Thomas Deller

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression
    Sascha W Weyer
    Department of Bioinformatics and Functional Genomics, Ruprecht Karls University Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Im Neuenheimer Feld 364, Heidelberg D 69120, Germany
    Acta Neuropathol Commun 2:36. 2014
  2. ncbi request reprint A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity
    Thomas Deller
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Ann Anat 189:5-16. 2007
  3. ncbi request reprint Plasticity of synaptopodin and the spine apparatus organelle in the rat fascia dentata following entorhinal cortex lesion
    Thomas Deller
    Institute of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 499:471-84. 2006
  4. ncbi request reprint Structural reorganization of the dentate gyrus following entorhinal denervation: species differences between rat and mouse
    Thomas Deller
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Prog Brain Res 163:501-28. 2007
  5. ncbi request reprint Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neurons
    Thomas Deller
    Department of Clinical Neuroanatomy, JW Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 453:33-44. 2002
  6. doi request reprint Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle
    Peter Jedlicka
    Department of Clinical Neuroanatomy, Goethe University of Frankfurt, Frankfurt am Main, Germany
    Hippocampus 19:130-40. 2009
  7. doi request reprint Calcium homeostasis of acutely denervated and lesioned dentate gyrus in organotypic entorhino-hippocampal co-cultures
    Christian M Müller
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Cell Calcium 47:242-52. 2010
  8. doi request reprint 3D-reconstruction and functional properties of GFP-positive and GFP-negative granule cells in the fascia dentata of the Thy1-GFP mouse
    Mario Vuksic
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Hippocampus 18:364-75. 2008
  9. pmc Synaptopodin regulates denervation-induced homeostatic synaptic plasticity
    Andreas Vlachos
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Proc Natl Acad Sci U S A 110:8242-7. 2013
  10. pmc Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures
    Andreas Vlachos
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt, Germany
    PLoS ONE 7:e32883. 2012

Detail Information

Publications86

  1. pmc Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression
    Sascha W Weyer
    Department of Bioinformatics and Functional Genomics, Ruprecht Karls University Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Im Neuenheimer Feld 364, Heidelberg D 69120, Germany
    Acta Neuropathol Commun 2:36. 2014
    ..Collectively, these studies reveal a combined role of APP and APLP2 for dendritic architecture and a unique function of secreted APPs for spine density. ..
  2. ncbi request reprint A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity
    Thomas Deller
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Ann Anat 189:5-16. 2007
    ..Future studies will be aimed at finding the molecular link between synaptopodin, the spine apparatus organelle, and synaptic plasticity...
  3. ncbi request reprint Plasticity of synaptopodin and the spine apparatus organelle in the rat fascia dentata following entorhinal cortex lesion
    Thomas Deller
    Institute of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 499:471-84. 2006
    ....
  4. ncbi request reprint Structural reorganization of the dentate gyrus following entorhinal denervation: species differences between rat and mouse
    Thomas Deller
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Prog Brain Res 163:501-28. 2007
    ..Finally, we will discuss the use of the entorhinal denervation model in mutant mice...
  5. ncbi request reprint Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neurons
    Thomas Deller
    Department of Clinical Neuroanatomy, JW Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 453:33-44. 2002
    ..The intracellular sorting process, however, is independent of positional cues...
  6. doi request reprint Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle
    Peter Jedlicka
    Department of Clinical Neuroanatomy, Goethe University of Frankfurt, Frankfurt am Main, Germany
    Hippocampus 19:130-40. 2009
    ....
  7. doi request reprint Calcium homeostasis of acutely denervated and lesioned dentate gyrus in organotypic entorhino-hippocampal co-cultures
    Christian M Müller
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Cell Calcium 47:242-52. 2010
    ....
  8. doi request reprint 3D-reconstruction and functional properties of GFP-positive and GFP-negative granule cells in the fascia dentata of the Thy1-GFP mouse
    Mario Vuksic
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Hippocampus 18:364-75. 2008
    ..Taken together, this study provides morphometric data on granule cells of mice bred on a C57BL/6 background and establishes the Thy1-GFP mouse as a tool to study granule cell neurobiology...
  9. pmc Synaptopodin regulates denervation-induced homeostatic synaptic plasticity
    Andreas Vlachos
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Proc Natl Acad Sci U S A 110:8242-7. 2013
    ..Thus, our results disclose an important role for SP/SA in homeostatic synaptic plasticity...
  10. pmc Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures
    Andreas Vlachos
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt, Germany
    PLoS ONE 7:e32883. 2012
    ..Taken together, our data show that entorhinal denervation results in homeostatic functional changes of excitatory postsynapses of denervated dentate granule cells in vitro...
  11. ncbi request reprint Laser microdissection reveals regional and cellular differences in GFAP mRNA upregulation following brain injury, axonal denervation, and amyloid plaque deposition
    Guido J Burbach
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Glia 48:76-84. 2004
    ..Because astrocytic GFAP mRNA upregulation differs among the three lesioning paradigms, we conclude that the lesion type is an important determinant of postlesional astrocytic reactivity...
  12. doi request reprint Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo
    Peter Jedlicka
    Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Neuroscience Center, D 60590 Frankfurt am Main, Germany
    Cereb Cortex 21:357-67. 2011
    ..Collectively, our data demonstrate for the first time that deletion of NL2 increases excitability of cortical neurons in the hippocampus of intact animals, most likely through impaired GABA(A)R clustering...
  13. ncbi request reprint Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus
    Carlos Bas Orth
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Comp Neurol 487:227-39. 2005
    ..We conclude, that this organelle is distributed in a region- and layer-specific manner in the mouse hippocampus and suggest that differences in the activity of afferent fiber systems could determine its distribution...
  14. ncbi request reprint Loss of the cisternal organelle in the axon initial segment of cortical neurons in synaptopodin-deficient mice
    Carlos Bas Orth
    Institute of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 504:441-9. 2007
    ..Taken together, our data demonstrate that synaptopodin is an essential component of the cisternal organelle of axons and of the dendritic spine apparatus, two organelles that are structurally and molecularly related...
  15. ncbi request reprint Neuronal hyperactivity induces astrocytic expression of neurocan in the adult rat hippocampus
    Stephan W Schwarzacher
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Glia 53:704-14. 2006
    ..In conclusion, our data indicate that synaptic activity regulates the astrocytic expression of neurocan in a graded manner...
  16. doi request reprint Reduced excitability in the dentate gyrus network of betaIV-spectrin mutant mice in vivo
    Raphael Winkels
    Institute of Clinical Neuroanatomy, Goethe University, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Hippocampus 19:677-86. 2009
    ..Taken together, our findings demonstrate that betaIV-spectrin is required for normal granule cell firing and for physiological levels of network excitability in the mouse dentate gyrus in vivo...
  17. doi request reprint Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo
    Peter Jedlicka
    Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Mol Cell Neurosci 41:94-100. 2009
    ..In conclusion, our data provide the first evidence that Cb-deficiency leads to significant changes of GABAergic inhibition, network excitability and synaptic plasticity in vivo...
  18. ncbi request reprint Comparison of commissural sprouting in the mouse and rat fascia dentata after entorhinal cortex lesion
    Domenico Del Turco
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Hippocampus 13:685-99. 2003
    ..These data demonstrate an important species difference in the commissural/associational sprouting response between rats and mice that needs to be taken into account in future studies...
  19. doi request reprint Time-lapse imaging of granule cells in mouse entorhino-hippocampal slice cultures reveals changes in spine stability after entorhinal denervation
    Andreas Vlachos
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt 60590, Germany
    J Comp Neurol 520:1891-902. 2012
    ..We conclude that biphasic changes in spine loss rate and spine stability but not in the rate of spine formation play a central role in the reorganization of dentate granule cells after entorhinal denervation in vitro...
  20. doi request reprint Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice
    Stefanie Frank
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Neurosci Lett 453:41-4. 2009
    ..Since TLR-upregulation is restricted to plaques, modifying TLR-signaling may be a promising therapeutic strategy for plaque removal...
  21. doi request reprint TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice
    Stefanie Frank
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Glia 56:1438-47. 2008
    ..At the same time, TREM2 signaling may also account for the failure to sufficiently eliminate extracellular amyloid with the help of a systemic immune response...
  22. doi request reprint Unilateral entorhinal denervation leads to long-lasting dendritic alterations of mouse hippocampal granule cells
    Mario Vuksic
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, D 60590 Frankfurt Main, Germany
    Exp Neurol 230:176-85. 2011
    ..Spontaneously occurring reinnervation processes, such as the sprouting of surviving afferent fibers, are insufficient to maintain the granule cell dendritic arbor...
  23. pmc Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures
    Denise Becker
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt, Germany
    PLoS ONE 7:e48500. 2012
    ....
  24. doi request reprint Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases
    Estifanos Ghebremedhin
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Neuropathol Exp Neurol 69:442-8. 2010
    ..05 each). In conclusion, DLB and PD patients with advanced LB pathology were less likely to show severe cerebrovascular disease or history of stroke...
  25. doi request reprint sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress
    Ekaterini Copanaki
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, D 60590 Frankfurt, Germany
    Mol Cell Neurosci 44:386-93. 2010
    ..Taken together, our data demonstrate that sAPPalpha is neuroprotective under conditions of proteasomal stress...
  26. doi request reprint Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7
    Udo Rüb
    Dr Senckenberg Chronomedical Institute, Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Prog Neurobiol 104:38-66. 2013
    ..Furthermore, we provide an overview of the structure, interactions and functions of the different disease proteins. On the basis of these comprehensive data, similarities, differences and possible disease mechanisms are discussed...
  27. doi request reprint Differential regulation of chondroitin sulfate proteoglycan mRNAs in the denervated rat fascia dentata after unilateral entorhinal cortex lesion
    Ruth Schäfer
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Neurosci Lett 439:61-5. 2008
    ....
  28. ncbi request reprint Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage
    Guido J Burbach
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Neurobiol Aging 28:202-12. 2007
    ..Minor structural alterations of the vessel wall, however, cannot be excluded due to the sample size of our study and the high complexity of the three-dimensional vessel wall ultrastructure...
  29. ncbi request reprint Laminar organization of the mouse dentate gyrus: insights from BETA2/Neuro D mutant mice
    Domenico Del Turco
    Department of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 477:81-95. 2004
    ..These data indicate that granule cells are able to differentiate in the absence of BETA2/NeuroD and suggest that the signals underlying the laminar anatomy of the dentate gyrus are present in the absence of most target cells...
  30. pmc AnkyrinG is required to maintain axo-dendritic polarity in vivo
    Jürgen Markus Sobotzik
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, D 60590 Frankfurt Main, Germany
    Proc Natl Acad Sci U S A 106:17564-9. 2009
    ..Collectively, these findings demonstrate that axons of ankG-deficient mice acquire hallmark features of dendrites. AnkG thus is important for maintaining appropriate axo-dendritic polarity in vivo...
  31. ncbi request reprint Homozygosity for the K variant of BCHE gene increases the risk for development of neurofibrillary pathology but not amyloid deposits at young ages
    Estifanos Ghebremedhin
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Acta Neuropathol 114:359-63. 2007
    ..These findings suggest that homozygosity, but not heterozygosity, for BCHE-K is a potential risk factor for the development of NFT pathology in young individuals implicating BCHE-K in the pathogenesis of early AD...
  32. doi request reprint Repetitive magnetic stimulation induces functional and structural plasticity of excitatory postsynapses in mouse organotypic hippocampal slice cultures
    Andreas Vlachos
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, D 60590 Frankfurt Main, Germany
    J Neurosci 32:17514-23. 2012
    ..These results provide first experimental evidence that rMS induces coordinated functional and structural plasticity of excitatory postsynapses, which is consistent with a long-term potentiation of synaptic transmission...
  33. ncbi request reprint Lesion-induced axonal sprouting in the central nervous system
    Thomas Deller
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goether University, Frankfurt am Main, Germany
    Adv Exp Med Biol 557:101-21. 2006
    ..Finally, we discuss both the beneficial as well as disadvantageous functional implications of axonal sprouting for the injured organism in question...
  34. doi request reprint Computational modeling of GABAA receptor-mediated paired-pulse inhibition in the dentate gyrus
    Peter Jedlicka
    Institute of Clinical Neuroanatomy, Goethe University, Neuroscience Center, 60590, Frankfurt am Main, Germany
    J Comput Neurosci 29:509-19. 2010
    ..In summary, computer modeling provides a useful tool for determining the role of synaptic and intrinsic cellular mechanisms in paired-pulse field potential responses...
  35. ncbi request reprint Laser microdissection of immunolabeled astrocytes allows quantification of astrocytic gene expression
    Guido J Burbach
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Neurosci Methods 138:141-8. 2004
    ..It may similarly be employed in different settings where other cell types need to be identified and microdissected for gene expression profiling...
  36. ncbi request reprint Excitotoxic hippocampal neuron loss following sustained electrical stimulation of the perforant pathway in the mouse
    Friederike Kienzler
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe Universitat, D 60590 Frankfurt am Main, Germany
    Brain Res 1085:195-8. 2006
    ..Therefore, this mouse model of seizure-induced hippocampal injury can be used for a wide variety of studies in genetically altered conditions not available in rats...
  37. doi request reprint Activity-dependent intracellular chloride accumulation and diffusion controls GABA(A) receptor-mediated synaptic transmission
    Peter Jedlicka
    Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Neuroscience Center, Frankfurt am Main, Germany
    Hippocampus 21:885-98. 2011
    ..The simulations suggest that E(GABA) may differ even along a single dendrite supporting the idea that it is necessary to assign E(GABA) to a given GABAergic input and not to a given neuron...
  38. ncbi request reprint Associational sprouting in the mouse fascia dentata after entorhinal lesion in vitro
    Peter Prang
    Institute of Clinical Neuroanatomy, JW Goethe University, Theodor Stern Kai 7, D 60590, Frankfurt Main, Germany
    Brain Res 978:205-12. 2003
    ..Using organotypic entorhino-hippocampal slices of genetically engineered mice, this sprouting model can be used to identify molecules involved in the regulation of sprouting following brain injury...
  39. doi request reprint A role for the spine apparatus in LTP and spatial learning
    Peter Jedlicka
    Institute of Clinical Neuroanatomy, J W Goethe University of Frankfurt, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Behav Brain Res 192:12-9. 2008
    ....
  40. doi request reprint New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease)
    Udo Rüb
    Institute for Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    Curr Opin Neurol 21:111-6. 2008
    ..This review summarizes recent neuropathological findings in spinocerebellar ataxia type 3 and discusses their relevance for clinical neurology...
  41. ncbi request reprint Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice
    Carl Gebhardt
    Department of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 445:278-92. 2002
    ..These data provide further evidence for a role of granule cells in the laminar termination of commissural/associational afferents to the fascia dentata...
  42. doi request reprint Spinocerebellar ataxia type 2 (SCA2): identification of early brain degeneration in one monozygous twin in the initial disease stage
    Franziska Hoche
    Institute of Clinical Neuroanatomy, Dr Senckenberg Anatomy, Goethe University, 60590, Frankfurt am Main, Germany
    Cerebellum 10:245-53. 2011
    ..Since they were already involved in our patient within 3 years after disease onset, we think that we were for the first time able to identify the early brain targets of the pathological process of SCA2...
  43. ncbi request reprint Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice
    Guido J Burbach
    Institute of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt, Germany
    J Neurosci 24:2421-30. 2004
    ..Taken together, our data demonstrate a plaque-associated upregulation of BDNF in APP23 transgenic mice and implicate this neurotrophin in the regulation of inflammatory and axonal growth processes in the plaque vicinity...
  44. ncbi request reprint NG2 upregulation in the denervated rat fascia dentata following unilateral entorhinal cortex lesion
    Doris Dehn
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Glia 53:491-500. 2006
    ..This suggests that NG2 could regulate lesion-induced axonal growth in denervated areas of the brain...
  45. pmc Inhibition of Protease-Activated Receptor 1 Does not Affect Dendritic Homeostasis of Cultured Mouse Dentate Granule Cells
    Gerlind Schuldt
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt Frankfurt, Germany
    Front Neuroanat 10:64. 2016
    ..These results indicate that drugs targeting neural PAR1-signals may not affect the stability and structural integrity of neuronal networks in healthy brain regions. ..
  46. doi request reprint Repetitive magnetic stimulation induces plasticity of excitatory postsynapses on proximal dendrites of cultured mouse CA1 pyramidal neurons
    Maximilian Lenz
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Brain Struct Funct 220:3323-37. 2015
    ....
  47. doi request reprint Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus
    Matej Vnencak
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, Frankfurt am Main, Germany
    J Comp Neurol 523:1717-29. 2015
    ..Based on these results we conclude that APLP1 deficiency on its own does not lead to defects in synaptic plasticity, but affects synaptic transmission and network inhibition in the dentate gyrus...
  48. ncbi request reprint Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons
    Christian Schultz
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Mol Cell Neurosci 33:68-80. 2006
    ..These data provide the first evidence for a compartmentalized clustering of NF-kappaB pathway components in the AIS and implicate this neuronal compartment in the activation of NF-kappaB...
  49. pmc Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus
    Domenico Del Turco
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Germany
    Front Mol Neurosci 9:134. 2016
    ..This regional difference in APP expression may explain why loss-of-function approaches using APP-deficient mice revealed a role for APP in Hebbian plasticity in area CA1, whereas this could not be shown in the DG of the same APP mutants...
  50. doi request reprint Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging
    Donat Kogel
    Experimental Neurosurgery, Neuroscience Center, Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Exp Brain Res 217:471-9. 2012
    ....
  51. doi request reprint Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo
    Peter Jedlicka
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, Frankfurt am Main, Germany
    Exp Brain Res 217:441-7. 2012
    ....
  52. doi request reprint Neuroanatomical characteristics of the human pre-Bötzinger complex and its involvement in neurodegenerative brainstem diseases
    Stephan W Schwarzacher
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Brain 134:24-35. 2011
    ....
  53. ncbi request reprint Organotypic entorhino-hippocampal slice cultures--a tool to study the molecular and cellular regulation of axonal regeneration and collateral sprouting in vitro
    Domenico Del Turco
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt, Germany
    Methods Mol Biol 399:55-66. 2007
    ....
  54. ncbi request reprint Quantification of layer-specific gene expression in the hippocampus: effective use of laser microdissection in combination with quantitative RT-PCR
    Guido J Burbach
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Neurosci Methods 131:83-91. 2003
    ....
  55. pmc Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy
    Laurent M Willems
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Theodor Stern Kai 7, Frankfurt, 60590, Germany
    Acta Neuropathol Commun 4:28. 2016
    ..We conclude that inhibition of S1PR signaling prevents dendritic destabilization and denervation-induced dendrite loss. These results suggest a novel neuroprotective effect for pharmaceuticals targeting neural S1PR pathways. ..
  56. pmc Repetitive magnetic stimulation induces plasticity of inhibitory synapses
    Maximilian Lenz
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, Frankfurt Main 60590, Germany
    Nat Commun 7:10020. 2016
    ..These results disclose that rTMS induces coordinated Ca(2+)-dependent structural and functional changes of specific inhibitory postsynapses on principal neurons. ..
  57. pmc Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling
    Afsaneh Majdazari
    Reseach Group Developmental Neurobiology, Max Planck Institute for Brain Research, Frankfurt M, Germany, Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt M, Germany, Genetics of Development and Disease Branch, NIDDK, NIH, Bethesda, Maryland 20892, Department of Biologic and Materials Sciences, University of Michigan, School of Dentistry, Ann Arbor, Michigan 48109 1078, and Department Molecular Biology of the Cell I German Cancer Research Center, D 69120 Heidelberg, Germany
    J Neurosci 33:15132-44. 2013
    ..BMPR1 signaling controls dendrite complexity postnatally during the major dendritic growth period of sympathetic neurons. ..
  58. ncbi request reprint Consistent affection of the central somatosensory system in spinocerebellar ataxia type 2 and type 3 and its significance for clinical symptoms and rehabilitative therapy
    Udo Rüb
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Brain Res Rev 53:235-49. 2007
    ....
  59. doi request reprint First appraisal of brain pathology owing to A30P mutant alpha-synuclein
    Kay Seidel
    Institute of Clinical Neuroanatomy, Dr Senckenberg Anatomy, Goethe University, Frankfurt am Main, Germany
    Ann Neurol 67:684-9. 2010
    ....
  60. ncbi request reprint Corneal femtosecond laser keratotomy results in isolated stromal injury and favorable wound-healing response
    Christian Meltendorf
    Department of Ophthalmology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Invest Ophthalmol Vis Sci 48:2068-75. 2007
    ..To examine the corneal repair response after intrastromal femtosecond (fs) laser keratotomy...
  61. pmc Tumor necrosis factor alpha maintains denervation-induced homeostatic synaptic plasticity of mouse dentate granule cells
    Denise Becker
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt Frankfurt, Germany
    Front Cell Neurosci 7:257. 2013
    ..We conclude that TNFα-signaling is a major regulatory system that aims at maintaining the homeostatic synaptic response of denervated neurons...
  62. pmc A general homeostatic principle following lesion induced dendritic remodeling
    Steffen Platschek
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, D 60590, Frankfurt Main, Germany
    Acta Neuropathol Commun 4:19. 2016
    ..Denervated neurons lose part of their dendritic tree, and are considered "atrophic", i.e. pathologically altered and damaged. The functional consequences of this phenomenon are poorly understood...
  63. doi request reprint Functional neuroanatomy of the human premotor oculomotor brainstem nuclei: insights from postmortem and advanced in vivo imaging studies
    Udo Rüb
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Exp Brain Res 187:167-80. 2008
    ..This will help radiologists to identify these nuclei in living patients and will enable clinicians to monitor the progression of neurological disorders affecting the oculomotor system...
  64. ncbi request reprint Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord
    Achim Schmidtko
    Pharmazentrum Frankfurt, Institut für Klinische Pharmakologie ZAFES, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Pain 115:171-81. 2005
    ..The distinctive role of synapsin II for pain signaling probably results from its specific localization and possibly from a specific control of glutamate release...
  65. pmc Tumor necrosis factor (TNF)-receptor 1 and 2 mediate homeostatic synaptic plasticity of denervated mouse dentate granule cells
    Denise Becker
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt D 60590, Germany
    Sci Rep 5:12726. 2015
    ....
  66. pmc Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition
    Namrata Mohapatra
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt Main, Germany
    Sci Rep 6:23196. 2016
    ..Altogether, our results suggest a fundamental role of dendritic spines in shaping Cl(-) diffusion, which could be of relevance in the context of pathological conditions where spine densities and neural excitability are perturbed. ..
  67. pmc Upregulation of APP, ADAM10 and ADAM17 in the denervated mouse dentate gyrus
    Domenico Del Turco
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, Frankfurt Main, Germany
    PLoS ONE 9:e84962. 2014
    ..This suggests that APP-processing could be shifted towards the non-amyloidogenic pathway in denervated areas of the brain and, thus, towards the formation of neuroprotective APP cleavage products, such as APPsα. ..
  68. ncbi request reprint Relationship of apolipoprotein E and age at onset to Parkinson disease neuropathology
    Estifanos Ghebremedhin
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    J Neuropathol Exp Neurol 65:116-23. 2006
    ..001). In conclusion, our findings suggest that APOE may express its effect on the risk of PD by modifying the occurrence of PD pathology, but age of PD onset seems to be the principal determinant of the progression rate of PD pathology...
  69. ncbi request reprint Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6
    Hans Hermann Hoepken
    Section for Molecular Neurogenetics, Clinic for Neurology, University Hospital, Theodor Stern Kai 7, 60590 Frankfurt M, Germany
    Neurobiol Dis 25:401-11. 2007
    ..These data indicate that PINK1 function is critical to prevent oxidative damage and that peripheral cells may be useful for studies of progression and therapy of PARK6...
  70. pmc Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis
    Joanna C Jen
    Department of Neurology, University of California, Los Angeles, CA 90095, USA
    Science 304:1509-13. 2004
    ..Like its murine homolog Rig1/Robo3, but unlike other Robo proteins, ROBO3 is required for hindbrain axon midline crossing...
  71. ncbi request reprint Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport
    Sara K Custer
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
    Nat Neurosci 9:1302-11. 2006
    ..Our studies indicate that impairment of glutamate transport secondary to glial dysfunction contributes to SCA7 neurodegeneration, and suggest a similar role for glial dysfunction in other polyglutamine diseases and SCAs...
  72. ncbi request reprint Spinocerebellar ataxia type 3 (SCA3): thalamic neurodegeneration occurs independently from thalamic ataxin-3 immunopositive neuronal intranuclear inclusions
    Udo Rüb
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe Univeristy, Frankfurt Main, Germany
    Brain Pathol 16:218-27. 2006
    ..This lack of correlation may suggest that ataxin-3 immunopositive NI are not immediately decisive for the fate of affected nerve cells but rather represent unspecific and pathognomonic morphological markers of SCA3...
  73. ncbi request reprint Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice
    Alexander Drakew
    Institute of Anatomy, University of Freiburg, Albertstrasse 17, Freiburg, D 79104, Germany
    Exp Neurol 176:12-24. 2002
    ....
  74. ncbi request reprint Induction of STAT3 signaling in activated astrocytes and sprouting septal neurons following entorhinal cortex lesion in adult rats
    Xu Gang Xia
    Institute of Anatomy I, University of Freiburg, PO Box 111, Albertstrasse 23, D 79001, Freiburg, Germany
    Mol Cell Neurosci 21:379-92. 2002
    ..These data indicate that CNTF or related gp130-associated cytokines play a dual role after brain lesion: (1). regulation of astrocytic responses to deafferentation and (2). regulation or modulation of axonal sprouting...
  75. ncbi request reprint CNTF and CNTF receptor alpha are constitutively expressed by astrocytes in the mouse brain
    Christine Dallner
    Institute of Anatomy I, University of Freiburg, Freiburg, Germany
    Glia 37:374-8. 2002
    ..The nonoverlapping locations of astrocytes expressing detectable levels of CNTF and CNTFRalpha, respectively, may be related to distinct postlesional functions of these two glial cell populations...
  76. ncbi request reprint Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling
    Matthias Stanke
    Research Group Developmental Neurobiology, Max Planck Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt M, Germany
    Development 133:141-50. 2006
    ..These results demonstrate an essential role of gp 130-signaling in the target-dependent specification of the cholinergic neurotransmitter phenotype...
  77. ncbi request reprint Postnatal development of synaptopodin expression in the rodent hippocampus
    Kathrin Czarnecki
    Institute of Anatomy and Cell Biology, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 490:133-44. 2005
    ..However, no immunolabeling for synaptopodin was observed in identified interneurons, confirming that the protein is mainly present in spine-bearing principal cells...
  78. ncbi request reprint Entorhinal cortex lesion in the mouse induces transsynaptic death of perforant path target neurons
    Adam D Kovac
    Institute of Anatomy, Deptment of Cell and Neurobiology, Charite, University Medicine, Berlin, Germany
    Brain Pathol 14:249-57. 2004
    ....
  79. ncbi request reprint Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice
    Karl Heinz Weiss
    Anatomisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 460:56-65. 2003
    ..Our results suggest that Reelin signaling via ApoER2, VLDLR, and Dab1 is required for the formation of a regular radial glial scaffold in the dentate gyrus...
  80. pmc Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity
    Thomas Deller
    Institute of Anatomy, University of Freiburg, P O Box 111, D 79001 Freiburg, Germany
    Proc Natl Acad Sci U S A 100:10494-9. 2003
    ..This genetic analysis points to a role of the spine apparatus in synaptic plasticity...
  81. ncbi request reprint Corneal trephination with the femtosecond laser
    Christian Meltendorf
    Department of Ophthalmology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Cornea 25:1090-2. 2006
    ..To evaluate the feasibility and cut quality of corneal trephination in human donor corneal tissue with the femtosecond laser...
  82. pmc Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 101:3253-7. 2004
    ..The paucity of substance P in laminae I-III may contribute to the reduction of nociception in PKG-I(-/-) mice and suggests a role of PKG-I in substance P synthesis...
  83. ncbi request reprint Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation
    Suzana Gispert
    Department of Anatomy II Experimental Neurobiology, University Frankfurt M, Frankfurt, Germany
    Mol Cell Neurosci 24:419-29. 2003
    ..Transgenic animals expressing mutant alpha-synuclein may be a valuable model to assess specific aspects of the pathogenesis of synucleinopathies...
  84. ncbi request reprint The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1
    Uwe Schulte
    Logopharm GmbH, Hermann Herder Str 7, 79104 Freiburg, Germany
    Neuron 49:697-706. 2006
    ..The results establish Lgi1 as a novel subunit of Kv1.1-associated protein complexes and suggest that changes in inactivation gating of presynaptic A-type channels may promote epileptic activity...
  85. ncbi request reprint Anterograde tracing of human hippocampus in vitro-a neuroanatomical tract tracing technique for the analysis of local fiber tracts in human brain
    Thomas M Freiman
    Department of Neurosurgery, Neurozentrum, University Clinic of Freiburg, Breisacher Strasse 64, D 79106, Freiburg, Germany
    J Neurosci Methods 120:95-103. 2002
    ..These data demonstrate that in vitro anterograde tracing can be employed to study the local connectivity of the human brain at the light and electron microscopic level...
  86. ncbi request reprint Hereditary early-onset Parkinson's disease caused by mutations in PINK1
    Enza Maria Valente
    CSS IRCCS, Mendel Institute, Viale Regina Margherita 261, 00198 Rome, Italy
    Science 304:1158-60. 2004
    ..These data provide a direct molecular link between mitochondria and the pathogenesis of PD...