Agnes Gorlach

Summary

Affiliation: Deutsches Herzzentrum
Country: Germany

Publications

  1. pmc Calcium and ROS: A mutual interplay
    Agnes Gorlach
    Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Germany DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany Electronic address
    Redox Biol 6:260-71. 2015
  2. ncbi request reprint Redox signaling through NADPH oxidases: involvement in vascular proliferation and coagulation
    Agnes Gorlach
    Klinik für Kinderkardiologie und angeborene Herzfehler, Deutsches Herzzentrum München des Freistaates Bayern, Klinik an der Technischen Universität München, Munchen, Germany
    Ann N Y Acad Sci 973:505-7. 2002
  3. ncbi request reprint Regulation of HIF-1alpha at the transcriptional level
    Agnes Gorlach
    Experimental Pediatric Cardiology, German Heart Center Munich, TU Munich, Germany
    Curr Pharm Des 15:3844-52. 2009
  4. doi request reprint The cross-talk between NF-kappaB and HIF-1: further evidence for a significant liaison
    Agnes Gorlach
    Experimentelle Kinderkardiologie, Deutsches Herzzentrum München an der Technischen Universität München, Lazarettstrasse 36, D 80636 München, Germany
    Biochem J 412:e17-9. 2008
  5. ncbi request reprint Redox regulation of the coagulation cascade
    Agnes Gorlach
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, Munich, Germany
    Antioxid Redox Signal 7:1398-404. 2005
  6. ncbi request reprint Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression
    Agnes Gorlach
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, Lazarettstrasse 36, 80636 Munich, Germany
    Thromb Haemost 93:1168-75. 2005
  7. ncbi request reprint Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1
    Agnes Gorlach
    Experimentelle Kinderkardiologie, Deutsches Herzzentrum Müchen and der Technischen Universität Müchen, Munich, Germany
    Thromb Haemost 89:926-35. 2003
  8. ncbi request reprint Rac-1 promotes pulmonary artery smooth muscle cell proliferation by upregulation of plasminogen activator inhibitor-1: role of NFkappaB-dependent hypoxia-inducible factor-1alpha transcription
    Isabel Diebold
    Experimentelle Kinderkardiologie, Deutsches Herzzentrum Munchen, an der Technischen Universität München, Lazarettstr 36, D 80636 München, Germany
    Thromb Haemost 100:1021-8. 2008
  9. pmc The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1
    Isabel Diebold
    Experimental and Molecular Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University, 80636 Munich, Germany
    Mol Biol Cell 21:2087-96. 2010
  10. ncbi request reprint The serum- and glucocorticoid-inducible kinase Sgk-1 is involved in pulmonary vascular remodeling: role in redox-sensitive regulation of tissue factor by thrombin
    Rachida S BelAiba
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich, Technical University Munich, Munich, Germany
    Circ Res 98:828-36. 2006

Collaborators

Detail Information

Publications38

  1. pmc Calcium and ROS: A mutual interplay
    Agnes Gorlach
    Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Germany DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany Electronic address
    Redox Biol 6:260-71. 2015
    ..However, dysfunction in either of the systems might affect the other system thus potentiating harmful effects which might contribute to the pathogenesis of various disorders. ..
  2. ncbi request reprint Redox signaling through NADPH oxidases: involvement in vascular proliferation and coagulation
    Agnes Gorlach
    Klinik für Kinderkardiologie und angeborene Herzfehler, Deutsches Herzzentrum München des Freistaates Bayern, Klinik an der Technischen Universität München, Munchen, Germany
    Ann N Y Acad Sci 973:505-7. 2002
    ....
  3. ncbi request reprint Regulation of HIF-1alpha at the transcriptional level
    Agnes Gorlach
    Experimental Pediatric Cardiology, German Heart Center Munich, TU Munich, Germany
    Curr Pharm Des 15:3844-52. 2009
    ..In fact, transcriptional regulatory networks seem to be an additional way of controlling HIF-1alpha levels and may open new therapeutic options to modulate HIF-1alpha also under non-hypoxic conditions...
  4. doi request reprint The cross-talk between NF-kappaB and HIF-1: further evidence for a significant liaison
    Agnes Gorlach
    Experimentelle Kinderkardiologie, Deutsches Herzzentrum München an der Technischen Universität München, Lazarettstrasse 36, D 80636 München, Germany
    Biochem J 412:e17-9. 2008
    ..The identification of HIF-1alpha as a target gene of NF-kappaB will have important implications for a variety of disorders related to hypoxia-ischaemia and/or inflammation and oxidative stress...
  5. ncbi request reprint Redox regulation of the coagulation cascade
    Agnes Gorlach
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, Munich, Germany
    Antioxid Redox Signal 7:1398-404. 2005
    ..Recently, evidence accumulated that ROS and the redox state are also important in the control of blood coagulation and thrombosis...
  6. ncbi request reprint Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression
    Agnes Gorlach
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, Lazarettstrasse 36, 80636 Munich, Germany
    Thromb Haemost 93:1168-75. 2005
    ..Thus, PAK may play an important role in promoting vascular remodelling processes in pulmonary hypertension...
  7. ncbi request reprint Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1
    Agnes Gorlach
    Experimentelle Kinderkardiologie, Deutsches Herzzentrum Müchen and der Technischen Universität Müchen, Munich, Germany
    Thromb Haemost 89:926-35. 2003
    ..In contrast, NFkappaB activation was enhanced in RacG12V-cells, but abolished by RacT17N. Thus, these findings suggest a mechanism explaining modified fibrinolysis and tissue remodeling in an oxidized environment...
  8. ncbi request reprint Rac-1 promotes pulmonary artery smooth muscle cell proliferation by upregulation of plasminogen activator inhibitor-1: role of NFkappaB-dependent hypoxia-inducible factor-1alpha transcription
    Isabel Diebold
    Experimentelle Kinderkardiologie, Deutsches Herzzentrum Munchen, an der Technischen Universität München, Lazarettstr 36, D 80636 München, Germany
    Thromb Haemost 100:1021-8. 2008
    ..These findings indicate that Rac-1 is an important mediator of thrombin signaling and may contribute to pulmonary vascular remodeling via HIF-1-dependent upregulation of PAI-1 leading to enhanced proliferation of PASMC...
  9. pmc The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1
    Isabel Diebold
    Experimental and Molecular Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University, 80636 Munich, Germany
    Mol Biol Cell 21:2087-96. 2010
    ....
  10. ncbi request reprint The serum- and glucocorticoid-inducible kinase Sgk-1 is involved in pulmonary vascular remodeling: role in redox-sensitive regulation of tissue factor by thrombin
    Rachida S BelAiba
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich, Technical University Munich, Munich, Germany
    Circ Res 98:828-36. 2006
    ..Because enhanced procoagulant activity can promote pulmonary vascular remodeling, and Sgk-1 and TF were present in the media of remodeled pulmonary vessels, this pathway may play a critical role in vascular remodeling in PH...
  11. ncbi request reprint Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site
    Steve Bonello
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the TU Munich, Lazarettstr 36, D 80636 Munich, Germany
    Arterioscler Thromb Vasc Biol 27:755-61. 2007
    ..We therefore aimed to elucidate the link between these 2 important redox-sensitive transcription factors...
  12. doi request reprint Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling
    Isabel Diebold
    Department of Pediatric Cardiology, Technical University Munich, Munich, Germany
    Antioxid Redox Signal 13:399-412. 2010
    ....
  13. ncbi request reprint Insights into the redox control of blood coagulation: role of vascular NADPH oxidase-derived reactive oxygen species in the thrombogenic cycle
    Olaf Herkert
    Experimental Pediatric Cardiology, Clinic for Pediatric Cardiology and Congenital Heart Diseases, German Heart Center Munich at the Technical University Munich, 80636
    Antioxid Redox Signal 6:765-76. 2004
    ..In this review, we summarize the data supporting a substantial role of ROS in promoting a thrombogenic cycle in the vascular system...
  14. doi request reprint The hypoxia-inducible factor-2alpha is stabilized by oxidative stress involving NOX4
    Isabel Diebold
    Experimental Pediatric Cardiology, German Heart Center Munich, Munich, Germany
    Antioxid Redox Signal 13:425-36. 2010
    ..Together, these findings present the first evidence that HIF-2alpha is critically involved in the ROS-regulated vascular remodeling processes...
  15. doi request reprint Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2
    Isabel Diebold
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the TU Munich, Lazarettstr 36, D 80636 Munich, Germany
    Circ Res 104:1169-77. 2009
    ..Targeting PDE2 may provide a new therapeutic approach in diseases associated with endothelial dysfunction, oxidative stress, vascular proliferation, and angiogenesis...
  16. doi request reprint The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II
    Isabel Diebold
    Experimental and Molecular Pediatric Cardiology, Dept of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, Lazarettstr 36, 80636 Munich, Germany
    J Cell Sci 125:956-64. 2012
    ..Because U-II has been found to be elevated in cardiovascular disorders and in tumour tissues, this feed-forward mechanism could be an interesting anti-angiogenic therapeutic option in these disorders...
  17. ncbi request reprint Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells
    Talija Djordjevic
    Experimental Pediatric Cardiology, Clinic for Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University of Munich, Germany
    Arterioscler Thromb Vasc Biol 25:519-25. 2005
    ....
  18. ncbi request reprint The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells
    Talija Djordjevic
    Experimental Pediatric Cardiology, Clinic for Pediatric Cardiology and Congenital Heart Diseases, German Heart Center Munich at the Technical University Munich, Lazarettstrasse 36, D 80636 Munich, Germany
    Free Radic Biol Med 38:616-30. 2005
    ..These findings suggest a positive feedback mechanism whereby ROS, possibly generated by the NADPH oxidase, lead to elevated levels of p22phox and, thus, sustained ROS generation as is observed in endothelial dysfunction...
  19. ncbi request reprint Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells
    Rachida S BelAiba
    Experimentelle Kinderkardiologie, Klinik für Kinder Kardiologie und Angeborene Herzfehler, Deutsches Herzzentrum München an der Technischen Universität München, D 80636 München, Germany
    Biol Chem 385:249-57. 2004
    ..Thus, shifting the redox balance to a more reduced environment, thereby limiting VEGF expression, may be beneficial for treating remodeling processes during pulmonary hypertension...
  20. ncbi request reprint NOX5 variants are functionally active in endothelial cells
    Rachida S BelAiba
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the TU Munich, Lazarettstrasse 36, D 80636 Munich, Germany
    Free Radic Biol Med 42:446-59. 2007
    ..These findings suggest that NOX5 variants play a novel role in controlling ROS-dependent processes in the vasculature...
  21. pmc Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells
    Rachida S BelAiba
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, D 80636 Munich, Germany
    Mol Biol Cell 18:4691-7. 2007
    ..Together, these findings provide a novel mechanism in which hypoxia induces HIF-1alpha mRNA expression via the PI3K/AKT pathway and activation of NFkappaB...
  22. ncbi request reprint NOX2 and NOX4 mediate proliferative response in endothelial cells
    Andreas Petry
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Diseases, German Heart Center Munich at the Technical University Munich, Munich, Germany
    Antioxid Redox Signal 8:1473-84. 2006
    ..NOX2 and NOX4, but not NOX1, equally contributed to ROS generation and proliferation under basal conditions, indicating that a complex relation between NOX homologues controls endothelial function...
  23. pmc NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II
    Isabel Diebold
    Experimental and Molecular Pediatric Cardiology, Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, 80636 Munich, Germany
    Mol Biol Cell 22:4424-34. 2011
    ..FoxO3a may thus contribute to progression of cardiovascular diseases associated with vascular remodeling...
  24. ncbi request reprint Regulation of the hypoxia-inducible transcription factor HIF-1 by reactive oxygen species in smooth muscle cells
    Rachida Siham Bel Aiba
    Experimental Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Lazarettstr 36, 80636 Munich
    Adv Exp Med Biol 536:171-8. 2003
  25. ncbi request reprint The 'PAI-1 paradox' in vascular remodeling
    Isabel Diebold
    Experimentelle Kinderkardiologie, Deutsches Herzzentrum München an der Technischen Universität München, Lazarettstr 36, D 80636 München, Germany
    Thromb Haemost 100:984-91. 2008
    ..Since PAI-1 levels have been shown to be altered in various disorders associated with vascular remodelling of the systemic and pulmonary vascular bed, this serpin may play a pivotal role in the pathogenesis of these diseases...
  26. doi request reprint Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by hypoxia-inducible factor-1α
    Florian Schelter
    Institut für Experimentelle Onkologie und Therapieforschung des Klinikums rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675, Munchen, Germany
    Clin Exp Metastasis 28:91-9. 2011
    ..This connection between a protease inhibitor (TIMP-1) and a classically stress-related factor (HIF-1α) is a so far undiscovered impact of the "protease web" on tissue homeostasis with important implications for metastasis...
  27. ncbi request reprint Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway
    Talija Djordjevic
    Experimental Pediatric Cardiology, Clinic for Pediatric Cardiology and Congenital Heart Diseases, German Heart Center Munich at the Technical University Munich, 80636
    Antioxid Redox Signal 6:713-20. 2004
    ....
  28. doi request reprint Inhibition of endothelial nitric oxyde synthase increases capillary formation via Rac1-dependent induction of hypoxia-inducible factor-1α and plasminogen activator inhibitor-1
    Andreas Petry
    Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Munich, Germany
    Thromb Haemost 108:849-62. 2012
    ..Rac1 activity is sensitive to ROS and NO, thereby playing an essential role in fine tuning the endothelial response to thrombin...
  29. ncbi request reprint The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control
    Agnes Gorlach
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, Munich, Germany
    Antioxid Redox Signal 8:1391-418. 2006
    ..Thus, redox homeostasis appears to be a prerequisite for proper functioning of the ER...
  30. doi request reprint Receptor activation of NADPH oxidases
    Andreas Petry
    Experimental Pediatric Cardiology, Technical University Munich, Munich, Germany
    Antioxid Redox Signal 13:467-87. 2010
    ..We will thus summarize molecular pathways linking activation of different membrane-bound receptors with increased ROS production of NADPH oxidases...
  31. ncbi request reprint Comparative characterization of cellular and molecular anti-restenotic profiles of paclitaxel and sirolimus. Implications for local drug delivery
    Rainer Wessely
    Deutsches Herzzentrum, Department of Cardiology 1 Medizinische Klinik rechts der Isar, University of Technology, Munich, Germany
    Thromb Haemost 97:1003-12. 2007
    ..In comparison with PTX, SRL shows minor interference with endothelial cell proliferation and migration, lower levels of cytotoxicity and apoptosis, a broader therapeutic range and distinctive immunosuppressive properties...
  32. ncbi request reprint Urotensin-II in the lung: a matter for vascular remodelling and pulmonary hypertension?
    Talija Djordjevic
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Diseases, German Heart Center Munich at the Technical University Munich, Munich, Germany
    Thromb Haemost 98:952-62. 2007
    ..Such vascular remodelling processes are, in conjunction with enhanced vasoconstriction, involved in the pathogenesis of pulmonary hypertension, suggesting that UII may play a novel role in the pathogenesis of this disorder...
  33. pmc Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase
    Karel Chalupsky
    1 Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Munich, Germany
    Antioxid Redox Signal 23:1076-91. 2015
    ....
  34. pmc Identification of a survival-independent metastasis-enhancing role of hypoxia-inducible factor-1alpha with a hypoxia-tolerant tumor cell line
    Florian Schelter
    Institut für Experimentelle Onkologie und Therapieforschung des Klinikums rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    J Biol Chem 285:26182-9. 2010
    ..This study uncovers a new survival-independent biological function of HIF-1alpha contributing to the efficacy of metastases formation...
  35. ncbi request reprint Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors
    Agnes Gorlach
    Experimental Pediatric Cardiology, German Heart Center Munich, Munich, Germany
    Methods Enzymol 435:421-46. 2007
    ..We summarize here current knowledge about the mechanisms by which ROS can regulate HIF and give additional information about useful methods to determine ROS under various conditions...
  36. pmc NOX1 supports the metabolic remodeling of HepG2 cells
    Katharina Bertram
    Experimental and Molecular Paediatric Cardiology, German Heart Centre Munich at the Technical University Munich, Lazarettstr 36, Munich, Germany
    PLoS ONE 10:e0122002. 2015
    ....
  37. pmc Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?
    Agnes Gorlach
    Experimental and Molecular Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Germany DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany
    Redox Biol 6:372-85. 2015
    ..In this review we discuss aspects and problems on the role of intracellular ROS formation and nutrition with the link to diseases and their problematic therapeutical issues. ..
  38. pmc The β3-integrin binding protein β3-endonexin is a novel negative regulator of hypoxia-inducible factor-1
    Damir Kračun
    1 Experimental and Molecular Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany
    Antioxid Redox Signal 20:1964-76. 2014
    ..However, their functional role in angiogenesis is unclear. In this study, we investigated whether β3-endonexin isoforms are involved in endothelial angiogenic processes under hypoxia...