Stefan Bleich

Summary

Country: Germany

Publications

  1. ncbi request reprint Homocysteine and alcoholism
    S Bleich
    Department of Psychiatry, Georg August University of Gottingen, Federal Republic of Germany
    J Neural Transm Suppl . 2000
  2. ncbi request reprint Oxidative stress and an altered methionine metabolism in alcoholism
    S Bleich
    Department of Psychiatry, Georg August University, Von Siebold Strasse 5, D 37075, Gottingen, Germany
    Neurosci Lett 293:171-4. 2000
  3. ncbi request reprint Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS)
    Stefan Bleich
    Friedrich Alexander University of Erlangen Nuremberg, Department of Psychiatry and Psychotherapy, Schwabachanlage 6, 91054 Erlangen, Germany
    Alcohol Clin Exp Res 29:334-6. 2005
  4. ncbi request reprint [Glutamatergic neurotransmission in schizophrenics]
    S Bleich
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Georg August Universitat, Gottingen
    Fortschr Neurol Psychiatr 69:S56-61. 2001
  5. ncbi request reprint Apolipoprotein E gene polymorphism and previous alcohol withdrawal seizures
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 41:871-5. 2007
  6. doi request reprint Association of V89L SRD5A2 polymorphism with craving and serum leptin levels in male alcohol addicts
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, 91054 Erlangen, Germany
    Psychopharmacology (Berl) 224:421-9. 2012
  7. ncbi request reprint Apolipoprotein E4 genotype is not associated with short-term cognition deficits during alcohol withdrawal
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol 37:151-6. 2005
  8. doi request reprint The TTTAn aromatase (CYP19A1) polymorphism is associated with compulsive craving of male patients during alcohol withdrawal
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Psychoneuroendocrinology 36:1261-4. 2011
  9. doi request reprint Elevated cannabinoid 1 receptor mRNA is linked to eating disorder related behavior and attitudes in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:620-4. 2009
  10. doi request reprint ERK1/2 protein and mRNA levels in human blood are linked to smoking behavior
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Addict Biol 17:1026-35. 2012

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint Homocysteine and alcoholism
    S Bleich
    Department of Psychiatry, Georg August University of Gottingen, Federal Republic of Germany
    J Neural Transm Suppl . 2000
    ..Homocysteine neurotoxicity via overstimulation of N-methyl-D-aspartate receptors may contribute to the pathogenesis of both brain shrinkage and withdrawal seizures linked to alcoholism...
  2. ncbi request reprint Oxidative stress and an altered methionine metabolism in alcoholism
    S Bleich
    Department of Psychiatry, Georg August University, Von Siebold Strasse 5, D 37075, Gottingen, Germany
    Neurosci Lett 293:171-4. 2000
    ..120; P<0.01). We postulate that excitatory neurotransmitters and mechanisms of oxidative stress in patients with chronic alcoholism may partly mediate excitotoxic neuronal damage and hereby cause brain shrinkage...
  3. ncbi request reprint Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS)
    Stefan Bleich
    Friedrich Alexander University of Erlangen Nuremberg, Department of Psychiatry and Psychotherapy, Schwabachanlage 6, 91054 Erlangen, Germany
    Alcohol Clin Exp Res 29:334-6. 2005
    ..Therefore, this power analysis-based study was undertaken to determine whether plasma homocysteine levels are evidently altered in actively drinking alcoholic patients and patients with early abstinence...
  4. ncbi request reprint [Glutamatergic neurotransmission in schizophrenics]
    S Bleich
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Georg August Universitat, Gottingen
    Fortschr Neurol Psychiatr 69:S56-61. 2001
    ....
  5. ncbi request reprint Apolipoprotein E gene polymorphism and previous alcohol withdrawal seizures
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 41:871-5. 2007
    ..Our findings suggest an association between the apolipoprotein E3 gene variant and an elevated risk of alcohol withdrawal seizures. These preliminary results must be validated in further studies...
  6. doi request reprint Association of V89L SRD5A2 polymorphism with craving and serum leptin levels in male alcohol addicts
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, 91054 Erlangen, Germany
    Psychopharmacology (Berl) 224:421-9. 2012
    ..The steroid 5-α reductase 2 (SRD5A2) converts testosterone to dihydrotestosterone and thereby causes increased androgenic potency...
  7. ncbi request reprint Apolipoprotein E4 genotype is not associated with short-term cognition deficits during alcohol withdrawal
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol 37:151-6. 2005
    ....
  8. doi request reprint The TTTAn aromatase (CYP19A1) polymorphism is associated with compulsive craving of male patients during alcohol withdrawal
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Psychoneuroendocrinology 36:1261-4. 2011
    ..Future investigations should enrol women and consider sex hormone levels for further clarification of the observed TTTAn-craving relationship...
  9. doi request reprint Elevated cannabinoid 1 receptor mRNA is linked to eating disorder related behavior and attitudes in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:620-4. 2009
    ..The endocannabinoid system is involved in the regulation of appetite, food intake and energy balance...
  10. doi request reprint ERK1/2 protein and mRNA levels in human blood are linked to smoking behavior
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Addict Biol 17:1026-35. 2012
    ....
  11. doi request reprint Association of nerve growth factor and vascular endothelial growth factor A with psychometric measurements of opiate dependence: results of a pilot study in patients participating in a structured diamorphine maintenance program
    Annemarie Heberlein
    Center for Addiction Research, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany
    Eur Addict Res 18:213-9. 2012
    ..In conclusion, the results of this pilot study show that there might be an association between symptoms of opiate dependence and withdrawal and serum levels of VEGF-A and NGF...
  12. doi request reprint Prolactin serum levels during alcohol withdrawal are associated with the severity of alcohol dependence and withdrawal symptoms
    Julia Wilhelm
    Department of Psychiatry, Center for Addiction Research, Medical School Hanover, Germany
    Alcohol Clin Exp Res 35:235-9. 2011
    ..Alterations in prolactin levels may reflect disturbances of dopaminergic neurotransmission which is of crucial importance for alcohol-seeking behavior...
  13. doi request reprint Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 58:48-52. 2008
    ..Further investigations in patients with depression as a sole diagnosis are needed to support its role in the pathogenesis of major depression...
  14. doi request reprint N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal
    Teresa Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Erlangen, Germany
    J Neural Transm (Vienna) 116:615-22. 2009
    ..55; P = 0.013; daily ethanol intake: rho = -0.46; P = 0.043). These findings might explain the observation of an impact of alcohol consumption patterns on the gravity of withdrawal symptoms...
  15. doi request reprint Elevation of homocysteine levels is only partially reversed after therapy in females with eating disorders
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    J Neural Transm (Vienna) 117:521-7. 2010
    ..These findings add further evidence to the hypothesis that homocysteine might be involved in the pathophysiology of anorexia and bulimia nervosa...
  16. doi request reprint Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity
    Helge Frieling
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychopharmacology 33:2605-9. 2008
    ..ANP mRNA expression was inversely associated with impaired impulse regulation. We conclude that epigenetic mechanisms may contribute to the known alterations of ANP homeostasis in women with eating disorders...
  17. doi request reprint Decreased galanin serum levels are associated with alcohol-craving during withdrawal
    Annemarie Heberlein
    Center for Addiction Research, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 35:568-72. 2011
    ..The appetite stimulating effect of galanin is thought to underlie the positive association between alcohol consumption and hypothalamic galanin expression observed in preclinical studies...
  18. doi request reprint Epigenetic down regulation of nerve growth factor during alcohol withdrawal
    Annemarie Heberlein
    Center for Addiction Research, Department of Psychiatry, Social Psychiatry and Psychotherapy, Medical School Hanover, Carl Neuberg Strase 1, Hannover, Germany
    Addict Biol 18:508-10. 2013
    ..001). The NGF serum levels were significantly associated with the mean methylation of the investigated CpG-sites (F = 1.55, P < 0.001). These results imply an epigenetic regulation of the NGF gene during alcohol withdrawal...
  19. doi request reprint Sex hormone activity in alcohol addiction: integrating organizational and activational effects
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Prog Neurobiol 96:136-63. 2012
    ..The early sex hormone activity model of alcohol addiction may prove to be a valuable tool in the development of preventive and therapeutic strategies...
  20. ncbi request reprint Association of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependence
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 42:509-12. 2007
    ..Various studies have reported a role of the serotonin transporter-linked polymorphic region (5-HTTLPR) in alcoholism...
  21. ncbi request reprint Different allele-distribution of mthfr 677 C -> T and mthfr -393 C -> a in patients classified according to subtypes of Lesch's typology
    Dominikus Bönsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 91054 Erlangen, Germany
    Alcohol Alcohol 41:364-7. 2006
    ....
  22. ncbi request reprint An assessment of the potential value of elevated homocysteine in predicting alcohol-withdrawal seizures
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Epilepsia 47:934-8. 2006
    ..The aim of the present study was to calculate the best predictive cutoff value of plasma homocysteine levels in actively drinking alcoholics (n = 88) with first-onset alcohol-withdrawal seizures...
  23. doi request reprint Atrial natriuretic peptide, arginine vasopressin peptide and cortisol serum levels in opiate-dependent patients
    Alexander Glahn
    Center for Addiction Research CARe, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany
    Neuropsychobiology 67:111-5. 2013
    ..In conclusion, chronic drug abuse profoundly alters stress-responsive systems like the HPA axis. Alterations of AVP, ANP and cortisol appear to constitute an important component in the neurobiology of opiate-dependent patients...
  24. doi request reprint BDNF and GDNF serum levels in alcohol-dependent patients during withdrawal
    Annemarie Heberlein
    Department of Psychiatry, Hannover Medical School, Center for Addiction Research, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 34:1060-4. 2010
    ..GDNF serum levels were negatively associated with alcohol tolerance. Moreover BDNF serum levels were found to be associated with withdrawal severity...
  25. doi request reprint Serum levels of vascular endothelial growth factor A increase during alcohol withdrawal
    Annemarie Heberlein
    Department of Psychiatry, Social Psychiatry and Psychotherapy, Center for Addiction Research, Hannover Medical School, D 30625 Hanover, Germany
    Addict Biol 15:362-4. 2010
    ..252, P = 0.008). Increase of VEGF-A serum levels is closely associated to alcohol intoxication and severity of alcohol dependence...
  26. ncbi request reprint Volume intake and craving in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 41:61-5. 2006
    ..The present study was undertaken to evaluate whether the daily volume intake of alcoholic beverages is associated with craving in patients undergoing alcohol withdrawal...
  27. doi request reprint Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:555-60. 2009
    ..Further studies focusing on longitudinal changes of epigenetic regulation and gene expression of both peptides are needed to clarify the pathophysiological role of these findings...
  28. doi request reprint Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 43:388-92. 2009
    ..Furthermore, hypermethylation of the DAT-promoter may play an important role in dopaminergic neurotransmission and is associated with decreased alcohol craving...
  29. doi request reprint Epigenetic dysregulation of dopaminergic genes in eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Int J Eat Disord 43:577-83. 2010
    ....
  30. ncbi request reprint Alpha-synuclein protein levels are increased in alcoholic patients and are linked to craving
    Dominikus Bönsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Alcohol Clin Exp Res 29:763-5. 2005
    ..The aim of the current study was to investigate whether protein levels of alpha synuclein in alcoholics are changed and possibly influence alcohol craving...
  31. doi request reprint Increased levels of adiponectin and resistin in alcohol dependence--possible link to craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Drug Alcohol Depend 99:333-7. 2009
    ..Furthermore, adiponectin may be involved in the neurobiology of alcohol craving, possibly via its effects on the hypothalamic circuits...
  32. ncbi request reprint Role of appetite-regulating peptides in alcohol craving: an analysis in respect to subtypes and different consumption patterns in alcoholism
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Alcohol Clin Exp Res 31:950-4. 2007
    ..Aim of this analysis was to search for differences regarding an association between these peptides and alcohol craving with respect to different subtypes and beverage consumption patterns in patients with alcohol dependence...
  33. ncbi request reprint Elevated prolactin serum levels and history of alcohol withdrawal seizures
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    J Psychiatr Res 41:702-6. 2007
    ..Prolactin has been discussed to be useful for differential diagnosis in epilepsia. Aim of the present study was to investigate the association between prolactin serum levels and previous alcohol withdrawal seizures...
  34. ncbi request reprint Ghrelin levels are increased in alcoholism
    Thomas Kraus
    Department of Psychiatry and Psychotherapy, University Hospital, Erlangen, Germany
    Alcohol Clin Exp Res 29:2154-7. 2005
    ..Therefore, the aim of the present pilot study was to determine whether the gut-derived peptide ghrelin which increases hunger and food intake is altered and associated with alcohol craving in alcoholic patients..
  35. doi request reprint Polymorphism of the long polyglutamine tract in the human androgen receptor influences craving of men in alcohol withdrawal
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, D 91054 Erlangen, Germany
    Psychoneuroendocrinology 34:968-71. 2009
    ..In summary, the presented data points to an underestimated role of the genetic regulation of androgens in the pathogenesis of alcohol dependence and related disorders...
  36. ncbi request reprint Depressive symptoms may explain elevated plasma levels of homocysteine in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlagen, Germany
    J Psychiatr Res 42:83-6. 2008
    ..8; df = 42; P = 0.008). Presence of depressive symptoms may explain elevated homocysteine levels previously reported in patients with eating disorders or vice versa. Longitudinal studies are needed to unravel this hen or egg problem...
  37. ncbi request reprint Alcoholism and homicide with respect to the classification systems of Lesch and Cloninger
    Udo Reulbach
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg Germany Schwabachanlage 6, 91054 Erlangen, Germany
    Alcohol Alcohol 42:103-7. 2007
    ..A psychopathological subtyping of alcohol dependence in offenders who committed homicide has mainly been related to impulsive and dissocial personalities up to now...
  38. doi request reprint Emotional reactivity to odors: olfactory sensitivity and the span of emotional evaluation separate the genders
    Norbert Thuerauf
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neurosci Lett 456:74-9. 2009
    ..Investigating olfactory sensitivity females detected n-butanol and discriminated the 16 odors of the test significantly better than males. These results indicate that females possess higher olfactory sensitivity...
  39. ncbi request reprint Evidence of an association of leptin serum levels and craving in alcohol dependence
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Psychoneuroendocrinology 32:87-90. 2007
    ..160, t=5.793, p<0.001) with a power of 1.00. In contrast to previous results describing an association only in female patients, this power-based analysis shows that leptin is associated with alcohol craving in both genders...
  40. doi request reprint DNA methylation of the LEP gene is associated with craving during alcohol withdrawal
    Thomas Hillemacher
    Center for Addiction Research CARe, Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany Molecular Neurosciences Laboratory, Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany Electronic address
    Psychoneuroendocrinology 51:371-7. 2015
    ..These findings point towards a pathophysiological relevance of changes in DNA methylation of the LEP gene promoter region in alcohol dependence. ..
  41. doi request reprint Activity of secretory sphingomyelinase is increased in plasma of alcohol-dependent patients
    Martin Reichel
    Department of Psychiatry and Psychotherapy, University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Alcohol Clin Exp Res 35:1852-9. 2011
    ..However, the influence of ethanol on secretory ASM (S-ASM) has not been investigated so far...
  42. doi request reprint Smoking behaviour is associated with expression and phosphorylation of CREB in human buffy coat
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Int J Neuropsychopharmacol 13:207-15. 2010
    ..This kind of study may be helpful for translating findings from animal models and cell cultures...
  43. doi request reprint Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependence
    Martin Reichel
    Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
    Alcohol Clin Exp Res 34:46-50. 2010
    ..Ethanol-induced activation of ASM has been observed in different cell culture systems, thus raising the question about the effect of alcohol intoxication in human subjects on ASM activity in vivo...
  44. ncbi request reprint Prolactin serum levels and alcohol craving - an analysis using Lesch's typology
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 53:133-6. 2006
    ..Prolactin secretion is closely connected to dopaminergic transmission that is known to play a crucial role in mediating reinforcement and craving in alcoholism...
  45. doi request reprint NGF plasma levels increase due to alcohol intoxication and decrease during withdrawal
    Annemarie Heberlein
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Psychoneuroendocrinology 33:999-1003. 2008
    ..These results suggest that NGF plasma levels increase as part of a regulation mechanism that counteracts alcohol intoxication...
  46. doi request reprint Hippocampal volume loss in patients with alcoholism is influenced by the consumed type of alcoholic beverage
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 43:296-9. 2008
    ..Aim of the present study was to investigate different types of alcoholic beverages with regard to hippocampal volume loss in patients suffering from alcoholism...
  47. ncbi request reprint Plasma homocysteine concentrations do not influence craving in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol 34:211-5. 2004
    ..Therefore, further research about alcohol craving should focus on neurobiologic factors other than homocysteine...
  48. ncbi request reprint Nicotine dependence is associated with compulsive alcohol craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Addiction 101:892-7. 2006
    ..To investigate a possible association of nicotine dependence and alcohol craving...
  49. doi request reprint BDNF serum levels and promoter methylation of BDNF exon I, IV and VI in depressed patients receiving electroconvulsive therapy
    Alexandra Kleimann
    Laboratory for Molecular Neuroscience, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School MHH, Carl Neubergstr 1, 30625, Hannover, Germany
    J Neural Transm (Vienna) 122:925-8. 2015
    ..002). These findings may point to a depression subtype in which ECT is particularly beneficial...
  50. ncbi request reprint C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma
    Anselm G M Jünemann
    Department of Ophthalmology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Am J Ophthalmol 139:721-3. 2005
    ..To estimate the prevalence of C677T single nucleotide polymorphism in the 5,10-methylentetrahydrofolate reductase (MTHFR) gene in primary open-angle glaucoma (POAG) and pseudoexfoliation open-angle glaucoma (PEXG)...
  51. doi request reprint Lower levels of cannabinoid 1 receptor mRNA in female eating disorder patients: association with wrist cutting as impulsive self-injurious behavior
    Marc Schroeder
    Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, MHH, Carl Neuberg Str 1, 30625 Hannover, Germany
    Psychoneuroendocrinology 37:2032-6. 2012
    ..Due to the small sample size, our results should be regarded as preliminary and further studies are warranted to reveal the underlying mechanisms...
  52. doi request reprint Reduced plasma levels of asymmetric di-methylarginine (ADMA) in patients with alcohol dependence normalize during withdrawal
    Helge Frieling
    Center for Addiction Research CARe, Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, 30625 Hannover, Germany
    Eur Neuropsychopharmacol 22:836-40. 2012
    ..However an influence of alcohol on arginine metabolism may help explain the so called 'French paradox'...
  53. pmc Predictors of binge drinking in adolescents: ultimate and distal factors - a representative study
    Carolin Donath
    Department Medical Psychology and Medical Sociology, Psychiatric University Hospital Erlangen Friedrich Alexander Universität Erlangen Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    BMC Public Health 12:263. 2012
    ..We assessed the predictive value of these factors with respect to binge drinking in German adolescents, including the identification of influence direction...
  54. ncbi request reprint Homocysteine levels in patients classified according to Lesch's typology
    Stefan Bleich
    Friedrich Alexander, University of Erlangen Nuremberg, Department of Psychiatry and Psychotherapy, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 39:493-8. 2004
    ..This study was undertaken to investigate total plasma homocysteine levels in actively drinking patients with alcoholism who were classified according to Lesch's typology...
  55. doi request reprint Methanol levels in saliva--a non-invasive parameter that may be useful in detection of alcohol intoxication
    Annemarie Heberlein
    Department of Psychiatry, Socialpsychiatry and Psychotherapy, Center of Addiction Research, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Alcohol Alcohol 45:126-7. 2010
    ..786, P = 0.001, t = -1.106, P = 0.058). Therefore, methanol levels measured in saliva might be applicable in order to increase the validity of other non-invasive measurement methods like the ethanol breath analyzer...
  56. ncbi request reprint Decreased serum activity of semicarbazide-sensitive amine oxidase (SSAO) in patients treated with second generation antipsychotics: a link to impaired glucose metabolism?
    Veit Roessner
    Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany
    Eur J Clin Pharmacol 63:425-9. 2007
    ....
  57. ncbi request reprint Combinations of carbohydrate-deficient transferrin, mean corpuscular erythrocyte volume, gamma-glutamyltransferase, homocysteine and folate increase the significance of biological markers in alcohol dependent patients
    Daniela Rinck
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Drug Alcohol Depend 89:60-5. 2007
    ..This study focuses on the combination of established laboratory parameters with new meaningful biomarkers to advance the significance regarding alcohol dependence...
  58. doi request reprint NACP-Rep1 relates to Beck Depression Inventory scores in healthy humans
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, 91054 Erlangen, Germany
    J Mol Neurosci 44:41-7. 2011
    ..The reported results may contribute to a better understanding of the molecular mechanisms linked to depressive symptoms...
  59. ncbi request reprint Spontaneous magnetoencephalographic activity in patients with obsessive-compulsive disorder
    Christian Maihofner
    Department of Neurology, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Brain Res 1129:200-5. 2007
    ..Therefore, we provide further functional neuroimaging evidence that the complex features of OCD have neural correlates, which may help in a future understanding of this disease...
  60. ncbi request reprint Does alcohol craving decrease with increasing age? Results from a cross-sectional study
    Annelie K Hintzen
    Center for Addiction Research, Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Carl Neuberg Strase 1, 30625 Hannover, Germany
    J Stud Alcohol Drugs 72:158-62. 2011
    ..Alcohol craving has many analogies in psychopathology with obsessive-compulsive behavior patterns. The aim of the present study was to find evidence of a possible decrease of craving in elderly alcohol-dependent patients...
  61. ncbi request reprint Alcoholism-associated hyperhomocysteinemia and previous withdrawal seizures
    Kristina Bayerlein
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Biol Psychiatry 57:1590-3. 2005
    ....
  62. ncbi request reprint Influence of beer, wine and spirits consumption on craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Addict Biol 10:181-6. 2005
    ..In addition, it is an important predictor for both obsessive and compulsive craving. Further studies are needed to clarify the pathophysiological basis of this finding...
  63. ncbi request reprint Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Exp Cell Res 312:4049-55. 2006
    ..Complete methylation of the CpG islands resulted in suppressed gene expression...
  64. ncbi request reprint Homocysteine as a neurotoxin in chronic alcoholism
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, Erlangen 91054, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 28:453-64. 2004
    ..The most important pathophysiological and pathobiochemical features of glutamatergic neurotransmission and of ethanol-induced hyperhomocysteinaemia are reviewed in relation to their excitotoxic and apoptotic potential...
  65. ncbi request reprint Recurrent detoxifications are associated with craving in patients classified as type 1 according to Lesch's typology
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 41:66-9. 2006
    ..The aim of this investigation was to study the influence of preceding detoxifications on craving in patients with alcoholism classified according to Lesch's typology...
  66. ncbi request reprint Alteration of prolactin serum levels during alcohol withdrawal correlates with craving in female patients
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Addict Biol 10:337-43. 2005
    ....
  67. doi request reprint Relationship between lunar phases and serious crimes of battery: a population-based study
    Teresa Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Friedrich Alexander University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    Compr Psychiatry 50:573-7. 2009
    ..Therefore, a population-based study to assess the influence of lunar phases on violent crimes was conducted...
  68. doi request reprint Non-right-handedness and free serum testosterone levels in detoxified patients with alcohol dependence
    Wolfgang Sperling
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 45:237-40. 2010
    ..An increase in free serum testosterone levels has been found during and after the detoxification phase of patients with alcohol dependence...
  69. ncbi request reprint Neuroendocrine pathways in benzodiazepine dependence: new targets for research and therapy
    Annemarie Heberlein
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Hum Psychopharmacol 23:171-81. 2008
    ..Depending on the available results possible implications of NPY and CCK on benzodiazepine addiction and withdrawal symptoms are reviewed, thereby providing topics for further research...
  70. ncbi request reprint Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Brain Res 1052:156-62. 2005
    ..These results may provide a molecular explanation for beneficial effects of memantine on ethanol-induced glutamatergic hyperexcitability reflected in the ethanol withdrawal syndrome and on the development of ethanol dependence...
  71. doi request reprint DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence
    Marc Andre Nicolas Muschler
    Department of Psychiatry, Center for Addiction Research, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Neural Transm (Vienna) 117:513-9. 2010
    ..Further studies should more closely investigate the impact of these changes on the several derivatives of the POMC gene...
  72. ncbi request reprint Particularities of suicide in the elderly. A population-based study
    Teresa Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, D 91054 Erlangen, Germany
    Aging Clin Exp Res 21:470-4. 2009
    ..Suicide in later life stages is of growing concern as the life expectancy of Western populations is rising. Therefore, a population- based study concerning elderly suicide was undertaken...
  73. ncbi request reprint Late-onset schizophrenia in child survivors of the holocaust
    Udo Reulbach
    Department of Psychiatry and Psychotherapy, Friedich Alexander University of Erlangen Nuremberg, Nuremberg, Germany
    J Nerv Ment Dis 195:315-9. 2007
    ..9, p < 0.001). The strong association between late onset of schizophrenia and the degree of persecution suggest an influence of stress exposure...
  74. doi request reprint Assaults in the elderly--a population-based study with victim and perpetrator characteristics
    Teresa Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Forensic Sci 56:669-73. 2011
    ..1% vs. 68.8%) and were victimized significantly more in rural areas (p < 0.001; 41.2% vs. 30.2%). Violence in the elderly differs from that of the younger population. Further research is warranted to establish prevention measures...
  75. ncbi request reprint Specific and unspecific auditory hallucinations in patients with schizophrenia: a magnetoencephalographic study
    Udo Reulbach
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen Nuremberg, Germany
    Neuropsychobiology 55:89-95. 2007
    ..Auditory verbal hallucinations are thought to arise from a disorder of inner speech, but little is known about their origin...
  76. ncbi request reprint Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism
    D Bonsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen Nuremberg, Germany
    J Neural Transm (Vienna) 111:1611-6. 2004
    ..001). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings may have important implications for a possible subsequent derangement of epigenetic control these patients...
  77. doi request reprint Homocysteine, alcoholism and its molecular networks
    S Bleich
    Department of Psychiatry, Socialpsychiatry and Psychotherapy, Medical School Hannover, Germany
    Pharmacopsychiatry 42:S102-9. 2009
    ..So, alterations in human homocysteine levels can influence DNA-methylation of specific gene areas which may change expression and synthesis of proteins possibly important for the genesis and maintenance of alcohol dependence...
  78. ncbi request reprint Apolipoprotein E polymorphism, homocysteine serum levels and hippocampal volume in patients with alcoholism: an investigation of a gene-environment interaction
    J Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenomics J 8:117-21. 2008
    ..We suggest that the disadvantageous effects of apolipoprotein E4 on alcohol-related brain volume loss are based on certain gene-environment interactions...
  79. ncbi request reprint Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism
    S Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, D 91054 Erlangen, Germany
    Neurosci Lett 335:179-82. 2003
    ..001, multiple regression analysis). Raised plasma levels of homocysteine are associated with hippocampal (brain) atrophy in alcoholism...
  80. ncbi request reprint Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism
    D Bonsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    J Neural Transm (Vienna) 113:1299-304. 2006
    ..014). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings may have important implications for a possible subsequent derangement of epigenetic control in these patients...
  81. ncbi request reprint Short-term cognition deficits during early alcohol withdrawal are associated with elevated plasma homocysteine levels in patients with alcoholism
    J Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    J Neural Transm (Vienna) 113:357-63. 2006
    ..68, 95% CI=0.57-0.79, p=0.004). The present results show first evidence of an association between elevated plasma homocysteine levels in alcoholics and cognition deficits in patients undergoing alcohol withdrawal...
  82. ncbi request reprint DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism
    Dominikus Bönsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, D 91054 Erlangen, Germany
    Neuroreport 16:167-70. 2005
    ....
  83. ncbi request reprint Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Alcohol Clin Exp Res 30:587-91. 2006
    ....
  84. ncbi request reprint CPAP-therapy effectively lowers serum homocysteine in obstructive sleep apnea syndrome
    W Jordan
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    J Neural Transm (Vienna) 111:683-9. 2004
    ..005) and thus probably the (hyper)homocysteinemia-related cognitive dysfunction and the risk for cardio-/cerebrovascular diseases...
  85. doi request reprint Herp mRNA expression in patients classified according to Lesch's typology
    T Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol 43:91-5. 2009
    ..e., withdrawal seizures). These findings may be useful in the understanding and treatment considerations of different subtypes of alcohol dependence...
  86. doi request reprint Treatment with clomethiazole is associated with lower rates of premature discharge during alcohol withdrawal
    T Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Pharmacopsychiatry 41:134-7. 2008
    ..The aim of the present study was to assess the risk of different possible influencing factors...
  87. ncbi request reprint Evaluation of oxidative stress measurements in obstructive sleep apnea syndrome
    W Jordan
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    J Neural Transm (Vienna) 113:239-54. 2006
    ..05). Gender effects in ROS generation also have to be considered. At present, we recommend the application of several oxidative stress measurements at different time points, preferably involving plasma MDA and urinary o,o'-dityrosine...
  88. ncbi request reprint Advances in alcoholism research in Germany
    L G Schmidt
    Department of Psychiatry, Johannes Gutenberg University, Mainz, Germany
    Alcohol Clin Exp Res 29:1282-7. 2005
  89. ncbi request reprint Cognitive impairment and its association with homocysteine plasma levels in females with eating disorders - findings from the HEaD-study
    H Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Bad Oeynhausen, Germany
    J Neural Transm (Vienna) 112:1591-8. 2005
    ..566, OR=24.75, CI 2.89 - 212.23, P=0.003). These results indicate that under the special circumstances of eating disorders elevated homocysteine levels improve memory signaling possibly by facilitating long-term potentiation...
  90. ncbi request reprint Leptin is associated with craving in females with alcoholism
    T Kraus
    Department of Psychiatry and Psychotherapy, University Hospital, Erlangen, Germany
    Addict Biol 9:213-9. 2004
    ..Hence, gender differences have to be taken into account when searching for neurobiological models of alcohol craving...
  91. ncbi request reprint Dopamine and N-methyl-D-aspartate receptor expression in peripheral blood of patients undergoing alcohol withdrawal
    T Biermann
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen Nuremberg, Germany
    J Neural Transm (Vienna) 114:1081-4. 2007
    ..A significant difference in D1 receptor expression (T = 2.361; p = 0.035) in terms of up-regulation could be shown, though there were no significant changes concerning D2, NMDA1 or NMDA2B receptor expression...
  92. ncbi request reprint Creutzfeldt-Jakob disease and homocysteine levels in plasma and cerebrospinal fluid
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Gerontology 51:142-4. 2005
    ..There is evidence that homocysteine contributes to various neurodegenerative disorders...
  93. ncbi request reprint Elevated alpha synuclein mRNA levels are associated with craving in patients with alcoholism
    Dominikus Bönsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Biol Psychiatry 56:984-6. 2004
    ..Alpha synuclein has been found elevated in dopamine neurons of cocaine abusers and in rats whose alcohol preference is inbred...
  94. ncbi request reprint Daily variations of homocysteine concentration may influence methylation of DNA in normal healthy individuals
    Dominikus Bönsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Chronobiol Int 24:315-26. 2007
    ..001). Males showed higher overall homocysteine levels compared to females (p=0.002). Genomic DNA methylation showed a significant rhythm with increased levels at night (p=0.021), which was inverse to plasma homocysteine levels...
  95. ncbi request reprint Elevated homocysteine levels in aqueous humor of patients with pseudoexfoliation glaucoma
    Stefan Bleich
    Dept of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Am J Ophthalmol 138:162-4. 2004
    ..To determine total homocysteine levels in aqueous humor of pseudoexfoliation open-angle glaucoma patients...
  96. doi request reprint Neurobiology and treatment in alcoholism--recent findings regarding Lesch's typology of alcohol dependence
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 43:341-6. 2008
    ..This applies in particular for genetic and neuroendocrinological factors, differences in the regulation of NMDA receptor-mediated glutamatergic neurotransmission, and in response to acamprosate and naltrexone treatment...
  97. ncbi request reprint The etiopathogenesis of schizophrenias
    J Kornhuber
    Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Friedrich Alexander Universität zu Erlangen Nürnberg, Schwabachanlage 6 10, 91054 Erlangen, Germany
    Pharmacopsychiatry 37:S103-12. 2004
    ..Such systemic models will explain more aspects of schizophrenias than the recent confined hypotheses...
  98. ncbi request reprint Homocysteine induces cell death of rat astrocytes in vitro
    J M Maler
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Neurosci Lett 347:85-8. 2003
    ..g. Alzheimer's disease, glaucomatous optic neuropathy). This is the first study to report that homocysteine induces cell death of astrocytes. The mechanisms by which homocysteine induces cell death of astrocytes warrant further study...
  99. ncbi request reprint Apolipoprotein E epsilon 4 is associated with hippocampal volume reduction in females with alcoholism
    S Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen Nuremberg, Germany
    J Neural Transm (Vienna) 110:401-11. 2003
    ..These findings indicate a genetic disposition for alcohol related brain atrophy in female carrying the ApoE4 genotype, which may also explain why female alcoholics are more susceptible to alcohol-induced brain damage...
  100. ncbi request reprint Lack of association between hippocampal volume reduction and first-onset alcohol withdrawal seizure. A volumetric MRI study
    S Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Alcohol Alcohol 38:40-4. 2003
    ..Until recently, no data as to whether hippocampal volume reductions in alcoholics might serve as a predictor of withdrawal seizures were available...
  101. ncbi request reprint Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence
    D Bonsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremburg, 91054 Erlangen, Germany
    Hum Mol Genet 14:967-71. 2005
    ..83; df=2, P=0.012). The present results point to a novel approach for a genetic determination of craving, a key factor in the genesis and maintenance not only of alcoholism but also of addiction in general...