Florian Eckhardt

Summary

Affiliation: Epigenomics AG
Country: Germany

Publications

  1. ncbi Future potential of the Human Epigenome Project
    Florian Eckhardt
    Epigenomics AG, Kleine Präsidentenstrasse 1, 10178 Berlin, Germany
    Expert Rev Mol Diagn 4:609-18. 2004
  2. ncbi DNA methylation markers: a versatile diagnostic tool for routine clinical use
    Ralf Lesche
    Epigenomics AG, Kleine Praisidentenstrasse 1, 10178 Berlin, Germany
    Curr Opin Mol Ther 9:222-30. 2007
  3. pmc DNA methylation profiling of human chromosomes 6, 20 and 22
    Florian Eckhardt
    Epigenomics AG, Kleine Präsidentstrasse 1, 10178 Berlin, Germany
    Nat Genet 38:1378-85. 2006
  4. pmc Genome-wide screen for differential DNA methylation associated with neural cell differentiation in mouse
    Rene Cortese
    Epigenomics AG, Berlin, Germany
    PLoS ONE 6:e26002. 2011
  5. doi Correlative gene expression and DNA methylation profiling in lung development nominate new biomarkers in lung cancer
    Rene Cortese
    Epigenomics AG, Kleine Präsidentstrasse 1, 10178 Berlin, Germany
    Int J Biochem Cell Biol 40:1494-508. 2008
  6. doi DNA methylation profiling of pseudogene-parental gene pairs and two gene families
    Rene Cortese
    Epigenomics AG, Kleine Präsidentstrasse 1, 10178 Berlin, Germany
    Genomics 91:492-502. 2008
  7. ncbi Comparative DNA methylation analysis in normal and tumour tissues and in cancer cell lines using differential methylation hybridisation
    Joern Lewin
    Epigenomics AG, Kleine Präsidentenstrasse 1, 10178 Berlin, Germany
    Int J Biochem Cell Biol 39:1539-50. 2007
  8. ncbi DNA methylation profiling of transcription factor genes in normal lymphocyte development and lymphomas
    Claudia Ivascu
    Epigenomics AG, Kleine Präsidentenstrasse 1, 10178 Berlin, Germany
    Int J Biochem Cell Biol 39:1523-38. 2007
  9. ncbi DNA methylation analysis as a tool for cell typing
    Udo Baron
    Epiontis GmbH, Berlin, Germany
    Epigenetics 1:55-60. 2006
  10. ncbi IL-10 is excluded from the functional cytokine memory of human CD4+ memory T lymphocytes
    Jun Dong
    Clinical Immunology Group, Deutsches Rheuma ForschungsZentrum Berlin, Berlin, Germany
    J Immunol 179:2389-96. 2007

Collaborators

Detail Information

Publications10

  1. ncbi Future potential of the Human Epigenome Project
    Florian Eckhardt
    Epigenomics AG, Kleine Präsidentenstrasse 1, 10178 Berlin, Germany
    Expert Rev Mol Diagn 4:609-18. 2004
    ..Like single nucleotide polymorphisms, methylation variable positions will greatly advance our ability to elucidate and diagnose the molecular basis of human diseases...
  2. ncbi DNA methylation markers: a versatile diagnostic tool for routine clinical use
    Ralf Lesche
    Epigenomics AG, Kleine Praisidentenstrasse 1, 10178 Berlin, Germany
    Curr Opin Mol Ther 9:222-30. 2007
    ..Recent improvements in DNA methylation marker discovery and efforts to transfer these into routine clinical use are summarized in this review...
  3. pmc DNA methylation profiling of human chromosomes 6, 20 and 22
    Florian Eckhardt
    Epigenomics AG, Kleine Präsidentstrasse 1, 10178 Berlin, Germany
    Nat Genet 38:1378-85. 2006
    ..Our data suggest DNA methylation to be ontogenetically more stable than previously thought...
  4. pmc Genome-wide screen for differential DNA methylation associated with neural cell differentiation in mouse
    Rene Cortese
    Epigenomics AG, Berlin, Germany
    PLoS ONE 6:e26002. 2011
    ..Our results provide robust evidence for the relevance of DNA methylation in early neural development and identify novel marker candidates for neural cell differentiation...
  5. doi Correlative gene expression and DNA methylation profiling in lung development nominate new biomarkers in lung cancer
    Rene Cortese
    Epigenomics AG, Kleine Präsidentstrasse 1, 10178 Berlin, Germany
    Int J Biochem Cell Biol 40:1494-508. 2008
    ..MEOX2 was uniformly higher methylated in all lung cancer samples (n=15), while the methylation of the other three genes was correlated with either the differentiation state of the tumor (MDK, LAPTM5) or the tumor type itself (FGFR3)...
  6. doi DNA methylation profiling of pseudogene-parental gene pairs and two gene families
    Rene Cortese
    Epigenomics AG, Kleine Präsidentstrasse 1, 10178 Berlin, Germany
    Genomics 91:492-502. 2008
    ..However, for the majority of unprocessed pseudogenes and for all processed pseudogenes examined, we found that tissue-specific methylation arose de novo after gene duplication...
  7. ncbi Comparative DNA methylation analysis in normal and tumour tissues and in cancer cell lines using differential methylation hybridisation
    Joern Lewin
    Epigenomics AG, Kleine Präsidentenstrasse 1, 10178 Berlin, Germany
    Int J Biochem Cell Biol 39:1539-50. 2007
    ..Overall, our data therefore provide further evidence that permanent cell lines are good model systems for cancer specific methylation patterns, but deviate with regard to tissue-specific methylation...
  8. ncbi DNA methylation profiling of transcription factor genes in normal lymphocyte development and lymphomas
    Claudia Ivascu
    Epigenomics AG, Kleine Präsidentenstrasse 1, 10178 Berlin, Germany
    Int J Biochem Cell Biol 39:1523-38. 2007
    ..Aberrant methylation of transcription factor genes is frequently observed in diffuse large B-cell lymphomas and might have a functional role during tumorigenesis...
  9. ncbi DNA methylation analysis as a tool for cell typing
    Udo Baron
    Epiontis GmbH, Berlin, Germany
    Epigenetics 1:55-60. 2006
    ..Thus, methylation based analytics suggest themselves as promising tools for the characterization and quality control of ex vivo manipulated cells...
  10. ncbi IL-10 is excluded from the functional cytokine memory of human CD4+ memory T lymphocytes
    Jun Dong
    Clinical Immunology Group, Deutsches Rheuma ForschungsZentrum Berlin, Berlin, Germany
    J Immunol 179:2389-96. 2007
    ..The exclusion of IL-10, but not effector cytokines, from the functional memory of human CD4(+) T lymphocytes ex vivo may reflect the need for appropriate regulation of IL-10 secretion, due to its potent immunoregulatory potential...