Christian Schmahl

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. pmc Positron tomographic emission study of olfactory induced emotional recall in veterans with and without combat-related posttraumatic stress disorder
    Eric Vermetten
    University Medical Center, Utrecht, The Netherlands
    Psychopharmacol Bull 40:8-30. 2007
  2. doi request reprint Motives for nonsuicidal self-injury among women with borderline personality disorder
    Nikolaus Kleindienst
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Nerv Ment Dis 196:230-6. 2008
  3. pmc Gene expression profiles in relation to tension and dissociation in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    PLoS ONE 8:e70787. 2013
  4. doi request reprint [Importance of neurobiology for modular psychotherapy]
    C Schmahl
    Klinik für Psychosomatik und Psychotherapeutische Medizin, Zentralinstitut fur Seelische Gesundheit Mannheim, J 5, 68159, Mannheim, Deutschland
    Nervenarzt 84:1316-20. 2013
  5. doi request reprint Pain sensitivity is reduced in borderline personality disorder, but not in posttraumatic stress disorder and bulimia nervosa
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 11:364-71. 2010
  6. pmc Hippocampus and amygdala volumes in patients with borderline personality disorder with or without posttraumatic stress disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Psychiatry Neurosci 34:289-95. 2009
  7. ncbi request reprint Neural correlates of antinociception in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 63:659-67. 2006
  8. pmc Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations
    Gabriele Ende
    Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 41:410-8. 2016
  9. doi request reprint Amygdala deactivation as a neural correlate of pain processing in patients with borderline personality disorder and co-occurrent posttraumatic stress disorder
    Anja Kraus
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 65:819-22. 2009
  10. doi request reprint Correlation of glutamate levels in the anterior cingulate cortex with self-reported impulsivity in patients with borderline personality disorder and healthy controls
    Mareen Hoerst
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 67:946-54. 2010

Detail Information

Publications80

  1. pmc Positron tomographic emission study of olfactory induced emotional recall in veterans with and without combat-related posttraumatic stress disorder
    Eric Vermetten
    University Medical Center, Utrecht, The Netherlands
    Psychopharmacol Bull 40:8-30. 2007
    ..Primitive brain systems involved in fear responsivity and survival also mediate smell, including the olfactory cortex and amygdala. The purpose of this study was to measure neural correlates of olfaction in PTSD...
  2. doi request reprint Motives for nonsuicidal self-injury among women with borderline personality disorder
    Nikolaus Kleindienst
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Nerv Ment Dis 196:230-6. 2008
    ..NSSI was usually preceded by a large variety of negative feelings that were reported to clearly improve with NSSI. In conclusion, therapists should anticipate a multidimensional functional spectrum when exploring motives of NSSI...
  3. pmc Gene expression profiles in relation to tension and dissociation in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    PLoS ONE 8:e70787. 2013
    ..Major limitations of the study are the the possibly heterogeneous cell proportions in whole blood and the heterogeneous medication. ..
  4. doi request reprint [Importance of neurobiology for modular psychotherapy]
    C Schmahl
    Klinik für Psychosomatik und Psychotherapeutische Medizin, Zentralinstitut fur Seelische Gesundheit Mannheim, J 5, 68159, Mannheim, Deutschland
    Nervenarzt 84:1316-20. 2013
    ..In addition, the use of neurobiological investigations within classical psychotherapy trials in the fields of borderline personality disorder and posttraumatic stress disorder will be depicted. ..
  5. doi request reprint Pain sensitivity is reduced in borderline personality disorder, but not in posttraumatic stress disorder and bulimia nervosa
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 11:364-71. 2010
    ..To establish whether these findings are specific for BPD, we compared pain thresholds in patients with BPD, posttraumatic stress disorder (PTSD), bulimia nervosa, and healthy controls...
  6. pmc Hippocampus and amygdala volumes in patients with borderline personality disorder with or without posttraumatic stress disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Psychiatry Neurosci 34:289-95. 2009
    ..Both groups exhibit volume reductions of the hippocampus and amygdala. Our aim was to investigate the influence of comorbid PTSD on hippocampus and amygdala volumes in patients with BPD...
  7. ncbi request reprint Neural correlates of antinociception in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 63:659-67. 2006
    ..We predicted that heat stimuli in patients with BPD would activate brain areas concerned with cognitive and emotional evaluation of pain...
  8. pmc Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations
    Gabriele Ende
    Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 41:410-8. 2016
    ..If distinct associations of Glu/tCr and GABA for BPD and ADHD can be confirmed in future studies, this might yield implications for more specific pharmacological treatments. ..
  9. doi request reprint Amygdala deactivation as a neural correlate of pain processing in patients with borderline personality disorder and co-occurrent posttraumatic stress disorder
    Anja Kraus
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 65:819-22. 2009
    ..This study aimed at clarifying whether central antinoceptive mechanisms discriminate BPD patients with and without co-occurrent PTSD...
  10. doi request reprint Correlation of glutamate levels in the anterior cingulate cortex with self-reported impulsivity in patients with borderline personality disorder and healthy controls
    Mareen Hoerst
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 67:946-54. 2010
    ..Impulsivity is a key feature of BPD and can be related to anterior cingulate cortex function...
  11. pmc Pain sensitivity and neural processing during dissociative states in patients with borderline personality disorder with and without comorbid posttraumatic stress disorder: a pilot study
    Petra Ludäscher
    Central Institute of Mental Health, Department of Psychosomatic Medicine and Psychotherapy, Mannheim, Germany
    J Psychiatry Neurosci 35:177-84. 2010
    ..Our aim was to investigate the psychologic, somatosensory (pain sensitivity) and neural correlates of dissociative states in patients with these disorders...
  12. doi request reprint Differentiation of pain ratings in combat-related posttraumatic stress disorder
    Anja Kraus
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Pain 143:179-85. 2009
    ..Our results suggest an association of PTSD with reduced pain sensitivity, which could be related to PTSD-related (neuro-)psychological alterations or to a pre-existing risk factor for the disorder...
  13. pmc Emotional learning during dissociative states in borderline personality disorder
    Ulrich W Ebner-Priemer
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Germany
    J Psychiatry Neurosci 34:214-22. 2009
    ..The aim of our study was to determine whether high states of dissociative experience would specifically alter emotional learning, but not declarative knowledge...
  14. doi request reprint Impulsivity in relation to stress in patients with borderline personality disorder with and without co-occurring attention-deficit/hyperactivity disorder: an exploratory study
    Annegret Krause-Utz
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Nerv Ment Dis 201:116-23. 2013
    ..We suggest that stress levels and co-occurring ADHD should receive attention in future studies on impulsivity in BPD...
  15. doi request reprint The role of seeing blood in non-suicidal self-injury in female patients with borderline personality disorder
    Janina Naoum
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany Electronic address
    Psychiatry Res 246:676-682. 2016
    ..For tension relief by non-damaging mechanical painful stimulus the addition of visible blood showed neither subjective (arousal, urge for NSSI), nor objective (heart rate) advantages...
  16. doi request reprint Emotions and memory in borderline personality disorder
    Dorina Winter
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Psychopathology 47:71-85. 2014
    ..This review discusses methodological challenges of studies on memory and emotions in BPD and makes suggestions for future research and clinical implications...
  17. doi request reprint Do improvements after inpatient dialectial behavioral therapy persist in the long term? A naturalistic follow-up in patients with borderline personality disorder
    Nikolaus Kleindienst
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Nerv Ment Dis 196:847-51. 2008
    ..The effects of inpatient dialectical behavior therapy seem to persist after patients returned to their usual lives...
  18. doi request reprint Dissociation predicts poor response to Dialectial Behavioral Therapy in female patients with Borderline Personality Disorder
    Nikolaus Kleindienst
    Central Institute of Mental Health, Mannheim, Germany
    J Pers Disord 25:432-47. 2011
    ..The results suggest that dissociation in borderline-patients should be closely monitored and targeted during DBT. At this stage, research on treatment of dissociation (e.g., specific skills training) is warranted...
  19. pmc Alterations in default mode network connectivity during pain processing in borderline personality disorder
    Rosemarie C Kluetsch
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 69:993-1002. 2012
    ..Findings in healthy subjects indicate that painful stimulation leads to blood oxygenation level-dependent signal decreases and changes in the functional architecture of the DMN...
  20. ncbi request reprint Differential nociceptive deficits in patients with borderline personality disorder and self-injurious behavior: laser-evoked potentials, spatial discrimination of noxious stimuli, and pain ratings
    Christian Schmahl
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mannheim, Germany
    Pain 110:470-9. 2004
    ..These findings suggest that hypoalgesia in BPD may primarily be due to altered intracortical processing similar to certain meditative states...
  21. pmc COMT val158met polymorphism and neural pain processing
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    PLoS ONE 7:e23658. 2012
    ....
  22. doi request reprint A novel human surrogate model of noninjurious sharp mechanical pain
    Polina Shabes
    aDepartment of Neurophysiology, Centre of Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, GermanybDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Pain 157:214-24. 2016
    ..Hence, we suggest the blade as novel model of sharp mechanical pain, which will be useful in investigating postoperative/mechanical pain and the role of self-injurious behavior in, eg, patients with borderline personality disorder...
  23. pmc State dissociation moderates response to dialectical behavior therapy for posttraumatic stress disorder in women with and without borderline personality disorder
    Nikolaus Kleindienst
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany
    Eur J Psychotraumatol 7:30375. 2016
    ..Patients with posttraumatic stress disorder (PTSD) are prone to dissociation, which in theory should interfere with successful treatment. However, most empirical studies do not substantiate this assumption...
  24. doi request reprint Women with borderline personality disorder do not show altered BOLD responses during response inhibition
    Julia van Eijk
    Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Germany
    Psychiatry Res 234:378-89. 2015
    ..Our results provide evidence that under emotionally neutral conditions response inhibition is not impaired in patients with BPD without co-occurring ADHD. ..
  25. doi request reprint Dialectical behaviour therapy for post-traumatic stress disorder after childhood sexual abuse in patients with and without borderline personality disorder: a randomised controlled trial
    Martin Bohus
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany martin bohus zi mannheim de
    Psychother Psychosom 82:221-33. 2013
    ..The aim of the present study was to determine the efficacy of a newly developed modular treatment programme (DBT-PTSD) that combines principles of dialectical behaviour therapy (DBT) and trauma-focused interventions...
  26. doi request reprint Individual modulation of pain sensitivity under stress
    Tatyana Reinhardt
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Pain Med 14:676-85. 2013
    ..The aim of our study was to investigate the effect of stress on individual pain sensitivity in a relatively large female sample...
  27. pmc Alterations of amygdala-prefrontal connectivity with real-time fMRI neurofeedback in BPD patients
    Christian Paret
    Department Neuroimaging, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany, Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Soc Cogn Affect Neurosci 11:952-60. 2016
    ..A randomized-controlled trial is needed to investigate whether amygdala NF is instrumental for improving neural regulation and emotion regulation in BPD patients. ..
  28. pmc Computer-Assisted In Sensu Exposure for Posttraumatic Stress Disorder: Development and Evaluation
    Nora Görg
    Institute of Psychiatric and Psychosomatic Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    JMIR Ment Health 3:e27. 2016
    ..Hence, we developed the computer program MORPHEUS that supports the application of self-administered exposure exercises. MORPHEUS continuously monitors the level of dissociative states and offers state-related antidissociative skills...
  29. doi request reprint ACC GABA levels are associated with functional activation and connectivity in the fronto-striatal network during interference inhibition in patients with borderline personality disorder
    Guo Ying Wang
    Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany Electronic address
    Neuroimage 147:164-174. 2016
    ..The ACC GABAergic system seems to play a crucial role in regulating regional BOLD activations and functional connectivity in this network, which are further associated with impulsive sensation seeking in BPD...
  30. doi request reprint Incision and stress regulation in borderline personality disorder: neurobiological mechanisms of self-injurious behaviour
    Sarah Reitz
    Sarah Reitz, MD, Rosemarie Kluetsch, Inga Niedtfeld, PhD, Teresa Knorz, MD, Stefanie Lis, PhD, Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Mannheim Christian Paret, Department Neuroimaging, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Mannheim Peter Kirsch, PhD, Department of Clinical Psychology, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Mannheim Andreas Meyer Lindenberg, MD, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Mannheim Rolf Detlef Treede, MD, Ulf Baumgärtner, MD, Department of Neurophysiology, Center for Biomedicine and Medical Technology, Medical Faculty Mannheim Heidelberg University, Mannheim Martin Bohus, MD, Christian Schmahl, MD, Department of Psychosomatic Medicine and Psychotherapy, Department of Medicine
    Br J Psychiatry 207:165-72. 2015
    ..Patients with borderline personality disorder frequently show non-suicidal self-injury (NSSI). In these patients, NSSI often serves to reduce high levels of stress...
  31. doi request reprint Non-suicidal self-injury during an exposure-based treatment in patients with posttraumatic stress disorder and borderline features
    Antje Krüger
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany Department of Psychology and Sports Sciences, Institute of Psychology, University of Munster, Germany Electronic address
    Behav Res Ther 61:136-41. 2014
    ..Similar results were observed for the frequency of NSSI. At the end of treatment, participants showed comparable improvement in PTSD symptoms regardless of whether or not they had exhibited NSSI beforehand. ..
  32. pmc Voxel-based morphometry in women with borderline personality disorder with and without comorbid posttraumatic stress disorder
    Inga Niedtfeld
    Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    PLoS ONE 8:e65824. 2013
    ..We could replicate earlier findings of diminished limbic GMV in patients with BPD and additionally show that patients with co-morbid PTSD feature increased GMV in prefrontal regions associated with cognitive control...
  33. doi request reprint Evaluation of naltrexone for dissociative symptoms in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Int Clin Psychopharmacol 27:61-8. 2012
    ..However, the effects were too small to reach statistical significance. Our data provide the first estimate of the pure pharmacological antidissociative efficacy of naltrexone from a rigorously designed trial...
  34. doi request reprint Confidence in facial emotion recognition in borderline personality disorder
    Janine Thome
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
    Personal Disord 7:159-68. 2016
    ..The link to loneliness and social rejection sensitivity points to the necessity to target these alterations in psychotherapeutical interventions...
  35. ncbi request reprint The role of nociceptive input and tissue injury on stress regulation in Borderline Personality Disorder
    Franziska Willis
    aDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany bDepartment of Neurology, Johann Wolfgang Goethe University, Frankfurt, Germany cDepartment of Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany dDepartment of Neurophysiology, Centre of Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany eDepartment of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
    Pain . 2016
    ..In contrast, the impact of tissue damage on stress reduction was relatively small. In addition the results suggest that painful stimuli lead to a greater stress reduction in BPD patients compared to HCs...
  36. doi request reprint Neural correlates of distraction in borderline personality disorder before and after dialectical behavior therapy
    Dorina Winter
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, J5, 68159, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 267:51-62. 2017
    ..These changes point to lower emotional susceptibility during distraction after BPD symptom improvement...
  37. pmc Modification of Fear Memory by Pharmacological and Behavioural Interventions during Reconsolidation
    Janine Thome
    Institute of Psychiatric and Psychosomatic Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany
    PLoS ONE 11:e0161044. 2016
    ..It has been proposed that interventions applied during reconsolidation may modify the original fear memory, and thus prevent the spontaneous recovery and reinstatement of the fear response...
  38. pmc Adverse Social Experiences in Adolescent Rats Result in Enduring Effects on Social Competence, Pain Sensitivity and Endocannabinoid Signaling
    Peggy Schneider
    Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of HeidelbergMannheim, Germany Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of HeidelbergMannheim, Germany
    Front Behav Neurosci 10:203. 2016
    ..These behavioral impairments are accompanied by persistent alterations in CB1R signaling. Finally, we provide a novel translational approach to characterize neurobiological processes underlying social peer-rejection in adolescence...
  39. pmc Pain Processing after Social Exclusion and Its Relation to Rejection Sensitivity in Borderline Personality Disorder
    Melanie Bungert
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    PLoS ONE 10:e0133693. 2015
    ....
  40. doi request reprint Dissociation in borderline personality disorder: Disturbed cognitive and emotional inhibition and its neural correlates
    Dorina Winter
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Germany Electronic address
    Psychiatry Res 233:339-51. 2015
    ..In conclusion, experimentally induced dissociation in BPD was associated with inefficient cognitive inhibition, particularly of negative stimuli, in the emotional Stroop task. ..
  41. doi request reprint Susceptibility to distraction by social cues in borderline personality disorder
    Annegret Krause-Utz
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Psychopathology 47:148-57. 2014
    ..The aim of this study was to investigate the influence of task-irrelevant (neutral vs. negatively arousing) social cues on working memory performance in BPD patients compared to healthy controls (HC)...
  42. doi request reprint Salivary cortisol, heart rate, electrodermal activity and subjective stress responses to the Mannheim Multicomponent Stress Test (MMST)
    Tatyana Reinhardt
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Psychiatry Res 198:106-11. 2012
    ..As social-evaluative threat is not the main stress component of the MMST, this procedure represents a useful and complementary alternative to other established stress protocols...
  43. pmc Functional connectivity of pain-mediated affect regulation in Borderline Personality Disorder
    Inga Niedtfeld
    Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Heidelberg, Germany
    PLoS ONE 7:e33293. 2012
    ..This study provides new insights in pain processing in BPD, including enhanced coupling of limbic structures and basal ganglia...
  44. doi request reprint [Development of the "Mannheim Multicomponent Stress Test" (MMST)]
    Tatyana Kolotylova
    Zentralinstitut fur Seelische Gesundheit Mannheim, Klinik für Psychosomatik und Psychotherapeutische Medizin, Universitat Jena, Jena, Germany
    Psychother Psychosom Med Psychol 60:64-72. 2010
    ..We conclude that the Mannheim Multicomponent Stress Test (MMST) induces high levels of physiological and psychological stress and can serve as an economical method to investigate stress reactions in a laboratory setting...
  45. doi request reprint Metabolic alterations in the amygdala in borderline personality disorder: a proton magnetic resonance spectroscopy study
    Mareen Hoerst
    Department of Neuroimaging, Central Institute of Mental Health, 68159 Mannheim, Germany
    Biol Psychiatry 67:399-405. 2010
    ..0 T in which we acquire data within only the small amygdala. The purpose of this study was to determine alterations of the metabolism in the amygdala in BPD patients...
  46. doi request reprint Classical conditioning in borderline personality disorder: an fMRI study
    Annegret Krause-Utz
    Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health Mannheim, Heidelberg University, J 5, 68159, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 266:291-305. 2016
    ..Our findings suggest altered temporal response patterns in terms of increased vigilance already during early acquisition and delayed extinction processes in individuals with BPD. ..
  47. doi request reprint Evaluation and memory of social events in borderline personality disorder: Effects of valence and self-referential context
    Dorina Winter
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany Electronic address
    Psychiatry Res 240:19-25. 2016
    ..Further, only BPD patients tended to preferentially recall self-referential social events. These findings suggest altered self-referential processing of social events that affects both the evaluation and the memory for social events. ..
  48. doi request reprint No evidence for differential dose effects of hydrocortisone on intrusive memories in female patients with complex post-traumatic stress disorder--a randomized, double-blind, placebo-controlled, crossover study
    Petra Ludäscher
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Psychopharmacol 29:1077-84. 2015
    ..The present study investigated the impact of two different doses of hydrocortisone on automatic memory retrieval using a randomized, double-blind, placebo-controlled, crossover study in 30 inpatients with post-traumatic stress disorder...
  49. doi request reprint Voluntary exercise does not ameliorate context memory and hyperarousal in a mouse model for post-traumatic stress disorder (PTSD)
    Raffaele Cacciaglia
    Institute of Neuropsychology and Clinical Psychology, Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 14:403-9. 2013
    ..However, studies that have tried to link physical exercise and contextual conditioning in an animal model of PTSD, revealed mixed findings...
  50. doi request reprint Affect regulation and pain in borderline personality disorder: a possible link to the understanding of self-injury
    Inga Niedtfeld
    Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, University of Heidelberg, Heidelberg, Germany
    Biol Psychiatry 68:383-91. 2010
    ..Pain in BPD has further been observed to lead to a reduction in neural activity in the amygdala and anterior cingulate cortex, which may be attributed to patients' perception of relaxation...
  51. ncbi request reprint Facing the Problem: Impaired Emotion Recognition During Multimodal Social Information Processing in Borderline Personality Disorder
    Inga Niedtfeld
    Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    J Pers Disord . 2016
    ..In line with the major body of facial emotion recognition studies, we conclude that deficits in the interpretation of facial expressions lead to the difficulties observed in multimodal emotion processing in BPD...
  52. pmc Pain-mediated affect regulation is reduced after dialectical behavior therapy in borderline personality disorder: A longitudinal fMRI study
    Inga Niedtfeld
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental, Health, Medical Faculty Mannheim Heidelberg University, Germany
    Soc Cogn Affect Neurosci . 2017
    ..We replicated the role of pain as a means of affect regulation in BPD, indicated by increased amygdale coupling. For the first time, we could demonstrate that pain-mediated affect regulation can be changed by DBT...
  53. doi request reprint Transient and sustained BOLD signal time courses affect the detection of emotion-related brain activation in fMRI
    Christian Paret
    Department of Neuroimaging, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Germany Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Germany Electronic address
    Neuroimage 103:522-32. 2014
    ..This may bias conclusions from empirical reports and meta-analyses towards an underestimation of these regions and their role in emotion and emotion regulation. The cognitive processes underlying differential time courses are discussed...
  54. pmc Negative evaluation bias for positive self-referential information in borderline personality disorder
    Dorina Winter
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    PLoS ONE 10:e0117083. 2015
    ..This bias did not affect the storage of information in memory, but may be related to self-attributions of negative events in everyday life in BPD. ..
  55. doi request reprint The latest neuroimaging findings in borderline personality disorder
    Jana Mauchnik
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Curr Psychiatry Rep 12:46-55. 2010
    ..Therefore, these findings convey a good impression of the current findings from neuroimaging research in this disorder and also of the necessary next steps with regard to content and methodology...
  56. ncbi request reprint Emotional modulation of pain: a clinical perspective
    Iris Klossika
    Department of Psychosomatic Medicine and Psychotherapy, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Pain 124:264-8. 2006
  57. ncbi request reprint Bispectral index monitoring during dissociative pseudo-seizure
    Alexander Sartorius
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    World J Biol Psychiatry 10:603-5. 2009
    ..This makes former assumptions plausible that hypnosis and severe forms of dissociation (or conversion) may share common aetiologies...
  58. doi request reprint Associations of emotional arousal, dissociation and symptom severity with operant conditioning in borderline personality disorder
    Christian Paret
    Department Neuroimaging, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Germany Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, Germany Electronic address
    Psychiatry Res 244:194-201. 2016
    ..Conclusions are limited due to the correlational study design and the small sample size. ..
  59. pmc Borderline Personality and the Detection of Angry Faces
    Johanna Hepp
    Department of Psychosomatic Medicine, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    PLoS ONE 11:e0152947. 2016
    ..In contrast, their ability to detect emotions has been investigated sparsely. The only two studies that assessed emotion detection abilities found contradictory evidence on patients' ability to detect angry faces...
  60. doi request reprint Reduced amygdala responsivity during conditioning to trauma-related stimuli in posttraumatic stress disorder
    Slawomira J Diener
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Psychophysiology 53:1460-71. 2016
    ..These findings suggest maladaptive anticipatory coping with trauma-related stimuli in patients with PTSD, indicated by enhanced conditioning, with related abnormal amygdala reactivity and connectivity, and delayed extinction. ..
  61. pmc Life Balance - a mindfulness-based mental health promotion program: conceptualization, implementation, compliance and user satisfaction in a field setting
    Lisa Lyssenko
    Central Institute of Mental Health, Mannheim, Heidelberg University, Heidelberg, Germany
    BMC Public Health 15:740. 2015
    ....
  62. pmc Cerebral processing of social rejection in patients with borderline personality disorder
    Melanie Domsalla
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68072 Mannheim, Germany and Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68072 Mannheim, Germany
    Soc Cogn Affect Neurosci 9:1789-97. 2014
    ..Our data suggest that individuals with BPD have difficulty in discriminating between social situations, and tend to hypermentalize during social encounters that are not determined by the intentions of others. ..
  63. doi request reprint Pain perception in female adolescents with borderline personality disorder
    Petra Ludäscher
    Central Institute of Mental Health, Department of Psychosomatic Medicine and Psychotherapy, J5, University of Heidelberg, Mannheim, Germany
    Eur Child Adolesc Psychiatry 24:351-7. 2015
    ..This provides support for the idea that disturbed pain processing is not only a consequence of chronic BPD but is already present in early stages of BPD. ..
  64. doi request reprint The latest neuroimaging findings in borderline personality disorder
    Annegret Krause-Utz
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Curr Psychiatry Rep 16:438. 2014
    ..To clarify whether findings are specific to BPD, comparisons with other clinical groups are needed. ..
  65. ncbi request reprint New developments in the neurobiology of borderline personality disorder
    Martin Bohus
    Central Institute of Mental Health Mannheim, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Curr Psychiatry Rep 6:43-50. 2004
    ..Most of the neuropsychologic, physiologic, endocrinologic, and neuroimaging data support the theory that a dual brain pathology, affecting prefrontal and limbic circuits, may underlie this hyperarousal-dyscontrol syndrome...
  66. doi request reprint Sleep and dreaming in patients with borderline personality disorder: a polysomnographic study
    Michael Schredl
    Central Institute of Mental Health, Mannheim, Germany
    Psychiatry Res 200:430-6. 2012
    ....
  67. pmc Neuroimaging in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    J Psychiatr Res 40:419-27. 2006
    ..Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology...
  68. pmc Deficits in pain perception in borderline personality disorder: results from the thermal grill illusion
    Robin Bekrater-Bodmann
    aDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany bDepartment of Psychology, Florida State University, Tallahassee, FL, USA cDepartment of General Psychiatry, Heidelberg University, Heidelberg, Germany dDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Pain 156:2084-92. 2015
    ..We discuss these findings against the background of neurophysiological evidence for the TGI in general and reduced pain sensitivity in BPD and suggest a relationship to alterations in N-methyl-D-aspartate neurotransmission. ..
  69. doi request reprint Adolescent peer-rejection persistently alters pain perception and CB1 receptor expression in female rats
    Peggy Schneider
    Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Eur Neuropsychopharmacol 24:290-301. 2014
    ..The present animal model therefore represents a novel approach to assess the long-term consequences of peer-rejection during adolescence. ..
  70. ncbi request reprint Altered pain processing in veterans with posttraumatic stress disorder
    Elbert Geuze
    Department of Military Psychiatry, Central Military Hospital, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 64:76-85. 2007
    ..Several brain areas related to pain processing are implicated in PTSD. To our knowledge, no functional imaging study has discussed whether patients with PTSD experience and process pain in a different way than control subjects...
  71. ncbi request reprint Elevated pain thresholds correlate with dissociation and aversive arousal in patients with borderline personality disorder
    Petra Ludäscher
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Psychiatry Res 149:291-6. 2007
    ..Measuring electric pain thresholds is a valid and reasonable method for larger studies...
  72. ncbi request reprint Neuroimaging of pain perception in Dutch veterans with and without posttraumatic stress disorder: preliminary results
    Elbert Geuze
    Department of Military Psychiatry, Central Military Hospital, Heidelberglaan, 100 3584, CX, Utrecht, The Netherlands
    Ann N Y Acad Sci 1071:401-4. 2006
    ..Fixed affects analysis demonstrated that stimuli subjectively perceived as more painful resulted in increased activation of the caudal ACC, whereas less painful stimuli resulted in increased activation of the rostral ACC in both groups...
  73. ncbi request reprint Increased delta power and discrepancies in objective and subjective sleep measurements in borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Haupt strasse 5, 79104 Freiburg, Germany
    J Psychiatr Res 39:489-98. 2005
    ..Earlier findings in sleep EEG abnormalities in BPD may have been confounded by concomitant depressive symptoms...
  74. ncbi request reprint Effectiveness of inpatient dialectical behavioral therapy for borderline personality disorder: a controlled trial
    Martin Bohus
    Department of Psychiatry and Psychotherapy with Polyclinic, Albert Ludwig University of Freiburg, Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Behav Res Ther 42:487-99. 2004
    ..Within a relatively short time frame, improvement was found across a broad range of psychopathological features. Stability of the recovery after one month following discharge, however, was not evaluated and requires further study...
  75. doi request reprint Attention-deficit hyperactivity disorder as a potentially aggravating factor in borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Br J Psychiatry 192:118-23. 2008
    ..Clinical experience suggests that people with borderline personality disorder often meet criteria for attention-deficit hyperactivity disorder (ADHD). However, empirical data are sparse...
  76. pmc Hippocampal and amygdalar volumes in dissociative identity disorder
    Eric Vermetten
    Department of Psychiatry, Rudolf Magnus Institute of Neurosciences, University Medical Center, Int mailbox B01206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Am J Psychiatry 163:630-6. 2006
    ..The authors examined hippocampal and amygdalar volumes in patients with dissociative identity disorder, a disorder that has been associated with a history of severe childhood trauma...
  77. pmc Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    Psychol Med 35:791-806. 2005
    ..No studies have examined neural correlates of fear conditioning and extinction in patients with post-traumatic stress disorder (PTSD)...
  78. ncbi request reprint Clonidine in acute aversive inner tension and self-injurious behavior in female patients with borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    J Clin Psychiatry 65:1414-9. 2004
    ....
  79. ncbi request reprint Borderline personality disorder
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Lancet 364:453-61. 2004
    ..Current strategies are focusing on the neurobiological underpinnings of the disorder and the development and dissemination of better and more cost-effective treatments to clinicians...
  80. ncbi request reprint Neural correlates of the classic color and emotional stroop in women with abuse-related posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 55:612-20. 2004
    ..Dysfunction of the anterior cingulate/medial prefrontal cortex has been implicated in posttraumatic stress disorder (PTSD). The purpose of this study was to use the Stroop task as a probe of anterior cingulate function in PTSD...