Thomas Duning

Summary

Country: Germany

Publications

  1. ncbi request reprint Excellent cognitive performance despite massive cerebral white matter changes
    Thomas Duning
    Department of Neurology, University of Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Neuroradiology 47:749-52. 2005
  2. pmc G-CSF prevents the progression of structural disintegration of white matter tracts in amyotrophic lateral sclerosis: a pilot trial
    Thomas Duning
    Department of Neurology, University Hospital Muenster, Muenster, Germany
    PLoS ONE 6:e17770. 2011
  3. doi request reprint Specific pattern of early white-matter changes in pure hereditary spastic paraplegia
    Thomas Duning
    Department of Neurology, University Hospital of Munster, Munster, Germany
    Mov Disord 25:1986-92. 2010
  4. doi request reprint Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy
    Thomas Duning
    Department of Neurology, University Hospital Muenster, Albert Schweitzer Str 33, 48149 Muenster, Germany
    J Neurol Neurosurg Psychiatry 81:136-9. 2010
  5. ncbi request reprint Is hypoglycaemia dangerous?
    Thomas Duning
    Department of Neurology, University Hospital of Munster, Albert Schweitzer Strafle 33, D 48149 Munster, Germany
    Best Pract Res Clin Anaesthesiol 23:473-85. 2009
  6. doi request reprint [Acute polyneuritis and polyradiculoneuritis: uncommon causes and their pathomechanisms]
    T Duning
    Klinik und Poliklinik für Neurologie des Universitätsklinikums Münster, Munster
    Fortschr Neurol Psychiatr 77:218-27. 2009
  7. doi request reprint Diffusion tensor imaging in a case of Kearns-Sayre syndrome: striking brainstem involvement as a possible cause of oculomotor symptoms
    Thomas Duning
    Department of Neurology, University Hospital Muenster, Germany
    J Neurol Sci 281:110-2. 2009
  8. doi request reprint Pattern and progression of white-matter changes in a case of posterior cortical atrophy using diffusion tensor imaging
    T Duning
    Department of Neurology, University Hospital of Munster, Munster, Germany
    J Neurol Neurosurg Psychiatry 80:432-6. 2009
  9. doi request reprint Diffusion-weighted magnetic resonance imaging at 3.0 Tesla in alcohol intoxication
    Thomas Duning
    University Hospital of Munster, Department of Neurology, Albert Schweitzer Str 33, 48149 Munster, Germany
    Psychiatry Res 163:52-60. 2008
  10. ncbi request reprint Dehydration confounds the assessment of brain atrophy
    T Duning
    Department of Neurology, University of Munster, Albert Schweitzer Str 22, 48129 Munster, Germany
    Neurology 64:548-50. 2005

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Excellent cognitive performance despite massive cerebral white matter changes
    Thomas Duning
    Department of Neurology, University of Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Neuroradiology 47:749-52. 2005
    ..Here we present a case of massive white matter changes but excellent cognitive performance, to avoid the automatism of drawing conclusions on intellectual ability by just interpreting the imaging data of elderly patients...
  2. pmc G-CSF prevents the progression of structural disintegration of white matter tracts in amyotrophic lateral sclerosis: a pilot trial
    Thomas Duning
    Department of Neurology, University Hospital Muenster, Muenster, Germany
    PLoS ONE 6:e17770. 2011
    ..It therefore appears as an attractive and feasible drug candidate for the treatment of amyotrophic lateral sclerosis (ALS). The current pilot study was performed to determine whether treatment with G-CSF in ALS patients is feasible...
  3. doi request reprint Specific pattern of early white-matter changes in pure hereditary spastic paraplegia
    Thomas Duning
    Department of Neurology, University Hospital of Munster, Munster, Germany
    Mov Disord 25:1986-92. 2010
    ..Thus, early alterations of nerve fibres, which can be detected by DTI, might serve as a biological marker in HSP, in particular with respect to future longitudinal studies...
  4. doi request reprint Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy
    Thomas Duning
    Department of Neurology, University Hospital Muenster, Albert Schweitzer Str 33, 48149 Muenster, Germany
    J Neurol Neurosurg Psychiatry 81:136-9. 2010
    ..The objectives of the present study were to identify focal FA abnormalities in patients with CPE who were deemed MRI negative during routine presurgical evaluation...
  5. ncbi request reprint Is hypoglycaemia dangerous?
    Thomas Duning
    Department of Neurology, University Hospital of Munster, Albert Schweitzer Strafle 33, D 48149 Munster, Germany
    Best Pract Res Clin Anaesthesiol 23:473-85. 2009
    ..This review focusses on the clinical manifestations of hypoglycaemia in the critically ill and highlights its potential short- and long-term consequences specifically concerning neurocognitive function...
  6. doi request reprint [Acute polyneuritis and polyradiculoneuritis: uncommon causes and their pathomechanisms]
    T Duning
    Klinik und Poliklinik für Neurologie des Universitätsklinikums Münster, Munster
    Fortschr Neurol Psychiatr 77:218-27. 2009
    ..We provide a detailed review of the pertinent literature discussing possible pathomechanisms, its clinical associations and possible dispositions...
  7. doi request reprint Diffusion tensor imaging in a case of Kearns-Sayre syndrome: striking brainstem involvement as a possible cause of oculomotor symptoms
    Thomas Duning
    Department of Neurology, University Hospital Muenster, Germany
    J Neurol Sci 281:110-2. 2009
    ..These early DTI changes support the hypothesis that regional affection of the brainstem may play a role in the pathogenesis of the early oculomotor symptoms. DTI might be helpful to detect an early involvement of the CNS in KSS...
  8. doi request reprint Pattern and progression of white-matter changes in a case of posterior cortical atrophy using diffusion tensor imaging
    T Duning
    Department of Neurology, University Hospital of Munster, Munster, Germany
    J Neurol Neurosurg Psychiatry 80:432-6. 2009
    ..The progression of white-matter changes in a case of posterior cortical atrophy (PCA) was examined over a period of 15 months using diffusion tensor imaging (DTI) and the association with neuropsychological variables was studied...
  9. doi request reprint Diffusion-weighted magnetic resonance imaging at 3.0 Tesla in alcohol intoxication
    Thomas Duning
    University Hospital of Munster, Department of Neurology, Albert Schweitzer Str 33, 48149 Munster, Germany
    Psychiatry Res 163:52-60. 2008
    ..Second, processes involving neurotransmitters that are primarily linked to cognitive function might not be viewable with high-field diffusion MRI...
  10. ncbi request reprint Dehydration confounds the assessment of brain atrophy
    T Duning
    Department of Neurology, University of Munster, Albert Schweitzer Str 22, 48129 Munster, Germany
    Neurology 64:548-50. 2005
    ..55% (SD, +/-0.69), and after rehydration total cerebral volume increased by 0.72% (SD, +/-0.21)...
  11. ncbi request reprint [Treatment strategies for tetanus]
    T Duning
    Klinik und Poliklinik fur Neurologie, Universitatsklinikum Munster
    Nervenarzt 78:145-6, 149-52, 155. 2007
    ..This report provides information about clinical features, diagnosis and prophylaxis of the disease and gives an overview of the therapeutic principles of generalized tetanus, focusing on the management of autonomic instability...
  12. doi request reprint A novel splice site mutation in the SPG7 gene causing widespread fiber damage in homozygous and heterozygous subjects
    Tobias Warnecke
    Department of Neurology, University Hospital of Munster, Munster, Germany
    Mov Disord 25:413-20. 2010
    ..The detection of cerebral WM alterations in the corpus callosum of asymptomatic heterozygote carriers confirms this brain region as the most prominent and early location of fiber damage in ARHSP...
  13. doi request reprint Cortical plasticity is preserved in nondemented older individuals with severe ischemic small vessel disease
    Jonathan List
    Department of Neurology, University Hospital of Munster, Chariteplatz 1, Munster, Germany
    Hum Brain Mapp 34:1464-76. 2013
    ..Enhanced cortical plasticity in subjects with lower white matter integrity in memory-relevant areas might thus indicate a compensatory mechanism to counteract memory decline in severe SVD...
  14. doi request reprint Enhanced rapid-onset cortical plasticity in CADASIL as a possible mechanism of preserved cognition
    Jonathan List
    Department of Neurology, University Hospital of Munster, 48149 Munster, Germany
    Cereb Cortex 21:2774-87. 2011
    ..ctDCS revealed no evidence of cortical dysplasticity. We conclude that increased rapid-onset cortical plasticity may contribute to largely preserved cognitive and motor function despite extensive ischemic SVD...
  15. doi request reprint Supraventricular premature beats and short atrial runs predict atrial fibrillation in continuously monitored patients with cryptogenic stroke
    Simon Kochhäuser
    From the Division of Electrophysiology, Department of Cardiovascular Medicine S K, D G D, F R, S R, G F, L E and Department of Neurology R D, M A R, T D, University of Muenster, Muenster, Germany
    Stroke 45:884-6. 2014
    ..Supraventricular premature beats (SPBs) may help to assess the risk of atrial fibrillation (AF) in patients with cryptogenic stroke and therefore guide therapy...
  16. doi request reprint Executive performance is related to regional gray matter volume in healthy older individuals
    Ruth Ruscheweyh
    Department of Neurology, University Hospital of Munster, Munster, Germany Department of Neurology, University of München, Munchen, Germany
    Hum Brain Mapp 34:3333-46. 2013
    ....
  17. ncbi request reprint Diffusion-tensor imaging at 3 T: detection of white matter alterations in neurological patients on the basis of normal values
    Michael Deppe
    Department of Neurology, University Hospital Munster, Munster, Germany
    Invest Radiol 42:338-45. 2007
    ..We attempted to develop an observer-independent, fully automated technique for quantitative FA assessment...
  18. doi request reprint Diagnostic criteria for Susac syndrome
    Ilka Kleffner
    Department of Neurology, University Hospital of Munster, Munster, Germany
    J Neurol Neurosurg Psychiatry 87:1287-1295. 2016
    ..This leads to a critical delay in the initiation of appropriate treatment. Our objective was to establish criteria for diagnosis of either definite or probable Susac syndrome...
  19. pmc Hypoglycemia aggravates critical illness-induced neurocognitive dysfunction
    Thomas Duning
    Department of Neurology, University Hospital of Muenster, Muenster, Germany
    Diabetes Care 33:639-44. 2010
    ....
  20. doi request reprint Atrial fibrillation in stroke-free patients is associated with memory impairment and hippocampal atrophy
    Stefan Knecht
    Department of Neurology, University of Munster, A Schweitzer Street 33, 48129 Munster, Germany
    Eur Heart J 29:2125-32. 2008
    ..AF contributes to stroke and secondary cognitive decline. In the absence of manifest stroke, AF can activate coagulation and cause cerebral microembolism which could damage the brain...
  21. ncbi request reprint Renal function predicts long-term outcome on enzyme replacement therapy in patients with Fabry disease
    Malte Lenders
    Department of Nephrology, Hypertension, and Rheumatology, Internal Medicine D, University Hospital Muenster, Albert Schweitzer Campus 1, D 48149 Muenster, Germany
    Nephrol Dial Transplant . 2016
    ..We analysed the incidence of FD-related renal, cardiac and neurologic end points in patients with FD on long-term enzyme replacement therapy (ERT)...
  22. pmc Alpha-Galactosidase A p.A143T, a non-Fabry disease-causing variant
    Malte Lenders
    Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Albert Schweitzer Campus 1, D 48149, Muenster, Germany
    Orphanet J Rare Dis 11:54. 2016
    ..Fabry disease (FD) is an X-linked multisystemic disorder with a heterogeneous phenotype. Especially atypical or late-onset type 2 phenotypes present a therapeutical dilemma...
  23. pmc Granulocyte-colony stimulating factor (G-CSF) in stroke patients with concomitant vascular disease--a randomized controlled trial
    Agnes Floel
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e19767. 2011
    ..G-CSF has been shown in animal models of stroke to promote functional and structural regeneration of the central nervous system. It thus might present a therapy to promote recovery in the chronic stage after stroke...
  24. doi request reprint Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy
    M Deppe
    Department of Neurology, University of Muenster, Albert Schweitzer Str 33, 48129 Muenster, Germany
    Neurology 71:1981-5. 2008
    ..Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized epilepsy (IGE) without structural brain abnormalities detectable by MRI or CT...
  25. doi request reprint Apraxia profile differentiates behavioural variant frontotemporal from Alzheimer's dementia in mild disease stages
    Andreas Johnen
    Department of Neurology, University Hospital Munster, Munster, Germany
    J Neurol Neurosurg Psychiatry 86:809-15. 2015
    ..We explore apraxia in bvFTD and investigate the differential validity of apraxia screening tests to distinguish between AD, bvFTD and healthy controls (HC)...
  26. doi request reprint High-normal blood pressure is associated with poor cognitive performance
    Stefan Knecht
    Department of Neurology, University of Munster, A Schweitzer Str 33, 48129 Munster, Germany
    Hypertension 51:663-8. 2008
    ..291, P<0.005). Thus, even in the normotensive range increasing systolic blood pressure is inversely related to cognition...
  27. doi request reprint Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function
    H Wersching
    Institute of Epidemiology and Social Medicine, University of Munster, Domagkstrasse 3, 48149 Munster, Germany
    Neurology 74:1022-9. 2010
    ..To better understand potential underlying mechanisms, we assessed microstructural brain integrity and cognitive performance relative to serum levels of high-sensitivity C-reactive protein (hs-CRP)...
  28. pmc Serum-Mediated Inhibition of Enzyme Replacement Therapy in Fabry Disease
    Malte Lenders
    Department of Nephrology, Hypertension, and Rheumatology, Internal Medicine D, University Hospital Muenster, Muenster, Germany
    J Am Soc Nephrol 27:256-64. 2016
    ....
  29. doi request reprint A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis
    Amgad Droby
    Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany Neuroimaging Center NIC of the Focus Program Translational Neuroscience FTN, Johannes Gutenberg University, Mainz, Germany
    Br J Ophthalmol 100:484-90. 2016
    ..Using this method, we also aimed to reproduce previous findings showing retinal degeneration following optic neuritis (ON) in MS...
  30. doi request reprint Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease
    Gero Lueg
    Department of Neurology, University Hospital Munster, Munster, Germany
    Neurobiol Aging 36:81-9. 2015
    ..Lymphocyte activation seems to have a clinical impact because levels of activated CD8(+) T-cells were correlated with clinical and structural markers of AD pathology...
  31. pmc Increased cortical curvature reflects white matter atrophy in individual patients with early multiple sclerosis
    Michael Deppe
    Department of Neurology, Westfalische Wilhelms University, Munster, Germany
    Neuroimage Clin 6:475-87. 2014
    ..Based on geometrical considerations we hypothesized that cortical curvature increases if WMV decreases and the cortical surface area remains constant...
  32. pmc Brainstem involvement as a cause of central sleep apnea: pattern of microstructural cerebral damage in patients with cerebral microangiopathy
    Thomas Duning
    Department of Neurology, University Hospital of Muenster, Muenster, Germany
    PLoS ONE 8:e60304. 2013
    ..White matter lesions are early and frequent findings in FD. Thus, FD can serve as a "model disease" of cerebral microangiopathy to study in more detail the impact of cerebral lesions on central sleep apnea...
  33. ncbi request reprint A novel form of autosomal recessive hereditary spastic paraplegia caused by a new SPG7 mutation
    T Warnecke
    Department of Neurology, University Hospital of Munster, Munster, Germany
    Neurology 69:368-75. 2007
    ..Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous neurodegenerative disorder characterized by progressive spastic paraparesis of the lower limbs...
  34. doi request reprint Susac syndrome treated with subcutaneous immunoglobulin
    Ilka Kleffner
    Department of Neurology, University of Munster, Munster, Germany
    Eur Neurol 71:89-92. 2014
    ..Medical therapy consists of glucocorticoids, immunosuppressants, acetyl salicylic acid, and immunomodulatory agents such as intravenous immunoglobulin...
  35. doi request reprint Occult atrial fibrillation in cryptogenic stroke: detection by 7-day electrocardiogram versus implantable cardiac monitors
    Martin A Ritter
    Department of Neurology, University of Muenster, Muenster, Germany
    Stroke 44:1449-52. 2013
    ..We investigated whether implantation of an insertable cardiac monitor (ICM) is feasible in patients with cryptogenic stroke, and compared the iAF detection rate of the ICM with 7-day Holter monitoring...
  36. pmc Case report of MR perfusion imaging in sinking skin flap syndrome: growing evidence for hemodynamic impairment
    Andre Kemmling
    Institute for Clinical Radiology, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
    BMC Neurol 10:80. 2010
    ..We report a case of sinking skin flap syndrome (SSFS) with recovery from neurological sensorimotor deficits after cranioplasty correlated with pre- and postsurgical MR brain perfusion studies...
  37. pmc Multicenter Female Fabry Study (MFFS) - clinical survey on current treatment of females with Fabry disease
    Malte Lenders
    Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Albert Schweitzer Campus 1, D 48149, Muenster, Germany
    Orphanet J Rare Dis 11:88. 2016
    ..The aim of the present study was to assess manifestations of and applied treatment concepts for females with Fabry disease (FD) according to the current European Fabry Guidelines...
  38. doi request reprint Retinal pathology in Susac syndrome detected by spectral-domain optical coherence tomography
    Marius Ringelstein
    From the Departments of Neurology M R, P A, B B, J H, A K M, H P H, O A and Ophthalmology D F, R G, Medical Faculty, Heinrich Heine University Düsseldorf the Department of Neurology I K, T D, University of Münster the Department of Ophthalmology R B, NeuroCure Clinical Research Center F P, A B, T O, J M, J D, and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology F P, J D, Charité Universitätsmedizin Berlin the Department of Neurology M K, Alfried Krupp Hospital, Essen and Molecular Neuroimmunology B W, S J, Department of Neurology, University of Heidelberg, Germany
    Neurology 85:610-8. 2015
    ....
  39. doi request reprint Progressive cognitive deficits in a mouse model of recurrent photothrombotic stroke
    Antje Schmidt
    From the Department of Neurology, University of Munster, Munster, Germany A S, K D, J K S, B G, M H, T D, J M and Department of Neurology, Bethel EvKB, Bielefeld, Germany W R S
    Stroke 46:1127-31. 2015
    ..Therefore, we aimed to evaluate whether a mouse model of recurrent photothrombotic stroke is suitable for the preclinical investigation of multi-infarct dementia...
  40. ncbi request reprint Management of autonomic dysfunction in severe tetanus: the importance of deep analgosedation
    Thomas Duning
    Intensive Care Med 33:380-1. 2007