Urs Christen

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?
    Urs Christen
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Int J Mol Sci 17:. 2016
  2. ncbi request reprint An Update on Animal Models of Autoimmune Hepatitis: Are we There Yet?
    Urs Christen
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Curr Pharm Des 21:2391-400. 2015
  3. pmc Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice
    Selina Christen
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital, Frankfurt am Main, Germany
    PLoS ONE 8:e54675. 2013
  4. doi request reprint The role of autoantibodies in autoimmune hepatitis type 2
    Urs Christen
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Immunotherapy 5:247-56. 2013
  5. pmc Infection as a cause of type 1 diabetes?
    Urs Christen
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital, Frankfurt am Main, Germany
    Curr Opin Rheumatol 24:417-23. 2012
  6. pmc Viral triggers for autoimmunity: is the 'glass of molecular mimicry' half full or half empty?
    Urs Christen
    Pharmazentrum ZAFES, Clinic of the Goethe University Frankfurt, Frankfurt am Main, Germany
    J Autoimmun 34:38-44. 2010
  7. pmc Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus-induced mouse model
    S Christen
    Pharmazentrum frankfurt ZAFES, Klinikum der Goethe Universität, Frankfurt am Main, Germany
    Clin Exp Immunol 165:318-28. 2011
  8. pmc Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?
    Urs Christen
    Pharmazentrum frankfurt ZAFES, Klinikum der Goethe Universität, Frankfurt am Main, Germany
    Cell Mol Immunol 8:193-8. 2011
  9. pmc Cytochrome P450 2D6 as a model antigen
    Urs Christen
    Klinikum der Goethe Universität Frankfurt am Main, Pharmazentrum ZAFES, Frankfurt am Main, Germany
    Dig Dis 28:80-5. 2010
  10. doi request reprint New animal models for autoimmune hepatitis
    Urs Christen
    Clinic of the Goethe University Frankfurt am Main, Pharmazentrum frankfurt ZAFES, 60590 Frankfurt am Main, Germany
    Semin Liver Dis 29:262-72. 2009

Collaborators

Detail Information

Publications50

  1. pmc Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?
    Urs Christen
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Int J Mol Sci 17:. 2016
    ..Here we will review the insight on the immunopathogenesis of AIH as gained from clinical observation and from animal models...
  2. ncbi request reprint An Update on Animal Models of Autoimmune Hepatitis: Are we There Yet?
    Urs Christen
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Curr Pharm Des 21:2391-400. 2015
    ..Here we will review the past and present attempts to develop a consistent animal model for autoimmune hepatitis. ..
  3. pmc Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice
    Selina Christen
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital, Frankfurt am Main, Germany
    PLoS ONE 8:e54675. 2013
    ..In summary, our data suggest that JAM-C might be involved in the final steps of trafficking and transmigration of antigen-specific autoaggressive T-cells to the islets of Langerhans...
  4. doi request reprint The role of autoantibodies in autoimmune hepatitis type 2
    Urs Christen
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Immunotherapy 5:247-56. 2013
    ..This review will reflect on the evidence of how specific autoantibodies influence AIH and will further provide insight into the necessities for generating therapeutic antibodies to treat AIH in the future...
  5. pmc Infection as a cause of type 1 diabetes?
    Urs Christen
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital, Frankfurt am Main, Germany
    Curr Opin Rheumatol 24:417-23. 2012
    ..Human enteroviruses have dominated the literature associated with the etiology of T1D. However, virus infections have also been reported to protect from autoimmune disorders...
  6. pmc Viral triggers for autoimmunity: is the 'glass of molecular mimicry' half full or half empty?
    Urs Christen
    Pharmazentrum ZAFES, Clinic of the Goethe University Frankfurt, Frankfurt am Main, Germany
    J Autoimmun 34:38-44. 2010
    ..We focus on the RIP-LCMV model for type 1 diabetes and the novel cytochrome P450 2D6 (CYP2D6) model for autoimmune hepatitis, which use either identical or similar triggering and target antigens...
  7. pmc Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus-induced mouse model
    S Christen
    Pharmazentrum frankfurt ZAFES, Klinikum der Goethe Universität, Frankfurt am Main, Germany
    Clin Exp Immunol 165:318-28. 2011
    ....
  8. pmc Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?
    Urs Christen
    Pharmazentrum frankfurt ZAFES, Klinikum der Goethe Universität, Frankfurt am Main, Germany
    Cell Mol Immunol 8:193-8. 2011
    ..Therefore, it is important to integrate more than just one possible environmental triggering factor for autoimmune diseases to occur...
  9. pmc Cytochrome P450 2D6 as a model antigen
    Urs Christen
    Klinikum der Goethe Universität Frankfurt am Main, Pharmazentrum ZAFES, Frankfurt am Main, Germany
    Dig Dis 28:80-5. 2010
    ..The CYP2D6 model provides a platform to investigate mechanisms involved in the immunopathogenesis of autoimmune-mediated chronic hepatic injury and evaluate possible ways of therapeutic interference...
  10. doi request reprint New animal models for autoimmune hepatitis
    Urs Christen
    Clinic of the Goethe University Frankfurt am Main, Pharmazentrum frankfurt ZAFES, 60590 Frankfurt am Main, Germany
    Semin Liver Dis 29:262-72. 2009
    ....
  11. ncbi request reprint Animal models for autoimmune hepatitis
    Urs Christen
    Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Autoimmun Rev 6:306-11. 2007
    ..However, most models were only successful in causing a transient form of hepatic damage and often used rather complex ways of disease induction...
  12. ncbi request reprint Chemokines as drug targets in type 1 diabetes
    Urs Christen
    Pharmazentrum Frankfurt, Zentrum fur Arzneimittelforschung, Entwicklung und Sicherheit ZAFES, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Endocr Metab Immune Disord Drug Targets 7:7-12. 2007
    ..This review focuses on blocking of chemokines in animal models of type 1 diabetes and discusses the possible applications of such treatments in human autoimmune disease...
  13. doi request reprint Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis
    Janine Ehser
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Autoimmun 42:39-49. 2013
    ..Our data indicate that self/non-self molecular mimicry, rather than molecular identity, is a prerequisite for breaking T-cell tolerance in the liver...
  14. doi request reprint Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6
    Edith Hintermann
    Pharmazentrum frankfurt ZAFES, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Autoimmun 44:49-60. 2013
    ....
  15. doi request reprint Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model
    Edith Hintermann
    Pharmazentrum frankfurt ZAFES, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, Goethe University Hospital, Frankfurt am Main, Germany
    J Autoimmun 37:242-53. 2011
    ..Our study demonstrates that epitope spreading does indeed occur during the pathogenesis of AIH and supports the concept of molecular mimicry as a possible initiating mechanism for AIH...
  16. doi request reprint Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model
    Peter Muller
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
    J Autoimmun 69:51-8. 2016
    ..Our data suggest that a pre-existing metabolic liver injury constitutes an additional risk for the severity of an autoimmune condition of the liver, such as AIH. ..
  17. pmc Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection
    Martin Holdener
    Pharmazentrum Frankfurt Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany
    J Exp Med 205:1409-22. 2008
    ..Our novel model system should be instrumental for studying mechanisms involved in the initiation, propagation, and precipitation of virus-induced autoimmune liver diseases...
  18. pmc Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis
    Edith Hintermann
    a Pharmazentrum Frankfurt ZAFES, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
    Cell Adh Migr 10:419-33. 2016
    ..Increased hepatic stellate cell contraction mediated by JAM-C/JAM-C interaction may cause intrahepatic vasoconstriction, which is a major complication in liver cirrhosis. ..
  19. doi request reprint Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes
    Christine Bender
    Institute for Pharmacology and Toxicology, pharmazentrum frankfurt Center for Drug Research, Development, and Safety ZAFES, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
    Diabetes 66:113-126. 2017
    ..CXCL10 might therefore constitute a potential therapeutic target to prolong islet graft survival...
  20. pmc CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation
    Edith Hintermann
    Pharmazentrum frankfurt ZAFES, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Autoimmun 35:424-35. 2010
    ..NK cells seem to play an important role in controlling HSC activity and fibrosis. CXCL10 blockade may constitute a possible therapeutic intervention for hepatic fibrosis...
  21. doi request reprint Anti-CD3/Anti-CXCL10 Antibody Combination Therapy Induces a Persistent Remission of Type 1 Diabetes in Two Mouse Models
    Stanley Lasch
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
    Diabetes 64:4198-211. 2015
    ..A sequential temporal inactivation of T cells and blockade of T-cell migration might constitute a novel therapy for patients with type 1 diabetes. ..
  22. ncbi request reprint Viral infection--a cure for type 1 diabetes?
    Edith Hintermann
    Pharmazentrum frankfurt ZAFES, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Curr Med Chem 14:2048-52. 2007
    ....
  23. pmc Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes
    Anika Berner
    Pharmazentrum frankfurt ZAFES, University Hospital Goethe University Frankfurt Frankfurt am Main, Germany
    Front Pharmacol 6:317. 2015
    ....
  24. doi request reprint Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution
    Edith Hintermann
    Pharmazentrum frankfurt ZAFES, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Liver Int 35:1265-73. 2015
    ..All these matrix components get upregulated during hepatic scar tissue formation. Therefore, we tested whether matrilin-2 has an influence on the formation and/or the resolution of fibrotic tissue in the mouse liver...
  25. doi request reprint GAD autoantibody affinity in schoolchildren from the general population
    Christine Bender
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Diabetologia 57:1911-8. 2014
    ..Here, we asked whether GADA affinity is a useful marker to stratify the risk of type 1 diabetes in GADA-positive schoolchildren from the general population...
  26. doi request reprint Pathogen infection as a possible cause for autoimmune hepatitis
    Urs Christen
    Pharmazentrum frankfurt ZAFES, Goethe University Hospital, Frankfurt am Main, Germany
    Int Rev Immunol 33:296-313. 2014
    ....
  27. pmc Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1
    Malte Bachmann
    Pharmazentrum frankfurt ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany
    PLoS Pathog 6:e1001144. 2010
    ....
  28. ncbi request reprint Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages
    Itamar Goren
    Pharmazentrum Frankfurt, ZAFES, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Invest Dermatol 127:2259-67. 2007
    ....
  29. ncbi request reprint Manipulating the type 1 vs type 2 balance in type 1 diabetes
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Res 30:309-25. 2004
    ..In this review we will focus on the pathogenesis of T1D in a virus-induced transgenic mouse model and discuss possibilities of how an aggressive type 1-dominated immune response can be restrained and autoimmunity be abrogated...
  30. ncbi request reprint IP-10 and type 1 diabetes: a question of time and location
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Autoimmunity 37:273-82. 2004
    ....
  31. ncbi request reprint Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics
    Mette Ejrnaes
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:2746-55. 2005
    ..Thus, secretion of IFN-gamma-inducible protein-10 by autoaggressive CD8(+) lymphocytes might determine their diabetogenic capacity by affecting recruitment of cells to the insulitic lesion...
  32. ncbi request reprint IP-10 and type 1 diabetes: a question of time and location
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA, USA
    Autoimmunity 37:273-82. 2004
    ....
  33. ncbi request reprint Virally induced inflammation and therapeutic avenues in type 1 diabetes
    Urs Christen
    Immune Regulation Laboratory, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Endocrinol Metab Clin North Am 33:45-58, viii. 2004
  34. ncbi request reprint Cytokines and chemokines in virus-induced autoimmunity
    Urs Christen
    The Scripts Research Institute, Division of Virology, La Jolla, California, USA
    Adv Exp Med Biol 520:203-20. 2003
  35. ncbi request reprint Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development
    Antje Rhode
    Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:3516-24. 2005
    ..Our results indicate that CXCL10 expression accelerates the autoimmune process by enhancing the migration of Ag-specific lymphocytes to their target site...
  36. ncbi request reprint Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 171:6838-45. 2003
    ....
  37. pmc Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease
    Robert S Fujinami
    Department of Neurology, University of Utah School of Medicine, 30 N 1900 E, 3R330 SOM, Salt Lake City, UT 84132 2305, USA
    Clin Microbiol Rev 19:80-94. 2006
    ..These mechanisms are discussed in the context of multiple sclerosis, myocarditis, and diabetes, three immune-medicated diseases often linked with virus infections...
  38. ncbi request reprint Transgenic animal models for type 1 diabetes: linking a tetracycline-inducible promoter with a virus-inducible mouse model
    Urs Christen
    Department of Immune Regulation, IR 3, La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Transgenic Res 11:587-95. 2002
    ....
  39. pmc Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 113:74-84. 2004
    ..Thus, virally induced proinflammatory cytokines and chemokines can influence the ongoing autoaggressive process beneficially at the preclinical stage, if produced at the correct location, time, and levels...
  40. ncbi request reprint Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells
    Urs Christen
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Diabetes 53:591-6. 2004
    ..Expression of Fas-L therefore might not be protective in situations in which viral inflammation can be expected, resulting in Fas induction on the targeted cell itself...
  41. ncbi request reprint Induction, acceleration or prevention of autoimmunity by molecular mimicry
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Mol Immunol 40:1113-20. 2004
    ..Already activated autoreactive cells might be easier re-activated and primed for effector functions by cross-reactive ligands than naive lymphocytes...
  42. pmc A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes
    Urs Christen
    Immune Regulation Lab, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 114:1290-8. 2004
    ..Sequential heterologous viral infections might therefore act in concert to precipitate clinical autoimmune disease, even if single exposure to a viral mimic does not always cause sufficient tissue destruction...
  43. ncbi request reprint Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-alpha expression at a time when the autoimmune process is already ongoing
    Urs Christen
    Departments of Neuropharmacology and Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 958:166-9. 2002
    ..Here we provide a model of how experienced autoaggressive CD8 lymphocytes are dying by apoptosis as a result of beta cell-specific TNF-alpha expression at a time when the autoimmune process is already ongoing...
  44. ncbi request reprint Infections and autoimmunity--good or bad?
    Urs Christen
    Immune Regulation Laboratory, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:7481-6. 2005
    ..Knowledge of mechanisms that underlie either positive or negative effects of infections on autoimmunity will facilitate exploration of molecular details for prospective clinical studies in the future...
  45. ncbi request reprint Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice
    Marianne M Martinic
    Immune Regulation Lab DI 3, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Diabetes 56:1059-68. 2007
    ..Thus, autoreactivity toward de novo-expressed beta-cell autoantigens will not accelerate autoimmunity unless large numbers of antigen-experienced autoreactive T-cells expressing the appropriate chemokine receptors are present...
  46. pmc Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies
    Mette Ejrnaes
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Clin Dev Immunol 13:337-47. 2006
    ..First, we review recent findings that blockade of IL-10/IL-10R interaction can resolve chronic viral infection and second, we reflect on how neutralization of the chemokine CXCL10 can abrogate virus-induced type 1 diabetes...
  47. pmc Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies
    Mette Ejrnaes
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Clin Dev Immunol 13:67-77. 2006
    ..First, we review recent findings that blockade of IL-10/IL-10R interaction can resolve chronic viral infection and second, we reflect on how neutralization of the chemokine CXCL10 can abrogate virus-induced type 1 diabetes...