Michael Bitzer

Summary

Country: Germany

Publications

  1. pmc Sendai virus efficiently infects cells via the asialoglycoprotein receptor and requires the presence of cleaved F0 precursor proteins for this alternative route of cell entry
    M Bitzer
    Abteilung Innere Medizin I, Medizinische Universitätsklinik Tübingen, Germany
    J Virol 71:5481-6. 1997
  2. pmc Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32)
    M Bitzer
    Abteilung Innere Medizin I, Medizinische Universitätsklinik Tübingen, 72076 Tubingen, Germany
    J Virol 73:702-8. 1999
  3. doi Resminostat plus sorafenib as second-line therapy of advanced hepatocellular carcinoma - The SHELTER study
    Michael Bitzer
    Department of Internal Medicine I, Eberhard Karls University, Tuebingen, Germany Electronic address
    J Hepatol 65:280-8. 2016
  4. doi Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumor cells
    Sascha Venturelli
    Corresponding Author Michael Bitzer, Medical University Hospital, University of Tuebingen, Otfried Mueller Str 10, Tuebingen D 72076, Germany
    Mol Cancer Ther 12:2226-36. 2013
  5. ncbi Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells
    Michael Bitzer
    Department of Internal Medicine I, University Clinic Tübingen, D 72076 Tubingen, Germany
    J Biol Chem 277:29817-24. 2002
  6. ncbi [Malabsorption syndrome. Rare differential diagnosis in a young patient]
    M Bitzer
    Abteilung Innere Medizin I, Medizinische Universitätsklinik Tübingen
    Internist (Berl) 45:211-5. 2004
  7. ncbi A young woman with splenic infarction
    Michael Bitzer
    Department of Internal Medicine I and III, University Tübingen, D 72076, Tubingen, Germany
    Lancet 362:1456. 2003
  8. ncbi Negative-strand RNA viral vectors: intravenous application of Sendai virus vectors for the systemic delivery of therapeutic genes
    Michael Bitzer
    Internal Medicine I, University Clinic Tübingen, D 72076 Tubingen, Germany
    Mol Ther 7:210-7. 2003
  9. ncbi Sendai virus vectors as an emerging negative-strand RNA viral vector system
    Michael Bitzer
    Internal Medicine I, Medical University Clinic Tubingen, 72076 Tubingen, Germany
    J Gene Med 5:543-53. 2003
  10. ncbi HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL
    Anita Pathil
    Department of Internal Medicine I, Medical University Clinic, Tubingen, Germany
    Hepatology 43:425-34. 2006

Detail Information

Publications73

  1. pmc Sendai virus efficiently infects cells via the asialoglycoprotein receptor and requires the presence of cleaved F0 precursor proteins for this alternative route of cell entry
    M Bitzer
    Abteilung Innere Medizin I, Medizinische Universitätsklinik Tübingen, Germany
    J Virol 71:5481-6. 1997
    ..Interestingly, infection via ASGP-R was found to be nearly as efficient as infection via conventional sialic acid-containing SV receptors. A possible physiological role of the ASGP-R-mediated route of SV infection is discussed...
  2. pmc Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32)
    M Bitzer
    Abteilung Innere Medizin I, Medizinische Universitätsklinik Tübingen, 72076 Tubingen, Germany
    J Virol 73:702-8. 1999
    ..In conclusion, SV-induced cell injury is mediated by CD95- and TNF-R1-independent activation of caspases, leading to the death of host cells without impairment of the viral life cycle...
  3. doi Resminostat plus sorafenib as second-line therapy of advanced hepatocellular carcinoma - The SHELTER study
    Michael Bitzer
    Department of Internal Medicine I, Eberhard Karls University, Tuebingen, Germany Electronic address
    J Hepatol 65:280-8. 2016
    ..This phase I/II trial investigated safety, pharmacokinetics and potential biomarkers of the histone deacetylase inhibitor resminostat and a combination therapy with resminostat and sorafenib...
  4. doi Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumor cells
    Sascha Venturelli
    Corresponding Author Michael Bitzer, Medical University Hospital, University of Tuebingen, Otfried Mueller Str 10, Tuebingen D 72076, Germany
    Mol Cancer Ther 12:2226-36. 2013
    ..These findings together with other reported differences enable and facilitate a rational design of new combination strategies to further exploit the epigenetic mode of action of these two drugs in different areas of clinical oncology...
  5. ncbi Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells
    Michael Bitzer
    Department of Internal Medicine I, University Clinic Tübingen, D 72076 Tubingen, Germany
    J Biol Chem 277:29817-24. 2002
    ..Our results therefore suggest an alternative mechanism for caspase-9 activation in virally infected cells beside the well characterized pathways via death receptors or mitochondrial cytochrome c release...
  6. ncbi [Malabsorption syndrome. Rare differential diagnosis in a young patient]
    M Bitzer
    Abteilung Innere Medizin I, Medizinische Universitätsklinik Tübingen
    Internist (Berl) 45:211-5. 2004
    ..After discontinuation of the antibiotic therapy the patient reached a sustained response...
  7. ncbi A young woman with splenic infarction
    Michael Bitzer
    Department of Internal Medicine I and III, University Tübingen, D 72076, Tubingen, Germany
    Lancet 362:1456. 2003
  8. ncbi Negative-strand RNA viral vectors: intravenous application of Sendai virus vectors for the systemic delivery of therapeutic genes
    Michael Bitzer
    Internal Medicine I, University Clinic Tübingen, D 72076 Tubingen, Germany
    Mol Ther 7:210-7. 2003
    ..In conclusion, our investigations demonstrate for the first time that intravenous administration of negative-strand RNA viral vectors may become a useful tool for the wide area of gene replacement requirements...
  9. ncbi Sendai virus vectors as an emerging negative-strand RNA viral vector system
    Michael Bitzer
    Internal Medicine I, Medical University Clinic Tubingen, 72076 Tubingen, Germany
    J Gene Med 5:543-53. 2003
    ..So far, Sendai virus vectors have been identified to be a highly efficient transduction tool for a broad range of different tissues and applications. Future directions in vector design and development are discussed...
  10. ncbi HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL
    Anita Pathil
    Department of Internal Medicine I, Medical University Clinic, Tubingen, Germany
    Hepatology 43:425-34. 2006
    ..Specific upregulation of intracellular FLIP protein levels in nonmalignant hepatocytes could enhance the therapeutic window for clinical applications of TRAIL, opening up a highly specific new treatment option for advanced HCC...
  11. doi Adenovirus-mediated cytosine deaminase/5-fluorocytosine suicide gene therapy of human hepatoblastoma in vitro
    Steven W Warmann
    Department of Pediatric Surgery, University Children s Hospital Tubingen, Tubingen, Germany
    Pediatr Blood Cancer 53:145-51. 2009
    ....
  12. pmc Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone [corrected] proteins in human-derived hepatoblastoma cells
    Sascha Venturelli
    Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany
    PLoS ONE 8:e73097. 2013
    ..Moreover, resveratrol may serve as a lead structure for chemical optimization of bioavailability, pharmacology or HDAC inhibition. ..
  13. ncbi Epigenetic combination therapy as a tumor-selective treatment approach for hepatocellular carcinoma
    Sascha Venturelli
    Department of Internal Medicine I, Medical University Clinic, Tubingen, Germany
    Cancer 109:2132-41. 2007
    ..A comprehensive preclinical investigation was performed on the potential of a combined HDAC-I/DA epigenetic regimen for the highly chemotherapy-resistant HCC entity...
  14. ncbi Fusion of HSV-1 VP22 to a bifunctional chimeric SuperCD suicide gene compensates for low suicide gene transduction efficiencies
    Marie Luise Lemken
    Department of Internal Medicine I, University Clinic Tübingen, Tubingen, Germany
    Int J Oncol 30:1153-61. 2007
    ..Immunofluorescence analysis of adenoviral transduced COS-1 cells coplated with naïve HeLa cells further confirmed the unique property of VP22 for intercellular trafficking...
  15. doi Comparison of different tumor response criteria in patients with hepatocellular carcinoma after systemic therapy with the multikinase inhibitor sorafenib
    Daniel Spira
    Department of Diagnostic Radiology, Eberhard Karls University, Tubingen, Germany
    Acad Radiol 18:89-96. 2011
    ..1...
  16. doi Enhanced killing of therapy-induced senescent tumor cells by oncolytic measles vaccine viruses
    Timo Weiland
    Department of Internal Medicine I, Medical University Hospital, University of Tubingen, Germany
    Int J Cancer 134:235-43. 2014
    ..These observations open up a new field for preclinical and clinical research to further investigate TIS and oncolytic viruses as an attractive combinatorial future treatment approach. ..
  17. doi Direct and natural killer cell-mediated antitumor effects of low-dose bortezomib in hepatocellular carcinoma
    Sorin Armeanu
    Department of Gastroenterology and Hepatology, Medical University Hospital, Tubingen, Germany
    Clin Cancer Res 14:3520-8. 2008
    ..We studied the consequences of proteasome inhibition with regard to direct and NK cell-mediated effects against HCC...
  18. doi Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation
    Sascha Venturelli
    Department of Internal Medicine I, Medical University Hospital, Otfried Mueller Str 10, D 72076 Tuebingen, Germany
    Gut 60:156-65. 2011
    ..Therefore, 5-aza-CR and 5-aza-dC were investigated in the context of TRAIL resistance...
  19. ncbi Optimizing vector application for gene transfer into human hepatoblastoma cells
    Steven W Warmann
    Department of Pediatric Surgery, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Pediatr Surg Int 22:733-42. 2006
    ..Furthermore, enhanced activity of the liver-specific promoters in HUH6 cells compared to HepT1 cells supports the observation of varying biological behavior in histologically differing HB tissues...
  20. ncbi Cell cycle independent infection and gene transfer by recombinant Sendai viruses
    Sorin Armeanu
    Internal Medicine I, University Clinic Tübingen, D 72076, Tubingen, Germany
    J Virol Methods 108:229-33. 2003
    ..In conclusion, the results demonstrate SeV based vector particles to be an ideal tool to reach equally cells coexisting in different cell cycle phases...
  21. doi Evaluation of response in malignant tumors treated with the multitargeted tyrosine kinase inhibitor sorafenib: a multitechnique imaging assessment
    Olga Maksimovic
    Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    AJR Am J Roentgenol 194:5-14. 2010
    ..The purpose of this article is to illustrate the characteristic changes induced in different tumor types by the multitargeted tyrosine kinase inhibitor sorafenib...
  22. ncbi Evidence for intercellular trafficking of VP22 in living cells
    Marie Luise Lemken
    Department of Internal Medicine I, University Clinic Tübingen, Tubingen, Germany
    Mol Ther 15:310-9. 2007
    ..We thus confirmed the ability of VP22-mediated intercellular trafficking in live unfixed cells...
  23. ncbi In vitro gene targeting in human hepatoblastoma
    Steven W Warmann
    Department of Pediatric Surgery, University of Tubingen, Hoppe Seyler Street 3, 72076 Tubingen, Germany
    Pediatr Surg Int 22:16-23. 2006
    ..Additionally, we successfully investigated a model of adenovirus-based suicide gene therapy in HB cell cultures. Our data strongly encourage further studies assessing these alternative treatment approaches...
  24. doi Diffusion-weighted MRI of advanced hepatocellular carcinoma during sorafenib treatment: initial results
    Christina Schraml
    Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    AJR Am J Roentgenol 193:W301-7. 2009
    ..The objective of our study was to evaluate signal changes of advanced hepatocellular carcinoma in diffusion-weighted MRI in the early-response monitoring of oral therapy with the multikinase inhibitor sorafenib...
  25. ncbi Efficient propagation of single gene deleted recombinant Sendai virus vectors
    Christian Bernloehr
    Internal Medicine I, University Clinic Tübingen, D 72076, Tubingen, Germany
    Virus Res 99:193-7. 2004
    ..Such optimized propagation procedures even led to a successful propagation of HN-deleted viral particles (SeVV-DeltaHN), which has not been reported before...
  26. ncbi Adenoviral gene transfer of tumor necrosis factor-related apoptosis-inducing ligand overcomes an impaired response of hepatoma cells but causes severe apoptosis in primary human hepatocytes
    Sorin Armeanu
    Medical University Clinic, Department of Internal Medicine I, Tubingen, Germany
    Cancer Res 63:2369-72. 2003
    ..Our data imply that Ad-TRAIL administration in vivo must either be restricted to tumor tissue or controlled by a tumor-specific promoter to avoid severe liver damage in human trials...
  27. pmc Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model
    Florian Graepler
    Department of Internal Medicine I, Medical University Clinic Tubingen, Germany
    World J Gastroenterol 11:6910-9. 2005
    ..To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model...
  28. ncbi Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate
    Sorin Armeanu
    Departments of Internal Medicine I, Internal Medicine II, and Immunology, Eberhard Karls University, Tuebingen, Germany
    Cancer Res 65:6321-9. 2005
    ..These results suggest the clinical evaluation of HDAC-I in solid tumors such as hepatocellular carcinoma, especially in combination with immunotherapy approaches employing adoptive NK cell transfer...
  29. pmc Selective protection of human liver tissue in TNF-targeting of cancers of the liver by transient depletion of adenosine triphosphate
    Timo Weiland
    Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany
    PLoS ONE 7:e52496. 2012
    ....
  30. ncbi Severe impairment of dendritic cell allostimulatory activity by Sendai virus vectors is overcome by matrix protein gene deletion
    Sorin Armeanu
    Department of Internal Medicine I, University Clinic Tübingen, Tubingen, Germany
    J Immunol 175:4971-80. 2005
    ....
  31. doi Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases
    Alexander Berger
    Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany
    J Nutr Biochem 24:977-85. 2013
    ..Moreover, kaempferol may serve as a novel lead structure for chemical optimization of pharmacokinetics, pharmacology or inhibitory activities...
  32. pmc Expression liver-directed genes by employing synthetic transcriptional control units
    Marie Luise Lemken
    Department of Internal Medicine I, Medical University Clinic Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    World J Gastroenterol 11:5295-302. 2005
    ..To generate and characterize the synthetic transcriptional control units for transcriptional targeting of the liver, thereby compensating for the lack of specificity of currently available gene therapeutic vector systems...
  33. pmc A novel armed oncolytic measles vaccine virus for the treatment of cholangiocarcinoma
    Sebastian Lange
    Department of Gastroenterology and Hepatology, Medical University Hospital Tübingen, 72076 Tubingen, Germany
    Hum Gene Ther 24:554-64. 2013
    ..On the basis of these encouraging preclinical data on employment of SCD-armed MeV for the virotherapeutic treatment of chemotherapy-resistant CC, a clinical virotherapy trial is set up currently...
  34. pmc Attenuated and protease-profile modified sendai virus vectors as a new tool for virotherapy of solid tumors
    Martina Zimmermann
    Department of Internal Medicine I, Medical University Hospital, Tubingen, Germany
    PLoS ONE 9:e90508. 2014
    ..In conclusion, we successfully developed novel tumor-selective oncolytic rSeV vectors, constituting a new tool for virotherapy of solid tumors being ready for further preclinical and clinical development to address distinct tumor types. ..
  35. ncbi Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357
    Sorin Armeanu
    Department of Internal Medicine I, Medical University Clinic, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Hepatol 42:210-7. 2005
    ..However, little is known about tumor cell death mechanisms and HDAC-I influences on healthy hepatocytes...
  36. doi Primary resistance phenomena to oncolytic measles vaccine viruses
    Markus Noll
    Department of Internal Medicine I, University Hospital Tubingen, D 72076 Tubingen, Germany
    Int J Oncol 43:103-12. 2013
    ....
  37. pmc Early MRI response monitoring of patients with advanced hepatocellular carcinoma under treatment with the multikinase inhibitor sorafenib
    Marius Horger
    Department of Gastroenterology and Hepatology, Medical University Hospital, Eberhard Karls University, D 72076 Tubingen, Germany
    BMC Cancer 9:208. 2009
    ..As a unique feature, HCC usually develops in a diseased liver and current imaging technologies employing classical response criteria have not been prospectively evaluated for this new treatment...
  38. ncbi Human precision-cut liver tumor slices as a tumor patient-individual predictive test system for oncolytic measles vaccine viruses
    Martina Zimmermann
    Department of Gastroenterology and Hepatology, Medical University Hospital, D 72076 Tubingen, Germany
    Int J Oncol 34:1247-56. 2009
    ..In conclusion, the PCLS technology is suitable to perform a tumor-patient individualized preselection of oncolytic agents prior to clinical virotherapeutic applications...
  39. doi Kinetic tracking of therapy-induced senescence using the real-time cell analyzer single plate system
    Timo Weiland
    Department of Internal Medicine I, Medical University Clinic, Tuebingen, Germany
    Assay Drug Dev Technol 10:289-95. 2012
    ..This technique is suitable for high-throughput TIS screening by measuring several compounds, small molecules, and/or cell lines simultaneously...
  40. doi Enhanced erythrocyte membrane exposure of phosphatidylserine following sorafenib treatment: an in vivo and in vitro study
    Adrian Lupescu
    Department of Physiology, Tuebingen, Tubingen, Germany
    Cell Physiol Biochem 30:876-88. 2012
    ..Signaling leading to eryptosis include increase in cytosolic Ca(2+)activity ([Ca(2+)](i)), formation of ceramide, ATP-depletion and oxidative stress. The present study explored, whether sorafenib triggers eryptosis in vitro and in vivo...
  41. doi Preclinical testing of virotherapeutics for primary and secondary tumors of the liver
    Martina Zimmermann
    Department of Gastroenterology and Hepatology, Medical University Hospital, Tuebingen, Germany
    Methods Mol Biol 806:121-36. 2012
    ..In this three-dimensional model, we observed a preferential tumor infection and the penetration of oncolytic measles vaccine virus into deeper cell layers of tumor tissues, which is an essential feature of an effective oncolytic virus...
  42. ncbi Establishing a novel single-copy primer-internal intron-spanning PCR (spiPCR) procedure for the direct detection of gene doping
    Thomas Beiter
    Department of Sports Medicine, Medical Clinic, University of Tuebingen, Germany
    Exerc Immunol Rev 14:73-85. 2008
    ..Apart from the interesting perspectives that this spiPCR procedure offers in the fight against gene doping, this technology could also be of interest in biodistribution and biosafety studies for gene therapeutic applications...
  43. doi Emerging gene-directed anti-tumor strategies against human hepatoblastoma
    Steven W Warmann
    University Children s Hospital Tubingen, Department of Pediatric Surgery, 72076 Tubingen, Germany
    Expert Opin Biol Ther 9:1155-61. 2009
    ..Gene-directed anti-HB treatment approaches have been newly identified as promising option in this regard...
  44. doi Spectrum of imaging findings in immunocompromised patients with HHV-6 infection
    Alexander Sauter
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    AJR Am J Roentgenol 193:W373-80. 2009
    ..The aim of this article is to review systemic manifestations of human herpes virus 6 (HHV-6) associated diseases in immunocompromised patients...
  45. pmc Improved reproducibility in preparing precision-cut liver tissue slices
    Martina Zimmermann
    Department of Gastroenterology and Hepatology, University Hospital Tuebingen, Otfried Mueller Str 10, 72076, Tuebingen, Germany
    Cytotechnology 61:145-52. 2009
    ..The quality of the sliced tissue was determined via measurement of the ATP content. As a result, we found an improved accuracy and reproducibility of rat, mouse and human tissue slices using the new Leica vibrating blade microtome...
  46. ncbi "PULSED" versus "CONTINUOUS" application of the prodrug 5-FC for enhancing oncolytic effectiveness of a measles vaccine virus armed with a suicide gene
    Can Yurttas
    Medical University Hospital, Department of Gastroenterology and Hepatology, Tubingen, Germany
    Hum Gene Ther Clin Dev . 2014
    ..e. on virus replication. These findings should be helpful for the rational design of further trials (preclinical, clinical) using suicide gene armed virotherapeutics, such as MeV-SCD...
  47. ncbi Virtual bronchoscopy: comparison of different surface rendering models
    Marcus D Seemann
    Department of Diagnostic Radiology, Eberhard Karls University of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Technol Cancer Res Treat 2:273-9. 2003
    ....
  48. ncbi Preoperative marking of musculoskeletal tumors guided by magnetic resonance imaging
    Philippe L Pereira
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Strasse 3, D 72076 Tuebingen, Germany
    J Bone Joint Surg Am 86:1761-7. 2004
    ..The purpose of this study was to evaluate a new stereotactic method for preoperative coil-marking of musculoskeletal tumors with use of interventional magnetic resonance imaging...
  49. doi [Unexpected complication following esophageal variceal hemorrhage - Case 2/2011]
    Christoph R Werner
    Abteilung für Gastroenterologie, Hepatologie und Infektiologie, Medizinische Universitätsklinik Tübingen
    Dtsch Med Wochenschr 136:217. 2011
    ..A 50-year-old patient with alcoholic liver cirrhosis was admitted due to hematemesis and melaena...
  50. ncbi [Possibilities of the prophylaxis of arterial restenoses with dexamethasone -- an in-vitro study of human aortic smooth muscle cells]
    M Bitzer
    Abteilung Radiologische Diagnostik, Universitat Tubingen
    Rofo 176:1485-92. 2004
    ..To evaluate the effect of dexamethasone on the growth of cultured human aortic smooth muscle cells in an in-vitro model depending on the dose applied...
  51. ncbi [The characteristic values in the MR study of cerebral blood flow with high spatial and temporal resolution]
    U Klose
    Sektion für experimentelle Kernspinresonanz des zentralen Nervensystems, Eberhard Karls Universitat Tubingen
    Rofo 170:474-81. 1999
    ..Different parameters for the evaluation of perfusion studies with dynamic MR measurements after the administration of paramagnetic contrast agent were compared...
  52. ncbi Alterations in diffusion and perfusion in the pathogenesis of peritumoral brain edema in meningiomas
    M Bitzer
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Eur Radiol 12:2062-76. 2002
    ..Ischemic alterations can be regarded as secondary, facultative phenomena in the pathogenesis of meningioma-related brain edema...
  53. ncbi [Hybrid 3-D rendering of the thorax and surface-based virtual bronchoscopy in surgical and interventional therapy control]
    M D Seemann
    Radiologische Klinik, Abteilung Radiologische Diagnostik, Universitatsklinikum Tubingen
    Rofo 173:650-7. 2001
    ....
  54. ncbi Classification of acquired lesions of the corpus callosum with MRI
    S A Friese
    Department of Neuroradiology, Eberhard Karls University, D 72074 Tubingen, Germany
    Neuroradiology 42:795-802. 2000
    ..Lesions in Marchiafava-Bignami disease were large, often symmetrically in the midline in the splenium and did not reach the edge of the corpus callosum...
  55. ncbi Quantification of VP22-GFP spread by direct fluorescence in 15 commonly used cell lines
    W A Wybranietz
    Medical University Clinic Tubingen, Germany
    J Gene Med 1:265-74. 1999
    ....
  56. doi Lysozyme activates Enterococcus faecium to induce necrotic cell death in macrophages
    Sabine Gröbner
    Interfaculty Institute of Microbiology and Infection Medicine, University of Tubingen, Elfriede Aulhorn Str 6, 72076 Tubingen, Germany
    Cell Mol Life Sci 67:3331-44. 2010
    ..Altogether, our results show that enterococci, under specific conditions such as exposure to lysozyme, induce necrotic cell death in macrophages, which might contribute to disseminated infections by these facultative pathogenic bacteria...
  57. pmc Innate immune defense defines susceptibility of sarcoma cells to measles vaccine virus-based oncolysis
    Susanne Berchtold
    Department of Internal Medicine I, University Hospital Tubingen, Tubingen, Germany
    J Virol 87:3484-501. 2013
    ....
  58. doi Pulsed versus continuous application of the prodrug 5-fluorocytosine to enhance the oncolytic effectiveness of a measles vaccine virus armed with a suicide gene
    Can Yurttas
    1 Department of Gastroenterology and Hepatology, Medical University Hospital Tübingen, D 72076 Tubingen, Germany
    Hum Gene Ther Clin Dev 25:85-96. 2014
    ..These findings should be helpful for the rational design of further trials (preclinical, clinical) using suicide gene armed virotherapeutics, such as MeV-SCD. ..
  59. doi Imaging findings in immunosuppressed patients with Epstein Barr virus-related B cell malignant lymphoma
    Alexander Sauter
    Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tuebingen, Germany
    AJR Am J Roentgenol 194:W141-9. 2010
    ..The purpose of this study was to describe multimodality imaging findings in immunosuppressed patients with Epstein-Barr virus (EBV)-related malignant lymphoproliferative diseases...
  60. ncbi Enhanced suicide gene effect by adenoviral transduction of a VP22-cytosine deaminase (CD) fusion gene
    W A Wybranietz
    Internal Medicine I, , Germany
    Gene Ther 8:1654-64. 2001
    ..Thereby employment of Ad-vectors encoding VP22 fusion proteins opens up new possibilities to potentiate the efficiency of suicide gene therapy for the treatment of solid tumours...
  61. pmc Correlation of magnetic resonance signal characteristics and perfusion parameters assessed by volume perfusion computed tomography in hepatocellular carcinoma: Impact on lesion characterization
    Gerd Grözinger
    Gerd Grözinger, Roland Syha, Dominik Ketelsen, Konstantin Nikolaou, Marius Horger, Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 72076 Tubingen, Germany
    World J Radiol 8:683-92. 2016
    ..To find out if magnetic resonance (MR)-signal characteristics of hepatocellular carcinomas (HCC) correlate with perfusion parameters assessed by volume perfusion computed tomography (VPCT)...
  62. ncbi The benefit of functional-anatomical imaging with [18F]fluorodeoxyglucose utilizing a dual-head coincidence gamma camera with an integrated X-ray transmission system in non-small cell lung cancer
    Susanne M Eschmann
    Departments of Nuclear Medicine, University of Tuebingen, Otfried Müller Strasse 14, D 72076 Tuebingen, Germany
    Nucl Med Commun 25:909-15. 2004
    ....
  63. pmc Plants Release Precursors of Histone Deacetylase Inhibitors to Suppress Growth of Competitors
    Sascha Venturelli
    Department of Internal Medicine I, Medical University Clinic, University of Tubingen, 72076 Tubingen, Germany
    Plant Cell 27:3175-89. 2015
    ..Our multilevel analysis collectively shows how plant-plant interactions interfere with a fundamental cellular process, histone acetylation, by targeting an evolutionarily highly conserved class of enzymes. ..
  64. ncbi [Efficient selection mechanisms: requirement for successful gene therapy. 5th Congress of the American Society of Gene Therapy]
    Michael Bitzer
    Abteilung Innere Medizin I, Universitatsklinikum Tubingen, Germany
    Dtsch Med Wochenschr 127:1623-4. 2002
  65. ncbi Synchronous gastrointestinal and musculoskeletal manifestations of different subtypes of inflammatory myofibroblastic tumor: CT, MRI and pathological features
    Marius Horger
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Eur Radiol 15:1713-6. 2005
    ....
  66. doi Subgroup analysis of patients with G2 gastroenteropancreatic neuroendocrine tumors
    Lisa Hauck
    a Department of Internal Medicine I, University Hospital, Tubingen, Germany
    Scand J Gastroenterol 51:55-9. 2016
    ..Thus, our data clearly show that patients with higher G2 proliferation index should be treated differently. Finally, LDH has been found to be a new prognostic factor in patients with G2 NET. ..
  67. doi Analysis of second-line chemotherapies for ductal pancreatic adenocarcinoma in a German single-center cohort
    Constantin Maier-Stocker
    Department of Internal Medicine I, University Hospital, Tubingen, Germany
    Scand J Gastroenterol 49:1480-5. 2014
    ..More prospective, randomized and larger studies are necessary to evaluate new strategies for second-line chemotherapies...
  68. ncbi Recurrent spinal fistula as result of a rare combination of a perimedullary and peridural spinal fistula: case report
    Matthias Hubert Morgalla
    Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany
    Surg Neurol 61:347-52. 2004
    ..The clinical course and diagnostic steps reveal important observations helpful in the management of this pathology...
  69. ncbi [Oncolytic viruses for genetic therapy of gastrointestinal tumors]
    M Bitzer
    Abteilung Innere Medizin I, Medizinische Universitatsklinik, Tubingen
    Z Gastroenterol 41:667-74. 2003
    ..Techniques of molecular virology are required for further improvement of current vectors, particularly with respect to oncolytic activity, tumour selectivity, tumour spread capacity, and safety...
  70. ncbi Response of radiochemotherapy-associated cerebral edema to a phytotherapeutic agent, H15
    J R Streffer
    Department of Neurology, , Medical School, , Germany
    Neurology 56:1219-21. 2001
    ..Edema was reduced in two of seven patients with glioblastoma with tumor progression and in three of five patients with treatment-related leukoencephalopathy. All patients with leukoencephalopathy improved clinically for several months...
  71. ncbi Recombinant Sendai virus for efficient gene transfer to human airway epithelium
    Olaf Pinkenburg
    Hospital of the University of Marburg, Department of Internal Medicine, Division of Pulmonology, Philipps UniverstätMarburg, Marburg, Germany
    Exp Lung Res 30:83-96. 2004
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