounts of AuCl3 constitute synthetic equivalents of alpha-diazoketones as illustrated by a concise entry into the carene family of natural products...
  11. ncbi request reprint Alkyne metathesis
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2005
    ..This review discusses the emergence of alkyne metathesis as a valuable synthetic tool applicable in the synthesis of complex molecules and polymer science...
  12. ncbi request reprint Cyclobutenes by platinum-catalyzed cycloisomerization reactions of enynes
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 127:8244-5. 2005
    ....
  13. ncbi request reprint Heterocycles by PtCl2-catalyzed intramolecular carboalkoxylation or carboamination of alkynes
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 127:15024-5. 2005
    ..A mechanistic rationale is proposed, implying activation of the alkyne by the carbophilic Pt(2+) template as the primary step of the catalytic cycle...
  14. ncbi request reprint Total synthesis of aspercyclide C
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470, Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2005
    ..The first total synthesis of (+)-aspercyclide C (1) is reported using a kinetically controlled RCM reaction to form the 11-membered, unsaturated lactone ring of this bioactive diaryl ether macrolide...
  15. ncbi request reprint PtCl2-catalyzed rearrangement of methylenecyclopropanes
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 128:6306-7. 2006
    ....
  16. ncbi request reprint Convenient, scalable and flexible method for the preparation of imidazolium salts with previously inaccessible substitution patterns
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470, Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2006
    ..A high yielding and modular approach to N,N'-disubstituted imidazolium salts is described, providing access to substitution patterns that are beyond the reach of established methodology...
  17. ncbi request reprint Catalytic carbophilic activation: catalysis by platinum and gold pi acids
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Angew Chem Int Ed Engl 46:3410-49. 2007
    ..The application of platinum- and gold-catalyzed transformations in natural product synthesis is also discussed...
  18. ncbi request reprint Toward the total synthesis of spirastrellolide A. Part 3: intelligence gathering and preparation of a ring-expanded analogue
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470, Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2007
    ..Different methods for the formation of the C.25-C.26 bond of spirastrellolide A () are evaluated that might qualify for the end game of the projected total synthesis, with emphasis on metathetic ways to forge the macrocyclic frame...
  19. doi request reprint Formal total synthesis of (-)-haouamine A
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470, Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2008
    ..A largely catalysis based approach to optically active haouamine A (-)-1 is presented, which provides the hexacyclic compound previously used to construct this cytotoxic marine alkaloid...
  20. doi request reprint From oblivion into the limelight: iron (domino) catalysis
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Angew Chem Int Ed Engl 48:1364-7. 2009
    ....
  21. ncbi request reprint Ring-closing alkyne metathesis. Application to the total synthesis of sophorolipid lactone
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Org Chem 65:8758-62. 2000
    ..The two beta-glycosidic linkages of compound 21 were installed by means of the glucal epoxide method and a modified Koenigs-Knorr reaction promoted by AgOTf/lutidine, respectively...
  22. ncbi request reprint Alkyne cross metathesis reactions of extended scope
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Org Lett 3:221-3. 2001
    ..An application to the synthesis of prostaglandin E2 (PGE2) 19 and the acetylated PGE derivative 18b shows the compatibility of this method with sensitive substrates...
  23. ncbi request reprint Indenylidene complexes of ruthenium: optimized synthesis, structure elucidation, and performance as catalysts for olefin metathesis--application to the synthesis of the ADE-ring system of nakadomarin A
    A Fürstner
    Max Planck Institut fur Kohlenforschung, Mulheim Ruhr, Germany
    Chemistry 7:4811-20. 2001
    ....
  24. ncbi request reprint Microwave-assisted synthesis of pinacol boronates from aryl chlorides catalyzed by a palladium/imidazolium salt system
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Org Lett 4:541-3. 2002
    ..The reaction is greatly accelerated when carried out under microwave heating...
  25. ncbi request reprint N-Heterocyclic carbenes can coexist with alkenes and C-H acidic sites
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2001
    ..The isolation of compounds 3 and 7a,b proves that a singlet carbene center can coexist with alkenes or C-H acidic sites in proximity without spontaneous annihilation...
  26. ncbi request reprint Concise total synthesis of the aporphine alkaloid 7,7'-bisdehydro-O-methylisopiline by an InCl3 mediated cycloisomerization reaction
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2003
    ....
  27. ncbi request reprint Cycloisomerization of enynes catalyzed by iron(0)-ate complexes
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 127:12236-7. 2005
    ..Likewise, the alkene substructure can be varied to a large extent, with cycloalkenes of ring sizes >/=7 being particularly suitable...
  28. ncbi request reprint Platinum- and gold-catalyzed rearrangement reactions of propargyl acetates: total syntheses of (-)-alpha-cubebene, (-)-cubebol, sesquicarene and related terpenes
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 12:3006-19. 2006
    ..The alternative phasing of events, implying initial attack of the acetate (rather than the alkene moiety) onto the metal-alkyne complex, is inconsistent with the stereochemical data obtained during this total synthesis campaign...
  29. ncbi request reprint Facile formation of iodocyclobutenes by a ruthenium-catalyzed enyne cycloisomerization
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470, Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2007
    ..Enynes bearing an iodide (bromide) at their alkyne terminus react with catalytic amounts of [Cp*Ru(MeCN)3]PF6 in DMF to give strained iodo(bromo)cyclobutene derivatives in good to excellent yields...
  30. doi request reprint A versatile protocol for Stille-Migita cross coupling reactions
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470, Mulheim Ruhr, Germany
    Chem Commun (Camb) . 2008
    ....
  31. doi request reprint A gold-catalyzed entry into the sesquisabinene and sesquithujene families of terpenoids and formal total syntheses of cedrene and cedrol
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 14:9181-91. 2008
    ..Moreover, the preparation of 6 also constitutes a formal total synthesis of cedrene (11) and cedrol (12)...
  32. ncbi request reprint Concise synthesis of (S,S)-(+)-dehydrohomoancepsenolide
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Org Lett 2:2463-5. 2000
    ..A Lindlar reduction completes this synthesis which delivers product 3 in only five steps with an overall yield of 25%...
  33. ncbi request reprint Total synthesis of cristatic acid
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Org Lett 2:2467-70. 2000
    ....
  34. ncbi request reprint Total syntheses of (S)-(-)-zearalenone and lasiodiplodin reveal superior metathesis activity of ruthenium carbene complexes with imidazol-2-ylidene ligands
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Org Chem 65:7990-5. 2000
    ..This direct comparison clearly ends in favor of metathesis which turned out to be superior in all preparatively relevant respects...
  35. ncbi request reprint Asymmetric synthesis of the fully functional macrolide core of salicylihalamide: remote control of olefin geometry during RCM
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Org Lett 2:3731-4. 2000
    ..NEt(3) and an RCM-based macrocyclization effected by the NHC-containing ruthenium carbene 21. The stereochemical outcome of the latter reaction is controlled by remote substituents on the phenolic OH group of the cyclization precursor 23...
  36. ncbi request reprint Exploiting the reversibility of olefin metathesis. Syntheses of macrocyclic trisubstituted alkenes and (R,R)-(-)-pyrenophorin
    A Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Org Lett 3:449-51. 2001
    ..When applied to acrylate 11, these catalysts trigger a cyclooligomerization process that evolves with time and serves as key step en route to the lactide antibiotic (-)-pyrenophorin 8...
  37. ncbi request reprint Total synthesis of (-)-salicylihalamide
    A Fürstner
    Max Planck Institut für Kohlenforschung Mülheim an der Ruhr, Germany
    Chemistry 7:5286-98. 2001
    ..Compound 42 was derived from a palladium-catalyzed Negishi coupling between butynylzinc chloride and 3-iodoacrylate 39 followed by a Lindlar reduction of enyne 40 thus obtained and a final aminolysis of the ester group...
  38. ncbi request reprint Synthesis and biological evaluation of nonylprodigiosin and macrocyclic prodigiosin analogues
    A Fürstner
    Max Planck Institut fur Kohlenforschung, Kaiser Wilhelm Platz 1, 45470 Mülheim Ruhr Germany
    Chembiochem 2:60-8. 2001
    ....
  39. ncbi request reprint A concise synthesis of the fully functional lactide core of cycloviracin B with implications for the structural assignment of related glycolipids
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 124:1168-9. 2002
    ..NEt3, and a beta-selective glycosylation reaction using trichloroacetimidate 6. The unsymmetrical dilactone 14, in contrast, is prepared by a stepwise approach based on a Yamaguchi lactonization as the means to close the macrocyclic ring...
  40. ncbi request reprint Total synthesis of the turrianes and evaluation of the DNA-cleaving properties
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, Mulheim Ruhr, Germany
    Chemistry 8:1856-71. 2002
    ..Turrianes 3-5 are shown to be potent DNA cleaving agents under oxidative conditions when administered in the presence of copper ions...
  41. ncbi request reprint Total syntheses of the phytotoxic lactones herbarumin I and II and a synthesis-based solution of the pinolidoxin puzzle
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 124:7061-9. 2002
    ..A further noteworthy design feature is the fact that D-ribose is used as a convenient starting material for the preparation of both enantiomers of the key building block 14 by means of a "head-to-tail" interconversion strategy...
  42. ncbi request reprint Iron-catalyzed cross-coupling reactions
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 124:13856-63. 2002
    ..In contrast to the clean reaction of (hetero)aryl chlorides, the corresponding bromides and iodides are prone to a reduction of their C-X bonds in the presence of the iron catalyst...
  43. ncbi request reprint Total synthesis of amphidinolide T4
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim an der Ruhr, Germany
    Angew Chem Int Ed Engl 41:4763-6. 2002
  44. ncbi request reprint Total synthesis of woodrosin I--part 1: preparation of the building blocks and evaluation of the glycosylation strategy
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 9:307-19. 2003
    ..A particularly noteworthy finding is the fact that diol 22 can be regioselectively glycosylated at the 3'-OH group in high yield without protection of the neighboring 2'-OH function...
  45. ncbi request reprint Total synthesis of woodrosin I--part 2: final stages involving RCM and an orthoester rearrangement
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 9:320-6. 2003
    ..Cleavage of the chloroacetate followed by exhaustive hydrogenation completes the total synthesis of the targeted glycolipid 1...
  46. ncbi request reprint A catalytic approach to (R)-(+)-muscopyridine with integrated "self-clearance"
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim an der Ruhr, Germany
    Angew Chem Int Ed Engl 42:308-11. 2003
  47. ncbi request reprint Total synthesis of (s)-(+)-citreofuran by ring closing alkyne metathesis
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Org Chem 68:1521-8. 2003
    ..An X-ray crystallographic study reveals conformational details about this natural product. Finally, it is shown that 4 as well as its protected precursor 23 are able to cleave double-stranded DNA under oxidative conditions...
  48. ncbi request reprint Chemistry and biology of roseophilin and the prodigiosin alkaloids: a survey of the last 2500 years
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, Kaiser Wilhelm Platz 1, 45470 Mulheim Ruhr, Germany
    Angew Chem Int Ed Engl 42:3582-603. 2003
    ..Furthermore, the chemistry of the closely related and structurally rather unique alkaloid roseophilin is summarized, a cytotoxic agent that recently became the focal point of many innovative total syntheses...
  49. ncbi request reprint Structure assignment, total synthesis, and antiviral evaluation of cycloviracin B1
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 125:13132-42. 2003
    ....
  50. ncbi request reprint Catalysis-based total synthesis of latrunculin B
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45 470 Mülheim an der Ruhr, Germany
    Angew Chem Int Ed Engl 42:5358-60. 2003
  51. ncbi request reprint Total synthesis and reassessment of the phosphatase-inhibitory activity of the antitumor agent TMC-69-6H
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45 470 Mülheim an der Ruhr, Germany
    Angew Chem Int Ed Engl 42:5361-4. 2003
  52. ncbi request reprint Structure assignment, total synthesis, and evaluation of the phosphatase modulating activity of glucolipsin A
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, Kaiser Wilhelm Platz 1, D 45470 Mulheim Ruhr, Germany
    J Org Chem 69:459-67. 2004
    ..This activity profile was compared to that of other glycolipids previously prepared in this laboratory, including cycloviracin B(1) (2), caloporoside (38), woodrosin I (39), sophorolipid lactone (40), and tricolorin G (41)...
  53. ncbi request reprint Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720
    Gunter Seidel
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Org Chem 69:3950-2. 2004
    ..This 2-amino-1,3-propanediol derivative shows highly promising immunosuppressive properties and is currently in human clinical phase III trials...
  54. ncbi request reprint Chasing a phantom by total synthesis: the butylcycloheptylprodigiosin case
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, Mulheim Ruhr, Germany
    Angew Chem Int Ed Engl 44:2777-81. 2005
  55. ncbi request reprint Concise and practical synthesis of latrunculin a by ring-closing enyne-yne metathesis
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Angew Chem Int Ed Engl 44:3462-6. 2005
  56. pmc Diverted total synthesis: preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Proc Natl Acad Sci U S A 102:8103-8. 2005
    ..16 is well accommodated. From the purely chemical perspective, this investigation attests to the maturity of alkyne metathesis, a method that has received attention as efficient means for the formation of macrocycles only recently...
  57. ncbi request reprint Total synthesis of dictyodendrin B
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 127:11620-1. 2005
    ..Moreover, it was shown that global deprotection of the peripheral -OH groups in pyrrolo[2,3-c]carbazole 13 is accompanied by spontaneous air-oxidation to form the quinone core of dictyodendrin C...
  58. ncbi request reprint Concise approach to the "higher sugar" core of the nucleoside antibiotic hikizimycin
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 12:76-89. 2005
    ..It is particularly noteworthy that the conformational constraints of the acyclic substrate 30 enforce the dihydroxylation to violate Kishi's empirical rule for transformations of this type...
  59. ncbi request reprint Total syntheses of the telomerase inhibitors dictyodendrin B, C, and E
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 128:8087-94. 2006
    ....
  60. ncbi request reprint Toward the total synthesis of spirastrellolide A. Part 1: Strategic considerations and preparation of the southern domain
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Angew Chem Int Ed Engl 45:5506-10. 2006
  61. ncbi request reprint Total syntheses of amphidinolide X and Y
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 128:9194-204. 2006
    ..This methodological convergence ensures high efficiency and an excellent overall economy of steps for the entire synthesis campaign...
  62. ncbi request reprint Total syntheses of the tylophora alkaloids cryptopleurine, (-)-antofine, (-)-tylophorine, and (-)-ficuseptine C
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 12:7398-410. 2006
    ..Due to the flexibility and robust character of this approach, it might enable a systematic exploration of the pharmacological profile of this promising class of bioactive natural products...
  63. ncbi request reprint Toward the total synthesis of spirastrellolide A. Part 2: Conquest of the northern hemisphere
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Angew Chem Int Ed Engl 45:5510-5. 2006
  64. ncbi request reprint Total syntheses of the actin-binding macrolides latrunculin A, B, C, M, S and 16-epi-latrunculin B
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 13:115-34. 2007
    ....
  65. ncbi request reprint Latrunculin analogues with improved biological profiles by "diverted total synthesis": preparation, evaluation, and computational analysis
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 13:135-49. 2007
    ....
  66. ncbi request reprint Total synthesis and evaluation of the actin-binding properties of microcarpalide and a focused library of analogues
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 13:1452-62. 2007
    ..9-epi-Microcarpalide 26 and furanone 27 as representative examples of the "natural productlike" compounds investigated herein have been characterized by crystal structure analysis...
  67. ncbi request reprint Total synthesis, molecular editing and evaluation of a tripyrrolic natural product: the case of "butylcycloheptylprodigiosin"
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 13:1929-45. 2007
    ..Several cyclononane-, cyclononene- and cyclononadiene derivatives prepared en route to 6 have been characterized by crystal structure analysis, allowing the conformational behavior of nine-membered carbocycles to be studied...
  68. ncbi request reprint Total syntheses of ipomoeassin B and E
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 129:1906-7. 2007
  69. ncbi request reprint Total synthesis of the antibiotic erypoegin H and cognates by a PtCl2-catalyzed cycloisomerization reaction
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim an der Ruhr, Germany
    Angew Chem Int Ed Engl 46:4760-3. 2007
  70. ncbi request reprint What is amphidinolide V? Report on a likely conquest
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim an der Ruhr, Germany
    Angew Chem Int Ed Engl 46:5545-8. 2007
  71. ncbi request reprint Total synthesis of iejimalide A-D and assessment of the remarkable actin-depolymerizing capacity of these polyene macrolides
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 129:9150-61. 2007
    ..The iejimalides hence constitute an important new class of probe molecules for chemical biology in addition to their role as promising lead structures for the development of novel anticancer agents...
  72. ncbi request reprint Total synthesis of myxovirescin A1
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 13:8762-83. 2007
    ..AgF-mediated proto-desilylation of the isomeric silanes 79 and 80 followed by cleavage of the remaining acetal protecting groups afforded myxovirescin A1 and its hitherto unknown 14Z-isomer 81, respectively...
  73. ncbi request reprint Total syntheses of amphidinolide H and G
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim an der Ruhr, Germany
    Angew Chem Int Ed Engl 46:9265-70. 2007
  74. ncbi request reprint Concise total synthesis of cruentaren A
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim an der Ruhr, Germany
    Angew Chem Int Ed Engl 46:9275-8. 2007
  75. ncbi request reprint Total synthesis of epohelmin B and its analogues
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chem Asian J 3:310-8. 2008
    ....
  76. doi request reprint A cheap metal for a "noble" task: preparative and mechanistic aspects of cycloisomerization and cycloaddition reactions catalyzed by low-valent iron complexes
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 130:1992-2004. 2008
    ..The unusual cyclobutadiene complex 38 derived from 6 and tolane was characterized by X-ray crystallography...
  77. doi request reprint Total syntheses of amphidinolides B1, B4, G1, H1 and structure revision of amphidinolide H2
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 15:3983-4010. 2009
    ..Tris(dimethylamino)sulfonium difluorotrimethylsilicate (TASF) turned out to be a sufficiently mild fluoride source to allow for the final deprotection without damaging the precious macrolides...
  78. doi request reprint Molecular editing and biological evaluation of amphidinolide X and Y
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 15:4030-43. 2009
    ..The syntheses rely on the 9-MeO-9-BBN variant of the Suzuki coupling for the formation of the carbon frameworks, as well as on Yamaguchi lactonization reactions for the cyclization of the macrocyclic rings...
  79. doi request reprint Molecular editing and assessment of the cytotoxic properties of iejimalide and progeny
    Julien Gagnepain
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 17:6973-84. 2011
    ....
  80. doi request reprint Total synthesis and biological evaluation of the cytotoxic resin glycosides ipomoeassin A-F and analogues
    Takashi Nagano
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 15:9697-706. 2009
    ..Ipomoeassin F turned out to be the most promising member of the series, showing IC(50) values in the low nanomolar range...
  81. doi request reprint Total synthesis and biological evaluation of amphidinolide V and analogues
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 15:4011-29. 2009
    ....
  82. ncbi request reprint Total syntheses of amphidinolide T1, T3, T4, and T5
    Christophe Aïssa
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 125:15512-20. 2003
    ....
  83. doi request reprint Total synthesis of nominal gobienine A
    Azusa Kondoh
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 19:7731-8. 2013
    ....
  84. ncbi request reprint Platinum- and gold-catalyzed cycloisomerization reactions of hydroxylated enynes
    Victor Mamane
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 126:8654-5. 2004
    ..The outcome of a deuterium labeling experiment and the analysis of the stereochemical course of the cycloisomerization reaction are consistent with the formation of cyclopropylmethyl platinum carbene species as reactive intermediates...
  85. doi request reprint Preparation, modification, and evaluation of cruentaren A and analogues
    Martin Bindl
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 15:12310-9. 2009
    ..Three of these fully synthetic compounds turned out to be as or even more cytotoxic than cruentaren A itself against L-929 mouse fibroblast cells, reaching IC(50) values as low as 0.7 ng mL(-1)...
  86. doi request reprint Gram-scale synthesis of iejimalide B
    Julien Gagnepain
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 17:6964-72. 2011
    ....
  87. ncbi request reprint Synthesis of phenanthrenes and polycyclic heteroarenes by transition-metal catalyzed cycloisomerization reactions
    Victor Mamane
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 10:4556-75. 2004
    ....
  88. ncbi request reprint The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chembiochem 5:1575-9. 2004
  89. doi request reprint Coordination chemistry at carbon
    Manuel Alcarazo
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Nat Chem 1:295-301. 2009
    ..As the available data suggest that this unconventional interpretation of C-C and C-X bonds is more generally applicable than previously anticipated, it may well affect our understanding of organic chemistry in general...
  90. doi request reprint Formal total synthesis of the algal toxin (-)-polycavernoside A
    Lennart Brewitz
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 19:4532-7. 2013
    ....
  91. pmc Catalysis-based enantioselective total synthesis of the macrocyclic spermidine alkaloid isooncinotine
    Bodo Scheiper
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Proc Natl Acad Sci U S A 101:11960-5. 2004
    ....
  92. doi request reprint Chiral heterobimetallic complexes of carbodiphosphoranes and phosphinidene-carbene adducts
    Manuel Alcarazo
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim an der Ruhr, Germany
    Chem Commun (Camb) 49:3140-2. 2013
    ..Therefore these complexes are carbogenic yet captodative chiral entities...
  93. doi request reprint A total synthesis of spirastrellolide A methyl ester
    Alexander Arlt
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 19:3596-608. 2013
    ..Preliminary biological data suggest that the entire carbon framework, that is the macrocyclic core plus the lateral chain, might be necessary for high cytotoxicity...
  94. ncbi request reprint Total synthesis of the antiviral glycolipid cycloviracin B
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 124:10274-5. 2002
    ....
  95. doi request reprint Total synthesis of the aspercyclides
    Jiří Pospíšil
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 15:5956-68. 2009
    ....
  96. doi request reprint Total synthesis of neurymenolide A based on a gold-catalyzed synthesis of 4-hydroxy-2-pyrones
    Wojciech Chaładaj
    Max Planck Institut fur Kohlenforschung, Mulheim Ruhr, Germany
    Angew Chem Int Ed Engl 51:6929-33. 2012
    ..This challenge was met with a new gold-catalyzed pyrone synthesis in combination with a molybdenum-catalyzed ring-closing alkyne metathesis...
  97. doi request reprint Total synthesis of berkelic acid
    Thomas N Snaddon
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 16:12133-40. 2010
    ..Orthogonal ester groups for the benzoate and the aliphatic carboxylate terminus of the side chain secure an efficient liberation of free berkelic acid in the final step of the route...
  98. doi request reprint Protecting-group-free and catalysis-based total synthesis of the ecklonialactones
    Volker Hickmann
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 132:11042-4. 2010
    ..The final reduction of the cycloalkyne formed in the RCAM step to the required (Z)-alkene was accomplished either by Lindlar reduction or with the aid of nickel boride...
  99. ncbi request reprint One-point binding ligands for asymmetric gold catalysis: phosphoramidites with a TADDOL-related but acyclic backbone
    Henrik Teller
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 134:15331-42. 2012
    ..Crystallographic data in combination with computational studies allow the efficiency of the gold complexes endowed with such one-point binding ligands to be rationalized...
  100. doi request reprint Stereoselective synthesis of E,Z-configured 1,3-dienes by ring-closing metathesis. Application to the total synthesis of lactimidomycin
    Daniel Gallenkamp
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 133:9232-5. 2011
    ..The versatility of this concise approach to E,Z-configured 1,3-dienes of ring sizes of 12 or larger is demonstrated by an application to the total synthesis of lactimidomycin, a potent translation and cell-migration inhibitor...
  101. ncbi request reprint Optimized synthesis, structural investigations, ligand tuning and synthetic evaluation of silyloxy-based alkyne metathesis catalysts
    Johannes Heppekausen
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 18:10281-99. 2012
    ..The thermal and hydrolytic stability of representative molybdenum alkylidyne and -nitride complexes of this series was investigated and the structure of several decomposition products elucidated...