Detlev Arendt

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi request reprint Emerging systems: between vertebrates and arthropods, the Lophotrochozoa
    Kristin Tessmar-Raible
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012, Heidelberg, Germany
    Curr Opin Genet Dev 13:331-40. 2003
  2. doi request reprint The evolution of cell types in animals: emerging principles from molecular studies
    Detlev Arendt
    European Molecular Biology Laboratory, Meyerhofstrabetae 1, 69012 Heidelberg, Germany
    Nat Rev Genet 9:868-82. 2008
  3. doi request reprint The segmental pattern of otx, gbx, and Hox genes in the annelid Platynereis dumerilii
    Patrick R H Steinmetz
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Evol Dev 13:72-9. 2011
  4. ncbi request reprint Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain
    Detlev Arendt
    Developmental Biology Department, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Science 306:869-71. 2004
  5. pmc Ancient animal microRNAs and the evolution of tissue identity
    Foteini Christodoulou
    Developmental Biology Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Nature 463:1084-8. 2010
  6. ncbi request reprint Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria
    Alexandru S Denes
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, 69117, Germany
    Cell 129:277-88. 2007
  7. pmc The evolution of nervous system centralization
    Detlev Arendt
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany
    Philos Trans R Soc Lond B Biol Sci 363:1523-8. 2008
  8. ncbi request reprint Evolution of eyes and photoreceptor cell types
    Detlev Arendt
    European Molecular Biology Laboratory, Developmental Biology Programme, Heidelberg, Germany
    Int J Dev Biol 47:563-71. 2003
  9. ncbi request reprint Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution
    Kristin Tessmar-Raible
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69012 Heidelberg, Germany
    Cell 129:1389-400. 2007
  10. pmc Insights into bilaterian evolution from three spiralian genomes
    Oleg Simakov
    European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany
    Nature 493:526-31. 2013

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Emerging systems: between vertebrates and arthropods, the Lophotrochozoa
    Kristin Tessmar-Raible
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012, Heidelberg, Germany
    Curr Opin Genet Dev 13:331-40. 2003
    ..This is also reflected in the level of genes, making these groups ideally suited for developmental comparative studies...
  2. doi request reprint The evolution of cell types in animals: emerging principles from molecular studies
    Detlev Arendt
    European Molecular Biology Laboratory, Meyerhofstrabetae 1, 69012 Heidelberg, Germany
    Nat Rev Genet 9:868-82. 2008
    ....
  3. doi request reprint The segmental pattern of otx, gbx, and Hox genes in the annelid Platynereis dumerilii
    Patrick R H Steinmetz
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Evol Dev 13:72-9. 2011
    ..Our data thus support the view that an ancestral ground pattern of segmental identities existed in the trunk of the last common protostome ancestor that was lost or modified in protostomes lacking overt segmentation...
  4. ncbi request reprint Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain
    Detlev Arendt
    Developmental Biology Department, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Science 306:869-71. 2004
    ..Comparative analysis indicates that both types of photoreceptors, with distinct opsins, coexisted in Urbilateria, the last common ancestor of insects and vertebrates, and sheds new light on vertebrate eye evolution...
  5. pmc Ancient animal microRNAs and the evolution of tissue identity
    Foteini Christodoulou
    Developmental Biology Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Nature 463:1084-8. 2010
    ..Also, they outline a minimum set of cell types and tissues that existed in the protostome-deuterostome ancestor...
  6. ncbi request reprint Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria
    Alexandru S Denes
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, 69117, Germany
    Cell 129:277-88. 2007
    ..Our data indicate that this mediolateral architecture was present in the last common bilaterian ancestor and thus support a common origin of nervous system centralization in Bilateria...
  7. pmc The evolution of nervous system centralization
    Detlev Arendt
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany
    Philos Trans R Soc Lond B Biol Sci 363:1523-8. 2008
    ..This way, different aspects of the molecular architecture of the urbilaterian nervous system are reconstructed and yield insight into the degree of centralization that was in place in the bilaterian ancestors...
  8. ncbi request reprint Evolution of eyes and photoreceptor cell types
    Detlev Arendt
    European Molecular Biology Laboratory, Developmental Biology Programme, Heidelberg, Germany
    Int J Dev Biol 47:563-71. 2003
    ..I propose that the retinal ganglion, amacrine and horizontal cells are evolutionary sister cell types that evolved from a common rhabdomeric photoreceptor cell precursor...
  9. ncbi request reprint Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution
    Kristin Tessmar-Raible
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69012 Heidelberg, Germany
    Cell 129:1389-400. 2007
    ....
  10. pmc Insights into bilaterian evolution from three spiralian genomes
    Oleg Simakov
    European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany
    Nature 493:526-31. 2013
    ....
  11. doi request reprint Mechanism of phototaxis in marine zooplankton
    Gaspar Jekely
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany
    Nature 456:395-9. 2008
    ..We propose that the underlying direct coupling of light sensing and ciliary locomotor control was a principal feature of the proto-eye and an important landmark in the evolution of animal eyes...
  12. ncbi request reprint Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria
    Detlev Arendt
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 129:1143-54. 2002
    ..We propose that pax6-, six1/2- and ath-positive larval eyes, as found in today's trochophora, were present already in Urbilateria...
  13. pmc New animal models for evolution and development
    Kristin Tessmar-Raible
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Genome Biol 6:303. 2005
    ..A report on the annual UK Evolutionary Developmental Biology meeting, Oxford, UK, 13 September 2004...
  14. doi request reprint Profiling by image registration reveals common origin of annelid mushroom bodies and vertebrate pallium
    Raju Tomer
    Developmental Biology Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Cell 142:800-9. 2010
    ..These data indicate deep homology of pallium and mushroom bodies and date back the origin of higher brain centers to prebilaterian times...
  15. pmc Polychaete trunk neuroectoderm converges and extends by mediolateral cell intercalation
    Patrick R H Steinmetz
    European Molecular Biology Laboratory, Developmental Biology Unit, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Proc Natl Acad Sci U S A 104:2727-32. 2007
    ..Based on these findings, we propose that convergent extension movements of the trunk neuroectoderm represent an ancestral feature of bilaterian development that triggered the separation of mouth and anus along the elongating trunk...
  16. pmc Spiralians in the limelight
    Detlev Arendt
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69115 Germany
    Genome Biol 5:303. 2003
  17. ncbi request reprint Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii
    Florian Raible
    Developmental Unit, European Molecular Biological Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 310:1325-6. 2005
    ..A comparison of coding exon sequences confirms the ancestral nature of Platynereis and human genes. Thus, the urbilaterian ancestor had complex, intron-rich genes that have been retained in Platynereis and human...
  18. ncbi request reprint Cellular resolution expression profiling using confocal detection of NBT/BCIP precipitate by reflection microscopy
    Gaspar Jekely
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Biotechniques 42:751-5. 2007
    ..Whole-mount reflection CLSM will thus greatly facilitate large-scale cellular resolution expression profiling in vertebrate and invertebrate model organisms...
  19. doi request reprint The bilaterian forebrain: an evolutionary chimaera
    Maria Antonietta Tosches
    European Molecular Biology Laboratory, Developmental Biology Unit, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Curr Opin Neurobiol 23:1080-9. 2013
    ..Our 'chimeric brain hypothesis' sheds new light on the vast success and rapid diversification of bilaterian animals in the Cambrian and revises our understanding of brain architecture. ..
  20. ncbi request reprint Metazoan evolution: some animals are more equal than others
    Florian Raible
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Curr Biol 14:R106-8. 2004
    ..The most surprising outcome is that human genes seem to be closer to the bilaterian roots than previously assumed...
  21. doi request reprint CNS evolution: new insight from the mud
    Elia Benito-Gutiérrez
    Developmental Biology Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Curr Biol 19:R640-2. 2009
    ....
  22. doi request reprint AQUA: automated quality improvement for multiple sequence alignments
    Jean Muller
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Bioinformatics 26:263-5. 2010
    ..Our current implementation relies on two alignment programs (MUSCLE and MAFFT), one refinement program (RASCAL) and one assessment program (NORMD), but other programs could be incorporated at any of the three steps...
  23. ncbi request reprint Fluorescent two-color whole mount in situ hybridization in Platynereis dumerilii (Polychaeta, Annelida), an emerging marine molecular model for evolution and development
    Kristin Tessmar-Raible
    European Molecular Biology Laboratory, Heidelberg, Germany
    Biotechniques 39:460, 462, 464. 2005
  24. pmc 4DXpress: a database for cross-species expression pattern comparisons
    Yannick Haudry
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nucleic Acids Res 36:D847-53. 2008
    ..4DXpress will be an invaluable tool for developmental as well as for computational biologists interested in gene regulation and evolution. 4DXpress is available at http://ani.embl.de/4DXpress...
  25. ncbi request reprint Opsins and clusters of sensory G-protein-coupled receptors in the sea urchin genome
    Florian Raible
    Computational Unit, EMBL, 69117 Heidelberg, Germany
    Dev Biol 300:461-75. 2006
    ..Notably, these structures also express different opsins, indicating that sea urchins possess an intricate molecular set-up to sense their environment...
  26. pmc Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution
    Detlev Arendt
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany Centre for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Philos Trans R Soc Lond B Biol Sci 370:. 2015
    ..In the bilaterian lineage, the mucociliary sole was used mostly for creeping, or frequently lost. One possible remnant is the enigmatic Reissner's fibre in the ventral neural tube of cephalochordates and vertebrates. ..
  27. pmc Larval body patterning and apical organs are conserved in animal evolution
    Heather Marlow
    European Molecular Biology Laboratory, Development Biology Unit, EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
    BMC Biol 12:7. 2014
    ..These relationships have remained enigmatic due to the scarcity of comparative molecular data...
  28. pmc The 'division of labour' model of eye evolution
    Detlev Arendt
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2809-17. 2009
    ..Functional segregation of cell types in eye evolution also explains the emergence of more elaborate photosensory-motor axonal circuits, with interneurons relaying the visual information...
  29. ncbi request reprint Genes and homology in nervous system evolution: comparing gene functions, expression patterns, and cell type molecular fingerprints
    Detlev Arendt
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Theory Biosci 124:185-97. 2005
    ..Here, a similar "molecular fingerprint" of cells is taken as indication of cross-bilaterian homology. This approach makes it possible to reconstruct the cell-type repertoire of the urbilaterian nervous system...
  30. pmc Neurotrophin, p75, and Trk Signaling Module in the Developing Nervous System of the Marine Annelid Platynereis dumerilii
    Antonella Lauri
    Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany Institute for Biological and Medical Imaging and Institute of Developmental Genetics, Helmholtz Zentrum Munchen, Ingolstädter Landstraße 1, 85764 München, Germany
    Biomed Res Int 2016:2456062. 2016
    ..These annelid data corroborate the hypothesis that the neurotrophic signaling and its involvement in shaping neural networks predate the protostome-deuterostome split and were present in bilaterian ancestors. ..
  31. doi request reprint From nerve net to nerve ring, nerve cord and brain--evolution of the nervous system
    Detlev Arendt
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 699117 Heidelberg, Germany
    Nat Rev Neurosci 17:61-72. 2016
    ..We propose that expansion, integration and fusion of these centres gave rise to the bilaterian nerve cord and brain. ..
  32. pmc Somatic and visceral nervous systems - an ancient duality
    Paola Bertucci
    Developmental Biology Unit, Meyerhofstrasse 1, Heidelbergs 69012, Germany
    BMC Biol 11:54. 2013
    ..See research article: http://www.biomedcentral.com/1741-7007/11/53...
  33. pmc Six3 demarcates the anterior-most developing brain region in bilaterian animals
    Patrick R H Steinmetz
    University of Vienna, Department for Molecular Evolution and Development, Althanstrasse 14, A 1090 Vienna, Austria
    Evodevo 1:14. 2010
    ..Regionalisation genes subdivide developing animals into molecular regions and can be used to align head regions between remote animal phyla...
  34. ncbi request reprint Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium
    Gaspar Jekely
    European Molecular Biology Laboratory, Heidelberg, Germany
    Bioessays 28:191-8. 2006
    ..We propose a scenario for how the initial membrane patch gradually protruded to enhance exposure to the environment, then started to move, and finally compartmentalised to render receptor signalling and ciliary beating more efficient...
  35. doi request reprint Animal Evolution: The Hard Problem of Cartilage Origins
    Thibaut Brunet
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69017 Heidelberg, Germany Electronic address
    Curr Biol 26:R685-8. 2016
    ..Characterization of cartilage in cuttlefish and horseshoe crabs reveals surprising commonalities with chordate chondrocytes, suggesting a common evolutionary origin. ..
  36. pmc From damage response to action potentials: early evolution of neural and contractile modules in stem eukaryotes
    Thibaut Brunet
    European Molecular Biology Laboratory, Developmental Biology Unit, Heidelberg 69012, Germany
    Philos Trans R Soc Lond B Biol Sci 371:20150043. 2016
    ..These gave rise to mechanosensory receptor cells, neurons and muscle cells by division of labour and can be regarded as the founder cell type of the nervous system. ..
  37. pmc Did the notochord evolve from an ancient axial muscle? The axochord hypothesis
    Thibaut Brunet
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Bioessays 37:836-50. 2015
    ..Integrating comparative evidence at the cell and organ level, we propose that the notochord evolved by modification of a ventromedian muscle followed by the assembly of an axial complex supporting swimming in vertebrate ancestors. ..
  38. pmc Quantifying Preferences and Responsiveness of Marine Zooplankton to Changing Environmental Conditions using Microfluidics
    Nirupama Ramanathan
    European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS ONE 10:e0140553. 2015
    ..Taken together, our microfluidic approach allows precise assessment and functional understanding of environmental perception on planktonic behaviour...
  39. doi request reprint Evolution: ctenophore genomes and the origin of neurons
    Heather Marlow
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69012 Heidelberg, Germany Electronic address
    Curr Biol 24:R757-61. 2014
    ..The presence of neurodevelopmental genes, pre- and postsynaptic modules, and transmitter molecules is consistent with a single origin of neurons. ..
  40. pmc Melatonin signaling controls circadian swimming behavior in marine zooplankton
    Maria Antonietta Tosches
    European Molecular Biology Laboratory, Developmental Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany Electronic address
    Cell 159:46-57. 2014
    ..Based on our findings, we propose that melatonin signaling plays a role in the circadian control of ciliary swimming to adjust the vertical position of zooplankton in response to ambient light. ..
  41. pmc Methods for generating year-round access to amphioxus in the laboratory
    Elia Benito-Gutiérrez
    Developmental Biology Unit, European Molecular Biology Laboratory EMBL, Heidelberg, Germany
    PLoS ONE 8:e71599. 2013
    ..Spontaneous spawning, a major problem in previous setups, no longer occurs in our facility; instead, all breeding is induced and fertilization occurs fully in vitro. Our system makes amphioxus a standard laboratory animal model...
  42. doi request reprint Mesoteloblast-like mesodermal stem cells in the polychaete annelid Platynereis dumerilii (Nereididae)
    Antje H L Fischer
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    J Exp Zool B Mol Dev Evol 320:94-104. 2013
    ..In the course of annelid evolution, the number consecutive divisions of these cells would have been low initially with <10 division cycles, giving rise to larval segments only, and then increased up to 35 as observed in clitellates...
  43. ncbi request reprint Arthropod-like expression patterns of engrailed and wingless in the annelid Platynereis dumerilii suggest a role in segment formation
    Benjamin Prud'homme
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, UPR 2167, 1 Avenue de la Terrasse, 91190 Gif sur Yvette, France
    Curr Biol 13:1876-81. 2003
    ..In agreement with similarities in segment ontogeny and morphological organization in arthropods and annelids, we interpret our results as molecular evidence of a segmented ancestor of protostomes...
  44. ncbi request reprint The expression of a hunchback ortholog in the polychaete annelid Platynereis dumerilii suggests an ancestral role in mesoderm development and neurogenesis
    Pierre Kerner
    Laboratoire Evolution et Développement des protostomiens, Centre de Génétique Moléculaire CNRS UPR 2167, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Dev Genes Evol 216:821-8. 2006
    ..These data suggest altogether that these functions are ancestral to protostomes...
  45. ncbi request reprint Hox gene expression in larval development of the polychaetes Nereis virens and Platynereis dumerilii (Annelida, Lophotrochozoa)
    Milana Kulakova
    Laboratory of Experimental Embryology, Biological Institute of State University of St Petersburg, Oranienbaumskoe sh 2, 198504 Starii Petergoff, St Petersburg, Russia
    Dev Genes Evol 217:39-54. 2007
    ....
  46. pmc atonal- and achaete-scute-related genes in the annelid Platynereis dumerilii: insights into the evolution of neural basic-Helix-Loop-Helix genes
    Elena Simionato
    Evolution et Développement des métazoaires, Centre de Génétique Moléculaire UPR 2167 CNRS, 1, av de terrasse, 91198 Gif sur Yvette, France
    BMC Evol Biol 8:170. 2008
    ....