Francois Spitz

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. pmc TRACER: a resource to study the regulatory architecture of the mouse genome
    Chao Kung Chen
    European Bioinformatics Institute European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    BMC Genomics 14:215. 2013
  2. doi request reprint Transcription factors: from enhancer binding to developmental control
    Francois Spitz
    Developmental Biology Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Nat Rev Genet 13:613-26. 2012
  3. ncbi request reprint Control of vertebrate Hox clusters by remote and global cis-acting regulatory sequences
    Francois Spitz
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Adv Exp Med Biol 689:63-78. 2010
  4. pmc Functional and topological characteristics of mammalian regulatory domains
    Orsolya Symmons
    Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genome Res 24:390-400. 2014
  5. pmc A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes
    Taro Tsujimura
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Genet 11:e1004897. 2015
  6. doi request reprint Long-range enhancers regulating Myc expression are required for normal facial morphogenesis
    Veli Vural Uslu
    Developmental Biology Unit, European Molecular Biology Laboratory EMBL, Heidelberg, Germany
    Nat Genet 46:753-8. 2014
  7. doi request reprint Global control regions and regulatory landscapes in vertebrate development and evolution
    Francois Spitz
    Developmental Biology Unit, EMBL, 69117 Heidelberg, Germany
    Adv Genet 61:175-205. 2008
  8. pmc From remote enhancers to gene regulation: charting the genome's regulatory landscapes
    Orsolya Symmons
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Philos Trans R Soc Lond B Biol Sci 368:20120358. 2013
  9. doi request reprint The architecture of gene expression: integrating dispersed cis-regulatory modules into coherent regulatory domains
    Wibke Schwarzer
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Genet Dev 27:74-82. 2014
  10. doi request reprint Phenotypic impact of genomic structural variation: insights from and for human disease
    Joachim Weischenfeldt
    Genome Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, 69117, Germany
    Nat Rev Genet 14:125-38. 2013

Collaborators

Detail Information

Publications13

  1. pmc TRACER: a resource to study the regulatory architecture of the mouse genome
    Chao Kung Chen
    European Bioinformatics Institute European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    BMC Genomics 14:215. 2013
    ..The mechanisms that control the integration of these diverse inputs into specific gene expression patterns are still poorly understood. New approaches enabling the dissection of these mechanisms in vivo are needed...
  2. doi request reprint Transcription factors: from enhancer binding to developmental control
    Francois Spitz
    Developmental Biology Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Nat Rev Genet 13:613-26. 2012
    ....
  3. ncbi request reprint Control of vertebrate Hox clusters by remote and global cis-acting regulatory sequences
    Francois Spitz
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Adv Exp Med Biol 689:63-78. 2010
    ..We will further discuss how these mechanisms may have benefited from the structure of the vertebrate homeotic clusters and reciprocally contribute to shape their evolution towards an increased level of organisation and compaction...
  4. pmc Functional and topological characteristics of mammalian regulatory domains
    Orsolya Symmons
    Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genome Res 24:390-400. 2014
    ..These findings support a model of genomic organization where TADs confine regulatory activities to specific but large regulatory domains, contributing to the establishment of specific gene expression profiles. ..
  5. pmc A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes
    Taro Tsujimura
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Genet 11:e1004897. 2015
    ..Altogether, these data highlight the prime role of the topological organization of the genome in long-distance regulation of gene expression. ..
  6. doi request reprint Long-range enhancers regulating Myc expression are required for normal facial morphogenesis
    Veli Vural Uslu
    Developmental Biology Unit, European Molecular Biology Laboratory EMBL, Heidelberg, Germany
    Nat Genet 46:753-8. 2014
    ..This dual molecular etiology may account for the prominent influence of variants in the 8q24 region on human facial dysmorphologies. ..
  7. doi request reprint Global control regions and regulatory landscapes in vertebrate development and evolution
    Francois Spitz
    Developmental Biology Unit, EMBL, 69117 Heidelberg, Germany
    Adv Genet 61:175-205. 2008
    ..In some cases, these processes led to the formation of groups of adjacent genes that appear to be controlled by both global and shared mechanisms...
  8. pmc From remote enhancers to gene regulation: charting the genome's regulatory landscapes
    Orsolya Symmons
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Philos Trans R Soc Lond B Biol Sci 368:20120358. 2013
    ..We discuss the implications of these findings for our understanding of non-coding transcription, and of the possible consequences of structural genomic variations in disease and evolution...
  9. doi request reprint The architecture of gene expression: integrating dispersed cis-regulatory modules into coherent regulatory domains
    Wibke Schwarzer
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Genet Dev 27:74-82. 2014
    ....
  10. doi request reprint Phenotypic impact of genomic structural variation: insights from and for human disease
    Joachim Weischenfeldt
    Genome Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, 69117, Germany
    Nat Rev Genet 14:125-38. 2013
    ..We further present advances in delineating disease-causing elements that are affected by structural variants, and we discuss future directions for research on the functional consequences of structural variants...
  11. doi request reprint An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape
    Mirna Marinić
    Developmental Biology Unit, EMBL, Meyerhofstrasse 1, Heidelberg 69117, Germany
    Dev Cell 24:530-42. 2013
    ..We discuss the implications of such regulatory systems regarding the evolution of gene expression and the impact of human genomic structural variations...
  12. pmc Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences
    Laurence Ettwiller
    Developmental Biology Unit, EMBL Heidelberg, Meyerhofstrasse 1, Heidelberg, 69117, Germany
    Genome Biol 9:R172. 2008
    ....
  13. doi request reprint Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor
    Sandra Ruf
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Nat Genet 43:379-86. 2011
    ....