Affiliation: Friedrich Schiller University
- Frequency-specific cochlear damage in guinea pig after exposure to different types of realistic industrial noiseEdeltraut Emmerich
Institute of Physiology Neurophysiology, Friedrich Schiller University Jena, Teichgraben 8, D 07740 Jena, Germany
Hear Res 201:90-8. 2005..OHC loss was found in the middle turns of the cochleae corresponding to the diminution of DPOAE. We conclude that different kinds of industrial noise tend to produce typical changes in DPOAE levels...
- Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint painDaniel Brenn
Friedrich Schiller University of Jena, Jena, Germany
Arthritis Rheum 56:351-9. 2007..Because interleukin-6 (IL-6) is a major inflammatory mediator, we investigated whether this cytokine has the potential to sensitize joint afferents to mechanical stimuli...
- Blockade of voltage-gated calcium channels in rat inhibits repetitive cortical spreading depressionFrank Richter
Department of Physiology, Friedrich Schiller University of Jena, Teichgraben 8, D 07740 Jena, Germany
Neurosci Lett 334:123-6. 2002..The results suggest that cortical excitability resulting in repetitive CSD is markedly influenced by N- and P/Q-type VGCCs and less by L-type VGCCs...
- Spreading depression can be elicited in brain stem of immature but not adult ratsFrank Richter
Institute of Physiology, Neurophysiology, Friedrich Schiller University Jena, D 07740 Jena, Germany
J Neurophysiol 90:2163-70. 2003..Thus we demonstrate that the immature brain stem has the capacity to generate negative DC shifts, which could be relevant as a risk factor in newborn brain stem function...
- The relationship between sudden severe hypoxia and ischemia-associated spreading depolarization in adult rat brainstem in vivoFrank Richter
Institute of Physiology I Neurophysiology, University Hospital Jena, Teichgraben 8, D 07740 Jena, Germany
Exp Neurol 224:146-54. 2010..Thus, sudden severe hypoxia/ischemia evokes SDs in the brainstem, but the occurrence of the so-elicited SD does not influence the immediate cardiovascular response to SSH...
- Enhanced neuronal excitability in adult rat brainstem causes widespread repetitive brainstem depolarizations with cardiovascular consequencesFrank Richter
Institute of Physiology I Neurophysiology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
J Cereb Blood Flow Metab 32:1535-45. 2012..Brainstem RDs did not propagate into the cerebral cortex. We propose to consider brainstem RPs as a pathophysiological mechanism whose significance for brainstem disease states should be further explored...
- Spreading depression in the brainstem of the adult rat: electrophysiological parameters and influences on regional brainstem blood flowFrank Richter
Institute of Physiology I Neurophysiology, Friedrich Schiller University Jena, Jena, Germany
J Cereb Blood Flow Metab 28:984-94. 2008..These data show that proper conditioning renders the brainstem susceptible to spreading depression, and that spreading depression at this site elicits changes in local circulation and systemic blood pressure...
- Voltage-gated calcium channels are not involved in generation and propagation of spreading depression (SD) in the brainstem of immature ratsFrank Richter
Institute of Physiology I Neurophysiology, Friedrich Schiller University Jena, Teichgraben 8, D 07740 Jena, Germany
Neurosci Lett 390:15-20. 2005..In summary, it is likely that K(+) initiates and propagates brainstem SDs...
- Neuronal prostaglandin E2 receptor subtype EP3 mediates antinociception during inflammationGabriel Natura
Institute of Physiology I, Jena University Hospital, Friedrich Schiller University Jena, 07740 Jena, Germany
Proc Natl Acad Sci U S A 110:13648-53. 2013..Importantly, we identified the EP3 receptor in the joint nerves of patients with painful osteoarthritis. ..
- Noradrenergic agonists and antagonists influence migration of cortical spreading depression in rat-a possible mechanism of migraine prophylaxis and prevention of postischemic neuronal damageFrank Richter
Institute of Physiology Neurophysiology, Friedrich Schiller University Jena, Jena, Germany
J Cereb Blood Flow Metab 25:1225-35. 2005..The effect of beta-receptor antagonists in human migraine needs further exploration, since these drugs also work in migraine without aura...
- Joint painHans Georg Schaible
Institute of Physiology 1 Neurophysiology, University Hospital Jena, Teichgraben 8, 07740 Jena, Germany
Exp Brain Res 196:153-62. 2009..The overview will also address long-term changes of pain-related behavior, response properties of neurons and receptor expression in chronic animal models of arthritis...
- Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in ratsFrank Richter
Jena University Hospital, Friedrich Schiller University of Jena, Jena, Germany
Arthritis Rheum 62:3806-14. 2010....
- Is the audiologic status of professional musicians a reflection of the noise exposure in classical orchestral music?Edeltraut Emmerich
Institute of Physiology I Neurophysiology, Friedrich Schiller University Jena, Teichgraben 8, 07740, Jena, Germany
Eur Arch Otorhinolaryngol 265:753-8. 2008..A better education on the hearing hazards (use of hearing protectors) as well as sound protection in the rehearsal rooms is necessary. Hearing loss in professional musicians should be accepted as an occupational disease...
- Effects of discotheque music on audiometric results and central acoustic evoked neuromagnetic responsesEdeltraut Emmerich
Department of Physiology I, Faculty of Medicine, Friedrich Schiller University, Jena, Teichgraben 8, D 07740 Jena, Germany
Int Tinnitus J 8:13-9. 2002..Occurrence of tinnitus closely coincides with the changes in hearing threshold and AEF, thus, a limitation of loudness in discotheques is needed to prevent this kind of hearing hazard...
- The cochleogram of the guinea pigVolker Linss
Institute of Anatomy I, Friedrich Schiller University of Jena, Jena, Germany
Eur Arch Otorhinolaryngol 264:369-75. 2007..4 +/- 1.4 mm (mean +/- standard deviation) with sector lengths of 6.9, 4.2, 3.2, and 1.9 mm, thus adding relevant information to the morphology of the guinea pig cochlea...
- Pathophysiology of painHans Georg Schaible
Institut fur Physiologie, Friedrich Schiller Universitat Jena, Teichgraben 8, 07740 Jena, Germany
Langenbecks Arch Surg 389:237-43. 2004..This review will briefly describe the "pain system" and then address neuronal mechanisms that are involved in clinical pain states...
- Antinociceptive effects of tumor necrosis factor alpha neutralization in a rat model of antigen-induced arthritis: evidence of a neuronal targetMichael K Boettger
University Hospital of Jena, Jena, Germany
Arthritis Rheum 58:2368-78. 2008....
- Scalp-recorded contingent negative variation (CNV) increases during experimentally induced sustained ischemic pain in humansPhilipp Stude
Center for Pain Therapy, St Vincent Hospital, Schloss Strasse 85, D 40477 Duesseldorf, Germany
Neurosci Lett 348:9-12. 2003..357 microV*s, respectively (P=0.00071)). We conclude that deep somatic pain augments CNV. Reduced CNV amplitudes occurring during migraine attacks, however, reflect other mechanisms which may mask the effects of migraine headache on CNV...
- Androgen and retinoic acid interaction in LNCaP cells, effects on cell proliferation and expression of retinoic acid receptors and epidermal growth factor receptorMing Tang Li
Department of Surgery, Division of Urology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
BMC Cancer 2:16. 2002..Modulation of the expression of retinoic acid receptors (RAR) alpha and gamma in adult rat prostate by testosterone (T) suggests that RAR signaling events might mediate some of the androgen effects on prostate cells...