- Quantitative proteomic analysis of anticancer drug RH1 resistance in liver carcinomaMarija Ger
Vilnius University Institute of Biochemistry, Vilnius, Lithuania Electronic address
Biochim Biophys Acta 1864:219-32. 2016..Acquired resistance of tumor cells to the therapeutic treatment is a major challenge in virtually any chemotherapy. A novel anticancer agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1) is designed to be activated by..
- Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activityMarija Ger
Proteomics Centre, Vilnius University Institute of Biochemistry, Lithuania
Cell Signal 23:1651-8. 2011..This leads to the complex dissipation, decrease of RasGAP activity and the increase of H-Ras-GTP level in the detached cells. Our findings reveal unexpected feature of adaptor protein Nck1 as the regulator of RasGAP activity...
- Klebsiella phage vB_KleM-RaK2 - a giant singleton virus of the family MyoviridaeEugenijus Simoliunas
Department of Molecular Microbiology and Biotechnology, Institute of Biochemistry, Vilnius University, Vilnius, Lithuania
PLoS ONE 8:e60717. 2013..Overall, these results provide evidence that bacteriophage RaK2 differs profoundly from previously studied viruses of the Myoviridae family...