J Bauersachs

Summary

Country: Germany

Publications

  1. ncbi request reprint MicroRNAs in the broken heart
    J Bauersachs
    Medizinische Klinik und Poliklinik I, Kardiologie, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Eur J Clin Invest 37:829-33. 2007
  2. ncbi request reprint Simvastatin improves left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects
    Johann Bauersachs
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Universitat Wurzburg, Germany
    Cardiovasc Res 72:438-46. 2006
  3. ncbi request reprint [Aldosterone receptor blockade after acute myocardial infarction with heart failure]
    Johann Bauersachs
    Medizinische Klinik I, Universitatsklinikum, Josef Schneider Strasse 2, 97080 Wurzburg
    Med Klin (Munich) 101:458-66. 2006
  4. ncbi request reprint Endothelial progenitor cell dysfunction: mechanisms and therapeutic approaches
    J Bauersachs
    Medizinische Klinik und Poliklinik I, Kardiologie, Julius Maximilians Universitat Wurzburg, Germany
    Eur J Clin Invest 37:603-6. 2007
  5. ncbi request reprint HMG CoA reductase inhibition and left ventricular mass in hypertrophic cardiomyopathy: a randomized placebo-controlled pilot study
    J Bauersachs
    Medizinische Klinik und Poliklinik I, Kardiologie, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Eur J Clin Invest 37:852-9. 2007
  6. ncbi request reprint Cardioprotection by long-term ET(A) receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy
    Daniela Fraccarollo
    Medizinische Klinik, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, Germany
    Cardiovasc Res 54:85-94. 2002
  7. ncbi request reprint Eplerenone improves vascular function and reduces platelet activation in diabetic rats
    A Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    J Physiol Pharmacol 61:45-52. 2010
  8. ncbi request reprint High dose aspirin and left ventricular remodeling after myocardial infarction: aspirin and myocardial infarction
    Anna Adamek
    Medizinische Klinik und Poliklinik I der Universität Würzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Basic Res Cardiol 102:334-40. 2007
  9. ncbi request reprint Mineralocorticoid receptor blockade improves vasomotor dysfunction and vascular oxidative stress early after myocardial infarction
    Carmem Luíza Sartório
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
    Hypertension 50:919-25. 2007
  10. ncbi request reprint Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion
    Andreas Schafer
    Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Blood 103:407-12. 2004

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint MicroRNAs in the broken heart
    J Bauersachs
    Medizinische Klinik und Poliklinik I, Kardiologie, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Eur J Clin Invest 37:829-33. 2007
  2. ncbi request reprint Simvastatin improves left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects
    Johann Bauersachs
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Universitat Wurzburg, Germany
    Cardiovasc Res 72:438-46. 2006
    ..The aim of this study was to investigate the effects of hypercholesterolemia and statin treatment in rabbits with experimental MI...
  3. ncbi request reprint [Aldosterone receptor blockade after acute myocardial infarction with heart failure]
    Johann Bauersachs
    Medizinische Klinik I, Universitatsklinikum, Josef Schneider Strasse 2, 97080 Wurzburg
    Med Klin (Munich) 101:458-66. 2006
    ..This indication was recently reinforced by the guideline for chronic heart failure therapy of the German Cardiac Society, although there is no formal approval for spironolactone for this indication in Germany...
  4. ncbi request reprint Endothelial progenitor cell dysfunction: mechanisms and therapeutic approaches
    J Bauersachs
    Medizinische Klinik und Poliklinik I, Kardiologie, Julius Maximilians Universitat Wurzburg, Germany
    Eur J Clin Invest 37:603-6. 2007
  5. ncbi request reprint HMG CoA reductase inhibition and left ventricular mass in hypertrophic cardiomyopathy: a randomized placebo-controlled pilot study
    J Bauersachs
    Medizinische Klinik und Poliklinik I, Kardiologie, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Eur J Clin Invest 37:852-9. 2007
    ..We investigated the effect of the hydroxymethylglutaryl coenzyme A reductase inhibitor atorvastatin on left ventricular (LV) mass in patients with hypertrophic cardiomyopathy in a randomized placebo-controlled double-blind pilot study...
  6. ncbi request reprint Cardioprotection by long-term ET(A) receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy
    Daniela Fraccarollo
    Medizinische Klinik, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, Germany
    Cardiovasc Res 54:85-94. 2002
    ....
  7. ncbi request reprint Eplerenone improves vascular function and reduces platelet activation in diabetic rats
    A Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    J Physiol Pharmacol 61:45-52. 2010
    ..Platelet activation was significantly reduced by eplerenone. Selective MR blockade may constitute a useful therapeutic approach for treatment of vascular dysfunction in diabetes...
  8. ncbi request reprint High dose aspirin and left ventricular remodeling after myocardial infarction: aspirin and myocardial infarction
    Anna Adamek
    Medizinische Klinik und Poliklinik I der Universität Würzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Basic Res Cardiol 102:334-40. 2007
    ..High-dose aspirin inhibits cytokine activation. Therefore, we tested the influence of high-dose aspirin treatment on left ventricular remodeling in mice after myocardial infarction...
  9. ncbi request reprint Mineralocorticoid receptor blockade improves vasomotor dysfunction and vascular oxidative stress early after myocardial infarction
    Carmem Luíza Sartório
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
    Hypertension 50:919-25. 2007
    ..Underlying mechanisms involve inhibition of vascular angiotensin-converting enzyme upregulation and improvement of endothelial NO synthase-derived NO bioavailability...
  10. ncbi request reprint Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion
    Andreas Schafer
    Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Blood 103:407-12. 2004
    ....
  11. doi request reprint Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response
    Daniela Fraccarollo
    Medizinische Klinik und Poliklinik I, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Hypertension 51:905-14. 2008
    ....
  12. ncbi request reprint Detrimental effects of testosterone on post-myocardial infarction remodelling in female rats
    S Frantz
    Universitat Wurzburg, Medizinische Klinik und Poliklinik I, Germany
    J Physiol Pharmacol 58:717-27. 2007
    ..In conclusion, chronic anabolic T treatment causes myocardial hypertrophy under basal conditions and adversely affects left ventricular remodeling following myocardial infarction in female rats...
  13. pmc Role of p38 mitogen-activated protein kinase in cardiac remodelling
    S Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Germany
    Br J Pharmacol 150:130-5. 2007
    ..We therefore evaluated the effect of the selective p38 MAPK inhibitor SB 239063 on progression of left ventricular remodelling after myocardial infarction (MI) in rats...
  14. pmc Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice
    Peter J Kuhlencordt
    Medizinische Klinik I Herz Kreislaufzentrum, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, D97080 Würzburg, Germany
    Atherosclerosis 202:48-57. 2009
    ..The current study tests whether atheroprotection provided by a lipid lowering therapy with Ezetimibe depends on eNOS...
  15. doi request reprint [Primary diagnosis of heart failure in ambulatory and hospitalized patients]
    S Stork
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Schwerpunkt Kardiologie an der PoliklinikKlinikstr 6 8
    Dtsch Med Wochenschr 133:636-41. 2008
    ..As a primary diagnostic aim, the underlying cause of heart failure should be determined in all subjects because the therapeutic strategy may depend on this information...
  16. ncbi request reprint Impaired platelet responses to clopidogrel and ticlopidine in a patient with recurrent coronary stent stenosis
    Achim Obergfell
    Institut für Klinische Biochemie und Pathobiochemie and Zentrallabor, Universitatsklinikum, Wurzburg, Germany
    Thromb Haemost 92:1446-7. 2004
  17. doi request reprint Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction
    Daniela Fraccarollo
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Circulation 118:818-27. 2008
    ..In this study, we investigated whether the transcription enhancer of endothelial NO synthase (eNOS) AVE9488 improves cardiac remodeling and heart failure after experimental myocardial infarction (MI)...
  18. ncbi request reprint Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice
    Anna Adamek
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Germany
    Eur J Pharmacol 571:51-4. 2007
    ..In summary, inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response...
  19. doi request reprint The eNOS enhancer AVE 9488: a novel cardioprotectant against ischemia reperfusion injury
    S Frantz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Basic Res Cardiol 104:773-9. 2009
    ..2 +/- 0.5 vs. 0.8 +/- 0.07 micromol/l, P = 0.0003). Thus pharmacological interventions addressed to increase eNOS-derived NO production constitute a promising therapeutic approach to prevent myocardial ischemia/reperfusion injury...
  20. doi request reprint Reverse epidemiology in systolic and nonsystolic heart failure: cumulative prognostic benefit of classical cardiovascular risk factors
    Gülmisal Güder
    Medizinische Klinik und Poliklinik I, University Hospital Wurzburg, Wurzburg, Germany
    Circ Heart Fail 2:563-71. 2009
    ..We estimated the prognostic role of these risk factors in unselected patients with heart failure...
  21. ncbi request reprint Endothelial progenitor cells as potential drug targets
    T Thum
    Medizinische Klinik und Poliklinik I, Kardiologie, Universitatsklinikum, Bayerische Julius Maximilians Universität, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Curr Drug Targets Cardiovasc Haematol Disord 5:277-86. 2005
    ..In the present review we will highlight the current knowledge of the role of EPC dysfunction in various cardiovascular diseases and focus on potential causally related molecular mechanisms, which might be novel drug targets...
  22. pmc Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus
    A Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Wurzburg, Bavaria, Germany
    Br J Pharmacol 153:886-93. 2008
    ..Diabetes-associated vascular dysfunction contributes to increased cardiovascular risk. We investigated whether the phosphodiesterase-5 inhibitor sildenafil would improve vascular function in diabetic rats...
  23. ncbi request reprint Heart failure, platelet activation and inhibition of the renin-angiotensin-aldosterone system
    J Bauersachs
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    Arch Mal Coeur Vaiss 97:889-93. 2004
    ..Beneficial modulation of cardiac remodelling, left ventricular function, neurohumoral activation, endothelial dysfunction and platelet activation can be achieved by inhibition of the renin-angiotensin-aldosterone system...
  24. ncbi request reprint Prevention of endothelial dysfunction in heart failure by vitamin E: attenuation of vascular superoxide anion formation and increase in soluble guanylyl cyclase expression
    J Bauersachs
    Medizinische Klinik der Julius Maximilians Universität Würzburg, Wurzburg, Germany
    Cardiovasc Res 51:344-50. 2001
    ..Enhanced vascular superoxide anion generation contributes to endothelial dysfunction in heart failure. However, the effect of long-term treatment with the antioxidant vitamin E is unknown...
  25. ncbi request reprint High-altitude pulmonary edema: potential protection by red wine
    A Schafer
    Department of Medicine, Julius Maximilians University, Wurzburg, Germany
    Nutr Metab Cardiovasc Dis 12:306-10. 2002
    ..In this article, we review the potential mechanisms by which the components of red wine may beneficially affect the development of HAPE...
  26. ncbi request reprint Cytochrome P450 2C expression and EDHF-mediated relaxation in porcine coronary arteries is increased by cortisol
    J Bauersachs
    Medizinische Klinik der Julius Maximilians Universität Würzburg, Wurzburg, Germany
    Cardiovasc Res 54:669-75. 2002
    ....
  27. pmc The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats
    A Schafer
    Department of Internal Medicine I Cardiology, University Hospital Wurzburg, Julius Maximilians University, Wurzburg, Germany
    Br J Pharmacol 154:1047-54. 2008
    ..We investigated the effect of rimonabant on inflammation and enhanced platelet reactivity in type 2 diabetic Zucker rats, an experimental model of impaired glucose tolerance and the metabolic syndrome...
  28. ncbi request reprint Striking increase of natriuresis by low-dose spironolactone in congestive heart failure only in combination with ACE inhibition: mechanistic evidence to support RALES
    J Bauersachs
    Medizinische Universitätsklinik Würzburg, Zentrum für Medizinische Forschung, Germany
    Circulation 102:2325-8. 2000
    ..The aim of the present study was to examine a hypothesized interaction of spironolactone and ACE inhibitors in renal electrolyte and volume regulation...
  29. pmc Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusion
    U Hofmann
    Department of Internal Medicine I, University Hospital Wuerzburg, Wurzburg, Germany
    Br J Pharmacol 160:1243-51. 2010
    ..Therefore, we tested the hypothesis that pharmacological post-conditioning with FTY720 reduces infarct size after myocardial ischaemia-reperfusion in vivo...
  30. pmc Acquired right coronary artery fistula draining to the right ventricle: angiographic documentation of first appearance following reperfusion after acute myocardial infarction, with subsequent spontaneous closure
    P Schanzenbächer
    Medizinische Universitatsklinik, Wurzburg, Germany
    Heart 89:e22. 2003
    ..This is the first angiographic documentation of a coronary fistula acquired after myocardial infarction that subsequently closed spontaneously during follow up...
  31. doi request reprint Low circulating androgens and mortality risk in heart failure
    G Güder
    Medizinische Klinik und Poliklinik I Herz Kreislaufzentrum, Klinikum der Universität Würzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    Heart 96:504-9. 2010
    ..The pathophysiological implications of this phenomenon, however, have not been fully elucidated. This clinical study investigated the significance of low serum androgen levels in HF...
  32. ncbi request reprint Aldosterone antagonism in addition to angiotensin-converting enzyme inhibitors in heart failure
    J Bauersachs
    Medizinische Universitatsklinik, Wurzburg, Germany
    Minerva Cardioangiol 51:155-64. 2003
    ....
  33. ncbi request reprint Improvement of renal dysfunction in rats with chronic heart failure after myocardial infarction by treatment with the endothelin A receptor antagonist, LU 135252
    J Bauersachs
    II Medizinische Universitätsklinik Würzburg, Germany
    J Hypertens 18:1507-14. 2000
    ..To investigate the role of an activated endothelin system in the renal dysfunction observed in chronic heart failure after myocardial infarction...
  34. ncbi request reprint Endogenous cannabinoids mediate hypotension after experimental myocardial infarction
    J A Wagner
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    J Am Coll Cardiol 38:2048-54. 2001
    ..We sought to determine whether endocannabinoids influence hemodynamic variables in experimental models of acute myocardial infarction (MI)...
  35. ncbi request reprint Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme a reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction
    J Bauersachs
    Medizinische Klinik der Julius Maximilians Universität Würzburg, Germany
    Circulation 104:982-5. 2001
    ..Because angiotensin II is involved in left ventricular (LV) remodeling after myocardial infarction (MI), we examined the effects of statin treatment in an experimental model of chronic heart failure after MI...
  36. pmc Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Wurzburg, Germany
    Am J Pathol 171:507-12. 2007
    ..Bone marrow transplantation experiments indicate that impaired NF-kappaB activation in p50 KO leukocytes attenuates cardiac damage...
  37. ncbi request reprint Late thrombosis of a drug-eluting stent during combined anti-platelet therapy in a clopidogrel nonresponsive diabetic patient: shall we routinely test platelet function?
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Thromb Haemost 97:862-5. 2007
  38. ncbi request reprint Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Diabetes 56:666-74. 2007
    ..Subsequent reduction of EPC levels and impairment of EPC function likely contributes to the pathogenesis of vascular disease in diabetes...
  39. ncbi request reprint Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosis
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Wurzburg, Germany
    Curr Vasc Pharmacol 6:52-60. 2008
    ..Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis, the major complication of atherosclerosis triggering myocardial infarction and stroke...
  40. ncbi request reprint Improved endothelial function and reduced platelet activation by chronic HMG-CoA-reductase inhibition with rosuvastatin in rats with streptozotocin-induced diabetes mellitus
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Universitat Wurzburg, Germany
    Biochem Pharmacol 73:1367-75. 2007
    ..Therefore, rosuvastatin treatment normalizes endothelial function and reduces platelet activation in diabetic rats. These effects may contribute to the reduction of cardiovascular events by statins in diabetic patients...
  41. ncbi request reprint Severe neutropenia under clopidogrel treatment three weeks after coronary stenting
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Thromb Haemost 97:317-8. 2007
  42. ncbi request reprint Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress
    Thomas Thum
    Department of Cardiology, University of Wurzburg, University Hospital, Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 27:748-54. 2007
    ..Endothelial nitric oxide synthase (eNOS)-derived NO regulates EPC mobilization and function. Organic nitrates release NO, and therefore may favorably affect EPC biology...
  43. ncbi request reprint Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1
    Thomas Thum
    Universitat Wurzburg, Medizinische Klinik I Kardiologie, Wurzburg, Germany
    Circ Res 100:434-43. 2007
    ..Growth hormone-mediated increase in IGF-1 reverses age-related EPC dysfunction and may be a novel therapeutic strategy against vascular disorders with impairment of EPC...
  44. pmc Electrocardiography and outcome in patients with diabetes mellitus on maintenance hemodialysis
    Vera Krane
    University of Wurzburg, Department of Medicine, Division of Nephrology, University Clinic, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Clin J Am Soc Nephrol 4:394-400. 2009
    ..However, respective systematic evaluations are absent. Thus, the authors investigated whether routine ECG findings add prognostic information to standard risk assessment in hemodialysis...
  45. ncbi request reprint Mechanisms of disease: Toll-like receptors in cardiovascular disease
    Stefan Frantz
    Universitat Wurzburg, Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Wurzburg, Germany
    Nat Clin Pract Cardiovasc Med 4:444-54. 2007
    ..Here we review the rapid progress that has been made in this field, which has improved our understanding of vascular as well as myocardial TLR function in basic and clinical science...
  46. doi request reprint Impact of different bone marrow cell preparations on left ventricular remodelling after experimental myocardial infarction
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Germany
    Eur J Heart Fail 10:119-24. 2008
    ..Since the specific characteristics of different BM cell subsets could influence their therapeutic potential we determined the effect of different BM cell populations on left ventricular remodelling after MI...
  47. ncbi request reprint Endothelial dysfunction in heart failure
    Johann Bauersachs
    Medizinische Klinik and Poliklinik I, Herz Kreislaufzentrum, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Josef Schneider 2, Wurzburg, Germany
    Pharmacol Rep 60:119-26. 2008
    ..AVE 9488, ACE or HMG-CoA reductase inhibition result in significant increases in EPC levels, and beneficial effects on bone marrow molecular alterations after myocardial infarction...
  48. doi request reprint [Clopidogrel--clinical use and potential therapeutic problems]
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Wurzburg
    Herz 33:280-6. 2008
    ..Further prospective studies are needed to determine the risk reduction by an individually adjusted antiplatelet therapy...
  49. doi request reprint Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarction
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitatsklinikum Wurzburg, 97080, Wurzburg, Germany
    Basic Res Cardiol 103:485-92. 2008
    ..However, data regarding the function of TGF-beta after ischemic injury are inconclusive...
  50. ncbi request reprint ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
    Thromb Haemost 100:618-25. 2008
    ..PRI detected significantly more patients with impaired response than conventional platelet aggregation...
  51. ncbi request reprint Toll-like receptor signaling in the ischemic heart
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Universitatsklinikum Wurzburg, Wurzburg, Germany
    Front Biosci 13:5772-9. 2008
    ..Herein we review the experimental and clinical evidence for the involvement of TLR and its downstream signaling molecules in cardiac ischemic injury...
  52. ncbi request reprint Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I Kardiologie, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 92:4172-9. 2007
    ..We investigated whether improved systemic NO bioavailability and increased levels of EPC after GH treatment are related and mediated by the IGF-I...
  53. doi request reprint MicroRNAs: novel regulators in cardiac development and disease
    Thomas Thum
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat, Josef Schneider Street 2, D 97080 Wurzburg, Germany
    Cardiovasc Res 79:562-70. 2008
    ..Finally, we focus on the development and use of miRNA antagonists (antagomirs) to target miRNAs in vivo, which may translate into novel therapeutic strategies for heart disease in the future...
  54. ncbi request reprint Telmisartan improves vascular function and reduces platelet activation in rats with streptozotocin-induced diabetes mellitus
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Pharmacol Res 56:217-23. 2007
    ..Telmisartan normalizes vascular dysfunction and reduces platelet activation in diabetic rats. These effects may contribute to the reduction of cardiovascular events by angiotensin II receptor blockers in diabetic patients...
  55. doi request reprint The new INNOVANCE® PFA P2Y cartridge is sensitive to the detection of the P2Y₁₂ receptor inhibition
    Juergen Koessler
    Institut fuer Klinische Biochemie und Pathobiochemie mit Zentrallabor, Universitaetsklinikum Wuerzburg, Wuerzburg, Germany
    Platelets 22:20-7. 2011
    ..Its predictive value for risk assessment of thromboembolic events, e.g. after coronary stent implantation, needs to be evaluated in clinical trials...
  56. ncbi request reprint The CX3C chemokine fractalkine induces vascular dysfunction by generation of superoxide anions
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 27:55-62. 2007
    ..Expression of fractalkine and its receptor, CX3CR1, is elevated in coronary artery disease. We assessed the effects of fractalkine on vascular function in isolated rat aorta...
  57. doi request reprint The novel P2Y 12 antagonist AZD6140 rapidly and reversibly reduces platelet activation in diabetic rats
    Ulrike Flierl
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Germany
    Thromb Res 125:e93-9. 2010
    ..We investigated acute and chronic effects of AZD6140, a reversible oral rapid-onset P2Y(12) antagonist, on platelet reactivity in diabetic rats...
  58. ncbi request reprint Reduced basal nitric oxide bioavailability and platelet activation in young spontaneously hypertensive rats
    Andreas Schafer
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    Biochem Pharmacol 67:2273-9. 2004
    ..Phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) in platelets was used as a sensitive monitor of in vivo NO bioavailability...
  59. ncbi request reprint Endothelin receptor antagonists in heart failure: current status and future directions
    Georg Ertl
    Medizinische Klinik, Universitat Wurzburg, Wuerzburg, Germany
    Drugs 64:1029-40. 2004
    ..Finally, for the detection of improvement in left ventricular remodelling, a study needs to be conducted in patients with recent myocardial infarction and signs of heart failure...
  60. pmc Peroxisome proliferator activated-receptor agonism and left ventricular remodeling in mice with chronic myocardial infarction
    Stefan Frantz
    Medizinische Klinik der Universität Würzburg, Germany
    Br J Pharmacol 141:9-14. 2004
    ..5. In conclusion, PPARgamma activation did not adversely affect left ventricular remodeling and survival in mice with chronic MI. However, we were also not able to identify a protective effect of pioglitazone...
  61. pmc Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation
    Andreas Schafer
    Department of Internal Medicine I, University Hospital Wurzburg, Julius Maximilians University Würzburg, Wurzburg, Germany
    Diabetes 59:2001-9. 2010
    ..We investigated the mechanisms underlying vascular endothelial and contractile dysfunction in diabetes as well as the effect of HMR1766, a novel nitric oxide (NO)-independent activator of soluble guanylyl cyclase (sGC)...
  62. ncbi request reprint Trauma induced by nontraumatic coronary devices and its impact on vascular reactivity and morphology
    Jörg M Strotmann
    Medical University Clinic Würzburg, Germany
    Am J Physiol Heart Circ Physiol 283:H2356-62. 2002
    ..Thus interventions with so-called nontraumatic coronary devices can induce relevant vascular injury, with potential adverse clinical consequences...
  63. doi request reprint The H(2)-receptor antagonist ranitidine interferes with clopidogrel-mediated P2Y(12) inhibition in platelets
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Oberdürrbacher Str 6, 97080 Wurzburg, Germany
    Pharmacol Res 62:352-6. 2010
    ..We investigated whether ranitidine interacts with P2Y(12) inhibition on the platelet level...
  64. pmc CB(1) cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction
    Jens A Wagner
    Department of Medicine and Cardiology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Br J Pharmacol 138:1251-8. 2003
    ..Presumed CB(1) antagonism promotes remodeling despite unchanged myocardial CB(1) expression...
  65. ncbi request reprint Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure
    Stefan Frantz
    Medizinische Universitätsklinik Würzburg, Germany
    Cardiovasc Res 57:749-56. 2003
    ....
  66. pmc Post-infarct remodelling: contribution of wound healing and inflammation
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 81:474-81. 2009
    ..Healing in the heart occurs in overlapping phases. Herein, we review the inflammatory phase as a trigger of tissue formation...
  67. ncbi request reprint Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: an experimental serial cardiac magnetic resonance imaging study
    Matthias Nahrendorf
    Medizinische Universitatsklinik, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Am Coll Cardiol 40:1695-700. 2002
    ....
  68. ncbi request reprint Angiotensin-converting enzyme inhibition and endothelin antagonism for endothelial dysfunction in heart failure: mono-or combination therapy
    Johann Bauersachs
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    J Cardiovasc Pharmacol 40:594-600. 2002
    ..Although monotherapy with the ACE inhibitor trandolapril and the ET receptor antagonist LU 135252 improved endothelial dysfunction in experimental CHF, combination therapy was more effective...
  69. ncbi request reprint Collagen accumulation after myocardial infarction: effects of ETA receptor blockade and implications for early remodeling
    Daniela Fraccarollo
    Medizinische Klinik, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Cardiovasc Res 54:559-67. 2002
    ..We tested the hypothesis that inhibition of ETA receptors during the early phase of healing affects collagen synthesis and accumulation, and induces expansion of infarcted myocardium...
  70. ncbi request reprint Addition of spironolactone to angiotensin-converting enzyme inhibition in heart failure improves endothelial vasomotor dysfunction: role of vascular superoxide anion formation and endothelial nitric oxide synthase expression
    Johann Bauersachs
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg
    J Am Coll Cardiol 39:351-8. 2002
    ..We sought to investigate the effects of adding spironolactone (SP) to angiotensin-converting enzyme (ACE) inhibition on endothelium-dependent vasodilation in rats with chronic heart failure (CHF)...
  71. pmc Aminoethyl nitrate--the novel super nitrate?
    Johann Bauersachs
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Br J Pharmacol 158:507-9. 2009
    ..This work from Daiber's group is an important step forward in the understanding of nitrate bioactivation, tolerance phenomena and towards the development of better organic nitrates for clinical use...
  72. ncbi request reprint Endothelial dysfunction in heart failure: mechanisms and therapeutic approaches
    Johann Bauersachs
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    Curr Vasc Pharmacol 2:115-24. 2004
    ..This article reviews the current knowledge of the pathophysiological events contributing to endothelial dysfunction in CHF as well as several treatment options to reverse those changes...
  73. ncbi request reprint Soluble guanylyl cyclase activation with HMR1766 attenuates platelet activation in diabetic rats
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 26:2813-8. 2006
    ..Guanylyl cyclase activation enhances the reduced signaling via the NO/cGMP pathway. We investigated whether chronic guanylyl cyclase activation would beneficially modulate platelet activation in experimental diabetes mellitus...
  74. doi request reprint Inhibition of platelet activation in rats with severe congestive heart failure by a novel endothelial nitric oxide synthase transcription enhancer
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Eur J Heart Fail 11:336-41. 2009
    ..We investigated whether treatment with a novel endothelial NO synthase (eNOS)-transcription enhancer positively modulates systemic NO bioavailability and reduces platelet activation in rats with CHF...
  75. ncbi request reprint Microarray-based gene expression profiling to elucidate cellular responses to nitric oxide--a review from an analytical and biomedical point of view
    Thomas Thum
    Bayerische Julius Maximilians Universität, Universitatsklinikum, Medizinische Klinik und Poliklinik I, Kardiologie, Wurzburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:3-11. 2007
    ..We also point out the limitations of general microarray-based gene expression analyses and especially when investigating the effects of NO...
  76. ncbi request reprint Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Universitat Wurzburg, Germany
    FASEB J 20:1918-20. 2006
    ..Therefore, we investigated left ventricular remodeling in mice with a targeted deletion of the NF-kappaB subunit p50/NF-kappaB1 after myocardial infarction...
  77. ncbi request reprint Spotlight on endothelial progenitor cell inhibitors: short review
    Thomas Thum
    Medizinische Klinik, Kardiologie, Julius Maximilians Universitat Wurzburg, Germany
    Vasc Med 10:S59-64. 2005
    ..Drug-induced mobilization and improvement of EPC function, as well as reduction of EPC inhibitors, is likely to enhance endothelial function and reduce atherosclerotic processes...
  78. ncbi request reprint The dying stem cell hypothesis: immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle
    Thomas Thum
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College of Medicine, London, United Kingdom
    J Am Coll Cardiol 46:1799-802. 2005
    ..This leads to reduced scar formation, repressed myocardial apoptosis, and improved cardiac outcome...
  79. ncbi request reprint Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91PHOX
    Stefan Frantz
    Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Basic Res Cardiol 101:127-32. 2006
    ..Since NADPH oxidases are a major source of reactive oxygen species in the heart, we studied left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91(phox)...
  80. ncbi request reprint Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine
    Thomas Thum
    Bayerische Julius Maximilians Universität, Medizinische Klinik I, Wurzburg, Germany
    J Am Coll Cardiol 46:1693-701. 2005
    ..We tested the hypothesis that asymmetric dimethylarginine (ADMA) may be an endogenous inhibitor of endothelial progenitor cells (EPCs)...
  81. ncbi request reprint Additive amelioration of left ventricular remodeling and molecular alterations by combined aldosterone and angiotensin receptor blockade after myocardial infarction
    Daniela Fraccarollo
    Medizinische Klinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Cardiovasc Res 67:97-105. 2005
    ..The mechanisms underlying the clinical benefits of mineralocorticoid receptor antagonism in patients with left ventricular (LV) dysfunction and heart failure (CHF) after myocardial infarction (MI) are poorly understood...
  82. ncbi request reprint Innate immunity and the heart
    Stefan Frantz
    Medizinische Klinik der Universität Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Curr Pharm Des 11:1279-90. 2005
    ..e., the "Expanded Self-Non-Self" and the "Danger" theories of immune activation)...
  83. ncbi request reprint Rosuvastatin reduces platelet activation in heart failure: role of NO bioavailability
    Andreas Schafer
    Medizinische Klinik and Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
    Arterioscler Thromb Vasc Biol 25:1071-7. 2005
    ..We investigated whether 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibition would beneficially modulate vascular NO bioavailability and platelet activation in experimental CHF...
  84. ncbi request reprint Effect of chronic heart failure on nuclear factor kappa B in peripheral leukocytes
    Stefan Frantz
    Medizinische Klinik der Universität Würzburg, Germany
    Am J Cardiol 94:671-3. 2004
    ..In patients with stable heart failure with no obvious other reason for NF-kappaB activation, NF-kappaB was significantly activated...
  85. pmc Attenuation of angiotensin II-induced vascular dysfunction and hypertension by overexpression of Thioredoxin 2
    Julian D Widder
    Medizinische Klinik I, Universitatsklinikum, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Hypertension 54:338-44. 2009
    ..Thioredoxin 2 may represent an important therapeutic target for the prevention and treatment of hypertension and oxidative stress...
  86. ncbi request reprint Platelet activation in heart failure
    Andreas Schafer
    Medizinische Klinik der Julius Maximilians Universität Würzburg, Germany
    Clin Lab 50:559-66. 2004
    ....
  87. doi request reprint [Obesity and heart failure]
    S Frantz
    Herzkreislauf Zentrum, Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Internist (Berl) 49:389-90, 392-3. 2008
    ..Therapeutic approaches include weight control by dietary intervention and exercise, as well as bariatric surgery for the morbidly obese. Heart failure treatment should otherwise follow the general heart failure guidelines...
  88. doi request reprint [From cardiovascular risk to chronic heart failure]
    G Ertl
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Internist (Berl) 49:387-8. 2008
  89. ncbi request reprint Selective modulation of endogenous nitric oxide formation in ischemia/reperfusion injury in isolated rat hearts--effects on regional myocardial flow and enzyme release
    H Han
    Medizinische Universitatsklinik, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Basic Res Cardiol 98:165-74. 2003
    ..Selective iNOS inhibition reduced ischemic injury by reducing ischemic contracture and CK as well as LDH release during reperfusion...
  90. doi request reprint Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Circulation 117:3020-30. 2008
    ..We speculated that PAH patients are deficient in circulating endothelial progenitor cells (EPCs), potentially contributing to endothelial dysfunction and disease progression...
  91. ncbi request reprint Endothelium-dependent and -independent relaxation and VASP serines 157/239 phosphorylation by cyclic nucleotide-elevating vasodilators in rat aorta
    Andreas Schafer
    Medical Clinic, University of Wurzburg, Joseph Schneider Str 2, D 97080 Wurzburg, Germany
    Biochem Pharmacol 65:397-405. 2003
    ..We conclude that cAMP-elevating vasodilators, i.e. isoproterenol and to a lesser extent also forskolin, induce vasodilation and concomitant cyclic nucleotide protein kinase activation in the vessel wall in an endothelium-dependent way...
  92. doi request reprint Letter by Thum et al regarding article, "Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma ago
    Thomas Thum
    Circulation 117:e185; author reply e186. 2008
  93. ncbi request reprint Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibition
    Andreas Schafer
    Medizinische Universitatsklinik, Wurzburg, Germany
    Thromb Haemost 89:1024-30. 2003
    ..Increased nitric oxide bioavailability can only partially explain the reduced platelet activation by eplerenone and ACE inhibition...
  94. ncbi request reprint Addition of the selective aldosterone receptor antagonist eplerenone to ACE inhibition in heart failure: effect on endothelial dysfunction
    Andreas Schafer
    Medizinische Klinik der Julius Maximilians Universität Würzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Cardiovasc Res 58:655-62. 2003
    ..To investigate the effects of adding the selective aldosterone receptor antagonist eplerenone to ACE inhibition on endothelium-dependent vasodilation in rats with chronic heart failure (CHF)...
  95. ncbi request reprint Improvement of endothelial dysfunction by selective estrogen receptor-alpha stimulation in ovariectomized SHR
    Julian Widder
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    Hypertension 42:991-6. 2003
    ..The novel selective ERalpha agonist Cpd1471 prevented these pathophysiological changes to a similar extent as E2. Thus, the pharmacological principle of selective ERalpha activation mediates positive vascular effects...
  96. ncbi request reprint Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction
    Daniela Fraccarollo
    Medizinische Klinik der Julius Maximilians Universität Würzburg, Wurzburg, Germany
    J Am Coll Cardiol 42:1666-73. 2003
    ....
  97. ncbi request reprint Endothelial dysfunction in congestive heart failure: ACE inhibition vs. angiotensin II antagonism
    Andreas Schafer
    Medizinische Klinik der Julius Maximilians Universität Würzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Eur J Heart Fail 6:151-9. 2004
    ..The present study systematically investigated the effect of angiotensin II (AT(1))- receptor blockade on vascular superoxide (O(2)(-)) production and endothelial dysfunction...
  98. ncbi request reprint Rapid regulation of platelet activation in vivo by nitric oxide
    Andreas Schafer
    Department of Cardiovascular Medicine, University of Oxford, UK
    Circulation 109:1819-22. 2004
    ..We investigated whether acute inhibition of NO production in humans modulates platelet activation in vivo and whether exogenous NO would counteract such an effect...
  99. ncbi request reprint Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent
    Julian Widder
    Medizinische Klinik, Julius Maximilians Universitat, Wurzburg, Germany
    Cardiovasc Res 63:161-7. 2004
    ..The mitogen-activated protein (MAP) kinase system, especially the p38 MAP kinase, is activated in chronic heart failure (CHF). However, the role of vascular p38 MAP kinase in CHF has not been analyzed yet...
  100. ncbi request reprint Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo
    Andreas Schafer
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Arterioscler Thromb Vasc Biol 24:1720-6. 2004
    ..We investigated whether acute inhibition of NO production modulates platelet activation in mice and whether specific rescue of endothelial function in diabetes modifies platelet activation...
  101. ncbi request reprint Repetitive postprandial hyperglycemia increases cardiac ischemia/reperfusion injury: prevention by the alpha-glucosidase inhibitor acarbose
    Stefan Frantz
    Medizinische Klinik der Universität Würzburg, Wurzburg, Germany
    FASEB J 19:591-3. 2005
    ..In summary, repetitive postprandial hyperglycemia increases ischemia/reperfusion damage. This effect can be prevented by treatment with the alpha-glucosidase inhibitor acarbose...