D Thaci

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. doi Malignancy concerns of topical calcineurin inhibitors for atopic dermatitis: facts and controversies
    Diamant Thaci
    Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Clin Dermatol 28:52-6. 2010
  2. doi Efficacy and safety of fumaric acid esters in patients with psoriasis on medication for comorbid conditions - a retrospective evaluation (FACTS)
    Diamant Thaci
    Department of Dermatology, Venereology and Allergology, University of Frankfurt Main, Germany
    J Dtsch Dermatol Ges 11:429-35. 2013
  3. ncbi Calcipotriol solution for the treatment of scalp psoriasis: evaluation of efficacy, safety and acceptance in 3,396 patients
    D Thaci
    Department of Dermatology and Venereology, J W Goethe University Medical School, Frankfurt, Germany
    Dermatology 203:153-6. 2001
  4. doi Percutaneous absorption of pimecrolimus is not increased in patients with moderate to severe atopic dermatitis when pimecrolimus cream 1% is applied under occlusion
    Diamant Thaci
    Department of Dermatology and Venereology, J W Goethe University School of Medicine, Frankfurt, Germany
    Dermatology 221:342-51. 2010
  5. doi A phase IIIb, multicentre, randomized, double-blind, vehicle-controlled study of the efficacy and safety of adalimumab with and without calcipotriol/betamethasone topical treatment in patients with moderate to severe psoriasis: the BELIEVE study
    D Thaci
    Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Br J Dermatol 163:402-11. 2010
  6. doi Proactive disease management with 0.03% tacrolimus ointment for children with atopic dermatitis: results of a randomized, multicentre, comparative study
    D Thaci
    Department of Dermatology and Venerology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, D 60596 Germany
    Br J Dermatol 159:1348-56. 2008
  7. doi Long-term data in the treatment of psoriasis
    D Thaci
    Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Br J Dermatol 159:18-24. 2008
  8. ncbi The topical calcineurin inhibitor pimecrolimus in atopic dermatitis: a safety update
    Diamant Thaci
    Zentrum der Dermatologie und Venerologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Acta Dermatovenerol Alp Pannonica Adriat 16:58, 60-62. 2007
  9. ncbi [Long term management of childhood atopic dermatitis with calcineurin inhibitors]
    D Thaci
    Zentrum der Dermatologie und Venerologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main
    Hautarzt 54:418-23. 2003
  10. ncbi Occlusive treatment of chronic hand dermatitis with pimecrolimus cream 1% results in low systemic exposure, is well tolerated, safe, and effective. An open study
    Diamant Thaci
    Department of Dermatology and Venereology, J W Goethe University School of Medicine, Frankfurt, Germany
    Dermatology 207:37-42. 2003

Detail Information

Publications34

  1. doi Malignancy concerns of topical calcineurin inhibitors for atopic dermatitis: facts and controversies
    Diamant Thaci
    Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Clin Dermatol 28:52-6. 2010
    ..According to the latest knowledge, there is no scientific evidence of an increased risk for malignancy due to a topical treatment with calcineurin inhibitors...
  2. doi Efficacy and safety of fumaric acid esters in patients with psoriasis on medication for comorbid conditions - a retrospective evaluation (FACTS)
    Diamant Thaci
    Department of Dermatology, Venereology and Allergology, University of Frankfurt Main, Germany
    J Dtsch Dermatol Ges 11:429-35. 2013
    ..Safety and efficacy of fumaric acid esters (FAE) in patients with psoriasis requiring treated comorbidit condition were investigated...
  3. ncbi Calcipotriol solution for the treatment of scalp psoriasis: evaluation of efficacy, safety and acceptance in 3,396 patients
    D Thaci
    Department of Dermatology and Venereology, J W Goethe University Medical School, Frankfurt, Germany
    Dermatology 203:153-6. 2001
    ..Psoriasis of the scalp is a very common disease, cosmetically disturbing and therapeutically difficult to manage...
  4. doi Percutaneous absorption of pimecrolimus is not increased in patients with moderate to severe atopic dermatitis when pimecrolimus cream 1% is applied under occlusion
    Diamant Thaci
    Department of Dermatology and Venereology, J W Goethe University School of Medicine, Frankfurt, Germany
    Dermatology 221:342-51. 2010
    ..To evaluate the systemic exposure of pimecrolimus cream 1% applied under occlusion in atopic dermatitis (AD) patients...
  5. doi A phase IIIb, multicentre, randomized, double-blind, vehicle-controlled study of the efficacy and safety of adalimumab with and without calcipotriol/betamethasone topical treatment in patients with moderate to severe psoriasis: the BELIEVE study
    D Thaci
    Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Br J Dermatol 163:402-11. 2010
    ..Data are lacking on the use of topical therapies in combination with tumour necrosis factor blockers for the treatment of psoriasis...
  6. doi Proactive disease management with 0.03% tacrolimus ointment for children with atopic dermatitis: results of a randomized, multicentre, comparative study
    D Thaci
    Department of Dermatology and Venerology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, D 60596 Germany
    Br J Dermatol 159:1348-56. 2008
    ..Long-term treatment for atopic dermatitis (AD) using low-dose, intermittent, topical anti-inflammatory agents may control acute disease and prevent exacerbations...
  7. doi Long-term data in the treatment of psoriasis
    D Thaci
    Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Br J Dermatol 159:18-24. 2008
    ..This article discusses the data currently available on both conventional and biological systemic therapies for psoriasis, in terms of short-term and long-term use...
  8. ncbi The topical calcineurin inhibitor pimecrolimus in atopic dermatitis: a safety update
    Diamant Thaci
    Zentrum der Dermatologie und Venerologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Acta Dermatovenerol Alp Pannonica Adriat 16:58, 60-62. 2007
    ....
  9. ncbi [Long term management of childhood atopic dermatitis with calcineurin inhibitors]
    D Thaci
    Zentrum der Dermatologie und Venerologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main
    Hautarzt 54:418-23. 2003
    ..Long-term use of calcineurin inhibitors in atopic dermatitis is well tolerated locally and systemically, leads to reduction of disease flares and has a corticosteroid sparing effect...
  10. ncbi Occlusive treatment of chronic hand dermatitis with pimecrolimus cream 1% results in low systemic exposure, is well tolerated, safe, and effective. An open study
    Diamant Thaci
    Department of Dermatology and Venereology, J W Goethe University School of Medicine, Frankfurt, Germany
    Dermatology 207:37-42. 2003
    ..Pimecrolimus cream 1% (Elidel, SDZ ASM 981) is a novel, non-steroid inflammatory cytokine inhibitor, effective in the treatment of atopic dermatitis. Here, we evaluate the treatment of chronic hand dermatitis with pimecrolimus cream 1%...
  11. ncbi [Topical antibiotics in skin infections]
    D Thaci
    Zentrum der Dermatologie und Venerologie der Johann Wolfgang Goethe Universität, Frankfurt
    Hautarzt 56:381-94; quiz 395. 2005
    ..In this review the most important topical antibiotics used in Germany are evaluated with regards to efficacy and safety profile...
  12. ncbi Body-weight-independent dosing of cyclosporine micro-emulsion and three times weekly maintenance regimen in severe psoriasis. A randomised study
    D Thaci
    Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Dermatology 205:383-8. 2002
    ..Body-weight-dependent (BWD) treatment of psoriasis with cyclosporine A (CsA is well established. It has recently been reported that this is not necessary for the treatment of atopic dermatitis...
  13. doi Effective continuous systemic therapy of severe plaque-type psoriasis is accompanied by amelioration of biomarkers of cardiovascular risk: results of a prospective longitudinal observational study
    S Boehncke
    Department of Internal Medicine, Section for Diabetes, University Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Eur Acad Dermatol Venereol 25:1187-93. 2011
    ..Severe psoriasis is associated with significant cardiovascular mortality...
  14. ncbi Treatment of moderate-to-severe plaque psoriasis
    R Salgo
    Department of Dermatology, Goethe University, Frankfurt am Main, Germany
    G Ital Dermatol Venereol 144:701-11. 2009
    ..This review shortly presents the characteristics, safety and efficacy profile of the conventional and newer systemic drugs used in moderate-to-severe psoriasis...
  15. doi Twice-weekly treatment with tacrolimus 0.03% ointment in children with atopic dermatitis: clinical efficacy and economic impact over 12 months
    D Thaci
    Department of Dermatology and Venereology, JW Goethe University, Frankfurt, Germany
    J Eur Acad Dermatol Venereol 24:1040-6. 2010
    ..Rational healthcare decision-making based on clinical and economic evidence is essential to provide the best possible care for patients with atopic dermatitis (AD)...
  16. ncbi Treatment of psoriasis with alefacept in patients with hepatitis C infection: a report of two cases
    D Thaci
    Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Br J Dermatol 152:1048-50. 2005
    ..Alefacept has a selective mechanism of action that specifically targets memory T cells and this selectivity may account for its safety and tolerability in patients with hepatitis...
  17. ncbi [Cutaneous botryomycosis. A rarely diagnosed bacterial infection of the skin]
    M Meissner
    Zentrum der Dermatologie und Venerologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main
    Hautarzt 58:966-8. 2007
    ..A 16-year-old girl presented with multiple erythematous solid and partly purulent nodules which were extremely resistant to therapy. In this case we could diagnose a botryomycosis caused by Staphylococcus aureus...
  18. ncbi Psoriasis: a possible risk factor for development of coronary artery calcification
    R J Ludwig
    Department of Dermatology and Department of Radiology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Br J Dermatol 156:271-6. 2007
    ..Epidemiological data on the prevalence and degree of coronary artery calcification (CAC) as an indicator for cardiovascular diseases in patients with psoriasis are contradictory...
  19. pmc Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes
    Stefan Kippenberger
    Department of Dermatology and Venerology, J W Goethe University, 60590 Frankfurt Main, Germany
    Nucleic Acids Res 37:3850-64. 2009
    ..In summary the present data demonstrate DNA as a modulator of apoptosis which specifically targets skin epithelial cells...
  20. doi Ligation of beta4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament
    Stefan Kippenberger
    Department of Dermatology and Venerology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
    Biochim Biophys Acta 1803:940-50. 2010
    ..Taken together our data define a new model of beta4-dependent PKB/Akt and ERK1/2 activation demonstrating the keratin filament as a structure necessary in signal transmission...
  21. ncbi Detection of human beta defensin-1 and -2 by RT-competitive multiplex PCR
    Stefan Kippenberger
    Department of Dermatology and Venerology, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Arch Dermatol Res 296:539-42. 2005
    ..RT-competitive multiplex PCR is a simple and accurate method that enables new insights into defensin regulation under physiological and pathophysiological conditions...
  22. ncbi Restoration of E-cadherin sensitizes human melanoma cells for apoptosis
    Stefan Kippenberger
    Department of Dermatology, Division of Pneumology, University of Frankfurt Medical School, Frankfurt Main, Germany
    Melanoma Res 16:393-403. 2006
    ..In conclusion, our findings suggest therapeutic strategies that enable expression of E-cadherin in order to sensitize human melanoma cells towards apoptosis...
  23. ncbi Psoriasis patients show signs of insulin resistance
    S Boehncke
    Department of Internal Medicine, Section for Endocrinology, Metabolism and Diabetology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Br J Dermatol 157:1249-51. 2007
    ..Recent observations suggest that psoriasis is a risk factor for the development of coronary artery calcification which in turn represents an indicator for atherosclerosis...
  24. ncbi Oligonucleotides suppress IL-8 in skin keratinocytes in vitro and offer anti-inflammatory properties in vivo
    Annette Dorn
    Department of Dermatology and Venerology, J W Goethe University, Frankfurt Main, Germany
    J Invest Dermatol 127:846-54. 2007
    ..This effect seems to be independent from Toll-like receptor 9...
  25. doi Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne?
    M Schuster
    Department of Dermatology, Venereology and Allergology, University Hospital, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt Main 60590, Germany
    Br J Dermatol 164:182-6. 2011
    ..As peroxisome proliferator-activated receptors (PPARs) are known to control lipid metabolism in several human tissues they have been considered to be involved in the pathogenesis of acne vulgaris...
  26. doi Red ear syndrome and auricular erythromelalgia: the same condition?
    T J Brill
    Department of Dermatology, J W Goethe University, Frankfurt, Germany
    Clin Exp Dermatol 34:e626-8. 2009
    ..In this report, we discuss the similarities and differences between RES and erythromelalgia...
  27. doi Pictorial representation of illness and self measure (PRISM): an effective tool to assess the burden of psoriasis
    K Fotiou
    Department of Dermatology, Venereology and Allergology, Goethe University Frankfurt, Frankfurt, Germany
    J Eur Acad Dermatol Venereol 29:2356-62. 2015
    ..Capturing quality of life impairments in psoriasis is an integral part of assessing the overall disease severity and planning effective treatment strategies...
  28. doi Efficacy and safety of apremilast in subjects with moderate to severe plaque psoriasis: results from a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison study
    K A Papp
    Probity Medical Research, Waterloo, ON, Canada Department of Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University, Frankfurt Main, Germany Celgene Corporation, Summit, NJ, USA
    J Eur Acad Dermatol Venereol 27:e376-83. 2013
    ..Apremilast, a small molecule specific inhibitor of phosphodiesterase 4, works intracellularly to modulate pro-inflammatory and anti-inflammatory mediator production...
  29. doi Patient satisfaction with injection devices: a randomized controlled study comparing two different etanercept delivery systems in moderate to severe psoriasis
    C Paul
    Department of Dermatology, Paul Sabatier University, Toulouse, France
    J Eur Acad Dermatol Venereol 26:448-55. 2012
    ..There is limited information regarding the acceptability of injection devices for biological agents...
  30. doi Evaluation of beneficial and adverse effects of glucocorticoids on a newly developed full-thickness skin model
    Nadja Nicole Zöller
    Department of Dermatology and Venerology, J W Goethe University, Medical School, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Toxicol In Vitro 22:747-59. 2008
    ..The present study demonstrates the versatility of this FTSM in the validation of effectiveness and safety of GCs...
  31. ncbi Narrowband UVB and cream psoralen-UVA combination therapy for plaque-type psoriasis
    Marcella Grundmann-Kollmann
    Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt, Germany
    J Am Acad Dermatol 50:734-9. 2004
    ..To reduce side effects as a result of systemic resorption of psoralens, topical PUVA therapies have been developed and proven to be effective in the treatment of psoriasis...
  32. doi Topical methyl aminolevulinate photodynamic therapy using red light-emitting diode light for multiple actinic keratoses: a randomized study
    Rolf Markus Szeimies
    Department of Dermatology, Universitatsklinikum Regensburg, Regensburg, Germany
    Dermatol Surg 35:586-92. 2009
    ..Photodynamic therapy (PDT) is an effective treatment for actinic keratoses (AKs). Light-emitting diodes (LEDs) offer practical advantages when treating multiple lesions...
  33. doi A randomized, double-blind, vehicle-controlled study of 1% pimecrolimus cream in adult patients with perioral dermatitis
    Thomas Schwarz
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Am Acad Dermatol 59:34-40. 2008
    ..Perioral dermatitis (POD) is a common dermatosis without standard therapy...
  34. ncbi Treatment of scabies with 5% permethrin cream: results of a German multicenter study
    Henning Hamm
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    J Dtsch Dermatol Ges 4:407-13. 2006
    ..Therefore, a 5% permethrin cream formulation (InfectoScab 5%) was tested in a single-arm multi-center study including adults and children from 3 months of age with proven scabies...