Norbert W Brattig

Summary

Affiliation: Bernhard Nocht Institute for Tropical Medicine
Country: Germany

Publications

  1. pmc Localization of Wolbachia-like gene transcripts and peptides in adult Onchocerca flexuosa worms indicates tissue specific expression
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Parasit Vectors 6:2. 2013
  2. pmc Comparative evaluation of two rapid field tests for malaria diagnosis: Partec Rapid Malaria Test® and Binax Now® Malaria Rapid Diagnostic Test
    Bernard Nkrumah
    Kumasi Centre for Collaborative Research in Tropical Medicine, Ghana
    BMC Infect Dis 11:143. 2011
  3. doi request reprint Plasmodium falciparum glycosylphosphatidylinositol toxin interacts with the membrane of non-parasitized red blood cells: a putative mechanism contributing to malaria anemia
    Norbert W Brattig
    Section Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Microbes Infect 10:885-91. 2008
  4. pmc Strong expression of TGF-beta in human host tissues around subcutaneous Dirofilaria repens
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359, Hamburg, Germany
    Parasitol Res 108:1347-54. 2011
  5. pmc Immunohistology of ectopic secondary lymph follicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda)
    Norbert W Brattig
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine BNI, Bernhard Nocht Str 74, Hamburg, Germany
    Parasitol Res 107:657-66. 2010
  6. pmc Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells
    N W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, D 20359 Hamburg, Germany
    Parasitology 137:841-54. 2010
  7. ncbi request reprint The filarial parasite Onchocerca volvulus generates the lipid mediator prostaglandin E(2)
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Microbes Infect 8:873-9. 2006
  8. doi request reprint Identification of the lipid mediator prostaglandin E2 in tissue immune cells of humans infected with the filaria Onchocerca volvulus
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, D 20359 Hamburg, Germany
    Acta Trop 112:231-5. 2009
  9. doi request reprint Characterization of a secreted macrophage migration inhibitory factor homologue of the parasitic nematode Strongyloides acting at the parasite-host cell interface
    Abuelhassan Elshazly Younis
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Microbes Infect 14:279-89. 2012
  10. pmc Life cycle stage-resolved proteomic analysis of the excretome/secretome from Strongyloides ratti--identification of stage-specific proteases
    Hanns Soblik
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Mol Cell Proteomics 10:M111.010157. 2011

Collaborators

Detail Information

Publications30

  1. pmc Localization of Wolbachia-like gene transcripts and peptides in adult Onchocerca flexuosa worms indicates tissue specific expression
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Parasit Vectors 6:2. 2013
    ..Proteogenomic studies have shown that many of these Wolbachia-like sequences are expressed in adult worms...
  2. pmc Comparative evaluation of two rapid field tests for malaria diagnosis: Partec Rapid Malaria Test® and Binax Now® Malaria Rapid Diagnostic Test
    Bernard Nkrumah
    Kumasi Centre for Collaborative Research in Tropical Medicine, Ghana
    BMC Infect Dis 11:143. 2011
    ....
  3. doi request reprint Plasmodium falciparum glycosylphosphatidylinositol toxin interacts with the membrane of non-parasitized red blood cells: a putative mechanism contributing to malaria anemia
    Norbert W Brattig
    Section Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Microbes Infect 10:885-91. 2008
    ..f.-GPI can insert into non-parasitized RBC membranes and results in recognition by circulating anti-GPI antibodies and possibly subsequent elimination. This process may contribute to malaria-associated anemia...
  4. pmc Strong expression of TGF-beta in human host tissues around subcutaneous Dirofilaria repens
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359, Hamburg, Germany
    Parasitol Res 108:1347-54. 2011
    ..It is concluded that single non-productive Dirofilaria worms elicit a strong expression of TGF-beta. This result is in accordance with observations on Onchocerca volvulus from patients with the hyporeactive (generalised) form...
  5. pmc Immunohistology of ectopic secondary lymph follicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda)
    Norbert W Brattig
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine BNI, Bernhard Nocht Str 74, Hamburg, Germany
    Parasitol Res 107:657-66. 2010
    ..In conclusion, the ectopic secondary lymph follicles in onchocercomas and lymph nodes from hyperreactive onchocerciasis patients are equally composed...
  6. pmc Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells
    N W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, D 20359 Hamburg, Germany
    Parasitology 137:841-54. 2010
    ..In contrast, Wolbachia were not found in the cells of the neoplasms. Further, neoplasm-containing worms were not observed after more than 10 months after the start of sufficient treatment with doxycycline or doxycycline plus ivermectin...
  7. ncbi request reprint The filarial parasite Onchocerca volvulus generates the lipid mediator prostaglandin E(2)
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Microbes Infect 8:873-9. 2006
    ..Release of PGE(2) from live or moribund filariae can affect the host s metabolism and immune response in favor of the filarial parasite...
  8. doi request reprint Identification of the lipid mediator prostaglandin E2 in tissue immune cells of humans infected with the filaria Onchocerca volvulus
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, D 20359 Hamburg, Germany
    Acta Trop 112:231-5. 2009
    ..The presence of PGE(2) and TGF-beta in adjoining host cells infiltrating in the onchocercoma and dermis may indicate containment of inflammatory responses that could favour survival of the filarial parasite...
  9. doi request reprint Characterization of a secreted macrophage migration inhibitory factor homologue of the parasitic nematode Strongyloides acting at the parasite-host cell interface
    Abuelhassan Elshazly Younis
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Microbes Infect 14:279-89. 2012
    ..After exposure to Sra-MIF, monocytes released IL-10 but not TNF-alpha suggesting the involvement of the secreted parasite MIF in host immune responses...
  10. pmc Life cycle stage-resolved proteomic analysis of the excretome/secretome from Strongyloides ratti--identification of stage-specific proteases
    Hanns Soblik
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Mol Cell Proteomics 10:M111.010157. 2011
    ..The characterization of stage-related ESP from Strongyloides will help to further understand the interaction of this unique intestinal nematode with its host...
  11. pmc Stage-specific excretory-secretory small heat shock proteins from the parasitic nematode Strongyloides ratti--putative links to host's intestinal mucosal defense system
    Abuelhassan Elshazly Younis
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    FEBS J 278:3319-36. 2011
    ..1, but not to Sra-HSP-17.2. Exposed monocytes released interleukin-10 but not tumor necrosis factor-α in response to Sra-HSP-17s, suggesting the possible involvement of secreted female proteins in host immune responses...
  12. ncbi request reprint Onchocerca volvulus: expression and immunolocalization of a nematode cathepsin D-like lysosomal aspartic protease
    Abbas Jolodar
    Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse, 74, 20359 Hamburg, Germany
    Exp Parasitol 107:145-56. 2004
    ..The aspartic protease of O. volvulus appears to function in intestinal digestion and tissue degradation of the filaria...
  13. ncbi request reprint Cardiac involvement in dengue virus infections during the 2004/2005 dengue fever season in Sri Lanka
    Dominic Wichmann
    Medical Department Infectious Diseases and Tropical Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Southeast Asian J Trop Med Public Health 40:727-30. 2009
    ..Twenty-five percent of dengue virus infected patients had one or more of the above tests with abnormal results...
  14. doi request reprint SPARC (secreted protein acidic and rich in cysteine) of the intestinal nematode Strongyloides ratti is involved in mucosa-associated parasite-host interaction
    Emmanuela M Anandarajah
    Department of Molecular Physiology, Westfälische Wilhelms University Münster, Schlossplatz 8, D 48143 Munster, Germany Department Molecular Medicine, Bernhard Nocht Institute, Bernhard Nocht Strasse 74, 20259 Hamburg, Germany
    Mol Biochem Parasitol 207:75-83. 2016
    ..Here, we demonstrate for the first time that SPARC released from the nematode is a multifunctional protein affecting the mucosal immune system. ..
  15. ncbi request reprint Wolbachia endosymbionts of Onchocerca volvulus express a putative periplasmic HtrA-type serine protease
    Abbas Jolodar
    Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Microbes Infect 6:141-9. 2004
    ..volvulus-infected persons indicated the exposure to the protein and its recognition by the human immune system. Wol-Ov-HtrA is a candidate for an exported Wolbachia protein that may interact with the filarial host metabolism...
  16. ncbi request reprint The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4
    Norbert W Brattig
    Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    J Immunol 173:437-45. 2004
    ..Thus, filarial helminths, through products of their endobacteria such as WSP, acquire characteristics of a typical microbial pathogen inducing immune responses via TLR2 and TLR4...
  17. pmc Nematode-derived proteins suppress proliferation and cytokine production of antigen-specific T cells via induction of cell death
    Wiebke Hartmann
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS ONE 8:e68380. 2013
    ..In summary, we identified two suppressive excreted/secreted products from O. volvulus, which interfere with the function of antigen-specific T cells in vitro. ..
  18. ncbi request reprint Molecular cloning of an alpha-enolase from the human filarial parasite Onchocerca volvulus that binds human plasminogen
    Abbas Jolodar
    Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Biochim Biophys Acta 1627:111-20. 2003
    ..The recognition by antibodies in sera of O. volvulus-infected persons indicate an involvement of the protein in the interaction between the parasite and the human host...
  19. ncbi request reprint Onchocerca volvulus-exposed persons fail to produce interferon-gamma in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and IL-13 production that decrease with increasing microfilarial density
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    J Infect Dis 185:1148-54. 2002
    ....
  20. doi request reprint DNA vaccine encoding the moonlighting protein Onchocerca volvulus glyceraldehyde-3-phosphate dehydrogenase (Ov-GAPDH) leads to partial protection in a mouse model of human filariasis
    Vera Steisslinger
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, D 20359 Hamburg, Germany
    Vaccine 33:5861-7. 2015
    ..This suggests a transfer of the approach into the cattle Onchocerca ochengi model, where it is possible to investigate the effects of this vaccination in the context of a natural host-parasite relationship. ..
  21. pmc Reduced cardiac output in imported Plasmodium falciparum malaria
    Johanna Herr
    University Medical Center Hamburg Eppendorf, Section Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Malar J 10:160. 2011
    ..In the present study, cardiac function and cardiac proteins have been assessed and correlated with parasitological and immunologic parameters in patients with imported Plasmodium falciparum malaria...
  22. pmc IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB
    Thorsten Thye
    Bernhard Nocht Institute for Tropical Medicine, Department of Molecular Medicine, Hamburg, Germany
    PLoS ONE 4:e5420. 2009
    ..In these PPD-negative individuals, higher IL-10 production appears to reflect IL-10-dependent suppression of adaptive immune responses and sustained long-term specific anergy...
  23. ncbi request reprint Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus
    Nadine Borchert
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Microbes Infect 9:498-506. 2007
    ..Since a homologous metalloproteinase is part of a promising hookworm vaccine, Ov-AST-1 may be a candidate for intervention strategies in filarial infections...
  24. pmc Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic Nematodes Strongyloides ratti and Trichuris suis Affects Mucosal Homeostasis
    Dana Ditgen
    Department of Molecular Physiology, Westfalische Wilhelms University, Munster, Germany Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Parasitol Res 2016:8421597. 2016
    ..These results confirm that the parasite-secreted Trx-lps are multifunctional proteins that can affect the host intestinal mucosa...
  25. doi request reprint Molecular and functional characterisation of the heat shock protein 10 of Strongyloides ratti
    Yasmina Tazir
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Mol Biochem Parasitol 168:149-57. 2009
    ..Immunisation experiments finally revealed a strong immunogenicity of Sr-HSP10 and provided evidence for a role in regulating the host-parasite interaction...
  26. pmc Clinical relevance of different biomarkers in imported plasmodium falciparum malaria in adults: a case control study
    Sabine Stauga
    Section Tropical Medicine, I, Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Malar J 12:246. 2013
    ..The aim of this study was to determine the diagnostic and prognostic value of several biomarkers related to inflammation; endothelial and cardiac dysfunction; coagulation, and haemolysis in imported P. falciparum malaria...
  27. ncbi request reprint The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda)
    Achim Hoerauf
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Microbes Infect 4:37-42. 2002
    ..Arg110Gln has been suggested to lead to enhanced IL-13 signaling and thus may be involved in shifting the immune reaction towards the hyper-reactivity characteristic for the sowda form, thereby promoting defense mechanisms...
  28. ncbi request reprint High levels of circulating cardiac proteins indicate cardiac impairment in African children with severe Plasmodium falciparum malaria
    Stephan Ehrhardt
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Microbes Infect 7:1204-10. 2005
    ..These deleterious metabolic conditions contribute to myocardial affection which was evident but not predictive per se of fatal outcome...
  29. doi request reprint Glycosylphosphatidylinositol-induced cardiac myocyte death might contribute to the fatal outcome of Plasmodium falciparum malaria
    Kathrin Wennicke
    Department of Internal Medicine Cardiology, Philipps University of Marburg, University Hospital, Baldingerstrasse 1, 35043 Marburg Lahn, Germany
    Apoptosis 13:857-66. 2008
    ..Previous studies demonstrated cardiac involvement in patients suffering from severe malaria due to P. falciparum. Therefore, we tested the hypothesis that GPI induces apoptosis in cardiomyocytes...
  30. ncbi request reprint The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness
    Amélie v Saint André
    Division of Geographic Medicine, Department of Ophthalmology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA
    Science 295:1892-5. 2002
    ..In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells...