Lutz Wollin

Summary

Affiliation: ALTANA Pharma AG
Country: Germany

Publications

  1. ncbi request reprint Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors
    L Wollin
    ALTANA Pharma, Byk Gulden Strasse 2, 78467 Konstanz, Germany
    Pulm Pharmacol Ther 19:343-52. 2006
  2. ncbi request reprint Roflumilast inhibition of pulmonary leukotriene production and bronchoconstriction in ovalbumin-sensitized and -challenged Guinea pigs
    Lutz Wollin
    ALTANA Pharma, Konstanz, Germany
    J Asthma 42:873-8. 2005
  3. ncbi request reprint Cyclooxygenase-inhibition enhances the effects of rSP-C surfactant therapy in a rat lavage model of acute respiratory distress syndrome (ARDS)
    Dietrich Häfner
    Department of Respiratory Pharmacology, Byk Gulden, Konstanz, Germany
    Exp Toxicol Pathol 55:59-68. 2003
  4. ncbi request reprint Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    J Pharmacol Exp Ther 307:349-55. 2003
  5. ncbi request reprint Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke
    Piero A Martorana
    Department of Physiopathology and Experimental Medicine, University of Siena, Via Aldo Moro 6, I 53100 Siena, Italy
    Am J Respir Crit Care Med 172:848-53. 2005

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors
    L Wollin
    ALTANA Pharma, Byk Gulden Strasse 2, 78467 Konstanz, Germany
    Pulm Pharmacol Ther 19:343-52. 2006
    ..This study suggests that roflumilast has anti-inflammatory action and provides rationale for the investigation of roflumilast in asthmatic patients...
  2. ncbi request reprint Roflumilast inhibition of pulmonary leukotriene production and bronchoconstriction in ovalbumin-sensitized and -challenged Guinea pigs
    Lutz Wollin
    ALTANA Pharma, Konstanz, Germany
    J Asthma 42:873-8. 2005
    ..06 mg/kg) and LTB4 (ID50 = 0.05 mg/kg) release versus placebo-treated animals. Roflumilast did not affect LTD4-induced bronchoconstriction. These findings support the role of roflumilast as an anti-inflammatory treatment for asthma...
  3. ncbi request reprint Cyclooxygenase-inhibition enhances the effects of rSP-C surfactant therapy in a rat lavage model of acute respiratory distress syndrome (ARDS)
    Dietrich Häfner
    Department of Respiratory Pharmacology, Byk Gulden, Konstanz, Germany
    Exp Toxicol Pathol 55:59-68. 2003
    ....
  4. ncbi request reprint Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    J Pharmacol Exp Ther 307:349-55. 2003
    ..Roflumilast did not diminish accumulation of transforming growth factor-beta1, suggesting that it might affect remodeling by mechanisms distinct from glucocorticoids...
  5. ncbi request reprint Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke
    Piero A Martorana
    Department of Physiopathology and Experimental Medicine, University of Siena, Via Aldo Moro 6, I 53100 Siena, Italy
    Am J Respir Crit Care Med 172:848-53. 2005
    ..There is a need for new agents capable of suppressing the inflammatory response in chronic obstructive pulmonary disease...