Hannelore Daniel

Summary

Country: Germany

Publications

  1. ncbi request reprint From bacteria to man: archaic proton-dependent peptide transporters at work
    Hannelore Daniel
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Freising Weihenstephan, Germany
    Physiology (Bethesda) 21:93-102. 2006
  2. pmc 2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting
    Freek G Bouwman
    Department of Human Biology, NUTRIM, Maastricht University, Maastricht, The Netherlands
    BMC Med Genomics 4:24. 2011
  3. ncbi request reprint Nutrient-gene interactions: a single nutrient and hundreds of target genes
    Hannelore Daniel
    Molecular Nutrition Unit, Technical University of Munich, Life and Food Science Center, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    Biol Chem 385:571-83. 2004
  4. ncbi request reprint Molecular and integrative physiology of intestinal peptide transport
    Hannelore Daniel
    Molecular Nutrition Unit, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    Annu Rev Physiol 66:361-84. 2004
  5. pmc The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level
    Hannelore Daniel
    Molecular Nutrition Unit, Nutrition and Food Research Center, Technische Universitat Munchen, Freising, Germany
    Genes Nutr 3:101-6. 2008
  6. ncbi request reprint An update on renal peptide transporters
    Hannelore Daniel
    Molecular Nutrition Unit, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    Am J Physiol Renal Physiol 284:F885-92. 2003
  7. ncbi request reprint Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2
    Martin Foltz
    Molecular Nutrition Unit, Center of Life and Food Sciences, Technical University of Munich, Germany
    Eur J Biochem 271:3340-7. 2004
  8. ncbi request reprint Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    J Biol Chem 277:22966-73. 2002
  9. pmc Kinetics of bidirectional H+ and substrate transport by the proton-dependent amino acid symporter PAT1
    Martin Foltz
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Center of Life and Food Sciences, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Federal Republic of Germany
    Biochem J 386:607-16. 2005
  10. doi request reprint DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli
    Daniel Harder
    Molecular Nutrition Unit, Technical University of Munich, Freising, Germany
    FEBS J 275:3290-8. 2008

Collaborators

Detail Information

Publications99

  1. ncbi request reprint From bacteria to man: archaic proton-dependent peptide transporters at work
    Hannelore Daniel
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Freising Weihenstephan, Germany
    Physiology (Bethesda) 21:93-102. 2006
    ..Taking peptide transport as a general phenomenon found in nature, we also include peptide transport mechanisms in bacteria, yeast, invertebrates, and lower vertebrates, which are not that often addressed in physiology journals...
  2. pmc 2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting
    Freek G Bouwman
    Department of Human Biology, NUTRIM, Maastricht University, Maastricht, The Netherlands
    BMC Med Genomics 4:24. 2011
    ..Proteomic technologies applied for profiling human biofluids and blood cells are considered to reveal new biomarkers of exposure or provide insights into novel mechanisms of adaptation...
  3. ncbi request reprint Nutrient-gene interactions: a single nutrient and hundreds of target genes
    Hannelore Daniel
    Molecular Nutrition Unit, Technical University of Munich, Life and Food Science Center, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    Biol Chem 385:571-83. 2004
    ..However, it also becomes obvious that analysis of such complex nutrient-gene interactions beyond the descriptional level is a real challenge for systems biology...
  4. ncbi request reprint Molecular and integrative physiology of intestinal peptide transport
    Hannelore Daniel
    Molecular Nutrition Unit, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    Annu Rev Physiol 66:361-84. 2004
    ..Transcriptional and post-transcriptional regulation of PEPT1 occurs in response to alterations in the nutritional status and in disease states, suggesting a prime role of this transporter in amino acid absorption...
  5. pmc The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level
    Hannelore Daniel
    Molecular Nutrition Unit, Nutrition and Food Research Center, Technische Universitat Munchen, Freising, Germany
    Genes Nutr 3:101-6. 2008
    ..This review summarizes some of the concepts of a comparative approach to nutrigenomics research, identifies current lacks and proposes a concerted scientific effort to create the basis for nutritional systems biology...
  6. ncbi request reprint An update on renal peptide transporters
    Hannelore Daniel
    Molecular Nutrition Unit, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    Am J Physiol Renal Physiol 284:F885-92. 2003
    ....
  7. ncbi request reprint Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2
    Martin Foltz
    Molecular Nutrition Unit, Center of Life and Food Sciences, Technical University of Munich, Germany
    Eur J Biochem 271:3340-7. 2004
    ..Maximal transport currents are substrate-dependent which suggests that the translocation of the loaded carrier to the internal side is the rate-limiting step...
  8. ncbi request reprint Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    J Biol Chem 277:22966-73. 2002
    ..Phenotypically, the PAT1 transporter possesses the same functional characteristics as the previously described proton-dependent amino acid transport process in apical membranes of intestinal and renal epithelial cells...
  9. pmc Kinetics of bidirectional H+ and substrate transport by the proton-dependent amino acid symporter PAT1
    Martin Foltz
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Center of Life and Food Sciences, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Federal Republic of Germany
    Biochem J 386:607-16. 2005
    ..Surprisingly, PAT1 exhibits no pre-steady-state currents in the absence of substrate, even at low temperatures, and therefore PAT1 takes an exceptional position among the ion-coupled co-transporters...
  10. doi request reprint DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli
    Daniel Harder
    Molecular Nutrition Unit, Technical University of Munich, Freising, Germany
    FEBS J 275:3290-8. 2008
    ..We also propose to rename TppB as DtpA, to better describe its function as the first protein of the PTR family characterized in E. coli...
  11. ncbi request reprint Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions
    Uwe Wenzel
    Molecular Nutrition Unit, Department of Food and Nutrition, Technical University of Munich, Hochfeldweg 2, D 85350 Freising, Germany
    Carcinogenesis 25:703-12. 2004
    ..In conclusion, ascorbic acid functions as a potent antioxidant in mitochondria of human colon cancer cells and thereby blocks drug-mediated apoptosis induction allowing cancer cells to become insensitive to chemotherapeutics...
  12. doi request reprint Flavone induces changes in intermediary metabolism that prevent microadenoma formation in colonic tissue of carcinogen-treated mice
    Isabel Winkelmann
    Department of Food and Nutrition, Technical University of Munich, Freising, Germany
    Mol Nutr Food Res 54:S184-95. 2010
    ..Colorectal cancer is a major cause of cancer deaths worldwide with the need for improved therapeutics and adjuvants...
  13. pmc A glutathione peroxidase, intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. elegans
    Jacqueline Benner
    ZIEL Research Center of Nutrition and Food Sciences, Abteilung Biochemie, Technische Universitat Munchen, Freising, Germany
    PLoS ONE 6:e25624. 2011
    ..elegans supports evidence that intracellular peptide hydrolysis and amino acid concentration are a part of a sensing system that controls PEPT-1 expression and function and that involves the TOR complexes TORC1 and TORC2...
  14. ncbi request reprint Proteome analysis suggests that mitochondrial dysfunction in stressed endothelial cells is reversed by a soy extract and isolated isoflavones
    Dagmar Fuchs
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Am Forum 5, D 85350 Freising, Germany
    J Proteome Res 6:2132-42. 2007
    ....
  15. doi request reprint Substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes
    Manuela Mertl
    Molecular Nutrition Unit, Am Forum 5, Freising 85350, Germany
    Am J Physiol Cell Physiol 295:C1332-43. 2008
    ..Coexpression experiments with human Na(+)-glucose transporter 1 (hSGLT1) revealed that substrate exposure selectively affected PEPT1 but not the activity of hSGLT1...
  16. ncbi request reprint Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells
    Uwe Wenzel
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    Proteomics 4:2160-74. 2004
    ..Their identification as molecular targets of quercetin may explain the anti-cancer activities of this flavonoid...
  17. doi request reprint Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity
    Britta Spanier
    ZIEL Research Center of Nutrition and Food Sciences, Technische Universitat Munchen, Freising, Germany
    Aging Cell 9:636-46. 2010
    ..elegans lacking a proper function of the insulin receptor and lacking the intestinal peptide transporter...
  18. doi request reprint Amino acid absorption and homeostasis in mice lacking the intestinal peptide transporter PEPT1
    Anna Maria Nässl
    ZIEL Research Center of Nutrition and Food Sciences, Abteilung Biochemie, Technische Universitat Munchen, Freising, Germany
    Am J Physiol Gastrointest Liver Physiol 301:G128-37. 2011
    ..Since renal amino acid excretion remained unchanged, elevated basal concentrations of plasma amino acids in PEPT1-deficient animals seem to arise mainly from alterations in hepatic amino acid metabolism...
  19. doi request reprint Diet-induced obesity in ad libitum-fed mice: food texture overrides the effect of macronutrient composition
    Charles Desmarchelier
    Molecular Nutrition Unit, ZIEL Research Center for Nutrition and Food Sciences, Technische Universität München TUM, Gregor Mendel Strasse 2, 85350 Freising Weihenstephan, Germany
    Br J Nutr 109:1518-27. 2013
    ..A diet high in both fat and sugars seems to be more deleterious for the liver than a HF diet...
  20. ncbi request reprint The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1
    Isabel Rubio-Aliaga
    Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    J Biol Chem 279:2754-60. 2004
    ....
  21. ncbi request reprint Substrate recognition by the mammalian proton-dependent amino acid transporter PAT1
    Michael Boll
    Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    Mol Membr Biol 20:261-9. 2003
    ..A critical recognition criterion of PAT1 is the backbone charge separation distance and the side chain size, whereas substitutions on the amino group are well tolerated...
  22. ncbi request reprint PEPT1 as a paradigm for membrane carriers that mediate electrogenic bidirectional transport of anionic, cationic, and neutral substrates
    Gabor Kottra
    Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    J Biol Chem 277:32683-91. 2002
    ..The simultaneous presence of identically charged substrates on both membrane surfaces generates outward and, unexpectedly, enhanced inward transport currents probably by increasing the turnover rate...
  23. ncbi request reprint A cluster of proton/amino acid transporter genes in the human and mouse genomes
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    Genomics 82:47-56. 2003
    ..For the PAT3 subtype transporter, we could not yet identify its function. The human PAT1 and PAT2 transporters when functionally expressed in Xenopus laevis oocytes show characteristics similar to those of their mouse counterparts...
  24. ncbi request reprint A novel bifunctionality: PAT1 and PAT2 mediate electrogenic proton/amino acid and electroneutral proton/fatty acid symport
    Martin Foltz
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    FASEB J 18:1758-60. 2004
    ....
  25. doi request reprint Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1
    Tanja Heidler
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Am Forum 5, Freising, Germany
    Biogerontology 11:183-95. 2010
    ..1-dependent alterations in gene expression after a ROS challenge lead to a lifespan extension in C. elegans as long as the stressor concentration does not exceed the saturable protective capacity...
  26. ncbi request reprint Pleiotropic molecular effects of the pro-apoptotic dietary constituent flavone in human colon cancer cells identified by protein and mRNA expression profiling
    Angelika Herzog
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Freising, Germany
    Proteomics 4:2455-64. 2004
    ..In conclusion, flavone has a surprisingly broad spectrum of effects on mRNA and protein expression in a human colonic cancer cell line with clusters of targets related to its apoptosis-inducing activity and to cellular metabolism...
  27. pmc C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia
    Charles Desmarchelier
    Molecular Nutrition Unit, Technische Universitat Munchen, Molecular Nutrition Unit, Gregor Mendel Strasse 2, 85350 Freising Weihenstephan, Germany
    BMC Genomics 13:84. 2012
    ....
  28. ncbi request reprint Effects of increased cellular zinc levels on gene and protein expression in HT-29 cells
    Birgit Kindermann
    Molecular Nutrition Unit, Technical University of Munich, 85350 Freising Weihenstephan, Germany
    Biometals 18:243-53. 2005
    ..More than half of the targets participate in ATP production or stress response. Therefore, it appears that higher zinc concentrations mediate their effects mainly via impairments in cellular energy metabolism and stress response...
  29. ncbi request reprint Genistein blocks homocysteine-induced alterations in the proteome of human endothelial cells
    Dagmar Fuchs
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Freising, Germany
    Proteomics 5:2808-18. 2005
    ....
  30. ncbi request reprint Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system
    Anne Ruhl
    Department of Human Biology, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    J Comp Neurol 490:1-11. 2005
    ..PEPT2-mediated dipeptide transport in enteric glia could contribute to the clearance of neuropeptides in the ENS. In addition, the fluorophore-coupled dipeptide uptake via PEPT2 is a novel vital marker for glial cells in the ENS...
  31. ncbi request reprint Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2-/- mice
    Isabelle M Frey
    Molecular Nutrition Unit, Technical University of Munich, Freising, Germany
    Physiol Genomics 28:301-10. 2007
    ....
  32. ncbi request reprint The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes
    Isabel Winkelmann
    Molecular Nutrition Unit, Department of Food and Nutrition, Technical University of Munich, Am Forum 5, D 85350 Freising, Germany
    Carcinogenesis 28:1446-54. 2007
    ..Moreover, reduction in crypt multiplicity by flavone is most probably due to the preservation of a normal oxidative metabolism...
  33. doi request reprint The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption
    Tilo Wuensch
    Technische Universitat Munchen, Biochemistry Unit, ZIEL Research Center for Nutrition and Food Science, CDD Center for Diet and Disease, Freising Weihenstephan, Germany
    Am J Physiol Gastrointest Liver Physiol 305:G66-73. 2013
    ....
  34. doi request reprint Mice lacking the intestinal peptide transporter display reduced energy intake and a subtle maldigestion/malabsorption that protects them from diet-induced obesity
    Dominika Kolodziejczak
    Biochemistry, Technische Universitat Munchen, ZIEL Research Center of Nutrition and Food Sciences, Gregor Mendel Straße 2, D 85350 Freising, Germany
    Am J Physiol Gastrointest Liver Physiol 304:G897-907. 2013
    ..In search for the origin of this, we recorded markedly reduced systemic IL-6 levels in all Pept1(-/-) mice, suggesting that IL-6 could contribute to the lack of adaptation of the mucosal architecture to the diets...
  35. ncbi request reprint Flavonoid glycosides are not transported by the human Na+/glucose transporter when expressed in Xenopus laevis oocytes, but effectively inhibit electrogenic glucose uptake
    Gabor Kottra
    Molecular Nutrition Unit, Department of Food and Nutrition, Technische Universitat Munchen, Am Forum 5, D 85350 Freising, Germany
    J Pharmacol Exp Ther 322:829-35. 2007
    ..However, not only glycosylated but also a few nonglycosylated flavonoids show a structure-dependent capability for effective inhibition of SGLT1...
  36. ncbi request reprint Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo
    Katrin Lohner
    Molecular Nutrition Unit, Department of Food and Nutrition, Technical University of Munich, Freising, Germany
    Mol Nutr Food Res 51:293-300. 2007
    ..In conclusion, the increase in P-gp expression caused by flavonoids in intestinal epithelial cells in vitro and also in vivo may serve as an adaptation and defense mechanism limiting the entry of lipophilic xenobiotics into the organism...
  37. pmc Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice
    François Reichardt
    Professor M Schemann Lehrstuhl für Humanbiologie, Technische Universitat Munchen, Liesel Beckmann Straße 4, 85350 Freising Weihenstephan, Germany
    J Physiol 591:5125-39. 2013
    ..This questions the common assumption that increased mucosal inflammation and permeability initiate functional disorders in obesity...
  38. pmc Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism
    Christoph Dahlhoff
    Biochemistry Unit, PhD Group, Research Center for Nutrition and Food Sciences, Technische Universitat Munchen, Freising Weihenstephan, Germany
    PLoS ONE 8:e57387. 2013
    ....
  39. doi request reprint Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C. elegans
    Gregor Grünz
    ZIEL Research Center of Nutrition and Food Sciences, Abteilung Biochemie, Technische Universitat Munchen, Gregor Mendel Strasse 2, Freising, Germany
    Mech Ageing Dev 133:1-10. 2012
    ..An increased DAF-16 translocation and sod-3 promoter activity were observed with all flavonoids but was independent of their ROS scavenging capability and their effects on lifespan...
  40. ncbi request reprint Defining minimal structural features in substrates of the H(+)/peptide cotransporter PEPT2 using novel amino acid and dipeptide derivatives
    Stephan Theis
    Molecular Nutrition Unit, Institute of Nutritional Science, Technical University of Munich, Freising Weihenstephan, Germany
    Mol Pharmacol 61:214-21. 2002
    ..This information provides the framework for a rational design of peptidomimetic drugs for delivery via PEPT2...
  41. ncbi request reprint Differential protein expression profile in the intestinal epithelium from patients with inflammatory bowel disease
    Anna Shkoda
    Else Kroener Fresenius Center for Experimental Nutritional Medicine, Molecular Nutrition, Technical University of Munich, Freising Weihenstephan, Germany
    J Proteome Res 6:1114-25. 2007
    ..The induction of Rho GDI alpha expression may be associated with the destruction of IEC homeostasis under condition of chronic intestinal inflammation...
  42. ncbi request reprint Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products
    Uwe Wenzel
    Molecular Nutrition Unit, Department of Food and Nutrition, Technical University of Munich, Freising, Federal Republic of Germany
    Int J Cancer 116:236-42. 2005
    ..Our study provides evidence that melatonin potentiates flavone-induced apoptosis in HT-29 human colon cancer cells by enhancing the level of oxidizable substrates that can be transported into mitochondria in the presence of flavone...
  43. ncbi request reprint Increased carnitine-dependent fatty acid uptake into mitochondria of human colon cancer cells induces apoptosis
    Uwe Wenzel
    Molecular Nutrition Unit, Department of Food and Nutrition, Technical University of Munich, Hochfeldweg 2, D 85350 Freising, Germany
    J Nutr 135:1510-4. 2005
    ....
  44. ncbi request reprint Identification of genes responsive to intracellular zinc depletion in the human colon adenocarcinoma cell line HT-29
    Birgit Kindermann
    Molecular Nutrition Unit, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    J Nutr 134:57-62. 2004
    ..In conclusion, the pattern of zinc-affected genes may represent a reference for further studies to define the zinc regulon in mammalian cells...
  45. doi request reprint Proteome response in HT-29 human colorectal cancer cells to two apoptosis-inducing compounds with different mode of action
    Isabel Winkelmann
    Molecular Nutrition Unit, Department of Food and Nutrition, Technical University of Munich, Am Forum 5, Freising, Germany
    Int J Cancer 122:2223-32. 2008
    ..Some protein regulations, however, were specific for each compound and point to the mechanism of their action...
  46. ncbi request reprint Soy extract has different effects compared with the isolated isoflavones on the proteome of homocysteine-stressed endothelial cells
    Dagmar Fuchs
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Freising, Germany
    Mol Nutr Food Res 50:58-69. 2006
    ....
  47. ncbi request reprint Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of rats
    Ladislav Raschka
    Institute of Nutritional Science, Molecular Nutrition Unit, Technical University of Munich, Am Forum 5, 85350 Freising Weihenstephan, Germany
    Bone 37:728-35. 2005
    ....
  48. ncbi request reprint Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells
    Uwe Wenzel
    Molecular Nutrition Unit, Department of Food and Nutrition, Technical University of Munich, Freising, Germany
    J Cell Physiol 202:379-90. 2005
    ..Transformed colonocytes, however, seem especially vulnerable to O2-*, produced in mitochondria as a consequence of these metabolic alterations, and respond with the induction of apoptosis...
  49. ncbi request reprint Early and late apoptosis events in human transformed and non-transformed colonocytes are independent on intracellular acidification
    Uwe Wenzel
    Department of Food and Nutrition Science, Molecular Nutrition Unit, Technical University of Munich, Germany
    Cell Physiol Biochem 14:65-76. 2004
    ..Here too, imidazole prevented the pHi decline but failed to affect apoptosis execution. In conclusion, apoptosis in human colonocytes is not affected by alterations in pHi...
  50. pmc Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney
    Isabel Rubio-Aliaga
    Molecular Nutrition Unit, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    Mol Cell Biol 23:3247-52. 2003
    ..This indicates that PEPT2 is the main system responsible for tubular reabsorption of peptide-bound amino acids, although this does not lead to major changes in renal excretion of protein or free amino acids...
  51. ncbi request reprint Genistein reverses changes of the proteome induced by oxidized-LDL in EA.hy 926 human endothelial cells
    Dagmar Fuchs
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, D 85350 Freising, Germany
    J Proteome Res 4:369-76. 2005
    ..These alterations caused by genistein are functionally linked to the inhibition of ox-LDL induced apoptosis...
  52. pmc The intestinal peptide transporter PEPT1 is involved in food intake regulation in mice fed a high-protein diet
    Anna Maria Nässl
    ZIEL Research Center of Nutrition and Food Sciences, Abteilung Biochemie, Technische Universitat Munchen, Freising, Germany
    PLoS ONE 6:e26407. 2011
    ....
  53. doi request reprint Intestinal amino acid availability via PEPT-1 affects TORC1/2 signaling and the unfolded protein response
    Kerstin E Geillinger
    ZIEL Research Center of Nutrition and Food Sciences, Molecular Nutrition and Biochemistry Unit, Technische Universitat Munchen, Gregor Mendel Str 2, 85350 Freising, Germany
    J Proteome Res 13:3685-92. 2014
    ..These data argue for a central role of PEPT-1 in cellular amino acid homeostasis. In PEPT-1 deficiency, amino acid levels dropped systematically, leading to alterations in protein synthesis and in the IRE-1/XBP-1 pathway. ..
  54. pmc Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome
    Manuela Sailer
    Molecular Nutrition Unit, Research Center for Nutrition and Food Sciences, Technische Universitat Munchen, Freising Weihenstephan, Germany
    PLoS ONE 8:e63950. 2013
    ..Therefore, type 1 diabetic mice but not DIO mice show the "diabetic fingerprint" of plasma amino acid changes observed in humans. Additionally, citrulline may serve as an early indicator of the obesity-dependent metabolic impairments...
  55. doi request reprint Inhibition of intracellular dipeptide hydrolysis uncovers large outward transport currents of the peptide transporter PEPT1 in Xenopus oocytes
    Gabor Kottra
    Molecular Nutrition Unit, Technische Universitat Munchen, Freising, Germany
    Pflugers Arch 457:809-20. 2009
    ..Our data and preliminary model calculations suggest a faster turnover rate of rPEPT1 in the presence of high substrate concentrations on the cytosolic surface...
  56. ncbi request reprint Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays
    Heike tom Dieck
    Technical University of Munich, Molecular Nutrition Unit, D 85350 Freising Weihenstephan, Germany
    J Nutr 133:1004-10. 2003
    ....
  57. ncbi request reprint Proteomic biomarkers of peripheral blood mononuclear cells obtained from postmenopausal women undergoing an intervention with soy isoflavones
    Dagmar Fuchs
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Freising, Federal Republic of Germany
    Am J Clin Nutr 86:1369-75. 2007
    ..The incidence of cardiovascular diseases increases after menopause, and soy consumption is suggested to inhibit disease development...
  58. ncbi request reprint Functional and structural characterization of a prokaryotic peptide transporter with features similar to mammalian PEPT1
    Dietmar Weitz
    Molecular Nutrition Unit, Department of Food and Nutrition, Technical University of Munich, 85350 Freising, Germany
    J Biol Chem 282:2832-9. 2007
    ....
  59. doi request reprint Effect of flavonoids on basal and insulin-stimulated 2-deoxyglucose uptake in adipocytes
    Melina Claussnitzer
    Else Kroner Fresenius Center for Nutritional Medicine, Technische Universitat Munchen, Freising, Germany
    Mol Nutr Food Res 55:S26-34. 2011
    ..It has been proposed that dietary flavonoids may interfere with glucose transport processes...
  60. ncbi request reprint Zinc-sensitive genes as potential new target genes of the metal transcription factor-1 (MTF-1)
    Birgit Kindermann
    Institute of Nutritional Science, Molecular Nutrition Unit, Technical University of Munich, Freising Weihenstephan, Germany
    Biochem Cell Biol 83:221-9. 2005
    ..We conclude that zinc responsiveness of klf4, hhav, and cfbp in HT-29 cells is mediated at least in part by MTF-1...
  61. doi request reprint Selected tetrapeptides lead to a GLP-1 release from the human enteroendocrine cell line NCI-H716
    Boris Le Nevé
    Molecular Nutrition Unit, Technical University of Munich, Freising Weihenstephan, Germany
    Regul Pept 167:14-20. 2011
    ..This tetrapeptide sensing in NCI-H716 cells may be underlying the effective stimulation of hormone secretion shown for various protein hydrolysates, and could involve a novel G-protein-coupled receptor (GPCR)...
  62. doi request reprint Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice
    Tobias Ludwig
    Clinical Nutritional Medicine Unit, ZIEL Research Center for Nutrition and Food Sciences, Technische Universitat Munchen, Freising Weihenstephan, Germany
    Am J Physiol Endocrinol Metab 304:E1140-56. 2013
    ..LC-n-3 PUFA effects were pro- and anti-inflammatory and disclose T cell-immunosuppressive potential...
  63. ncbi request reprint Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis
    Angelika Herzog
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Freising, Federal Republic of Germany
    Int J Cancer 109:220-9. 2004
    ..In conclusion, proteome analysis allowed the identification of marker proteins that are involved in the initiation of apoptotic cell death in preneoplastic colonocytes and those may help to develop new strategies for cancer prevention...
  64. ncbi request reprint Phenotype analysis of mice deficient in the peptide transporter PEPT2 in response to alterations in dietary protein intake
    Isabelle M Frey
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, Am Forum 5, 85350, Freising Weihenstephan, Germany
    Pflugers Arch 452:300-6. 2006
    ..When fed diets with different protein contents, Pept2-/- mice adapted food intake to dietary protein content with higher consumption rates on low protein and reduced food intake rates on the high protein diet...
  65. ncbi request reprint A rapid in vitro screening for delivery of peptide-derived peptidase inhibitors as potential drug candidates via epithelial peptide transporters
    Martin Foltz
    Institute of Nutritional Sciences, Center of Life and Food Sciences, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    J Pharmacol Exp Ther 310:695-702. 2004
    ..In conclusion, we have applied an in vitro screening system that predicts efficient intestinal absorption of peptide-derived peptidase inhibitors via PEPT1 in vivo...
  66. ncbi request reprint The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology
    Hannelore Daniel
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, Hochfeldweg 2, 85354, Freising Weihenstephan, Germany
    Pflugers Arch 447:610-8. 2004
    ....
  67. doi request reprint Dynamic changes of the Caenorhabditis elegans proteome during ontogenesis assessed by quantitative analysis with 15N metabolic labeling
    Kerstin E Geillinger
    ZIEL Research Center of Nutrition and Food Sciences, Abteilung Biochemie, Technische Universitat Munchen, Gregor Mendel Strasse 2, 85350 Freising, Germany
    J Proteome Res 11:4594-604. 2012
    ..elegans in a quantitative manner during larval development. The data set generated provides the basis for further exploitation of the role of individual proteins or protein clusters during ontogenesis...
  68. doi request reprint Reduced amino acids in the bovine uterine lumen of cloned versus in vitro fertilized pregnancies prior to implantation
    Anna E Groebner
    Physiology Weihenstephan, Technische Universitaet Muenchen, Freising, Germany
    Cell Reprogram 13:403-10. 2011
    ..These are unlikely related to the major embryonic pregnancy recognition signal interferon-tau, because similar activities were detected in uterine flushings of the SCNT and IVF groups...
  69. pmc How the intestinal peptide transporter PEPT-1 contributes to an obesity phenotype in Caenorhabditits elegans
    Britta Spanier
    Abteilung Biochemie, ZIEL Research Center of Nutrition and Food Sciences, Technische Universitat Munchen, Freising, Germany
    PLoS ONE 4:e6279. 2009
    ..Transporter-deficient animals (pept-1(lg601)) show impaired growth, slowed postembryonal development and major changes in amino acid status...
  70. doi request reprint Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
    Sabine Buhner
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 137:1425-34. 2009
    ..Pathological features in irritable bowel syndrome (IBS) include alterations in mucosal cell content and mediator release that might alter signaling to nearby submucosal neurons...
  71. ncbi request reprint The human peripheral blood mononuclear cell proteome responds to a dietary flaxseed-intervention and proteins identified suggest a protective effect in atherosclerosis
    Dagmar Fuchs
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Freising, Germany
    Proteomics 7:3278-88. 2007
    ....
  72. ncbi request reprint The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, Hochfeldweg 2, 85350, Freising Weihenstephan, Germany
    Pflugers Arch 447:776-9. 2004
    ..SLC36 transporters are related distantly to other proton-coupled amino acid transporters, such as the vesicular neurotransmitter transporter VIAAT/VGAT (SLC32) and system N transporters (SLC38 family)...
  73. ncbi request reprint Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents
    Uwe Wenzel
    Department of Food and Nutrition, Molecular Nutrition Unit, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    Mol Pharmacol 64:1494-502. 2003
    ..In conclusion, our studies demonstrate that the intracellular levels of nitric oxide significantly change the apoptotic response to antineoplastic agents in colonic cells...
  74. ncbi request reprint Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation
    Anna Shkoda
    Else Kroener Fresenius Center for Experimental Nutritional Medicine, Technical University of Munich, 85350 Freising Weihenstephan, Germany
    Gastroenterology 132:190-207. 2007
    ..The aim of the study was to use functional epithelial cell proteomics to characterize anti-inflammatory mechanisms of interleukin 10 (IL-10)...
  75. ncbi request reprint Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions
    Uwe Wenzel
    Molecular Nutrition Unit, Department of Food and Nutrition, Technical University of Munich, Freising, Germany
    Int J Cancer 106:666-75. 2003
    ....
  76. ncbi request reprint Synthesis and characterization of high affinity inhibitors of the H+/peptide transporter PEPT2
    Stephan Theis
    Molecular Nutrition Unit, Institute of Nutritional Science, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    J Biol Chem 277:7287-92. 2002
    ....
  77. ncbi request reprint Mammalian peptide transporters as targets for drug delivery
    Isabel Rubio-Aliaga
    Institute of Nutritional Sciences, Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, D 85350, Freising, Germany
    Trends Pharmacol Sci 23:434-40. 2002
    ..Peptide transporters represent excellent targets for the delivery of pharmacologically active compounds because their substrate-binding site can accommodate a wide range of molecules of differing size, hydrophobicity and charge...
  78. ncbi request reprint Proteomics in nutrition research: principles, technologies and applications
    Dagmar Fuchs
    Molecular Nutrition Unit, Technical University of Munich, Am Forum 5, D 85 350 Freising Weihenstephan, Germany
    Br J Nutr 94:302-14. 2005
    ..Examples from nutritional studies employing proteomics are provided to demonstrate not only the advantages but also the limitations of current proteome analysis platforms...
  79. pmc PEPT1-mediated cefixime uptake into human intestinal epithelial cells is increased by Ca2+ channel blockers
    Uwe Wenzel
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    Antimicrob Agents Chemother 46:1375-80. 2002
    ..g., by Ca2+ channel blockers, affect pH regulatory systems, such as apical Na+ and H+ exchange, and thereby alter the H+ gradient that serves as the driving force for uptake of beta-lactams into intestinal epithelial cells...
  80. ncbi request reprint Proteome analysis for identification of target proteins of genistein in primary human endothelial cells stressed with oxidized LDL or homocysteine
    Dagmar Fuchs
    Dept of Food and Nutrition, Molecular Nutrition Unit Technical University of Munich, Hochfeldweg 2, 85350, Freising, Germany
    Eur J Nutr 44:95-104. 2005
    ..The proposed anti-atherogenic effects of soy appear to be carried by the soy isoflavones with genistein as the most abundant compound...
  81. ncbi request reprint Diet composition and age determine the effects of inulin-type fructans on intestinal calcium absorption in rat
    Ladislav Raschka
    Institute of Nutritional Science, Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, 85350, Freising Weihenstephan, Germany
    Eur J Nutr 44:360-4. 2005
    ....
  82. ncbi request reprint Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport
    David A Groneberg
    Deptartment of Pediatric Pneumology and Immunology Medicine, Charite School of Medicine, Humboldt University CVK OR 1 R 3 0073, Augustenburger Platz 1, D 13353 Berlin, Germany
    Am J Respir Cell Mol Biol 30:251-60. 2004
    ....
  83. ncbi request reprint Analysis of the transport properties of side chain modified dipeptides at the mammalian peptide transporter PEPT1
    Ilka Knutter
    Institute of Biochemistry, Department of Biochemistry Biotechnology, and Membrane Transport Group, Biozentrum, Martin Luther University Halle Wittenberg, Kurt Mothes Strasse 3, D 06120 Halle, Germany
    Eur J Pharm Sci 21:61-7. 2004
    ....
  84. ncbi request reprint Molecular and functional characterisation of the zebrafish (Danio rerio) PEPT1-type peptide transporter
    Tiziano Verri
    Department of Biological and Environmental Sciences and Technologies, University of Lecce, Via provinciale Lecce Monteroni, I 73100 Lecce, Italy
    FEBS Lett 549:115-22. 2003
    ..Moreover, zebrafish pept1 can be a useful marker for screening mutations that affect gut regionalisation, differentiation and morphogenesis...
  85. ncbi request reprint Renal assimilation of short chain peptides: visualization of tubular peptide uptake
    David A Groneberg
    Dept of Pediatric Pneumology and Immunology, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Pharm Res 19:1209-14. 2002
    ..The current study was designed to identify by visualization functional peptide transport activity along the nephron structures...
  86. ncbi request reprint H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1
    Ilka Knutter
    Institute of Biochemistry, Department of Biochemistry Biotechnology, Halle D 06120, D 85350 Germany
    Am J Physiol Gastrointest Liver Physiol 283:G222-9. 2002
    ..SK-ChA-1 cells represent a convenient model to study the physiological and clinical aspects of peptide transport in cholangiocytes...
  87. ncbi request reprint Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans
    Barbara Meissner
    Acolph Butenandt Institute Molecular Neurogenetics, Ludwig Maximilians University of Munich, D 80336 Munich, Germany
    J Biol Chem 279:36739-45. 2004
    ....
  88. ncbi request reprint Direct visualization of peptide uptake activity in the central nervous system of the rat
    David A Groneberg
    Biomedical Research Center, Otto Heubner Centre, Charite School of Medicine, Free University Berlin and Humboldt University, Augustenburger Platz 1 OR1, D 13353 Berlin, Germany
    Neurosci Lett 364:32-6. 2004
    ..The presence of PEPT2 was confirmed by RT-PCR and Northern blot analysis. This first CNS peptide and drug transport-visualizing assay may be used to examine new compounds which are carried by the proton-driven CNS peptide transporter...
  89. doi request reprint Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited
    Ilka Knutter
    Biozentrum of the Martin Luther University Halle Wittenberg, Membrane Transport Group, Halle, Germany
    J Pharmacol Exp Ther 327:432-41. 2008
    ..The present results suggest that peptide transporters do not control intestinal absorption and renal reabsorption of ACE inhibitors...
  90. doi request reprint Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells
    M Emília Juan
    Department of Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Spain
    J Agric Food Chem 56:4813-8. 2008
    ..Results of the present study provide evidence demonstrating the antitumor effect of trans-resveratrol via a ROS-dependent apoptosis pathway in colorectal carcinoma...
  91. ncbi request reprint Synthesis and characterization of a new and radiolabeled high-affinity substrate for H+/peptide cotransporters
    Ilka Knutter
    Biozentrum of the Martin Luther University Halle Wittenberg, Halle, Germany
    FEBS J 274:5905-14. 2007
    ..We conclude that Bip-[(3)H]Pro is a valuable substrate for both mechanistic and structural studies of H(+)/peptide transporter proteins...
  92. ncbi request reprint Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1
    Linda Metzner
    Membrane Transport Group, Biozentrum of the Martin Luther University Halle Wittenberg, Germany
    FASEB J 19:1468-73. 2005
    ..They may be considered as the carriers' naturally occurring inhibitors that may alter the transport function of PAT1...
  93. ncbi request reprint Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells
    M Emília Juan
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Spain
    J Nutr 136:2553-7. 2006
    ..Our results report for the first time, to our knowledge, the inhibition of cell proliferation without cytotoxicity and the restoration of apoptosis in colon cancer cells by maslinic and oleanolic acids present in olive fruit extracts...
  94. ncbi request reprint High-affinity peptide transporter PEPT2 (SLC15A2) of the zebrafish Danio rerio: functional properties, genomic organization, and expression analysis
    Alessandro Romano
    Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, University of Lecce, Lecce, Italy
    Physiol Genomics 24:207-17. 2006
    ..Moreover, it can represent a useful marker to screen mutations that affect choroid plexus and inner ear development...
  95. ncbi request reprint Hypothyroidism induces expression of the peptide transporter PEPT2
    Frank Döring
    Otto Heubner Center, Biomedical Research Center, Charité Medical School of the Free University and Humboldt University, D 13353 Berlin, Germany
    Biol Chem 386:785-90. 2005
    ..As PEPT2 reabsorbs filtered di- and tripeptides and peptide-like drugs, the present findings may have important implications in nutritional amino acid homeostasis and for drug dynamics in states of altered thyroid function...
  96. ncbi request reprint Transcriptome and proteome analysis identifies the pathways that increase hepatic lipid accumulation in zinc-deficient rats
    Heike tom Dieck
    Degussa Food Ingredients GmbH, Lise Meitner Strasse 34, 85354 Freising, Germany
    J Nutr 135:199-205. 2005
    ..These alterations in hepatic metabolism are discussed in the context of changes in mRNA and protein levels of enzymes and transporters responsible for fatty acid metabolism, sequestration, and their transcriptional control...
  97. ncbi request reprint H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat
    Catriona M H Anderson
    Faculty of Medical Sciences, nUniversity of Newcastle Upon Tyne, Newcasttle Upon Tyne, UK
    Gastroenterology 127:1410-22. 2004
    ....
  98. ncbi request reprint Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein
    David A Groneberg
    Dept of Pediatric Pneumology and Immunology, Charite Campus Virchow, Humboldt University, D 13353 Berlin, Germany
    Am J Physiol Endocrinol Metab 282:E1172-9. 2002
    ....