Kevin L Briggman
Affiliation: Abteilung Zellphysiologie
- Bulk electroporation and population calcium imaging in the adult mammalian retinaKevin L Briggman
Department of Biomedical Optics, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
J Neurophysiol 105:2601-9. 2011..Importantly, the ganglion cell layer remains accessible for subsequent intracellular recording and morphological identification...
- Wiring specificity in the direction-selectivity circuit of the retinaKevin L Briggman
Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg 69120, Germany
Nature 471:183-8. 2011..Our study demonstrates how otherwise intractable neurobiological questions can be addressed by combining functional imaging with the analysis of neuronal connectivity using large-scale electron microscopy...
- Multifunctional pattern-generating circuitsK L Briggman
Department of Biomedical Optics, Max Planck Institute for Medical Research, Heidelberg, 69120 Germany
Annu Rev Neurosci 31:271-94. 2008..Recent advances in both analytical and experimental tools have aided the study of these complex circuits...
- Connectomic reconstruction of the inner plexiform layer in the mouse retinaMoritz Helmstaedter
Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
Nature 500:168-74. 2013..Circuit motifs that emerge from our data indicate a functional mechanism for a known cellular response in a ganglion cell that detects localized motion, and predict that another ganglion cell is motion sensitive...
- High-accuracy neurite reconstruction for high-throughput neuroanatomyMoritz Helmstaedter
Max Planck Institute for Medical Research, Heidelberg, Germany
Nat Neurosci 14:1081-8. 2011..Focused reannotation of difficult locations promises a rather steep increase of reliability as a function of the average skeleton redundancy and thus the nearly error-free analysis of large neuroanatomical datasets...
- Structural neurobiology: missing link to a mechanistic understanding of neural computationWinfried Denk
Max Planck Institute for Medical Research, Heidelberg 69120, Germany
Nat Rev Neurosci 13:351-8. 2012..Given that the brain's algorithms are ultimately encoded by this network, knowing where all of these connections are should, at the very least, provide the data needed to distinguish between models of neural computation...
- 3D structural imaging of the brain with photons and electronsMoritz Helmstaedter
Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg, Germany
Curr Opin Neurobiol 18:633-41. 2008..Both photon-based and electron-based imaging methods will ultimately need highly automated data analysis, because the manual tracing of most networks of interest would require hundreds to tens of thousands of years in human labor...
- From crawling to cognition: analyzing the dynamical interactions among populations of neuronsKevin L Briggman
Max Planck Institute for Medical Research, Department of Biomedical Optics, Jahnstrasse 29, Heidelberg 69120, Germany
Curr Opin Neurobiol 16:135-44. 2006..An understanding of modern analysis techniques is crucially important for researchers interested in the co-varying activity among populations of neurons or even brain regions...
- Towards neural circuit reconstruction with volume electron microscopy techniquesKevin L Briggman
Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Curr Opin Neurobiol 16:562-70. 2006..Such reconstructions of complete neural wiring diagrams could rekindle the tradition of relating neural function to the underlying neuroanatomical circuitry...
- Optical imaging of neuronal populations during decision-makingK L Briggman
Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0357, USA
Science 307:896-901. 2005..The analysis highlighted the neuron cell 208. Hyperpolarizing cell 208 during a stimulus biases the leech to swim; depolarizing it biases the leech to crawl or to delay swimming...