Udo Rüb

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. doi request reprint Spinocerebellar ataxia type 1 (SCA1): new pathoanatomical and clinico-pathological insights
    U Rüb
    Institute of Clinical Neuroanatomy, Dr Senckenberg Anatomy, Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 38:665-80. 2012
  2. ncbi request reprint Spinocerebellar ataxia type 3 (Machado-Joseph disease): severe destruction of the lateral reticular nucleus
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Brain 125:2115-24. 2002
  3. ncbi request reprint Spinocerebellar ataxia type 7 (SCA7): first report of a systematic neuropathological study of the brain of a patient with a very short expanded CAG-repeat
    U Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Brain Pathol 15:287-95. 2005
  4. ncbi request reprint Spinocerebellar ataxias types 2 and 3: degeneration of the pre-cerebellar nuclei isolates the three phylogenetically defined regions of the cerebellum
    U Rüb
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Neural Transm (Vienna) 112:1523-45. 2005
  5. ncbi request reprint Extended pathoanatomical studies point to a consistent affection of the thalamus in spinocerebellar ataxia type 2
    U Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 31:127-40. 2005
  6. ncbi request reprint Damage to the reticulotegmental nucleus of the pons in spinocerebellar ataxia type 1, 2, and 3
    U Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Neurology 63:1258-63. 2004
  7. ncbi request reprint Degeneration of the central vestibular system in spinocerebellar ataxia type 3 (SCA3) patients and its possible clinical significance
    U Rüb
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 30:402-14. 2004
  8. ncbi request reprint Consistent affection of the central somatosensory system in spinocerebellar ataxia type 2 and type 3 and its significance for clinical symptoms and rehabilitative therapy
    Udo Rüb
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Brain Res Rev 53:235-49. 2007
  9. ncbi request reprint Thalamic involvement in a spinocerebellar ataxia type 2 (SCA2) and a spinocerebellar ataxia type 3 (SCA3) patient, and its clinical relevance
    U Rüb
    Institute for Clinical Neuroanatomy, Department of Neurology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Brain 126:2257-72. 2003
  10. ncbi request reprint Degeneration of ingestion-related brainstem nuclei in spinocerebellar ataxia type 2, 3, 6 and 7
    U Rüb
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 32:635-49. 2006

Detail Information

Publications81

  1. doi request reprint Spinocerebellar ataxia type 1 (SCA1): new pathoanatomical and clinico-pathological insights
    U Rüb
    Institute of Clinical Neuroanatomy, Dr Senckenberg Anatomy, Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 38:665-80. 2012
    ....
  2. ncbi request reprint Spinocerebellar ataxia type 3 (Machado-Joseph disease): severe destruction of the lateral reticular nucleus
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Brain 125:2115-24. 2002
    ..In view of its afferent and efferent connections, destruction of the LRT probably contributes to gait ataxia in individuals suffering from SCA3...
  3. ncbi request reprint Spinocerebellar ataxia type 7 (SCA7): first report of a systematic neuropathological study of the brain of a patient with a very short expanded CAG-repeat
    U Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Brain Pathol 15:287-95. 2005
    ..Finally, our immunocytochemical analysis confirms previous studies which described the presence of NI in obviously degenerated brain and retinal regions as well as in apparently well-preserved brain regions and retina of SCA7 patients...
  4. ncbi request reprint Spinocerebellar ataxias types 2 and 3: degeneration of the pre-cerebellar nuclei isolates the three phylogenetically defined regions of the cerebellum
    U Rüb
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Neural Transm (Vienna) 112:1523-45. 2005
    ....
  5. ncbi request reprint Extended pathoanatomical studies point to a consistent affection of the thalamus in spinocerebellar ataxia type 2
    U Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 31:127-40. 2005
    ....
  6. ncbi request reprint Damage to the reticulotegmental nucleus of the pons in spinocerebellar ataxia type 1, 2, and 3
    U Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Neurology 63:1258-63. 2004
    ....
  7. ncbi request reprint Degeneration of the central vestibular system in spinocerebellar ataxia type 3 (SCA3) patients and its possible clinical significance
    U Rüb
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 30:402-14. 2004
    ..The reported lesions can help to explain the truncal and postural instability as well as the impaired optokinetic nystagmus, vestibulo-ocular reaction, and horizontal gaze-holding present in SCA3 cases...
  8. ncbi request reprint Consistent affection of the central somatosensory system in spinocerebellar ataxia type 2 and type 3 and its significance for clinical symptoms and rehabilitative therapy
    Udo Rüb
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Brain Res Rev 53:235-49. 2007
    ....
  9. ncbi request reprint Thalamic involvement in a spinocerebellar ataxia type 2 (SCA2) and a spinocerebellar ataxia type 3 (SCA3) patient, and its clinical relevance
    U Rüb
    Institute for Clinical Neuroanatomy, Department of Neurology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Brain 126:2257-72. 2003
    ....
  10. ncbi request reprint Degeneration of ingestion-related brainstem nuclei in spinocerebellar ataxia type 2, 3, 6 and 7
    U Rüb
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 32:635-49. 2006
    ....
  11. ncbi request reprint The nucleus raphe interpositus in spinocerebellar ataxia type 3 (Machado-Joseph disease)
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    J Chem Neuroanat 25:115-27. 2003
    ....
  12. ncbi request reprint Spinocerebellar ataxia type 7 (SCA7): widespread brain damage in an adult-onset patient with progressive visual impairments in comparison with an adult-onset patient without visual impairments
    U Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 34:155-68. 2008
    ....
  13. ncbi request reprint Guidelines for the pathoanatomical examination of the lower brain stem in ingestive and swallowing disorders and its application to a dysphagic spinocerebellar ataxia type 3 patient
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt, Germany
    Neuropathol Appl Neurobiol 29:1-13. 2003
    ....
  14. ncbi request reprint Degeneration of the external cuneate nucleus in spinocerebellar ataxia type 3 (Machado-Joseph disease)
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Brain Res 953:126-34. 2002
    ....
  15. ncbi request reprint The evolution of Alzheimer's disease-related cytoskeletal pathology in the human raphe nuclei
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 26:553-67. 2000
    ....
  16. ncbi request reprint Progressive supranuclear palsy: neuronal and glial cytoskeletal pathology in the higher order processing autonomic nuclei of the lower brainstem
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt, Main, Germany
    Neuropathol Appl Neurobiol 28:12-22. 2002
    ..In view of their functional role, the neuronal pathology in the nuclei studied offers a possible explanation for the autonomic dysfunctions that eventually develop in the course of PSP...
  17. ncbi request reprint Parkinson's disease: the thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathology
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590, Frankfurt Main, Germany
    Neurobiol Aging 23:245-54. 2002
    ..Damage to the thalamic components of the limbic loop nuclei may contribute not only to the cognitive, emotional, and autonomic symptoms of PD but to the somatomotor and oculomotor dysfunctions as well...
  18. ncbi request reprint The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related cytoskeletal pathology
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Acta Neuropathol 101:555-64. 2001
    ..This relationship remains to be established, but it could provide insights into the illusive correlation between the AD-related cytoskeletal pathology and the function of affected neurons...
  19. ncbi request reprint Early involvement of the tegmentopontine reticular nucleus during the evolution of Alzheimer's disease-related cytoskeletal pathology
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Brain Res 908:107-12. 2001
    ....
  20. ncbi request reprint The premotor region essential for rapid vertical eye movements shows early involvement in Alzheimer's disease-related cytoskeletal pathology
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590, Frankfurt Main, Germany
    Vision Res 41:2149-56. 2001
    ..In the event that the cytoskeletal pathology impairs the function of the premotor neurons of the riMLF, one would predict a progressive slowing of vertical saccades corresponding to the advancing cortical NFT/NT-stages...
  21. ncbi request reprint Spinocerebellar ataxia type 3 (SCA3): thalamic neurodegeneration occurs independently from thalamic ataxin-3 immunopositive neuronal intranuclear inclusions
    Udo Rüb
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe Univeristy, Frankfurt Main, Germany
    Brain Pathol 16:218-27. 2006
    ..This lack of correlation may suggest that ataxin-3 immunopositive NI are not immediately decisive for the fate of affected nerve cells but rather represent unspecific and pathognomonic morphological markers of SCA3...
  22. doi request reprint Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases
    Estifanos Ghebremedhin
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Neuropathol Exp Neurol 69:442-8. 2010
    ..05 each). In conclusion, DLB and PD patients with advanced LB pathology were less likely to show severe cerebrovascular disease or history of stroke...
  23. doi request reprint Hierarchical Distribution of the Tau Cytoskeletal Pathology in the Thalamus of Alzheimer's Disease Patients
    Udo Rüb
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University, Frankfurt Main, Germany
    J Alzheimers Dis 49:905-15. 2016
    ..g., dementia), attention deficits, oculomotor dysfunctions, altered non-discriminative aspects of pain experience of AD patients, and the disruption of their waking and sleeping patterns. ..
  24. ncbi request reprint Two types of sporadic cerebral amyloid angiopathy
    Dietmar Rudolf Thal
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt am Main, Germany
    J Neuropathol Exp Neurol 61:282-93. 2002
    ..CAA-Type 2 is not associated with the epsilon4 allele as a risk factor but shows a higher epsilon2 allele frequency than CAA-Type 1 cases and controls in our sample...
  25. doi request reprint Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7
    Udo Rüb
    Dr Senckenberg Chronomedical Institute, Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Prog Neurobiol 104:38-66. 2013
    ..Furthermore, we provide an overview of the structure, interactions and functions of the different disease proteins. On the basis of these comprehensive data, similarities, differences and possible disease mechanisms are discussed...
  26. ncbi request reprint Where does parkinson disease pathology begin in the brain?
    Kelly Del Tredici
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt am Main, Germany
    J Neuropathol Exp Neurol 61:413-26. 2002
    ..e. hippocampal formation, temporal mesocortex, proneocortical cingulate areas, amygdala, basal nucleus of Meynert, interstitial nucleus of the diagonal band of Broca, hypothalamic tuberomamillary nucleus)...
  27. ncbi request reprint Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases
    Heiko Braak
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt am Main, Germany
    J Alzheimers Dis 9:35-44. 2006
    ..The severity of the neocortical lesions decreases in inverse proportion to the trajectories of increasing cortical differentiation and hierarchical refinement...
  28. ncbi request reprint Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)
    Heiko Braak
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Neurol 249:III/1-5. 2002
    ..IPD manifests itself in all of its dimensions, which under the influence of the supervening cortical pathology are subject to increasing complexity...
  29. pmc Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology
    Katharina Stratmann
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University, Frankfurt Main, Germany
    Brain Pathol 26:371-86. 2016
    ....
  30. pmc ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice
    Ewa Damrath
    Experimental Neurology, Department of Neurology, Goethe University Medical School, Frankfurt am Main, Germany
    PLoS Genet 8:e1002920. 2012
    ....
  31. doi request reprint Spinocerebellar ataxia type 2 (SCA2): identification of early brain degeneration in one monozygous twin in the initial disease stage
    Franziska Hoche
    Institute of Clinical Neuroanatomy, Dr Senckenberg Anatomy, Goethe University, 60590, Frankfurt am Main, Germany
    Cerebellum 10:245-53. 2011
    ..Since they were already involved in our patient within 3 years after disease onset, we think that we were for the first time able to identify the early brain targets of the pathological process of SCA2...
  32. ncbi request reprint High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe
    Christian Schultz
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, 60590 Frankfurt Main, Germany
    Neurobiol Aging 25:397-405. 2004
    ..In summary, this study suggests that TSA is a distinct form of glial tau pathology that occurs with a high frequency in elderly individuals...
  33. ncbi request reprint Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years
    Rene Maxime Gracien
    Department of Neurology, Goethe University, Frankfurt Main, Germany
    Eur Radiol . 2016
    ..In this longitudinal study over 7 years, T1 relaxometry was used to investigate the dynamics of age-related microstructural changes in older healthy subjects...
  34. doi request reprint New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease)
    Udo Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    Curr Opin Neurol 21:111-6. 2008
    ..This review summarizes recent neuropathological findings in spinocerebellar ataxia type 3 and discusses their relevance for clinical neurology...
  35. pmc Longitudinal changes of cortical microstructure in Parkinson's disease assessed with T1 relaxometry
    Lucas Nürnberger
    Department of Neurology, Goethe University, Frankfurt Main, Germany Brain Imaging Center, Goethe University, Frankfurt Main, Germany
    Neuroimage Clin 13:405-414. 2017
    ..The aim of this study was to investigate longitudinal cortical microstructural changes in PD with quantitative T1 relaxometry...
  36. doi request reprint Huntington's Disease (HD): Neurodegeneration of Brodmann's Primary Visual Area 17 (BA17)
    Udo Rüb
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University, Frankfurt Main, Germany
    Brain Pathol 25:701-11. 2015
    ....
  37. doi request reprint Degeneration of the cerebellum in Huntington's disease (HD): possible relevance for the clinical picture and potential gateway to pathological mechanisms of the disease process
    Udo Rüb
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University, Frankfurt Main, Germany
    Brain Pathol 23:165-77. 2013
    ....
  38. ncbi request reprint Relationship of apolipoprotein E and age at onset to Parkinson disease neuropathology
    Estifanos Ghebremedhin
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    J Neuropathol Exp Neurol 65:116-23. 2006
    ..001). In conclusion, our findings suggest that APOE may express its effect on the risk of PD by modifying the occurrence of PD pathology, but age of PD onset seems to be the principal determinant of the progression rate of PD pathology...
  39. ncbi request reprint Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered
    Heiko Braak
    Institute for Clinical Neuroanatomy, JW Goethe University, Frankfurt Main, Germany
    Mov Disord 21:2042-51. 2006
    ..Here, the staging hypothesis is critically reconsidered and discussed...
  40. ncbi request reprint Dissociation of grey and white matter reduction in spinocerebellar ataxia type 3 and 6: a voxel-based morphometry study
    Carsten Lukas
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Neurosci Lett 408:230-5. 2006
    ..In contrast, SCA3 represents a form of ponto-cerebellar atrophy with predominant affection of pontine nuclei and fibre tracts...
  41. doi request reprint On the Distribution of Intranuclear and Cytoplasmic Aggregates in the Brainstem of Patients with Spinocerebellar Ataxia Type 2 and 3
    Kay Seidel
    Institute of Clinical Neuroanatomy, Department of Anatomy II, J W Goethe University, Frankfurt, Germany
    Brain Pathol . 2016
    ..The severity of GCS was the best predictor of neurodegeneration in both disorders, while the inverse correlation of neurodegeneration and NNI in SCA3 tissue implies a protective role of these aggregates...
  42. pmc Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression
    Suzana Gispert
    Experimental Neurology, Department of Neurology, Goethe University Medical School, Building 89, 3rd Floor, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Hum Mol Genet 24:1061-76. 2015
    ..Thus, our study confirmed that SNCA-triggered neurotoxicity is exacerbated by the absence of PINK1 and identified a novel molecular signature that is detectable early in the course of this double pathology. ..
  43. pmc The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies
    Kay Seidel
    Dr Senckenbergisches Chronomedizinisches Institute, J W Goethe University, Frankfurt Main, Germany
    Brain Pathol 25:121-35. 2015
    ....
  44. pmc Huntington's disease (HD): degeneration of select nuclei, widespread occurrence of neuronal nuclear and axonal inclusions in the brainstem
    Udo Rüb
    Dr Senckenberg Chronomedical Institute, Goethe University, Frankfurt Main, Germany
    Brain Pathol 24:247-60. 2014
    ....
  45. ncbi request reprint Stages in the development of Parkinson's disease-related pathology
    Heiko Braak
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Cell Tissue Res 318:121-34. 2004
    ..At this point, most individuals probably cross the threshold to the symptomatic phase of the illness. In the end-stages 5-6, the process enters the mature neocortex, and the disease manifests itself in all of its clinical dimensions...
  46. ncbi request reprint Cognitive decline correlates with neuropathological stage in Parkinson's disease
    Heiko Braak
    Institute for Clinical Neuroanatomy, J W Goethe University Clinic, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    J Neurol Sci 248:255-8. 2006
    ..Since the median MMSE scores decreased from stages 3-6, it is probable that the risk of developing dementia in PD becomes greater as the disease process in the brain progresses...
  47. ncbi request reprint Staging of brain pathology related to sporadic Parkinson's disease
    Heiko Braak
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Neurobiol Aging 24:197-211. 2003
    ..This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions...
  48. doi request reprint Neuroanatomical characteristics of the human pre-Bötzinger complex and its involvement in neurodegenerative brainstem diseases
    Stephan W Schwarzacher
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Brain 134:24-35. 2011
    ....
  49. ncbi request reprint Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert
    I Sassin
    Department of Anatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Acta Neuropathol 100:259-69. 2000
    ..The considerable morphological diversity of cytoskeletal alterations is typical of stages III and IV. These results indicate that individual neurons of the bnM enter the sequence of cytoskeletal deterioration at different times...
  50. ncbi request reprint Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
    H Braak
    Institute for Clinical Neuroanatomy, University of Frankfurt, Frankfurt Main, Germany
    J Neural Transm 110:517-36. 2003
    ....
  51. ncbi request reprint The Brainstem Tau Cytoskeletal Pathology of Alzheimer's Disease: A Brief Historical Overview and Description of its Anatomical Distribution Pattern, Evolutional Features, Pathogenetic and Clinical Relevance
    Udo Rüb
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Curr Alzheimer Res 13:1178-97. 2016
    ..The very early occurrence of the AD-related cytoskeletal pathology in some of these brainstem nuclei points to a major and strategic role of the brainstem in the induction and brain spread of the AD-related cytoskeletal pathology. ..
  52. doi request reprint Brain pathology of spinocerebellar ataxias
    Kay Seidel
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University, Theodor Stern Kai 7, 60950, Frankfurt Main, Germany
    Acta Neuropathol 124:1-21. 2012
    ..Although inclusions may impair axonal transport, bind transcription factors, and block protein quality control, detailed molecular and pathogenetic consequences remain to be determined...
  53. doi request reprint First appraisal of brain pathology owing to A30P mutant alpha-synuclein
    Kay Seidel
    Institute of Clinical Neuroanatomy, Dr Senckenberg Anatomy, Goethe University, Frankfurt am Main, Germany
    Ann Neurol 67:684-9. 2010
    ....
  54. doi request reprint Spinocerebellar ataxia 2 (SCA2)
    Isabel Lastres-Becker
    Molecular Neurogenetics, Department of Neurology, Klinikum, J W Goethe University, Frankfurt am Main, Germany
    Cerebellum 7:115-24. 2008
    ....
  55. doi request reprint Functional neuroanatomy of the human premotor oculomotor brainstem nuclei: insights from postmortem and advanced in vivo imaging studies
    Udo Rüb
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Exp Brain Res 187:167-80. 2008
    ..This will help radiologists to identify these nuclei in living patients and will enable clinicians to monitor the progression of neurological disorders affecting the oculomotor system...
  56. ncbi request reprint Parkinson's disease: affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system
    H Braak
    Department of Anatomy, J W Goethe University, Frankfurt, Germany
    Acta Neuropathol 99:489-95. 2000
    ..This functional deficit most probably contributes to the overall dysfunction of the motor system typically evolving in the course of Parkinson's disease...
  57. ncbi request reprint Cognitive status correlates with neuropathologic stage in Parkinson disease
    H Braak
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neurology 64:1404-10. 2005
    ..None had received the clinical diagnosis of dementia with Lewy bodies (DLB)...
  58. ncbi request reprint Age-related progression of tau pathology in brains of baboons
    C Schultz
    Department of Anatomy, Johann Wolfgang Goethe University, 60590, Frankfurt Main, Germany
    Neurobiol Aging 21:905-12. 2000
    ..In conclusion, the present findings underline the value of the baboon as a potential nonhuman primate model for age-related tau pathology afflicting the human brain...
  59. ncbi request reprint Involvement of precerebellar nuclei in multiple system atrophy
    H Braak
    Institute for Clinical Neuroanatomy, JW Goethe University, Frankfurt am Main, Germany
    Neuropathol Appl Neurobiol 29:60-76. 2003
    ..The uniformly bilateral damage and, in some cases, even obliteration of the nuclei studied, supply additional evidence for the pathoanatomical substrata of the cerebellar dysfunction that reportedly emerges in the clinical course of MSA...
  60. ncbi request reprint alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei
    E Braak
    Department of Anatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Acta Neuropathol 101:195-201. 2001
    ..Fine, dust-like particles and small globular Lewy bodies were encountered solely within the limits of intraneuronal lipofuscin or neuromelanin deposits...
  61. ncbi request reprint Gender and age modify the association between APOE and AD-related neuropathology
    E Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt, Germany
    Neurology 56:1696-701. 2001
    ..To assess the impact of apolipoprotein E (APOE) polymorphism on AD-related neurofibrillary tangle (NFT) formation and senile plaques (SP)...
  62. ncbi request reprint The intralaminar nuclei assigned to the medial pain system and other components of this system are early and progressively affected by the Alzheimer's disease-related cytoskeletal pathology
    U Rüb
    Department of Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    J Chem Neuroanat 23:279-90. 2002
    ..Given this fact, the question arises as to whether non-discriminative aspects mediated by the medial pain system could be employed to identify individuals in the very earliest stages of AD...
  63. ncbi request reprint Nerve cells expressing heat-shock proteins in Parkinson's disease
    H Braak
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Acta Neuropathol 102:449-54. 2001
    ..Nevertheless, most of the telencephalic alphaB-crystallin-immunopositive neurons refrain from developing Lewy bodies and Lewy neurites and, vice versa, most of the nerve cells containing Lewy bodies do not accumulate alphaB-crystallin...
  64. ncbi request reprint Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 allele
    E Ghebremedhin
    Department of Anatomy, J W Goethe University, Frankfurt Main, Germany
    Acta Neuropathol 96:222-4. 1998
    ..0002). The association between AGD and epsilon2 allele of ApoE suggests that AGD can be distinguished from other neurodegenerative disorders not only neuropathologically, but also genetically...
  65. ncbi request reprint Phases of A beta-deposition in the human brain and its relevance for the development of AD
    Dietmar R Thal
    Department of Anatomy, J W Goethe University, Frankfurt am Main, Germany
    Neurology 58:1791-800. 2002
    ..The deposition of the amyloid beta protein (Abeta) is a histopathologic hallmark of AD. The regions of the medial temporal lobe (MTL) are hierarchically involved in Abeta-deposition...
  66. doi request reprint Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease
    Simon Baudrexel
    Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Neuroimage 51:512-20. 2010
    ....
  67. doi request reprint Spinocerebellar ataxia type 6 (SCA6): neurodegeneration goes beyond the known brain predilection sites
    K Gierga
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 35:515-27. 2009
    ....
  68. doi request reprint Widespread thalamic and cerebellar degeneration in a patient with a complicated hereditary spastic paraplegia (HSP)
    K Seidel
    Institute of Clinical Neuroanatomy, Dr Senckenberg Anatomy, Goethe University, D 60590 Frankfurt Main, Germany
    Ann Anat 191:203-11. 2009
    ..In view of their known functional role, damage to these central nervous gray and white matter components offers explanations for the patient's pyramidal signs, her cerebellar, psychiatric and neuropsychological disease symptoms...
  69. ncbi request reprint The Neuropathology of Huntington´s disease: classical findings, recent developments and correlation to functional neuroanatomy
    Udo Rüb
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University Frankfurt, Frankfurt, Germany
    Adv Anat Embryol Cell Biol 217:1-146. 2015
    ..Finally, the potential pathophysiological role of axonal transport deficit..
  70. ncbi request reprint Characterization of human melatonin synthesis using autoptic pineal tissue
    Katrin Ackermann
    Institute of Anatomy III, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Endocrinology 147:3235-42. 2006
    ..In particular, our results give strong experimental support for the idea that transcriptional mechanisms are not dominant for the generation of rhythmic melatonin synthesis in the human pineal gland...
  71. ncbi request reprint Cognitive function in multiple system atrophy of the cerebellar type
    Katrin Burk
    Department of Neurology, University of Ulm, Ulm, and Department of Neurology, University of Tubingen, Tubingen, Germany
    Mov Disord 21:772-6. 2006
    ..Test performance was not related to the severity of motor disability. Regarding the similar cognitive syndrome of MSA-P, the otherwise subclinical problems in MSA-C result from subcortical rather than from cerebellar dysfunction...
  72. doi request reprint Involvement of the auditory brainstem system in spinocerebellar ataxia type 2 (SCA2), type 3 (SCA3) and type 7 (SCA7)
    F Hoche
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 34:479-91. 2008
    ..Although recent clinical studies reported additional disease signs suggesting involvement of the brainstem auditory system, this has never been studied in detail in SCA2, SCA3 or SCA7...
  73. ncbi request reprint Involvement of the cranial nerves and their nuclei in spinocerebellar ataxia type 2 (SCA2)
    K Gierga
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Acta Neuropathol 109:617-31. 2005
    ....
  74. doi request reprint Intraneuronal Transport and Defense Mechanisms with Possible Pathogenetic Relevance in Huntington's Disease (HD)
    Udo Rüb
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University Frankfurt, Frankfurt, Germany
    Adv Anat Embryol Cell Biol 217:91-100. 2015
    ..8.1) (De Vos et al. 2008; Gunawardena and Goldstein 2005; Li and Conforti 2013; Millecamps and Julien 2013). ..
  75. doi request reprint Pathological Nerve Cell Alterations in Huntington's Disease (HD) and Their Possible Role for the Demise of Nerve Cells
    Udo Rüb
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University Frankfurt, Frankfurt, Germany
    Adv Anat Embryol Cell Biol 217:119-23. 2015
    ..2006; rüb et al. 2013a). ..
  76. doi request reprint Consistent and Widespread Degeneration of the Cerebellum in Huntington's Disease (HD)
    Udo Rüb
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University Frankfurt, Frankfurt, Germany
    Adv Anat Embryol Cell Biol 217:55-66. 2015
    ..2005; Ross and Tabrizi 2011; Rüb et al. 2009, 2013a, 2014a, b; The Huntington's disease Collaborative Research Group 1993; Vonsattel 2008; Vonsattel and DiFiglia 1998; Vonsattel et al. 1985; Walker 2007a, b). ..
  77. doi request reprint The Cerebral Cortex in Huntington's Disease (HD)
    Udo Rüb
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University Frankfurt, Frankfurt, Germany
    Adv Anat Embryol Cell Biol 217:25-39. 2015
    ..2004; Forno and Jose 1973; Hedreen et al. 1991; Heinsen et al. 1992, 1994, 1999; Heinsen and Rüb 1997; McCaughey 1961; Richardson 1990; Selemon et al. 2004; Sotrel et al. 1991; Vonsattel 2008; Vonsattel and DiFiglia 1998). ..
  78. pmc Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration
    Suzana Gispert
    Department of Neurology, University Medical School, Frankfurt am Main, Germany
    PLoS ONE 4:e5777. 2009
    ..We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive PARK6 variant of PD...
  79. doi request reprint The human premotor oculomotor brainstem system - can it help to understand oculomotor symptoms in Huntington's disease?
    U Rüb
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 35:4-15. 2009
    ..This knowledge may aid clinicians in the diagnosis and monitoring of the disease...
  80. ncbi request reprint Anatomically based guidelines for systematic investigation of the central somatosensory system and their application to a spinocerebellar ataxia type 2 (SCA2) patient
    U Rüb
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 29:418-33. 2003
    ..In proposing these new guidelines, we hope to enable others to study the hitherto unknown morphological counterparts of somatosensory dysfunctions in additional CAG-repeat disease patients...
  81. ncbi request reprint Stages of sleep pathology in spinocerebellar ataxia type 2 (SCA2)
    I Tuin
    Department of Neurology, J W Goethe University, Frankfurt Main, Germany
    Neurology 67:1966-72. 2006
    ....